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    Apparatus for applying material for selectively modifying the optical properties of metabolically different cells
    3.
    发明授权
    Apparatus for applying material for selectively modifying the optical properties of metabolically different cells 失效
    用于施加材料以选择性地改变代谢不同细胞的光学性质的装置

    公开(公告)号：US07163397B2

    公开(公告)日：2007-01-16

    申请号：US10753799

    申请日：2004-01-08

    申请人： Rainer Hahn ,  Klaus Irion

    发明人： Rainer Hahn ,  Klaus Irion

    IPC分类号： A61C5/00 ,  A61C5/04

    CPC分类号： A61K49/0036 ,  A61B5/0088 ,  A61C19/063 ,  A61K6/10 ,  A61K41/0057 ,  A61K49/0021 ,  A61K49/0073 ,  C08L91/00

    摘要： An apparatus for applying a viscous modification material includes a material source of the modification material and a needle connected to the source. A material for selectively modifying the optical properties of cells comprises a basic material and a modification substance distributed in the basic material at a prescribed concentration, wherein the basic material comprises a viscous fluid, a gel, a two-dimensional or three-dimensional porous substrate or a material which hardens in situ. A diagnostic apparatus for determining the optical properties of cells which have been exposed to such a material and an apparatus for irradiating cells whose optical properties have been differently modified with such a material are also provided.

    摘要翻译： 用于施加粘性改性材料的装置包括改性材料的材料源和连接到源的针。 用于选择性地改变电池的光学性质的材料包括以规定浓度分布在碱性材料中的碱性材料和改性物质，其中基本材料包括粘性流体，凝胶，二维或三维多孔基材 或原位硬化的材料。 还提供了一种用于确定暴露于这种材料的电池的光学特性的诊断装置和用于照射具有这种材料的光学性能被不同地修改的电池的装置。

    Diagnostic apparatus for determining the remineralization ability of tissue
    4.
    发明授权
    Diagnostic apparatus for determining the remineralization ability of tissue 失效
    用于确定组织再矿化能力的诊断装置

    公开(公告)号：US06997883B1

    公开(公告)日：2006-02-14

    申请号：US09402731

    申请日：1998-04-07

    申请人： Rainer Hahn

    发明人： Rainer Hahn

    IPC分类号： A61B5/00 ,  A61C19/04

    CPC分类号： A61C19/04 ,  A61B5/0059 ,  A61B5/05 ,  A61B5/4547 ,  A61B8/08 ,  A61C3/03

    摘要： The invention relates to a diagnostic apparatus with which diseased hard tissue, in particular carious dental tissue, can be examined through a small working channel, to see whether it can be made healthy again by remineralization. This diagnosis apparatus tightly (54) seals the working channel, produced in the tissue, from its environment, and places the cavity in the tissue under pressure, after which the pressurization is ended and a pressure drop is measured by means of a pressure measuring instrument (60). The speed of the drop in pressure is a measure of the extent of the changes to the diseased tissue. The invention also relates to a treatment device for supporting the remineralization or reinfiltration of diseased hard tissue and for preparing this, as well as to diagnosis and treatment agents and treatment substances.

    摘要翻译： 本发明涉及通过小工作通道检查病变硬组织，特别是龋牙组织的诊断装置，以便通过再矿化观察其是否可再次健康。 该诊断装置（54）紧密地密封在组织中产生的工作通道与其环境，并将空腔置于组织中的压力下，之后加压结束，并通过压力测量仪器测量压降 （60）。 压力下降的速度是对病变组织变化程度的度量。 本发明还涉及一种用于支持患病硬组织的再矿化或再渗透并用于制备其的治疗装置，以及诊断和治疗剂和治疗物质。

    Organic compounds
    7.
    发明申请
    Organic compounds 有权
    有机化合物

    公开(公告)号：US20090203069A1

    公开(公告)日：2009-08-13

    申请号：US11919257

    申请日：2006-04-25

    申请人： Alois Jungbauer ,  Rainer Hahn ,  Anne Tscheliessnig ,  Waltraud Kaar

    发明人： Alois Jungbauer ,  Rainer Hahn ,  Anne Tscheliessnig ,  Waltraud Kaar

    IPC分类号： C12P21/06 ,  C07K7/06 ,  C07K7/08

    CPC分类号： C12P21/02 ,  C07K1/22 ,  C07K17/06 ,  C12N9/506 ,  C12N15/62

    摘要： Disclosed is a method for the production of a heterologous polypeptide of interest with a homogenous N-terminus, using a fusion polypeptide comprising the polypeptide of interest and N-terminally thereto a polypeptide exhibiting autoproteolytic function, said method comprising the steps of a) binding of the fusion polypeptide in a soluble, autoproteolytically inactive form by an affinity chromatography system, b) refolding of the fusion polypeptide, thereby activating the autoproteolytic function of the fusion polypeptide and causing cleavage of the heterologous polypeptide of interest, and c) subsequently eluting the heterologous polypeptide of interest, wherein said steps are conducted on one affinity chromatography system.

