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    BRANCHED POLYESTERS WITH SULFONATE GROUPS
    1.
    发明申请
    BRANCHED POLYESTERS WITH SULFONATE GROUPS 有权
    分散聚酯与磺酸酯组

    公开(公告)号：US20120322950A1

    公开(公告)日：2012-12-20

    申请号：US13495512

    申请日：2012-06-13

    申请人： Monika Haberecht ,  Jürgen Detering ,  Bernd Bruchmann ,  Helmut Witteler ,  Heike Weber ,  Karl Kolter

    发明人： Monika Haberecht ,  Jürgen Detering ,  Bernd Bruchmann ,  Helmut Witteler ,  Heike Weber ,  Karl Kolter

    IPC分类号： C08G63/91

    CPC分类号： C02F5/10 ,  C08G63/6884 ,  C08G63/918 ,  C11D3/378

    摘要： Branched polyesters with sulfonate groups can be obtained by reacting components A, B, optionally C, and optionally D to yield branched polyesters, then reacting these branched polyesters with hydrogen sulfite. Component A is at least one α,β-olefinically unsaturated dicarboxylic acid, component B is at least one di- or higher-functional alcohol, optional component C is at least one di- or higher-functional carboxylic acid or hydroxycarboxylic acid without an α,β-olefinically unsaturated bond, and optional component D is at least one compound of formula CH3(—O—CH2—CH2)n—OH. In reacting the branched polyesters with hydrogen sulfite, a molar amount of hydrogen sulfite is at most 95 mol %, based on an amount of α,β-olefinically unsaturated dicarboxylic acid.

    摘要翻译： 具有磺酸盐基团的支链聚酯可以通过使组分A，B，任选地C和任选的D反应得到支链聚酯，然后使这些支化聚酯与亚硫酸氢钠反应而获得。 组分A是至少一种α，β-烯属不饱和二羧酸，组分B是至少一种二官能或更高官能的醇，任选的组分C是至少一种二官能或更高官能的羧酸或羟基羧酸，没有 α，β-烯属不饱和键，任选的组分D是至少一种式CH3（-O-CH2-CH2）n-OH的化合物。 在使支化聚酯与亚硫酸氢钠反应时，基于α，α-烯属不饱和二羧酸的量，亚硫酸氢的摩尔量为至多95摩尔％。

    Branched polyesters with sulfonate groups
    2.
    发明授权
    Branched polyesters with sulfonate groups 有权
    具有磺酸基团的支化聚酯

    公开(公告)号：US08901066B2

    公开(公告)日：2014-12-02

    申请号：US13495512

    申请日：2012-06-13

    申请人： Monika Haberecht ,  Juergen Detering ,  Bernd Bruchmann ,  Helmut Witteler ,  Heike Weber ,  Karl Kolter

    发明人： Monika Haberecht ,  Juergen Detering ,  Bernd Bruchmann ,  Helmut Witteler ,  Heike Weber ,  Karl Kolter

    IPC分类号： C11D3/37 ,  C11D1/00 ,  B08B3/04 ,  C08G63/91 ,  C02F5/10 ,  C08G63/688

    CPC分类号： C02F5/10 ,  C08G63/6884 ,  C08G63/918 ,  C11D3/378

    摘要： Branched polyesters with sulfonate groups can be obtained by reacting components A, B, optionally C, and optionally D to yield branched polyesters, then reacting these branched polyesters with hydrogen sulfite. Component A is at least one α,β-olefinically unsaturated dicarboxylic acid, component B is at least one di- or higher-functional alcohol, optional component C is at least one di- or higher-functional carboxylic acid or hydroxycarboxylic acid without an α,β-olefinically unsaturated bond, and optional component D is at least one compound of formula CH3(—O—CH2—CH2)n—OH. In reacting the branched polyesters with hydrogen sulfite, a molar amount of hydrogen sulfite is at most 95 mol %, based on an amount of α,β-olefinically unsaturated dicarboxylic acid.

