公开(公告)号：US20120301481A1

公开(公告)日：2012-11-29

申请号：US13554245

申请日：2012-07-20

申请人： Michael Otto ,  Stanislava Kocianova ,  Cuong Vuong ,  Jovanka Voyich ,  Yufeng Yao ,  Elizabeth Fischer ,  Frank De Leo

发明人： Michael Otto ,  Stanislava Kocianova ,  Cuong Vuong ,  Jovanka Voyich ,  Yufeng Yao ,  Elizabeth Fischer ,  Frank De Leo

IPC分类号： A61K39/085 ,  A61P31/04 ,  A61K39/40

CPC分类号： C12P21/02 ,  A61K39/085 ,  A61K2039/6037 ,  A61K2039/6056 ,  A61K2039/6081 ,  C07K16/1271 ,  C07K2317/77

摘要： Immunogenic compositions and methods for eliciting an immune response against S. epidermidis and other related staphylococci are provided. The immunogenic compositions can include immunogenic conjugates of poly-γ-glutamic acid (such as γDLPGA) polypeptides of S. epidermidis, or related staphylococci that express a γPGA polypeptide. The γPGA conjugates elicit an effective immune response against S. epidermidis, or other staphylococci, in subjects to which the conjugates are administered. A method of treating an infection caused by a Staphylococcus organism that expresses cap genes is also disclosed. The method can include selecting a subject who is at risk of or has been diagonosed with the infection by the Staphylococcus organism which expresses γPGA from the cap genes. Further, the expression of a γPGA polypeptide by the organism can then be altered.

摘要翻译： 提供了免疫原性组合物和引发针对表皮葡萄球菌和其他相关葡萄球菌的免疫应答的方法。 免疫原性组合物可以包括表达表皮葡萄球菌的多聚γ-谷氨酸（例如γDLPGA）多肽或表达γPGA多肽的相关葡萄球菌的免疫原性缀合物。 γPGA偶联物在施用共轭物的受试者中引起对表皮葡萄球菌或其他葡萄球菌的有效免疫应答。 还公开了治疗由表达帽基因的葡萄球菌生物引起的感染的方法。 该方法可以包括选择与帽基因表达γPGA的葡萄球菌生物有感染危险或已经发生交叉的对象。 此外，可以改变生物体的γPGA多肽的表达。

公开(公告)号：US08252550B2

公开(公告)日：2012-08-28

申请号：US13035716

申请日：2011-02-25

申请人： Michael Otto ,  Stanislava Kocianova ,  Cuong Vuong ,  Jovanka Voyich ,  Yufeng Yao ,  Elizabeth Fischer ,  Frank De Leo

发明人： Michael Otto ,  Stanislava Kocianova ,  Cuong Vuong ,  Jovanka Voyich ,  Yufeng Yao ,  Elizabeth Fischer ,  Frank De Leo

IPC分类号： A61K39/385

CPC分类号： C12P21/02 ,  A61K39/085 ,  A61K2039/6037 ,  A61K2039/6056 ,  A61K2039/6081 ,  C07K16/1271 ,  C07K2317/77

摘要： Immunogenic compositions and methods for eliciting an immune response against S. epidermidis and other related staphylococci are provided. The immunogenic compositions can include immunogenic conjugates of poly-γ-glutamic acid (such as γDLPGA) polypeptides of S. epidermidis, or related staphylococci that express a γPGA polypeptide. The γPGA conjugates elicit an effective immune response against S. epidermidis, or other staphylococci, in subjects to which the conjugates are administered. A method of treating an infection caused by a Staphylococcus organism that expresses cap genes is also disclosed. The method can include selecting a subject who is at risk of or has been diagnosed with the infection by the Staphylococcus organism which expresses γPGA from the cap genes. Further, the expression of a γPGA polypeptide by the organism can then be altered.

