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公开(公告)号：US10278810B2
公开(公告)日：2019-05-07
申请号：US13096729
申请日：2011-04-28
申请人： Liane Clamen , Paul Glazer , Michael T. Milbocker
发明人： Liane Clamen , Paul Glazer , Michael T. Milbocker
IPC分类号： A61F2/16
摘要： A device and method for forming an adaptive optic in the capsule of a human eye is disclosed, comprising a capsular interface enclosing an optically acceptable medium. The device establishes a physiologic range of optical power in response to a range of ciliary contractile states. The preferred bi-phasic medium of the device is comprised of a solid three dimensional polymeric network suspended in a liquid aqueous phase and bonded to a capsular interface. The polymeric network provides shape to the capsular interface, optical power, and a physiologic response to the suspensory ligament. The three dimensional network of the bi-phasic medium mimics the stacked fiber configuration and elasticity of a natural lens. An alternative embodiment utilizing a single phase medium is also disclosed with associated structural features provided in the capsular interface.
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公开(公告)号：US08869802B2
公开(公告)日：2014-10-28
申请号：US13086754
申请日：2011-04-14
CPC分类号： A61F2/442 , A61F2002/30069 , A61F2002/30586 , A61F2002/30733 , A61F2002/3092 , A61F2002/444
摘要： Disclosed herein are methods for treating a defect in a spinal disc nuclear space, comprising: (a) creating an opening by open, percutaneous or laparoscopic techniques to access the defect in the nuclear space; (b) removing a desired amount of tissue from the nuclear space; (c) positioning a delivery catheter through the opening; (d) fluidically isolating the nuclear space by blocking the opening with a blocking component of the catheter; (e) delivering an in-situ curable liquid material through a lumen of the catheter to the nuclear space; and (f) maintaining the isolating until the liquid material has cured. Also disclosed are treatment systems and materials for prostheses.
摘要翻译： 本文公开了用于治疗脊椎椎间盘核空间缺陷的方法，其包括：（a）通过开放，经皮或腹腔镜技术产生开放以接近核空间中的缺陷; （b）从核空间中去除所需量的组织; （c）将输送导管定位通过所述开口; （d）通过用导管的阻挡部件阻塞开口来流体地隔离核空间; （e）将原位可固化的液体材料通过导管的内腔递送到核空间; 和（f）保持隔离直到液体材料固化。 还公开了用于假体的处理系统和材料。
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公开(公告)号：US08604099B2
公开(公告)日：2013-12-10
申请号：US13422448
申请日：2012-03-16
申请人： Michael T. Milbocker
发明人： Michael T. Milbocker
CPC分类号： A61L27/50 , A61F2/0036 , A61L27/18 , C08L75/04
摘要： The present invention relates to a hydrated, biocompatible tissue-augmentation compound and methodology for its implantation into mammalian tissue. The tissue-augmentation compound is comprised of: living tissue, optionally body derived fluids, and at least one NCO-terminated hydrophilic urethane prepolymer derived from an organic polyisocyanate, and oxyethylene-containing diols or polyols in which essentially all of hydroxyl groups are capped with polyisocyanate.
摘要翻译： 本发明涉及水合的生物相容性组织增加化合物及其植入哺乳动物组织的方法。 组织增强化合物包括：活组织，任选的身体衍生的流体，以及至少一种衍生自有机多异氰酸酯的至少一种NCO封端的亲水氨基甲酸酯预聚物和含氧乙烯的二醇或多元醇，其中基本上所有的羟基被封端 多异氰酸酯。
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4.发明授权Passive cardiac restraint systems having multiple layers of inflatable elements 有权被动心脏约束系统具有多层可充气元件公开(公告)号：US06547716B1
公开(公告)日：2003-04-15
申请号：US09723565
申请日：2000-11-28
申请人： Michael T. Milbocker
发明人： Michael T. Milbocker
IPC分类号： A61F200
CPC分类号： A61F2/2481 , A61M1/1001 , A61M1/1003 , A61M1/106 , A61M1/1065 , A61M1/1068 , A61M1/1086 , A61M1/12 , A61M1/127 , A61M2205/33 , A61M2205/3303 , A61M2205/8243
摘要： A non-blood contacting, implantable heart assist system surrounds the natural heart and provides resistance to cardiac hypertrophy. The restraint system is composed of adjacent tube pairs arranged along a bias with respect to the axis of the heart and bound in a non-distensible sheath forming a heart wrap. The tube pairs are tapered at both ends such that when they are compressed they approximately follow the surface of the myocardium. Inflation of the tube pairs with a compressible fluid causes the wrap to exert a restraining force on the heart to prevent overexpansion during diastole.
