公开(公告)号：US20130105317A1

公开(公告)日：2013-05-02

申请号：US13664967

申请日：2012-10-31

申请人： Monika Weber ,  Siu Lung Lo ,  Hazael Fabrizio Montanaro Ochoa ,  Christopher Daniel Yerino ,  Mark A. Reed

发明人： Monika Weber ,  Siu Lung Lo ,  Hazael Fabrizio Montanaro Ochoa ,  Christopher Daniel Yerino ,  Mark A. Reed

IPC分类号： G01N27/447 ,  B82Y15/00

CPC分类号： B03C5/024 ,  B01L3/502753 ,  B01L2300/0874 ,  B01L2400/0406 ,  B01L2400/0424 ,  B01L2400/0487 ,  B03C5/005 ,  B03C2201/26 ,  G01N27/4145 ,  G01N33/487

摘要： An apparatus and method for separating an analyte from a test sample, such as bacteria from blood components, based on their dielectric properties, localizing or condensing the analyte, flushing substantially all remaining waste products from the test sample, and detecting low concentrations of the analyte. Species movement is caused by a module array imparting opposing dielectrophoretic forces. The module array includes a plurality of microfluidic channels with connecting microfluidic waste channels for directing undesired material away from the analyte. An electric field is applied causing a positive dielectrophoretic force to the analyte to capture the analyte. The Clausius-Mossotti factor of the analyte is changed by flushing the analyte with a reference solution, which causes a negative dielectrophoretic force to facilitate release of the analyte. A field effect nanowire or nanoribbon sensor detects the analyte after capture.

摘要翻译： 基于它们的介电特性，将分析物从测试样品例如细菌分离出来的装置和方法，定位或冷凝分析物，基本上冲洗来自测试样品的所有剩余废物，以及检测低浓度的分析物 。 物种移动是由赋予相反介电电泳力的模块阵列引起的。 模块阵列包括具有连接微流体废物通道的多个微流体通道，用于将不期望的材料引导离开分析物。 施加电场使得分析物具有正的介电电泳力以捕获分析物。 通过用参比溶液冲洗分析物来改变分析物的克劳修斯 - 莫索蒂（Clausius-Mossotti）因子，这引起负介电电泳力以促进分析物的释放。 场效应纳米线或纳米纤维传感器在捕获后检测分析物。

公开(公告)号：US09120105B2

公开(公告)日：2015-09-01

申请号：US13664967

申请日：2012-10-31

申请人： Monika Weber ,  Mark A. Reed

发明人： Monika Weber ,  Siu Lung Lo ,  Hazael Fabrizio Montanaro Ochoa ,  Christopher Daniel Yerino ,  Mark A. Reed

IPC分类号： G01N27/447 ,  B03C5/02 ,  G01N33/487 ,  B03C5/00 ,  B01L3/00 ,  G01N27/414

CPC分类号： B03C5/024 ,  B01L3/502753 ,  B01L2300/0874 ,  B01L2400/0406 ,  B01L2400/0424 ,  B01L2400/0487 ,  B03C5/005 ,  B03C2201/26 ,  G01N27/4145 ,  G01N33/487

摘要： An apparatus and method for separating an analyte from a test sample, such as bacteria from blood components, based on their dielectric properties, localizing or condensing the analyte, flushing substantially all remaining waste products from the test sample, and detecting low concentrations of the analyte. Species movement is caused by a module array imparting opposing dielectrophoretic forces. The module array includes a plurality of microfluidic channels with connecting microfluidic waste channels for directing undesired material away from the analyte. An electric field is applied causing a positive dielectrophoretic force to the analyte to capture the analyte. The Clausius-Mossotti factor of the analyte is changed by flushing the analyte with a reference solution, which causes a negative dielectrophoretic force to facilitate release of the analyte. A field effect nanowire or nanoribbon sensor detects the analyte after capture.