摘要翻译： 提供了免疫原性组合物和引发针对表皮葡萄球菌和其他相关葡萄球菌的免疫应答的方法。 免疫原性组合物可以包括表达表皮葡萄球菌的多聚γ-谷氨酸（例如γDLPGA）多肽或表达γPGA多肽的相关葡萄球菌的免疫原性缀合物。 γPGA偶联物在施用共轭物的受试者中引起对表皮葡萄球菌或其他葡萄球菌的有效免疫应答。 还公开了治疗由表达帽基因的葡萄球菌生物引起的感染的方法。 该方法可以包括从帽基因中选择具有表达γPGA的葡萄球菌生物的风险或被诊断患有感染的受试者。 此外，可以改变生物体的γPGA多肽的表达。

公开(公告)号：US20110217312A1

公开(公告)日：2011-09-08

申请号：US13035716

申请日：2011-02-25

申请人： Michael Otto ,  Stanislava Kocianova ,  Cuong Vuong ,  Jovanka Voyich ,  Yufeng Yao ,  Elizabeth Fischer ,  Frank De Leo

发明人： Michael Otto ,  Stanislava Kocianova ,  Cuong Vuong ,  Jovanka Voyich ,  Yufeng Yao ,  Elizabeth Fischer ,  Frank De Leo

IPC分类号： A61K39/385 ,  A61K39/40 ,  C12Q1/14 ,  C12P21/00 ,  A61P31/04

CPC分类号： C12P21/02 ,  A61K39/085 ,  A61K2039/6037 ,  A61K2039/6056 ,  A61K2039/6081 ,  C07K16/1271 ,  C07K2317/77

摘要： Immunogenic compositions and methods for eliciting an immune response against S. epidermidis and other related staphylococci are provided. The immunogenic compositions can include immunogenic conjugates of poly-γ-glutamic acid (such as γDLPGA) polypeptides of S. epidermidis, or related staphylococci that express a γPGA polypeptide. The γPGA conjugates elicit an effective immune response against S. epidermidis, or other staphylococci, in subjects to which the conjugates are administered. A method of treating an infection caused by a Staphylococcus organism that expresses cap genes is also disclosed. The method can include selecting a subject who is at risk of or has been diagnosed with the infection by the Staphylococcus organism which expresses γPGA from the cap genes. Further, the expression of a γPGA polypeptide by the organism can then be altered.

摘要翻译： 提供了免疫原性组合物和引发针对表皮葡萄球菌和其他相关葡萄球菌的免疫应答的方法。 免疫原性组合物可以包括表达表皮葡萄球菌的多聚γ-谷氨酸（例如γDLPGA）多肽或表达γPGA多肽的相关葡萄球菌的免疫原性缀合物。 γPGA偶联物在施用共轭物的受试者中引起对表皮葡萄球菌或其他葡萄球菌的有效免疫应答。 还公开了治疗由表达帽基因的葡萄球菌生物引起的感染的方法。 该方法可以包括从帽基因中选择具有表达γPGA的葡萄球菌生物的风险或被诊断患有感染的受试者。 此外，可以改变生物体的γPGA多肽的表达。

公开(公告)号：US08866064B2

公开(公告)日：2014-10-21

申请号：US13191260

申请日：2011-07-26

申请人： Yufeng Yao ,  Chee Heng Wong ,  Sze Ping Ong

发明人： Yufeng Yao ,  Chee Heng Wong ,  Sze Ping Ong

IPC分类号： H01J40/14 ,  H01L31/173 ,  H01L33/62 ,  H03K17/96 ,  G01V8/20

CPC分类号： G01V8/20 ,  H01L31/173 ,  H03K17/9629 ,  H03K17/9631

摘要： A proximity sensor with multi-directional movement detection is provided. The proximity sensor may include an ASIC chip; at least three light sources configured to emit light in a particular sequence; and a photo detector configured to receive light and generate an output signal. The multi-directional proximity sensor may have a first proximity sensor with at least one side surface and a second proximity sensor connected to the first proximity sensor configured to detect object movement over a plane substantially parallel to the at least one side surface of the first proximity sensor. The multi-directional movement detection proximity sensor may include a PCB, in which more than one proximity sensor may be disposed on the PCB and operatively integrated to detect multi-directional movement.

