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    Mutant delta-9 elongases and their use in making polyunsaturated fatty acids
    1.
    发明授权
    Mutant delta-9 elongases and their use in making polyunsaturated fatty acids 有权
    突变型Δ-9延伸酶及其在制备多不饱和脂肪酸中的应用

    公开(公告)号：US08980589B2

    公开(公告)日：2015-03-17

    申请号：US13218591

    申请日：2011-08-26

    申请人： Michael W. Bostick ,  Hongxian He ,  Yougen Li ,  Quinn Qun Zhu

    发明人： Michael W. Bostick ,  Hongxian He ,  Yougen Li ,  Quinn Qun Zhu

    IPC分类号： C12P21/06 ,  C12P7/64 ,  C12N9/10 ,  C12N15/81

    CPC分类号： C12N9/1029 ,  C12N15/815 ,  C12P7/6472 ,  C12Y203/01016

    摘要： Mutant delta-9 elongases having the ability to convert linoleic acid [18:2, LA] to eicosadienoic acid [20:2, EDA] and/or α-linolenic [18:3, ALA] to eicosatrienoic acid [20:3, ETrA] are disclosed herein. Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding mutant delta-9 elongases, along with a method of making long chain polyunsaturated fatty acids [“PUFAs”] using these mutant delta-9 elongases in oleaginous yeast are also disclosed.

    摘要翻译： 具有将亚油酸[18：2，LA]转化成二十碳烯酸[20：2，EDA]和/或α-亚麻酸[18：3，ALA]至二十碳三烯酸[20：3]的能力的突变型Δ-9延伸酶 ETrA]。 还公开了分离的核酸片段和包含编码突变型Δ-9延伸酶的这种片段的重组构建物，以及在含油酵母中使用这些突变型Δ-9延长酶制备长链多不饱和脂肪酸的方法[“PUFA”。

    Mutant delta-8 desaturase genes engineered by targeted mutagenesis and their use in making polyunsaturated fatty acids
    7.
    发明申请
    Mutant delta-8 desaturase genes engineered by targeted mutagenesis and their use in making polyunsaturated fatty acids 有权
    通过靶向诱变工程改造的突变型δ-8去饱和酶基因及其在制备多不饱和脂肪酸中的应用

    公开(公告)号：US20080138868A1

    公开(公告)日：2008-06-12

    申请号：US11635258

    申请日：2006-12-07

    申请人： Howard Glenn Damude ,  Hongxian He ,  Der-Ing Liao ,  Quinn Qun Zhu

    发明人： Howard Glenn Damude ,  Hongxian He ,  Der-Ing Liao ,  Quinn Qun Zhu

    IPC分类号： C12P7/64 ,  C07H21/04 ,  C07K1/00 ,  C12N1/00

    CPC分类号： C12N9/0083

    摘要： The present invention relates to mutant Δ8 desaturase genes, which have the ability to convert eicosadienoic acid [20:2 ω-6, EDA] to dihomo-γ-linolenic acid [20:3, DGLA] and/or eicosatrienoic acid [20:3 ω-3, ETrA] to eicosatetraenoic acid [20:3 ω-3, ETA]. Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding Δ8 desaturase along with methods of making long-chain polyunsaturated fatty acids (PUFAs) using these mutant Δ8 desaturases in plants and oleaginous yeast are disclosed.

    摘要翻译： 本发明涉及具有将二十碳二烯酸[20：2ω-6，EDA]转化为二高-γ-亚麻酸[20:3，DGLA]和/或二十碳三烯酸[20：3]的能力的突变型Δδ去饱和酶基因 3ω-3，ETrA]至二十碳四烯酸[20：3ω-3，ETA]。 公开了分离的核酸片段和重组构建体，其包含编码Δ8去饱和酶的片段以及使用这些突变型Delta8去饱和酶在植物和油质酵母中制备长链多不饱和脂肪酸（PUFA）的方法。