摘要翻译： 非血液接触植入式心脏辅助系统围绕天然心脏并提供对心脏肥大的抵抗力。 约束系统由相对于心脏的轴线的偏置布置的相邻管对组成并且结合在形成心脏包裹物的不可扩张的鞘中。 管对在两端是锥形的，使得当它们被压缩时，它们大致跟随心肌的表面。 管对与可压缩流体的膨胀导致包裹对心脏施加约束力以防止舒张期期间的过度扩张。
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公开(公告)号：US4856891A
公开(公告)日：1989-08-15
申请号：US14994
申请日：1987-02-17
CPC分类号： A61B3/113 , A61B2017/00694 , A61F2009/00846 , A61F9/00821
摘要： An eye movement tracker for stabilizing in two dimensions a diagnostic, treatment or other ophthalmic illumination on the fundus has a laser source which produces a narrow directed tracking beam, an optical steering assembly for controllably directing the beam to illuminate a region of the fundus, and an optical imaging assembly for imaging the illuminated region on a spatially-distributed photodetecting element. A tracking circuit scans the detecting element to detect motion of a spatially variant intensity feature and controls the optical steering assembly to redirect the optical path and maintain the feature in a fixed position. This repositions the diagnostic or other illumination, maintaining it in a fixed position on the fundus during eye movement. Scanning rates many times those of conventional systems are achieved, effectively stabilizing even very rapid eye movements. A viewing port provides an operator with a 30 degree field of the subject's eye fundus.
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公开(公告)号：US20130295037A1
公开(公告)日：2013-11-07
申请号：US13934788
申请日：2013-07-03
申请人： Michael T. Milbocker
发明人： Michael T. Milbocker
IPC分类号： A61L24/04
CPC分类号： A61L24/046 , C08G18/10 , C08G18/12 , C08G18/4812 , C08G18/4837 , C08G18/6677 , C08G18/755 , C08G2210/00 , C09J175/04 , C08L75/04 , C08G18/302
摘要： A biocompatible tissue-bonding adhesive composition having a polyol of functionality N. The polyol being terminated has at least one polyisocyanate in solution with at least (N−1) % of the solution having free polyisocyanate. N may be in the range 1.5-8. The polyol may be a branched polypropylene/polyethylene oxide copolymer.
摘要翻译： 具有功能性N的多元醇的生物相容性组织粘合剂组合物。封端的多元醇在溶液中具有至少一种多异氰酸酯，至少（N-1）％的溶液具有游离多异氰酸酯。 N可能在1.5-8的范围内。 多元醇可以是支化聚丙烯/聚环氧乙烷共聚物。
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公开(公告)号：US20120179176A1
公开(公告)日：2012-07-12
申请号：US13337393
申请日：2011-12-27
IPC分类号： A61B17/03
CPC分类号： A61L31/10 , A61F2/0063 , A61F2002/009 , A61F2210/0076 , A61F2250/0091 , A61L31/14 , A61L31/16 , C08L71/02
摘要： The present invention relates to a composite prosthesis including a coated mesh having at least one opening through a first surface and a second surface of the coated mesh; the coated mesh comprising a mesh and a biocompatible coating substantially surrounding each filament of the mesh, wherein the biocompatible coating is formed by coating the mesh with a polyol prepolymer and curing the prepolymer, the prepolymer comprising a polyalkylene oxide polyol end capped with isocyanate, the polyalkylene oxide polyol having from about 70% to about 95% ethylene oxide groups and the remainder propylene oxide; and a barrier material comprising a biocompatible membrane constructed and arranged to cover at least one surface of the coated mesh, wherein the barrier material comprises a biologic material.
摘要翻译： 复合假体技术领域本发明涉及一种复合假体，其包括具有穿过第一表面的至少一个开口和涂覆的网的第二表面的涂覆网格; 所述涂覆网包括网和基本上围绕所述网的每个细丝的生物相容性涂层，其中所述生物相容性涂层通过用多元醇预聚物涂覆所述网并固化所述预聚物形成，所述预聚物包含用异氰酸酯封端的聚环氧烷多元醇， 具有约70％至约95％环氧乙烷基团的聚环氧烷多元醇，其余为环氧丙烷; 以及阻挡材料，其包括构造和布置成覆盖所述涂覆网的至少一个表面的生物相容膜，其中所述阻挡材料包括生物材料。
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8.发明申请REVERSIBLY GELLING POLYURETHANE COMPOSITION FOR SURGICAL REPAIR AND AUGMENTATION 有权用于外科修复和补充的可逆性聚氨酯组合物公开(公告)号：US20090012462A1
公开(公告)日：2009-01-08
申请号：US12162039
申请日：2007-01-24
摘要： A new reversibly gelling polyurethane (RGP) polymer composition is described, as well as novel processes for its preparation, and its medical uses for filling spaces in tissue, or bulking tissue, or for restoring organ function. The novel RGP polymer forms a gel on standing, liquefies during shear and reversibly reforms a macroscopic gel on standing after being sheared. Methods of use include delivering the improved gel to a site on the body to fill voids or to augment local tissue bulk.