摘要翻译： 基于它们的介电特性，将分析物从测试样品例如细菌分离出来的装置和方法，定位或冷凝分析物，基本上冲洗来自测试样品的所有剩余废物，以及检测低浓度的分析物 。 物种移动是由赋予相反介电电泳力的模块阵列引起的。 模块阵列包括具有连接微流体废物通道的多个微流体通道，用于将不期望的材料引导离开分析物。 施加电场使得分析物具有正的介电电泳力以捕获分析物。 通过用参比溶液冲洗分析物来改变分析物的克劳修斯 - 莫索蒂（Clausius-Mossotti）因子，这引起负介电电泳力以促进分析物的释放。 场效应纳米线或纳米纤维传感器在捕获后检测分析物。

公开(公告)号：US20150107999A1

公开(公告)日：2015-04-23

申请号：US14582525

申请日：2014-12-24

申请人： Monika Weber ,  Mark A. Reed

发明人： Monika Weber ,  Siu Lung Lo ,  Hazael Fabrizio Montanaro Ochoa ,  Christopher Daniel Yerino ,  Mark A. Reed

IPC分类号： G01N27/447 ,  G01N27/414

CPC分类号： B01L3/502753 ,  B01L2300/0874 ,  B01L2400/0406 ,  B01L2400/0424 ,  B01L2400/0487 ,  B03C5/005 ,  B03C5/024 ,  B03C2201/18 ,  B03C2201/26 ,  G01N27/4145

摘要： An apparatus for separating an analyte from a test sample, such as bacteria from blood components, based on their dielectric properties, localizing or condensing the analyte, flushing substantially all remaining waste products from the test sample, and detecting low concentrations of the analyte. The module array includes a plurality of microfluidic channels with connecting microfluidic waste channels for directing undesired material away from the analyte. An electric field is applied causing a positive dielectrophoretic force to the analyte to capture the analyte. The electric field is applied to at least one electrode having a plurality of concentric rings or concentric arcs extending radially outwards from a center point, electrically connected to a voltage source such that when voltage is applied to the at least one electrode, the concentric rings or concentric arcs alternate in voltage potential.

摘要翻译： 基于它们的介电特性，将分析物从测试样品（例如细菌）中分离出来，将分析物定位或冷凝，基本上将所有剩余废物从测试样品中冲洗，并检测低浓度的分析物。 模块阵列包括具有连接微流体废物通道的多个微流体通道，用于将不期望的材料引导离开分析物。 施加电场使得分析物具有正的介电电泳力以捕获分析物。 电场被施加到至少一个电极，该至少一个电极具有多个同心圆或同心圆弧，其中心点从中心点径向向外延伸，电中连接到电压源，使得当电压施加到至少一个电极时，同心环或 同心弧交替电压。

公开(公告)号：US09188594B2

公开(公告)日：2015-11-17

申请号：US12535396

申请日：2009-08-04

申请人： Tarek M. Fahmy ,  Eric D. Stern ,  Mark A. Reed ,  Aleksandar Vacic ,  James F. Klemic

发明人： Tarek M. Fahmy ,  Eric D. Stern ,  Mark A. Reed ,  Aleksandar Vacic ,  James F. Klemic

IPC分类号： G01N33/543 ,  G01N33/68

CPC分类号： G01N33/54366 ,  G01N33/54373 ,  G01N33/6863 ,  G01N33/6866 ,  G01N33/6869 ,  G01N2333/54 ,  G01N2333/555 ,  G01N2333/98

摘要： The present invention relates to a device and method for determining the presence of a specific compound in solution. The device includes a nanosensor having an electrically conducting pathway between at least a first and second contact. The device also includes a first receptor, suitable for binding a specific compound in the solution, attached to the nanosensor, and a second receptor also suitable for binding the specific compound while the specific compound is bound to the first receptor. The second receptor is attached to an enzyme added to the solution. When the solution having the second receptor is added to the device, and a second compound that is a substrate for the enzyme is subsequently added to the solution, a measured difference in an electrical property in the device before and after the application of the second compound is indicative of the presence of the specific compound in the solution.

摘要翻译： 本发明涉及一种用于测定溶液中特定化合物的存在的装置和方法。 该装置包括在至少第一和第二接触之间具有导电路径的纳米传感器。 该装置还包括适于结合附着于纳米传感器的溶液中的特定化合物的第一受体，以及也适于结合特定化合物而第二受体，而特异性化合物与第一受体结合。 第二受体与添加到溶液中的酶连接。 当将具有第二受体的溶液加入到装置中，并且随后将另外作为酶底物的第二化合物加入到溶液中时，测量第二化合物施用前后装置的电性能差异 表明该溶液中特定化合物的存在。

公开(公告)号：US20140187556A1

公开(公告)日：2014-07-03

申请号：US14002031

申请日：2012-03-02

申请人： Mark A. Reed ,  Arun Yadav ,  Scott C. Banfield ,  Christopher J. Barden

发明人： Mark A. Reed ,  Arun Yadav ,  Scott C. Banfield ,  Christopher J. Barden

IPC分类号： C07D295/192 ,  C07C217/84 ,  C07D295/096 ,  C07D211/14 ,  C07D257/04

CPC分类号： C07D295/096 ,  C07C215/68 ,  C07C217/84 ,  C07C225/22 ,  C07C229/52 ,  C07C237/30 ,  C07C255/58 ,  C07C311/39 ,  C07D211/14 ,  C07D211/58 ,  C07D211/60 ,  C07D211/62 ,  C07D241/04 ,  C07D257/04 ,  C07D295/073 ,  C07D295/192

摘要： Anti-amyloid compounds are provided along with methods of use thereof.