摘要翻译： 提供了具有多向运动检测的接近传感器。 接近传感器可以包括ASIC芯片; 至少三个光源被配置为以特定顺序发光; 以及被配置为接收光并产生输出信号的光电检测器。 多向接近传感器可以具有至少一个侧表面的第一接近传感器和连接到第一接近传感器的第二接近传感器，第一接近传感器被配置成检测物体在基本上平行于第一接近的至少一个侧表面的平面上的移动 传感器。 多向运动检测接近传感器可以包括PCB，其中可以在PCB上布置多于一个接近传感器并且可操作地集成以检测多方向运动。

公开(公告)号：US08502151B2

公开(公告)日：2013-08-06

申请号：US12697276

申请日：2010-01-31

申请人： Yufeng Yao ,  Junhua He ,  Wee Sin Tan

发明人： Yufeng Yao ,  Junhua He ,  Wee Sin Tan

IPC分类号： G01J5/20 ,  G01J5/02 ,  H01L27/146 ,  H01L31/0232 ,  H01L31/0203 ,  H01L21/00

CPC分类号： H01L31/0203 ,  G01S7/4813 ,  G01S17/026 ,  H01L31/173 ,  H01L2224/48247 ,  H01L2224/49171 ,  H01L2924/3025 ,  H01L2924/00

摘要： Various embodiments of an optical proximity sensor having a lead frame and no overlying metal shield are disclosed. In one embodiment, a light emitter and a light detector are mounted on a lead frame comprising a plurality of discrete electrically conductive elements having upper and lower surfaces, at least some of the elements not being electrically connected to one another. An integrated circuit is die-attached to an underside of the lead frame. An optically-transmissive infrared pass compound is molded over the light detector and the light emitter and portions of the lead frame. Next, an optically non-transmissive infrared cut compound is molded over the optically-transmissive infrared pass compound to provide an optical proximity sensor having no metal shield but exhibiting very low crosstalk characteristics.

摘要翻译： 公开了具有引线框并且没有上覆金属屏蔽的光学接近传感器的各种实施例。 在一个实施例中，光发射器和光检测器安装在引线框架上，该引线框架包括具有上表面和下表面的多个分立的导电元件，至少一些元件不彼此电连接。 集成电路芯片附着在引线框架的下侧。 在光检测器和光发射器和引线框架的部分上模制光学透射的红外通过化合物。 接下来，在透光性红外线通过化合物上模制光学上不透光的红外线切割化合物，以提供没有金属屏蔽但具有非常低的串扰特性的光学接近传感器。

公开(公告)号：US08143608B2

公开(公告)日：2012-03-27

申请号：US12557516

申请日：2009-09-10

申请人： Yufeng Yao ,  Chi Boon Ong

发明人： Yufeng Yao ,  Chi Boon Ong

IPC分类号： H01J40/14 ,  H01L31/09

CPC分类号： G01S17/026 ,  G01S7/4813 ,  G01S17/48 ,  H01L25/167 ,  H01L31/0203 ,  H01L31/173 ,  H01L2224/48465 ,  H01L2924/3025 ,  H03K17/941 ,  H03K2217/94108 ,  H01L2924/00

摘要： Various embodiments of a package-on-package optical sensor comprising three distinct different packages are disclosed. The three different packages are combined to form the optical proximity sensor, where the first package is a light emitter package, the second package is a light detector package, and the third package is an integrated circuit package. First and second infrared light pass components are molded or casted atop the light emitter package and the light detector package after they have been mounted atop the integrated circuit package. An infrared light cut component is then molded or casted between and over portions of the light emitter package and the light detector package.

