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公开(公告)号:US20130171704A1
公开(公告)日:2013-07-04
申请号:US13821125
申请日:2011-09-20
摘要: Process for producing a dicarboxylic acid comprising fermenting a microorganism in a suitable fermentation medium wherein a gas flow comprising 30% to 100% v/v oxygen as measured under atmospheric pressure is added to the fermentation medium and producing the dicarboxylic acid.
摘要翻译: 制备二羧酸的方法,其包括在合适的发酵培养基中发酵微生物,其中将在大气压下测量的包含30%至100%v / v氧气的气流加入到发酵培养基中并产生二羧酸。
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公开(公告)号:US20100317086A1
公开(公告)日:2010-12-16
申请号:US12747979
申请日:2007-12-28
申请人: Laurent Segueilha , Ka-Yui San , George Bennett , Irene Martinez
发明人: Laurent Segueilha , Ka-Yui San , George Bennett , Irene Martinez
CPC分类号: C12P7/46 , C12N1/20 , C12P7/04 , C12P7/065 , C12P7/16 , C12P7/20 , C12P7/56 , Y02E50/10 , Y02E50/17
摘要: A new culture method for producing high levels of a metabolite, such as succinic acid uses oxygen rich culture without pH adjustment to increase the biomass, acclimation in under oxygen lean conditions having
摘要翻译: 用于生产高含量代谢物(如琥珀酸)的新培养方法使用富含氧气的培养物,无需pH调节,以增加生物量,适应氧气分压低于氧气的氧气条件下,以及产生高水平 琥珀酸在氧气剥夺条件下。 该方法可以在单个反应器中进行,并且可以有效地进行放大。
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3.
公开(公告)号:US06365383B1
公开(公告)日:2002-04-02
申请号:US09337909
申请日:1999-06-22
申请人: Laurent Segueilha
发明人: Laurent Segueilha
IPC分类号: C12P718
CPC分类号: C12P7/18 , Y02P20/582
摘要: The invention relates to a method of producing erythritol by fed-batch and repeated fermentation of sugars by microorganisms which produce erythritol, characterised by the fact that the fermentation is started by introducing said microorganisms into a fermentation medium containing a concentration of sugars lower than 200 g/l, and the fermentation is continued by carrying out at least one fermentation cycle which comprises: at least one phase of adding substrates so as to maintain the concentration of total sugars at a value of between 0 and 200 g/l, at least one phase of separation of the fermentation medium into a concentrated fraction of microorganisms and another fraction enriched with erythritol, when there is total consumption of sugars, at least one phase of recycling recovered and concentrated microorganisms in the fermentation medium.
摘要翻译: 本发明涉及通过补料分批并通过产生赤藓糖醇的微生物重复发酵糖来生产赤藓糖醇的方法,其特征在于通过将所述微生物引入含有低于200g糖的浓度的发酵培养基来开始发酵 通过进行至少一个发酵循环来继续发酵,所述发酵循环包括:添加底物的至少一个相,以便将总糖的浓度保持在0至200g / l的值,至少一个 当总消耗糖,至少一个回收阶段回收的发酵培养基中的浓缩微生物和发酵培养基中的浓缩微生物时,将发酵培养基分离成微生物浓缩部分和富含赤藓糖醇的另一部分。
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公开(公告)号:US06406895B1
公开(公告)日:2002-06-18
申请号:US09696622
申请日:2000-10-25
IPC分类号: C12P718
CPC分类号: C12P7/18
摘要: The present invention relates to a process for the production of 1,3-propanediol by the fermentation of a 1,3-propanediol-producing microorganism in a fermentation medium containing glucose, characterized in that the fermentation is carried out without mechanical agitation, with the maintenance of an air retention greater than or equal to 50%, expressed as the volume of gas relative to the total volume of the liquid phase of the fermentation medium, and with the maintenance of a high cell density and a microorganism viability value, determined by a test A, greater than or equal to 95%, preferably of between 95 and 99%, by controlling frothing in the fermentation medium.
摘要翻译: 本发明涉及通过在含有葡萄糖的发酵培养基中发酵1,3-丙二醇生产微生物来生产1,3-丙二醇的方法,其特征在于发酵在没有机械搅拌的情况下进行, 维持空气保持率大于或等于50%,表示为相对于发酵培养基液相总体积的气体体积,并维持高细胞密度和微生物活力值,由 通过控制发酵培养基中的发泡,测试A大于或等于95%,优选在95至99%之间。
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公开(公告)号:US06268190B1
公开(公告)日:2001-07-31
申请号:US09567386
申请日:2000-05-09
IPC分类号: C12P718
CPC分类号: C12P7/18 , Y10S435/813 , Y10S435/911 , Y10S435/921 , Y10S435/93 , Y10S435/94
摘要: A method of producing arabitol by continuous fermentation of at least one sugar by micro-organisms producing arabitol, characterised in that arabitol is produced in a first fermentation area including at least one fermenter in such a manner that some of the sugar introduced into the fermentation medium is consumed by said micro-organisms, some of the fermentation medium obtained in this way is transferred into a second fermentation area including at least one fermenter, the volume being maintained constant in the first fermentation area by adding sugar, production of arabitol continues in said second fermentation area in such a manner as to consume the residual sugar of the fermentation medium, the fermentation medium thus obtained from said second fermentation area is separated a continuously into a fraction concentrated in micro-organisms and another, soluble fraction enriched in arabitol, and the arabitol thus obtained is collected.