    摘要翻译： 公开了使用包含感兴趣的多肽的融合多肽和N末端具有表达自身蛋白水解功能的多肽来产生具有均质N末端的异源多肽的方法，所述方法包括以下步骤：a） 通过亲和层析系统以可溶性，自动蛋白水解无活性形式的融合多肽，b）融合多肽的折叠，从而激活融合多肽的自体蛋白水解功能，并导致感兴趣的异源多肽切割，以及c）随后将异源 多肽，其中所述步骤在一个亲和层析系统上进行。

    Storage container for a suspension used for medical purposes
    8.
    发明授权
    Storage container for a suspension used for medical purposes 失效
    用于医疗用途的悬浮液的储存容器

    公开(公告)号：US07044940B1

    公开(公告)日：2006-05-16

    申请号：US09547156

    申请日：2000-04-11

    申请人： Rainer Hahn ,  Uwe Grotz ,  Ulrich Prager

    发明人： Rainer Hahn ,  Uwe Grotz ,  Ulrich Prager

    IPC分类号： A61B7/00 ,  B65D83/10

    CPC分类号： A61C5/66 ,  B65D2231/002

    摘要： A storage container (1) for a suspension used for medical purposes, in particular for ultrasonically assisted treatment of periodontitis, dental cleaning or dental preparation, comprises a flexible pouch (2), the interior of which is accessible via a charging and discharging nozzle (5). Situated in the interior of the pouch (2) is a distance element (6), in which a groove system (8, 9, 10) is incorporated. The groove system communicates with the interior of the charging and discharging nozzle (5). When the pouch (2) of said storage container (1) is pressed flat during removal of the suspension it contains, the opposing sides (3, 4) of the pouch (3) are applied during the final phase of emptying against the distance element (6). The groove system (8, 9, 10) contained in the latter however remains clear and forms a path, via which even the last residues of the suspension may be reliably removed from the pouch (2).

    摘要翻译： 用于医疗用途，特别是用于牙周炎，牙齿清洁或牙科制剂的超声辅助治疗的悬液的储存容器（1）包括柔性袋（2），其内部可通过充放电喷嘴 5）。 位于袋（2）的内部的是距离元件（6），其中结合有凹槽系统（8,9,10）。 凹槽系统与充放电喷嘴（5）的内部连通。 当所述储存容器（1）的袋（2）在其包含的悬浮液的移除期间被压平时，在排空距离元件的最后阶段期间施加袋（3）的相对侧面（3,4） （6）。 然而，容纳在后者中的凹槽系统（8,9,10）保持透明并形成路径，甚至可以从袋（2）中可靠地移除悬架的最后残留物。

    Method for producing 6,10 and 6,9-dimethyl-5,10-undecadienyl-2-ones
    9.
    发明授权
    Method for producing 6,10 and 6,9-dimethyl-5,10-undecadienyl-2-ones 失效
    制备6,10和6,9-二甲基-5,10-十一二烯基-2-酮的方法

    公开(公告)号：US06310259B1

    公开(公告)日：2001-10-30

    申请号：US09446734

    申请日：2000-03-23

    申请人： Wilhelm Keim ,  Armin Kraus ,  Rainer Hahn ,  Klaus Huthmacher

    发明人： Wilhelm Keim ,  Armin Kraus ,  Rainer Hahn ,  Klaus Huthmacher

    IPC分类号： C07C4500

    CPC分类号： C07C45/676 ,  C07C49/203 ,  C07C67/347 ,  C07C69/738

    摘要： The present application refers to a process for preparing 6,10- and 6,9-dimethyl-5,10-undecadienyl-2-ones by telomerizing isoprene with alkyl acetoacetates in the presence of a catalyst system containing a transition metal compound catalyst and a phosphorus- or arsenic-containing compound cocatalyst, wherein the process is performed in the presence of a protic additive of the general formula in which: R1, R2, R3 represent an alkyl group with 1 to 9 carbon atoms, branched or unbranched, a cycloalkyl group with 6 to 8 carbon atoms, an aryl group, in particular phenyl, or an arylalkyl group, X(−) represents an inorganic or organic anion, y is 1 or 2, and the &bgr;-ketoester so obtained is saponified and decarboxylated in a manner known per se.

    摘要翻译： 本申请是指通过在含有过渡金属化合物催化剂的催化剂体系存在下将异戊二烯与乙酰乙酸烷基酯聚合来制备6,10-和6,9-二甲基-5,10-十一二烯基-2-酮的方法， 含磷或砷的化合物助催化剂，其中该方法在一般形式的质子添加剂存在下进行：其中R1，R2，R3代表具有1至9个碳原子的烷基，支链或非支链，环烷基 具有6至8个碳原子，芳基，特别是苯基或芳基烷基，X（ - ）表示无机或有机阴离子，y为1或2，所得到的β-酮酯被皂化并脱羧 本身已知的方式。

    Mold for producing a model of a tooth
    10.
    发明授权
    Mold for producing a model of a tooth 失效
    用于生产牙齿模型的模具

    公开(公告)号：US06217326B1

    公开(公告)日：2001-04-17

    申请号：US09424693

    申请日：2000-03-06

    申请人： Rainer Hahn

    发明人： Rainer Hahn

    IPC分类号： A61C900

    CPC分类号： A61C9/002

    摘要： The invention relates to a mold for producing the model of a tooth from a dental impression (28), comprising a peripheral wall (12), a model plate (38) which is tightly arranged on the top thereof and an impression spoon (14) bearing the dental impression (28). Said spoon is tightly inserted into the lower end of the peripheral wall (12). The hollow cavity (42) thus obtained is filled with molding material to give a highly precise tooth model requiring no further mechanical processing.

    摘要翻译： 本发明涉及一种用于从牙印模（28）制造牙齿模型的模具，其包括周壁（12），紧密地布置在其顶部的模板（38）和压勺（14）， 承载牙齿印模（28）。 所述勺子紧紧插入周壁（12）的下端。 由此获得的空腔（42）填充有模制材料，以提供不需要进一步机械加工的高精度的牙齿模型。