摘要翻译： 公开了包括三个不同的封装的封装封装的光学传感器的各种实施例。 三个不同的组合被组合以形成光学接近传感器，其中第一封装是光发射器封装，第二封装是光检测器封装，第三封装是集成电路封装。 第一和第二红外光通过部件在它们被安装在集成电路封装之上之后被模制或铸造在光发射器封装和光检测器封装之上。 然后将红外光切割部件模制或铸造在光发射器封装和光检测器封装的部分之间。

公开(公告)号：US20110186736A1

公开(公告)日：2011-08-04

申请号：US12697276

申请日：2010-01-31

申请人： Yufeng Yao ,  Junhua He ,  Wee Sin Tan

发明人： Yufeng Yao ,  Junhua He ,  Wee Sin Tan

IPC分类号： H01L31/167 ,  H01L31/0203 ,  H01L31/12

CPC分类号： H01L31/0203 ,  G01S7/4813 ,  G01S17/026 ,  H01L31/173 ,  H01L2224/48247 ,  H01L2224/49171 ,  H01L2924/3025 ,  H01L2924/00

摘要： Various embodiments of an optical proximity sensor having a lead frame and no overlying metal shield are disclosed. In one embodiment, a light emitter and a light detector are mounted on a lead frame comprising a plurality of discrete electrically conductive elements having upper and lower surfaces, at least some of the elements not being electrically connected to one another. An integrated circuit is die-attached to an underside of the lead frame. An optically-transmissive infrared pass compound is molded over the light detector and the light emitter and portions of the lead frame. Next, an optically non-transmissive infrared cut compound is molded over the optically-transmissive infrared pass compound to provide an optical proximity sensor having no metal shield but exhibiting very low crosstalk characteristics.

摘要翻译： 公开了具有引线框并且没有上覆金属屏蔽的光学接近传感器的各种实施例。 在一个实施例中，光发射器和光检测器安装在引线框架上，该引线框架包括具有上表面和下表面的多个分立的导电元件，至少一些元件不彼此电连接。 集成电路芯片附着在引线框架的下侧。 在光检测器和光发射器和引线框架的部分上模制光学透射的红外通过化合物。 接下来，在透光性红外线通过化合物上模制光学上不透光的红外线切割化合物，以提供没有金属屏蔽但具有非常低的串扰特性的光学接近传感器。

公开(公告)号：US08619267B2

公开(公告)日：2013-12-31

申请号：US13178665

申请日：2011-07-08

申请人： Chee Heng Wong ,  Yufeng Yao ,  Han Kang Chong

发明人： Chee Heng Wong ,  Yufeng Yao ,  Han Kang Chong

IPC分类号： G01B11/14

CPC分类号： G01S17/026 ,  G01S17/87 ,  H03K17/943 ,  H03K2217/94108 ,  H03K2217/94111

摘要： A proximity sensor with movement detection is provided. The proximity sensor may include an ASIC chip; at least three light sources configured to emit light in a particular sequence; and a photo detector configured to receive light and generate an output signal. The proximity sensor may have a compact size package, wherein the photo detector may be stacked on the ASIC chip and disposed at a substantially equal distance from the at least three light sources. The proximity sensor includes a driver operable to generate a current to a plurality of light sources in a particular timing sequence, a photo detector configured to receive light and generate an output signal, an ASIC configured to report the movement of an object near the proximity sensor if the output signal pattern generated matches one of the output signal patterns from among a set of known output signal patterns. The proximity sensor may be configured to be used as a counter or an on/off switch based on particular movements detected.