    摘要翻译： 具有磺酸盐基团的支链聚酯可以通过使组分A，B，任选地C和任选的D反应得到支链聚酯，然后使这些支化聚酯与亚硫酸氢钠反应而获得。 组分A是至少一种α，β-烯属不饱和二羧酸，组分B是至少一种二官能或更高官能的醇，任选的组分C是至少一种二官能或更高官能的羧酸或羟基羧酸，没有 α，β-烯属不饱和键，任选的组分D是至少一种式CH3（-O-CH2-CH2）n-OH的化合物。 在使支化聚酯与亚硫酸氢钠反应时，基于α，α-烯属不饱和二羧酸的量，亚硫酸氢的摩尔量为至多95摩尔％。

    BRANCHED POLYESTERS WITH SULFONATE GROUPS
    4.
    发明申请
    BRANCHED POLYESTERS WITH SULFONATE GROUPS 有权
    分散聚酯与磺酸酯组

    公开(公告)号：US20120322714A1

    公开(公告)日：2012-12-20

    申请号：US13495444

    申请日：2012-06-13

    申请人： Monika HABERECHT ,  Frank Ritting ,  Bernd Bruchmann ,  Claudia Esper ,  Roland Ettl ,  Karl Kolter

    发明人： Monika HABERECHT ,  Frank Ritting ,  Bernd Bruchmann ,  Claudia Esper ,  Roland Ettl ,  Karl Kolter

    IPC分类号： C08G63/91 ,  C11D3/37

    CPC分类号： C11D3/378 ,  C08G63/6888 ,  C08G63/918

    摘要： Branched polyesters with sulfonate groups obtainable by the reaction of the components A, B, optionally C and optionally D to give branched polyesters, where the component A is selected from the group of α,β-olefinically unsaturated dicarboxylic acids, and the component B is selected from the group of tri- or higher-functional alcohols, the optional component C is selected from the group of difunctional alcohols or of difunctional carboxylic acids without α,β-olefinically unsaturated bonds, the optional component D is selected from fatty acids or fatty alcohols, and the subsequent reaction of the resulting branched polyesters with hydrogen sulfite, where the molar amount of hydrogen sulfite is at most 95 mol %, based on the amount of α,β-olefinically unsaturated dicarboxylic acid.

    摘要翻译： 具有磺酸盐基团的支化聚酯可通过组分A，B，任选的C和任选的D反应获得，得到支链聚酯，其中组分A选自α，β-烯属不饱和二羧酸和组分B 选自三官能或更高官能的醇，任选的组分C选自二官能醇或不具有α，β-烯属不饱和键的双官能羧酸，任选的组分D选自脂肪酸 或脂肪醇，以及所得到的支链聚酯与亚硫酸氢盐的随后反应，其中亚硫酸氢盐的摩尔量基于α，α-烯属不饱和二羧酸的量为至多95摩尔％。

    Branched polyesters with sulfonate groups
    5.
    发明授权
    Branched polyesters with sulfonate groups 有权
    具有磺酸基团的支化聚酯

    公开(公告)号：US08846599B2

    公开(公告)日：2014-09-30

    申请号：US13495444

    申请日：2012-06-13

    申请人： Monika Haberecht ,  Frank Rittig ,  Bernd Bruchmann ,  Claudia Esper ,  Roland Ettl ,  Karl Kolter

    发明人： Monika Haberecht ,  Frank Rittig ,  Bernd Bruchmann ,  Claudia Esper ,  Roland Ettl ,  Karl Kolter

    IPC分类号： C11D1/00 ,  B08B3/04 ,  C11D3/37 ,  C08G63/91 ,  C08G63/688

    CPC分类号： C11D3/378 ,  C08G63/6888 ,  C08G63/918

    摘要： Branched polyesters with sulfonate groups obtainable by the reaction of the components A, B, optionally C and optionally D to give branched polyesters, where the component A is selected from the group of α,β-olefinically unsaturated dicarboxylic acids, and the component B is selected from the group of tri- or higher-functional alcohols, the optional component C is selected from the group of difunctional alcohols or of difunctional carboxylic acids without α,β-olefinically unsaturated bonds, the optional component D is selected from fatty acids or fatty alcohols, and the subsequent reaction of the resulting branched polyesters with hydrogen sulfite, where the molar amount of hydrogen sulfite is at most 95 mol %, based on the amount of α,β-olefinically unsaturated dicarboxylic acid.

