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公开(公告)号：US07513902B2
公开(公告)日：2009-04-07
申请号：US10845313
申请日：2004-05-13
IPC分类号： A61B17/50
CPC分类号： A61B17/32093 , A61B10/0233 , A61B17/0643 , A61B17/0644 , A61B17/068 , A61B17/08 , A61B17/30 , A61B17/32 , A61B17/3205 , A61B17/32053 , A61B17/3211 , A61B2010/0208 , A61B2017/00761 , A61B2017/0641 , A61B2017/081 , A61B2017/1225
摘要： A device for excising tissue and closing a wound that results from excision of the tissue includes structure defining an aperture into which tissue to be excised is exposed. The device also includes a cutting member for excising the tissue, a closure member for closing the wound, and an actuatable drive member associated with the structure. The drive member is actuatable to move the cutting member relative to the aperture for excising the tissue that is exposed in the aperture and for closing the wound with the closure member.
摘要翻译： 用于切除组织并闭合由组织切除引起的伤口的装置包括限定要被切除组织的孔的结构。 该装置还包括用于切除组织的切割构件，用于封闭伤口的关闭构件以及与该结构相关联的致动驱动构件。 驱动构件可致动以相对于孔移动切割构件，用于切除暴露在孔中的组织并且用闭合构件封闭伤口。
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2.发明授权公开(公告)号：US07905842B2
公开(公告)日：2011-03-15
申请号：US11639098
申请日：2006-12-14
IPC分类号： A61B10/00
CPC分类号： A61B17/32093 , A61B10/02 , A61B17/08 , A61B17/085 , A61B17/32 , A61B17/3211 , A61B17/322 , A61B2010/0208 , A61B2017/00747 , A61B2017/00761 , A61B2017/00774 , A61B2017/081
摘要： An apparatus (10) and method for excising tissue (208) and closing a wound (156) that results from excision of the tissue (208) is provided. The apparatus (10) includes structure (14) defining an aperture (34) into which tissue (208) to be excised is exposed and a cutting member (96). The apparatus (10) also includes an adhesive bandage (140) for closing the wound (156). The adhesive bandage (140) is secured relative to a lower surface (20) of the structure (14) in a location for contacting skin (154) adjacent to the tissue (208) to be excised. The apparatus (10) further includes a device (150) that is actuatable for closing the wound (156) with the adhesive bandage (140) and actuators (108 and 182) for moving the cutting member (96) relative to the structure (14) for excising the tissue (208) exposed in the aperture (34) and for actuating the device (150).
摘要翻译： 提供了一种用于切除组织（208）并关闭由组织（208）切除引起的伤口（156）的装置（10）和方法。 装置（10）包括限定要被切除的组织（208）暴露的孔（34）的结构（14）和切割构件（96）。 装置（10）还包括用于封闭伤口（156）的胶粘绷带（140）。 粘合绷带（140）相对于结构（14）的下表面（20）固定在用于接触待切除的组织（208）的皮肤（154）的位置。 装置（10）还包括一个装置（150），该装置可致动以用粘合绷带（140）和用于相对于结构（14）移动切割构件（96）的致动器（108和182）来闭合伤口 ），用于切除暴露在孔（34）中的组织（208）并用于致动装置（150）。
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公开(公告)号：US20080249549A1
公开(公告)日：2008-10-09
申请号：US12062085
申请日：2008-04-03
IPC分类号： A61B17/3205 , A61B17/064 , A61B17/068
CPC分类号： A61B17/32093 , A61B10/0233 , A61B17/0643 , A61B17/0644 , A61B17/068 , A61B17/08 , A61B17/30 , A61B17/32 , A61B17/3205 , A61B17/32053 , A61B17/3211 , A61B2010/0208 , A61B2017/00761 , A61B2017/0641 , A61B2017/081 , A61B2017/1225
摘要： A device for excising tissue and closing a wound that results from excision of the tissue includes structure defining an aperture into which tissue to be excised is exposed. The device also includes a cutting member for excising the tissue, a closure member for closing the wound, and an actuatable drive member associated with the structure. The drive member is actuatable to move the cutting member relative to the aperture for excising the tissue that is exposed in the aperture and for closing the wound with the closure member.
摘要翻译： 用于切除组织并闭合由组织切除引起的伤口的装置包括限定要被切除组织的孔的结构。 该装置还包括用于切除组织的切割构件，用于封闭伤口的关闭构件以及与该结构相关联的致动驱动构件。 驱动构件可致动以相对于孔移动切割构件，用于切除暴露在孔中的组织并且用闭合构件封闭伤口。
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公开(公告)号：US07806907B2
公开(公告)日：2010-10-05
申请号：US10261155
申请日：2002-09-30
IPC分类号： A61B17/32
CPC分类号： A61B17/32093 , A61B10/0233 , A61B17/0643 , A61B17/0644 , A61B17/068 , A61B17/08 , A61B17/30 , A61B17/32 , A61B17/3205 , A61B17/32053 , A61B17/3211 , A61B2010/0208 , A61B2017/00761 , A61B2017/0641 , A61B2017/081 , A61B2017/1225
摘要： A skin lesion exciser including a moving blade, wherein excision of a skin lesion placed in proximity to the blade is effected by movement of the blade against the skin, a moving engagement portion, wherein the blade and the engagement portion have coincident movement, and a skin-closure device having an open condition prior to excision of the skin lesion, and a closed condition in which the device holds the skin closed after excision of the skin lesion. The device is in engagement with the engagement portion during movement of the blade, and the device is moved from its open to its closed condition in response to movement of the engagement portion. The excision of the skin lesion and the closure of the skin are substantially simultaneous. The present invention also provides a method for excising a skin lesion including: positioning a skin lesion above a moving blade; slicing the lesion from the skin with the blade; and substantially simultaneously with excision of the lesion, closing the skin beneath the moving blade. The present invention also provides a skin-closure device which may be used in conjunction with an inventive exciser.