摘要翻译： 描述了新的可逆胶凝聚氨酯（RGP）聚合物组合物，以及其制备的新方法及其用于填充组织或膨胀组织中的空间或恢复器官功能的医疗用途。 新型RGP聚合物在静置时形成凝胶，在剪切过程中液化并在剪切后可立即重新形成宏观凝胶。 使用的方法包括将改进的凝胶递送到身体上的部位以填充空隙或增加局部组织体积。
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公开(公告)号：US06626821B1
公开(公告)日：2003-09-30
申请号：US09863887
申请日：2001-05-22
IPC分类号： A61M112
CPC分类号： A61M1/122 , A61M1/1008 , A61M1/106 , A61M1/1068 , A61M1/1086 , A61M1/12 , A61M2205/33 , A61M2205/3303
摘要： A flow-balanced cardiac wrap that assists the right and left ventricles of an affected heart to differing, and adjustable degrees is provided. The wrap generally applies an assist to the left ventricle that is greater than that applied to the right, or that reduces blood output from the right relative to the left. In one embodiment, the wrap comprises a material covering that is applied around the right and left ventricles of the heart, so that the left ventricle is assisted over a larger surface area than the right. The positioning of the right ventricular portion or the wrap is chosen so that desired pumping characteristics for the right ventricle are achieved.
摘要翻译： 提供了一种流量平衡的心脏包裹，其帮助受影响的心脏的右心室和左心室具有不同的和可调节的程度。 包裹通常对左心室施加大于右侧应用的辅助，或者减少右侧相对于左侧的血液输出。 在一个实施例中，包裹物包括围绕心脏的右心室和左心室施加的材料，使得左心室辅助于比右侧更大的表面积。 选择右心室部分或包裹物的定位，从而实现对右心室的期望的泵送特性。
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公开(公告)号：US06602182B1
公开(公告)日：2003-08-05
申请号：US09723805
申请日：2000-11-28
申请人： Michael T. Milbocker
发明人： Michael T. Milbocker
IPC分类号： A61B1700
CPC分类号： A61M1/122 , A61M1/1001 , A61M1/1003 , A61M1/106 , A61M1/1068 , A61M1/1086 , A61M1/12 , A61M1/127 , A61M2205/33 , A61M2205/3303 , A61M2205/8243 , A61M2230/04
摘要： A unified, non-blood contacting, implantable heart assist system surrounds the natural heart and provides circumferential contraction in synchrony with the heart's natural contractions. The pumping unit is composed of adjacent tube pairs arranged along a bias with respect to the axis of the heart and bound in a non-distensible sheath forming a heart wrap. The tube pairs are tapered at both ends such that when they are juxtaposed and deflated they approximately follow the surface of the diastolic myocardium. Inflation of the tube pairs causes the wrap to follow the motion of the myocardial surface during systole. A muscle-driven or electromagnetically powered energy converter inflates the tubes using hydraulic fluid pressure. An implanted electronic controller detects electrical activity in the natural heart, synchronizes pumping activity with this signal, and measures and diagnoses system as well as physiological operating parameters for automated operation. A transcutaneous energy transmission and telemetry subsystem allows the Unified System to be controlled and powered externally.
摘要翻译： 统一的非血液接触植入式心脏辅助系统围绕自然心脏，并与心脏的自然收缩同步提供周向收缩。 泵送单元由相对于心轴的偏置布置的相邻管对构成，并且结合在形成心脏包裹的不可扩张的鞘中。 管对在两端呈锥形，使得当它们并列并放气时，它们大致跟随舒张期心肌的表面。 在管收缩的情况下，管的通气使得包裹在收缩期间跟随心肌表面的运动。 肌肉驱动或电磁动力的能量转换器使用液压流体压力来充气管。 植入的电子控制器检测自然心脏中的电活动，使该活动与该信号同步，并且测量和诊断系统以及用于自动操作的生理操作参数。 经皮能量传输和遥测子系统允许统一系统从外部进行控制和供电。
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