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    Bis-transition-metal-chelate probes
    4.
    发明申请
    Bis-transition-metal-chelate probes 有权
    双过渡金属螯合探针

    公开(公告)号：US20050031545A1

    公开(公告)日：2005-02-10

    申请号：US10946786

    申请日：2004-09-21

    Applicant: Richard Ebright ,  Yon Ebright

    Inventor： Richard Ebright ,  Yon Ebright

    IPC: C07D209/14 ,  C12Q1/68 ,  G01N33/533 ,  A61K51/00

    CPC classification number: G01N33/533 ,  C07D209/14 ,  C12Q1/6825 ,  C12Q2563/113

    Abstract: A molecule for labeling a target material is provided including two transition-metal chelates and a detectable group. The molecule has the general structural formula (I): wherein: (a) Y and Y′ are each a transition metal, (b) R1 and R1′ are each independently CH(COO−), CH(COOH), or absent; (c) R2 and R2′ are linkers each having a length of from about 3.0 to about 20 Å; and (d) X is a detectable group. The linkers may be linear or branched, may contain aromatic moieties, and may optionally be further substituted. Methods of using the molecules of the invention as probes in detecting and analyzing target materials as well as kits including the molecule of the invention are also provided.

    Abstract translation: 提供了用于标记靶材料的分子，包括两个过渡金属螯合物和可检测的基团。 该分子具有通式结构式（I）：其中：（a）Y和Y'各自为过渡金属，（b）R 1和R 1'各自独立地为CH（COO - ）， CH（COOH）或不存在; （c）R 2和R 2'是各自具有约3.0至约20的长度的接头; 和（d）X是可检测的基团。 接头可以是直链或支链的，可以含有芳族部分，并且可以任选被进一步取代。 还提供了使用本发明的分子作为检测和分析靶材料的探针的方法以及包括本发明的分子的试剂盒。

    Target and method for inhibition of bacterial rna polymerase
    5.
    发明申请
    Target and method for inhibition of bacterial rna polymerase 审中-公开

    公开(公告)号：US20060160158A1

    公开(公告)日：2006-07-20

    申请号：US10526323

    申请日：2003-09-04

    Applicant: Richard Ebright

    Inventor： Richard Ebright

    IPC: G01N33/554 ,  A61K38/16 ,  C07K14/32 ,  C07H21/04

    CPC classification number: G01N33/533 ,  C07K14/245 ,  G01N33/502 ,  G01N33/569 ,  G01N2500/00

    Abstract: Target and method for inhibition of bacterial RNA polymerase disclosed are targets and methods for specific binding and inhibition of RNAP from bacterial species. Bacterial RNA polymerase RPOC_ECOLI (736) QIRQLAGMRGLM (779) ARK RPOC_HAEIN (737) QIRQLAGMRGLM (780) ARK RPOC_VIBCH (736) QIRQLAGMRGLM (779) ARK RPOC_PSEAE (736) QIRQLAGMRGLM (779) ARK RPOC_TREPA (703) QIRQLAGMRGLM (746) ARK RPOC_BORBU (699) QIRQLAGMRGLM (742) ARK RPOC_XYLFA (759) QIRQLAAMRGLM (802) ARK RPOC_CAMJE (734) QISQLAAMRGLM (777) ARK RPOC_NEIMA (738) QIKQLSGMRGLM (781) ARK RPOC_RICPR (730) QIKQLGGMRGLM (773) MRK RPOC_THEMA(1010) QVKQLAGIRGLM(1072) ARK RPOC_CHLTR (736) QLKQLGALRGLM (779) ARK RPOC_MYCPN (820) NFTQLFGMRGLM (874) ARK RPOC_BACSU (740) NFTQLAGMRGLM (783) ARK RPOC_STAAU (744) NFTQLAGMRGLM (787) ARK RPOC_MYCTU (813) QTRTLAGMKGLV (856) ARK RPOC_SYNY3 (763) QVRQLVGMRGLM (806) ARK RPOC_AQUAE (850) QIRQLAGMRGLM (893) ARK RPOC_DEIRA(1052) QIRQLAGMRGLM(1095) ARK RPOC_TTHER(1034) QIRQLCGLRGLM(1077) ARK RPOC_THEAQ(1034) QIRQLCGMRGLM(1077) ARK Human RNA polymerases I, II, and III RPA1_HUMAN (908) NTMQISCLLGQI (971) GRE RPB1_HUMAN (780) NISQVIAVVGQQ (843) GRE RPC1_HUMAN (791) NISQMIACVGQQ (854) GRE