摘要翻译： 一种包括动叶片的皮肤病变切除器，其中通过所述刀片抵靠所述皮肤的运动来实现放置在所述刀片附近的皮肤损伤的切除，其中所述刀片和所述接合部分具有一致的运动，以及 在切除皮肤损伤之前具有开放状态的皮肤闭合装置，以及在皮肤损伤切除后装置保持皮肤闭合的闭合状态。 该装置在叶片移动期间与接合部分接合，并且该装置响应于接合部分的移动而从其打开状态移动到其关闭状态。 皮肤损伤的消除和皮肤的闭合基本上同时发生。 本发明还提供了一种切除皮肤损伤的方法，包括：将皮肤损伤定位在动叶片上方; 用刀片从皮肤切片病变; 并且基本上同时切除病变，闭合移动刀片下面的皮肤。 本发明还提供了可以与本发明的切除器结合使用的皮肤闭合装置。
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公开(公告)号：US20100249919A1
公开(公告)日：2010-09-30
申请号：US12750800
申请日：2010-03-31
IPC分类号： A61F2/24
CPC分类号： A61F2/2427 , A61B17/0643 , A61F2/2457 , A61F2/2466
摘要： A pre-sized prosthetic chordae assembly includes a male attachment unit and a female securing member. The male attachment unit includes a plurality of pre-sized prosthetic chordae fixedly connected to at least one male attachment member and a papillary muscle penetration member that is connected to and extends substantially axial to the at least one male attachment member. The female securing member is for receiving the papillary penetration member.
摘要翻译： 预定尺寸的假肢腱索组件包括阳连接单元和阴固定构件。 阳性附接单元包括固定地连接到至少一个阳连接构件和乳头状肌穿透构件的多个预定尺寸的假肢腱索，其连接到并且基本上轴向延伸到至少一个阳连接构件。 阴固定构件用于接收乳头穿透构件。
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公开(公告)号：US08439969B2
公开(公告)日：2013-05-14
申请号：US12750800
申请日：2010-03-31
IPC分类号： A61F2/24
CPC分类号： A61F2/2427 , A61B17/0643 , A61F2/2457 , A61F2/2466
摘要： A pre-sized prosthetic chordae assembly includes a male attachment unit and a female securing member. The male attachment unit includes a plurality of pre-sized prosthetic chordae fixedly connected to at least one male attachment member and a papillary muscle penetration member that is connected to and extends substantially axial to the at least one male attachment member. The female securing member is for receiving the papillary penetration member.
摘要翻译： 预定尺寸的假肢腱索组件包括阳连接单元和阴固定构件。 阳性附接单元包括固定地连接到至少一个阳连接构件和乳头状肌穿透构件的多个预定尺寸的假肢腱索，其连接到并且基本上轴向延伸到至少一个阳连接构件。 阴固定构件用于接收乳头穿透构件。
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公开(公告)号：US20090088837A1
公开(公告)日：2009-04-02
申请号：US12238322
申请日：2008-09-25
CPC分类号： A61B17/0643 , A61B5/1072 , A61B5/6869 , A61B17/10 , A61B2017/00243 , A61B2090/061 , A61F2/2457 , A61F2/2466
摘要： A prosthetic chordae assembly includes a plurality of equally-sized, interconnected loop members formed from a single strand of a biocompatible material. Each of the loop members includes first and second ends respectively defining a first arcuate junction and a second arcuate junction. The prosthetic chordae assembly is adjustable to a pre-determined length by removing one of the loop members.
摘要翻译： 假肢腱索组件包括由生物相容性材料的单股形成的多个相等尺寸的互连的环形构件。 每个环构件包括分别限定第一弧形结和第二弧形结的第一端和第二端。 假肢腱索组件通过移除环形构件中的一个可调节到预定长度。
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8.发明授权公开(公告)号：US08021350B2
公开(公告)日：2011-09-20
申请号：US12320613
申请日：2009-01-29
申请人： Anthony Calabro , Aniq B. Darr , Kiyotaka Fukamachi , Richard A. Gross , Keiji Kamohara , Michael K. Banbury
发明人： Anthony Calabro , Aniq B. Darr , Kiyotaka Fukamachi , Richard A. Gross , Keiji Kamohara , Michael K. Banbury
CPC分类号： C08B37/0072 , A61K47/6903 , C08G73/02 , C08H1/00 , C08J3/24 , C08J3/246 , C12N5/0068 , C12N5/0655 , C12N2533/30
摘要： A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic macromolecular network for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are described. In an embodiment, the network is composed of tyramine-substituted and cross-linked hyaluronan molecules, wherein cross-linking is achieved via peroxidase-mediated dityramine-linkages that can be performed in vivo. The dityramine bonds provide a stable, coherent hyaluronan-based hydrogel with desired physical properties.
摘要翻译： 提供了可用于人造组织和组织工程应用的二羟基苯基交联的大分子网络，特别是提供用于各种组织类型的合成大分子网络。 特别地，描述人造或合成软骨，声带材料，玻璃体材料，软组织材料和二尖瓣材料。 在一个实施方案中，网络由酪胺取代和交联的透明质酸分子组成，其中通过可以在体内进行的过氧化物酶介导的二联胺连接来实现交联。 二联苯键提供具有所需物理性质的稳定的，一致的透明质酸基水凝胶。
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