    Mutant delta-8 desaturase genes engineered by targeted mutagensis and their use in making polyunsaturated fatty acids
    8.
    发明授权
    Mutant delta-8 desaturase genes engineered by targeted mutagensis and their use in making polyunsaturated fatty acids 有权
    突变型delta-8去饱和酶基因由目标mutagensis工程化及其在制备多不饱和脂肪酸中的应用

    公开(公告)号：US08017838B2

    公开(公告)日：2011-09-13

    申请号：US11951697

    申请日：2007-12-06

    申请人： Howard G. Damude ,  Hongxian He ,  Der-ing Liao ,  Quinn Qun Zhu

    发明人： Howard G. Damude ,  Hongxian He ,  Der-ing Liao ,  Quinn Qun Zhu

    IPC分类号： C12N15/82 ,  A01H5/00

    CPC分类号： C12N15/8247 ,  C12N9/0083

    摘要： The present invention relates to mutant delta-8 desaturase genes, which have the ability to convert eicosadienoic acid [20:2 omega-6, EDA] to dihomo-γ-linolenic acid [20:3, DGLA] and/or eicosatrienoic acid [20:3 omega-3, ETrA] to eicosatetraenoic acid [20:3 omega-3, ETA]. Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding delta-8 desaturase along with methods of making long-chain polyunsaturated fatty acids (PUFAs) using these mutant delta-8 desaturases in plants and oleaginous yeast are disclosed.

    摘要翻译： 本发明涉及具有将二十碳二烯酸[20：2ω-6，EDA]转化为二高-γ-亚麻酸[20:3，DGLA]和/或二十碳三烯酸[...]的能力的突变体δ-8去饱和酶基因[ 20：3ω-3，ETrA]至二十碳四烯酸[20：3ω-3，ETA]。 公开了分离的核酸片段和重组构建体，其包含编码δ-8去饱和酶的片段以及使用植物中的这些突变型δ-8去饱和酶和油性酵母制备长链多不饱和脂肪酸（PUFA）的方法。

    MUTANT DELTA-8 DESATURASE GENES ENGINEERED BY TARGETED MUTAGENESIS AND THEIR USE IN MAKING POLYUNSATURATED FATTY ACIDS
    9.
    发明申请
    MUTANT DELTA-8 DESATURASE GENES ENGINEERED BY TARGETED MUTAGENESIS AND THEIR USE IN MAKING POLYUNSATURATED FATTY ACIDS 有权
    突变的DELTA-8去饱和基因通过靶向的诱变工程及其在制备多糖脂肪酸中的应用

    公开(公告)号：US20100297713A1

    公开(公告)日：2010-11-25

    申请号：US12726390

    申请日：2010-03-18

    申请人： HOWARD GLENN DAMUDE ,  Hongxian He ,  Der-ing Liao ,  Quinn Qun Zhu

    发明人： HOWARD GLENN DAMUDE ,  Hongxian He ,  Der-ing Liao ,  Quinn Qun Zhu

    IPC分类号： C12P7/64 ,  C07H21/04 ,  C12N9/02 ,  C12N15/63 ,  C12N1/19 ,  C07C57/02

    CPC分类号： C12N9/0083

    摘要： The present invention relates to mutant Δ8 desaturase genes, which have the ability to convert eicosadienoic acid [20:2 ω-6, EDA] to dihomo-γ-linolenic acid [20:3, DGLA] and/or eicosatrienoic acid [20:3 ω-3, ETrA] to eicosatetraenoic acid [20:3 ω-3, ETA]. Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding Δ8 desaturase along with methods of making long-chain polyunsaturated fatty acids (PUFAs) using these mutant Δ8 desaturases in plants and oleaginous yeast are disclosed.

    摘要翻译： 本发明涉及具有将二十碳二烯酸[20:2ω-6，EDA]转化为二高-γ-亚麻酸[20:3，DGLA]和/或二十碳三烯酸[ 20：3ω-3，ETrA]至二十碳四烯酸[20：3ω-3，ETA]。 公开了分离的核酸片段和重组构建体，其包含编码“Dgr”8去饱和酶的片段以及使用这些突变体和Dgr。8去饱和酶在植物和油质酵母中制备长链多不饱和脂肪酸（PUFA）的方法。