    摘要翻译： 具有磺酸盐基团的支化聚酯可通过组分A，B，任选的C和任选的D反应获得，得到支链聚酯，其中组分A选自α，β-烯属不饱和二羧酸和组分B 选自三官能或更高官能的醇，任选的组分C选自二官能醇或不具有α，β-烯属不饱和键的双官能羧酸，任选的组分D选自脂肪酸 或脂肪醇，以及所得到的支链聚酯与亚硫酸氢盐的随后反应，其中亚硫酸氢盐的摩尔量基于α，α-烯属不饱和二羧酸的量为至多95摩尔％。

    Production of pulverulent coating compositions for stable protective coatings for pharmaceutical dosage forms
    9.
    发明授权
    Production of pulverulent coating compositions for stable protective coatings for pharmaceutical dosage forms 有权
    生产用于药物剂型的稳定保护性涂料的粉末涂料组合物

    公开(公告)号：US08962064B2

    公开(公告)日：2015-02-24

    申请号：US13406641

    申请日：2012-02-28

    申请人： Karl Kolter ,  Maximilian Angel ,  Bernhard Linner

    发明人： Karl Kolter ,  Maximilian Angel ,  Bernhard Linner

    IPC分类号： A61K9/28 ,  A61K47/32 ,  C09D5/03 ,  C09D133/26

    CPC分类号： A61K47/32 ,  A61K9/2846 ,  C08L2201/54 ,  C09D5/03 ,  C09D133/26 ,  Y10T428/31565 ,  C08K5/005

    摘要： Described is a process for producing pulverulent, antioxidant-comprising coating compositions, comprising providing an aqueous polymer dispersions comprising one or more antioxidants and a polymer obtained by radical polymerization of a) N,N-diethylaminoethyl methacrylate, and b) at least one radically polymerizable compound selected from esters of α,β-ethylenically unsaturated mono- and dicarboxylic acids with C1-C8-alkanols, wherein the antioxidants are incorporated into the aqueous polymer dispersion in the form of a solution or of a dispersion, and spray processing the aqueous polymer dispersion to provide a powder form.

    摘要翻译： 描述了一种生产含粉末，抗氧化剂的涂料组合物的方法，其包括提供包含一种或多种抗氧化剂的聚合物水分散体和通过a）N，N-二乙基氨基乙基甲基丙烯酸酯的自由基聚合获得的聚合物，和b）至少一种可自由基聚合的 选自α，β-烯键式不饱和单羧酸和二羧酸与C 1 -C 8 - 链烷醇的化合物的化合物，其中抗氧化剂以溶液或分散体的形式引入到聚合物水分散体中，并且将水性 聚合物分散体以提供粉末形式。

    Nanoporous foamed active compound-containing preparations based on pharmaceutically acceptable thermoplastically workable polymers
    10.
    发明授权
    Nanoporous foamed active compound-containing preparations based on pharmaceutically acceptable thermoplastically workable polymers 失效
    基于药学上可接受的热塑性可加工聚合物的纳米多孔泡沫活性成分制剂

    公开(公告)号：US08636929B2

    公开(公告)日：2014-01-28

    申请号：US13111999

    申请日：2011-05-20

    申请人： Jan Kurt Walter Sandler ,  Ingo Bellin ,  Dejan Djuric ,  Karl Kolter ,  Holger Ruckdäschel

    发明人： Jan Kurt Walter Sandler ,  Ingo Bellin ,  Dejan Djuric ,  Karl Kolter ,  Holger Ruckdäschel

    IPC分类号： B29C67/20

    CPC分类号： A61K31/235 ,  A61K9/146 ,  A61K31/496 ,  B82Y5/00

    摘要： Process for the production of nanoporous foamed active substance-containing preparations, wherein the active substance is present embedded in a pharmaceutically acceptable polymer, wherein, in stage a) loading of a polymeric molding composition or a polymer melt with a propellant is effected at a pressure and at a temperature at which the propellant is in the supercritical state, in stage b) heating of the laden polymer molding compound or melt is carried out under pressure at a temperature which lies in the range from −40 to +60° C., preferably −20 to +55° C., and especially preferably 0 to +50° C. around the glass transition temperature of the unladen (prior to loading) polymeric molding compound and in stage c) a depressurization of the polymeric molding compound or melt laden in stage a) and heated under pressure in stage b) is effected out with a depressurization rate in the range from 15,000 to 200,000 MPa/sec.

    摘要翻译： 制备纳米多孔泡沫活性物质制剂的方法，其中活性物质包含在药学上可接受的聚合物中，其中在阶段a）聚合物模塑组合物或聚合物熔体与推进剂的加载在压力 并且在推进剂处于超临界状态的温度下，在阶段b）加载聚合物模塑料或熔体在加压下在-40至+ 60℃的温度下进行， 优选为-20至+ 55℃，特别优选为0至+ 50℃，并且在阶段c）将聚合物模塑料或熔体的减压 在步骤a）中负载并且在阶段b）中加压，以15,000至200,000MPa /秒的减压速率进行。