    Reagents and procedures for multi-label high-specificity labeling
    6.
    发明申请
    Reagents and procedures for multi-label high-specificity labeling 有权
    多标签高特异性标记的试剂和程序

    公开(公告)号：US20060141530A1

    公开(公告)日：2006-06-29

    申请号：US11256900

    申请日：2005-10-24

    Applicant: Richard Ebright ,  Yon Ebright

    Inventor： Richard Ebright ,  Yon Ebright

    IPC: G01N33/53 ,  C07F9/80 ,  C07K14/47

    CPC classification number: G01N33/542 ,  C07K5/0827 ,  C07K5/1013 ,  C07K7/06 ,  C07K7/08 ,  G01N33/58 ,  G01N33/582 ,  Y10S435/968 ,  Y10S436/80 ,  Y10S436/805

    Abstract: A detectable complex and methods for use thereof are provided herein. The detectable complex includes: at least one target material; a first peptide tag bound to the at least one target material; and a second peptide tag bound to the at least one target material. The complex further includes a first conjugate having a detectable group and two pendant phenylarsine moieties comprising a first tag binding group; wherein the first conjugate preferentially associates with the first peptide tag; and a second conjugate having a detectable group and two pendant phenylarsine moieties comprising a second tag binding group; wherein the second conjugate preferentially associates with the second peptide tag. The mean distance and/or mean angle between the pendant phenylarsine moieties in the first conjugate is different from the mean distance and/or mean angle between the pendant phenylarsine moieties in the second conjugate. Further provided herein are useful peptide tag combinations, target materials or sets of target materials including these peptide tag combinations, and nucleic acids or nucleic acid sets encoding these compositions.

    Abstract translation: 本文提供可检测的复合物及其使用方法。 可检测的复合物包括：至少一种靶材料; 与所述至少一种靶材料结合的第一肽标签; 和与所述至少一种靶材料结合的第二肽标签。 所述复合物还包括具有可检测基团的第一缀合物和包含第一标签结合基团的两个侧链胂基部分; 其中所述第一缀合物优先与所述第一肽标签缔合; 和具有可检测基团的第二缀合物和包含第二标签结合基团的两个侧链胂基部分; 其中所述第二缀合物优先与所述第二肽标签相关联。 第一共轭物中的侧基胂基部分之间的平均距离和/或平均角度不同于第二共轭物中的侧基胂基部分之间的平均距离和/或平均角度。 本文进一步提供了有用的肽标签组合，靶标材料或包含这些肽标签组合的靶物质组以及编码这些组合物的核酸或核酸组。

    Rna-exit-channel: target and method for inhibition of bacterial rna polymerase
    7.
    发明申请
    Rna-exit-channel: target and method for inhibition of bacterial rna polymerase 有权
    Rna-exit-channel：目标和抑制细菌rna聚合酶的方法

    公开(公告)号：US20060127905A1

    公开(公告)日：2006-06-15

    申请号：US10527559

    申请日：2004-05-28

    Applicant: Richard Ebright

    Inventor： Richard Ebright

    IPC: C12Q1/68 ,  G01N33/554 ,  G01N33/569

    CPC classification number: C12Q1/18 ,  C12N9/1247 ,  C12Q1/48 ,  G01N2333/9125 ,  G01N2500/00

    Abstract: The invention provides a target and methods for specific binding and inhibition of RNAP from bacterial species. The invention is directed to a method for identifying agents that bind to a bacterial RNAP homologous RNA-exit-channel amino-acid sequence, comprising preparing a reaction solution comprising the agent to be tested and an entity comprising a bacterial RNAP homologous RNA-exit-channel amino-acid sequence, and detecting presence or amount of binding. The invention has applications in control of bacterial gene expression, control of bacterial growth, antibacterial chemistry, and antibacterial therapy.

    Abstract translation: 本发明提供了用于从细菌物种特异性结合和抑制RNAP的靶标和方法。 本发明涉及一种用于鉴定结合细菌RNAP同源的RNA-出口通道氨基酸序列的试剂的方法，包括制备包含待测试试剂的反应溶液和包含细菌RNAP同源RNA-出口通道氨基酸序列的实体， 通道氨基酸序列，并检测存在或结合量。 本发明可用于控制细菌基因表达，细菌生长控制，抗菌化学和抗菌治疗。

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