摘要翻译： 提供抗淀粉样化合物及其使用方法。

公开(公告)号：US20130267571A1

公开(公告)日：2013-10-10

申请号：US13822826

申请日：2011-09-14

申请人： Mark A. Reed ,  Donald Weaver ,  Shengguo Sun ,  Alexander McLellan ,  Erhu Lu

发明人： Mark A. Reed ,  Donald Weaver ,  Shengguo Sun ,  Alexander McLellan ,  Erhu Lu

IPC分类号： C07C233/09 ,  C07C43/166 ,  C07C57/03 ,  C07D257/04 ,  C07C233/65 ,  C07C233/05 ,  C07C233/07 ,  C07C235/60 ,  C07C43/15 ,  C07C211/21

CPC分类号： C07C233/09 ,  A61K31/045 ,  A61K31/08 ,  A61K31/10 ,  A61K31/12 ,  A61K31/13 ,  A61K31/16 ,  A61K31/18 ,  A61K31/201 ,  A61K31/41 ,  C07C43/15 ,  C07C43/166 ,  C07C57/03 ,  C07C211/21 ,  C07C233/05 ,  C07C233/07 ,  C07C233/65 ,  C07C235/60 ,  C07D257/04

摘要： The present application provides a terpene analogue of Formula (I) or a pharmaceutically acceptable isomer, salt or ester thereof, and methods and uses thereof for treating neurological conditions such as pain in general and neuropathic pain. These terpene analogues can also be used to treat other electrical disorders in the central and peripheral nervous system. Also provided are methods of synthesizing the terpene analogues of Formula I.

摘要翻译： 本申请提供了式（I）的萜烯类似物或其药学上可接受的异构体，盐或酯，以及其用于治疗神经学病症如一般疼痛和神经性疼痛的方法和用途。 这些萜烯类似物也可用于治疗中枢和外周神经系统中的其他电疗障碍。 还提供了合成式I的萜烯类似物的方法。

公开(公告)号：US09599614B2

公开(公告)日：2017-03-21

申请号：US14005056

申请日：2012-03-14

申请人： Tarek M. Fahmy ,  Aleksandar Vacic ,  Mark A. Reed

发明人： Tarek M. Fahmy ,  Aleksandar Vacic ,  Mark A. Reed

IPC分类号： G01N27/414 ,  G01N33/543

CPC分类号： G01N33/54373 ,  G01N27/4145 ,  G01N27/4146 ,  G01N33/5438

摘要： The present invention relates to uniform nanostructure biosensors and methods of calibrating the response of nanostructure biosensors. The invention overcomes device to device variability that has made quantitative detection difficult. The described biosensors have uniform characteristics that allow for more reliable comparison across devices. The methods of the invention comprise normalizing the initial current rate, as measured by the nanostructure biosensor following the addition of an analyte, to device characteristics of the biosensor. The device characteristics of the biosensor which can be used to normalize the response include baseline current and transconductance. Calibration of responses allows for the generation of calibration curves for use in all devices to quantitatively detect an analyte, without the need for individual device calibration.

公开(公告)号：US20100297608A1

公开(公告)日：2010-11-25

申请号：US12517230

申请日：2007-12-06

申请人： Eric D. Stern ,  Tarek M. Fahmy ,  Mark A. Reed ,  Pauline N. Wyremback ,  Daniel Turner-Evans ,  Andrew Hamilton ,  David A. Lavan ,  James F. Klemic ,  David A. Routenberg

发明人： Eric D. Stern ,  Tarek M. Fahmy ,  Mark A. Reed ,  Pauline N. Wyremback ,  Daniel Turner-Evans ,  Andrew Hamilton ,  David A. Lavan ,  James F. Klemic ,  David A. Routenberg