摘要翻译： 提供了具有运动检测的接近传感器。 接近传感器可以包括ASIC芯片; 至少三个光源被配置为以特定顺序发光; 以及被配置为接收光并产生输出信号的光电检测器。 接近传感器可以具有紧凑尺寸的封装，其中光电检测器可以堆叠在ASIC芯片上并且设置在与至少三个光源基本相等的距离处。 接近传感器包括驱动器，其可操作以在特定时序中产生电流到多个光源;配置成接收光并产生输出信号的光电检测器;被配置为报告物体靠近接近传感器的移动的ASIC 如果产生的输出信号模式与一组已知输出信号模式中的一个输出信号模式匹配。 接近传感器可以被配置为基于检测到的特定运动而用作计数器或开/关开关。

公开(公告)号：US08558161B2

公开(公告)日：2013-10-15

申请号：US12853566

申请日：2010-08-10

申请人： Chi Boon Ong ,  Yufeng Yao ,  Sze Ping Ong

发明人： Chi Boon Ong ,  Yufeng Yao ,  Sze Ping Ong

IPC分类号： H01J3/14

CPC分类号： H01L33/58 ,  G02B3/02 ,  G02B19/0028 ,  G02B19/0061 ,  G02B19/0071 ,  G02B19/008 ,  H01L25/167 ,  H01L33/54 ,  H01L2924/0002 ,  H01L2924/00

摘要： A lens element comprising a base, a plurality of lens sections and a top lens section is disclosed. The plurality of lens sections are formed above a planar parallel to the base with each of the lens sections being positioned rotationally symmetric about an optical axis. The lens sections define a dome shape with every adjoining lens sections being conjugated with each other. A top lens section is formed at the center above the other lens sections and conjugated therewith. All of the lens sections are conjugated with each of its neighboring lens sections. Each of the lens sections has a optical property to direct light towards a target point. The target point may be positioned along the optical axis.

摘要翻译： 公开了一种包括基座，多个透镜部分和顶部透镜部分的透镜元件。 多个透镜部分形成在平行于基部的平面上方，每个透镜部分围绕光轴旋转对称。 透镜部分限定圆顶形状，每个相邻的透镜部分彼此共轭。 顶透镜部分形成在其它透镜部分上方的中心并与之共轭。 所有透镜部分与其相邻透镜部分中的每一个共轭。 每个透镜部分具有将光引向目标点的光学性质。 目标点可以沿着光轴定位。

公开(公告)号：US20130010310A1

公开(公告)日：2013-01-10

申请号：US13178665

申请日：2011-07-08

申请人： Chee Heng Wong ,  Yufeng Yao ,  Han Kang Chong

发明人： Chee Heng Wong ,  Yufeng Yao ,  Han Kang Chong

IPC分类号： G01B11/14

CPC分类号： G01S17/026 ,  G01S17/87 ,  H03K17/943 ,  H03K2217/94108 ,  H03K2217/94111

摘要： A proximity sensor with movement detection is provided. The proximity sensor may include an ASIC chip; at least three light sources configured to emit light in a particular sequence; and a photo detector configured to receive light and generate an output signal. The proximity sensor may have a compact size package, wherein the photo detector may be stacked on the ASIC chip and disposed at a substantially equal distance from the at least three light sources. The proximity sensor includes a driver operable to generate a current to a plurality of light sources in a particular timing sequence, a photo detector configured to receive light and generate an output signal, an ASIC configured to report the movement of an object near the proximity sensor if the output signal pattern generated matches one of the output signal patterns from among a set of known output signal patterns. The proximity sensor may be configured to be used as a counter or an on/off switch based on particular movements detected.

摘要翻译： 提供了具有运动检测的接近传感器。 接近传感器可以包括ASIC芯片; 至少三个光源被配置为以特定顺序发光; 以及被配置为接收光并产生输出信号的光电检测器。 接近传感器可以具有紧凑尺寸的封装，其中光电检测器可以堆叠在ASIC芯片上并且设置在与至少三个光源基本相等的距离处。 接近传感器包括驱动器，其可操作以在特定时序中产生电流到多个光源;配置成接收光并产生输出信号的光电检测器;被配置为报告物体靠近接近传感器的移动的ASIC 如果产生的输出信号模式与一组已知输出信号模式中的一个输出信号模式匹配。 接近传感器可以被配置为基于检测到的特定运动而用作计数器或开/关开关。