摘要翻译: 一种通过生产阿拉伯糖醇的微生物连续发酵至少一种糖的阿拉伯糖醇的方法,其特征在于在包括至少一个发酵罐的第一发酵区域中产生阿糖醇,使得一些糖引入发酵培养基 被所述微生物消耗,将以这种方式获得的一些发酵培养基转移到包括至少一个发酵罐的第二发酵区域中,该体积通过加入糖在第一发酵区域保持恒定,所述 第二发酵区域以消耗发酵培养基的残留糖的方式,将从所述第二发酵区域获得的发酵培养基连续分离成浓缩在微生物中的级分,另一种富含阿拉伯糖醇的可溶级分,以及 收集如此得到的阿糖醇。
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公开(公告)号:US10087467B2
公开(公告)日:2018-10-02
申请号:US14118641
申请日:2012-05-18
申请人: Bernard Pora , Yun Qian , Bernard Caulier , Serge Comini , Philippe Looten , Laurent Segueilha
发明人: Bernard Pora , Yun Qian , Bernard Caulier , Serge Comini , Philippe Looten , Laurent Segueilha
摘要: The invention relates to a method for the production of squalene from microalgae belonging to the family of Thraustochytriales sp., preferably at concentrations of between 2 and 12 g per 100 g of dry biomass. The method is characterized in that it comprises steps consisting in: culturing microalgae belonging to the family of Thraustochytriales sp. at a temperature of between 25 and 35° C., preferably between 28 and 32° C., and more preferably of the order of 30° C.; and adding between 1 and 1000 μg of vitamin B12 per liter of culture medium to said culture medium.
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公开(公告)号:US08486686B2
公开(公告)日:2013-07-16
申请号:US12747979
申请日:2007-12-28
申请人: Laurent Segueilha , Ka-Yiu San , George Bennett , Irene Martinez
发明人: Laurent Segueilha , Ka-Yiu San , George Bennett , Irene Martinez
IPC分类号: C12N1/21
CPC分类号: C12P7/46 , C12N1/20 , C12P7/04 , C12P7/065 , C12P7/16 , C12P7/20 , C12P7/56 , Y02E50/10 , Y02E50/17
摘要: A new culture method for producing high levels of a metabolite, such as succinic acid uses oxygen rich culture without pH adjustment to increase the biomass, acclimation in under oxygen lean conditions having
摘要翻译: 用于生产高含量代谢物(如琥珀酸)的新培养方法使用富含氧气的培养物,无需pH调节,以增加生物量,适应氧气分压低于氧气的氧气条件下,以及产生高水平 琥珀酸在氧气剥夺条件下。 该方法可以在单个反应器中进行,并且可以有效地进行放大。
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8.
公开(公告)号:US20140088201A1
公开(公告)日:2014-03-27
申请号:US14118641
申请日:2012-05-18
申请人: Bernard Pora , Yun Qian , Bernard Caulier , Serge Comini , Philippe Looten , Laurent Segueilha
发明人: Bernard Pora , Yun Qian , Bernard Caulier , Serge Comini , Philippe Looten , Laurent Segueilha
IPC分类号: C12P5/02
摘要: The invention relates to a method for the production of squalene from microalgae belonging to the family of Thraustochytriales sp., preferably at concentrations of between 2 and 12 g per 100 g of dry biomass. The method is characterised in that it comprises steps consisting in: culturing microalgae belonging to the family of Thraustochytriales sp. at a temperature of between 25 and 35° C., preferably between 28 and 32° C., and more preferably of the order of 30° C.; and adding between 1 and 1000 μg of vitamin B12 per litre of culture medium to said culture medium.
摘要翻译: 本发明涉及从属于Thraustochytriales sp。家族的微藻生产角鲨烯的方法,优选浓度为每100g干生物量为2至12g。 该方法的特征在于它包括以下步骤:培养属于Thraustochytriales sp。 在25至35℃之间的温度下,优选28至32℃,更优选约30℃。 并将1升至1000微克维生素B12 /升培养基加入到所述培养基中。
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公开(公告)号:US20100297715A1
公开(公告)日:2010-11-25
申请号:US12747987
申请日:2008-12-15
CPC分类号: C12P7/46 , C07C51/02 , C07C51/412 , C07C51/43 , C07C55/10
摘要: The invention relates to methods for producing succinic acid and/or succinate ions by fermentation under anaerobic conditions.
摘要翻译: 本发明涉及通过在厌氧条件下发酵生产琥珀酸和/或琥珀酸离子的方法。
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