IPC分类号： C12Q1/70 ,  H01L29/772 ,  H01L21/302 ,  C12Q1/02 ,  G01N33/53 ,  C12Q1/68

CPC分类号： H01L29/0665 ,  B82Y10/00 ,  G01N27/4146 ,  H01L29/045 ,  H01L29/0673 ,  H01L29/16

摘要： The systems and methods described herein include a sensor for suitable for sensing chemical and biological substances. The sensor comprises a semiconductor layer formed in or on a substrate and a channel having nano-scale dimensions formed in the semiconductor layer, where the structure creates an electrically conducting pathway between a first contact and a second contact on the semiconductor layer. In certain preferred embodiments, the nano-scale channel has a trapezoidal cross-section with an effective width and exposed lateral faces, where the effective width is selected to have same order of magnitude as a Debye length (LD) of the semiconductor material of which the semiconductor layer is formed.

摘要翻译： 本文所述的系统和方法包括适于感测化学和生物物质的传感器。 传感器包括形成在衬底中或衬底上的半导体层和形成在半导体层中的具有纳米级尺寸的沟道，其中该结构在半导体层上的第一接触和第二接触之间形成导电通路。 在某些优选实施例中，纳米尺度通道具有具有有效宽度和暴露侧面的梯形横截面，其中有效宽度被选择为具有与其半导体材料的德拜长度（LD）相同的数量级 形成半导体层。

公开(公告)号：US20100184104A1

公开(公告)日：2010-07-22

申请号：US12535396

申请日：2009-08-04

申请人： Tarek M. FAHMY ,  Eric D. Stern ,  Mark A. Reed ,  Aleksandar Vacic

发明人： Tarek M. FAHMY ,  Eric D. Stern ,  Mark A. Reed ,  Aleksandar Vacic

IPC分类号： G01N33/53 ,  C12M1/00

CPC分类号： G01N33/54366 ,  G01N33/54373 ,  G01N33/6863 ,  G01N33/6866 ,  G01N33/6869 ,  G01N2333/54 ,  G01N2333/555 ,  G01N2333/98

摘要： The present invention relates to a device and method for determining the presence of a specific compound in solution. The device includes a nanosensor having an electrically conducting pathway between at least a first and second contact. The device also includes a first receptor, suitable for binding a specific compound in the solution, attached to the nanosensor, and a second receptor also suitable for binding the specific compound while the specific compound is bound to the first receptor. The second receptor is attached to an enzyme added to the solution. When the solution having the second receptor is added to the device, and a second compound that is a substrate for the enzyme is subsequently added to the solution, a measured difference in an electrical property in the device before and after the application of the second compound is indicative of the presence of the specific compound in the solution.

摘要翻译： 本发明涉及一种用于测定溶液中特定化合物的存在的装置和方法。 该装置包括在至少第一和第二接触之间具有导电路径的纳米传感器。 该装置还包括适于结合附着于纳米传感器的溶液中的特定化合物的第一受体，以及也适于结合特定化合物而第二受体，而特异性化合物与第一受体结合。 第二受体与添加到溶液中的酶连接。 当将具有第二受体的溶液加入到装置中，并且随后将另外作为酶底物的第二化合物加入到溶液中时，测量第二化合物施用前后装置的电性能差异 表明该溶液中特定化合物的存在。

公开(公告)号：US06756605B1

公开(公告)日：2004-06-29

申请号：US09551716

申请日：2000-04-18

申请人： Mark A. Reed ,  James M. Tour ,  Jia Chen ,  Adam M. Rawlett ,  David W. Price

发明人： Mark A. Reed ,  James M. Tour ,  Jia Chen ,  Adam M. Rawlett ,  David W. Price

IPC分类号： H01L3524

CPC分类号： G11C13/0014 ,  B82Y10/00 ,  B82Y30/00 ,  G11C13/0016 ,  H01L51/0595 ,  Y10S977/936

摘要： Molecular scale electronic devices are disclosed. Such devices include at least two conductive contacts, and a conductive path bridging the contacts. The conductive path is able to be written into a perturbed state by a voltage pulse, which can be of high or low conductivity, relative to an initial state. The conductive path comprises organic molecules including at least one electron-withdrawing group. Room temperature negative differential resistance is exhibited by the devices.

摘要翻译： 公开了分子规模的电子器件。 这样的装置包括至少两个导电触点和桥接触点的导电路径。 导电路径能够被相对于初始状态的电压脉冲写入扰动状态，电压脉冲可以具有高或低导电性。 导电路径包括包括至少一个吸电子基团的有机分子。 器件表现出室温负差分电阻。