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    Nanoelectronic-enzyme linked immunosorbent assay system and method
    1.
    发明授权
    Nanoelectronic-enzyme linked immunosorbent assay system and method 有权
    纳米电子酶联免疫吸附测定系统及方法

    公开(公告)号：US09188594B2

    公开(公告)日：2015-11-17

    申请号：US12535396

    申请日：2009-08-04

    申请人： Tarek M. Fahmy ,  Eric D. Stern ,  Mark A. Reed ,  Aleksandar Vacic ,  James F. Klemic

    发明人： Tarek M. Fahmy ,  Eric D. Stern ,  Mark A. Reed ,  Aleksandar Vacic ,  James F. Klemic

    IPC分类号： G01N33/543 ,  G01N33/68

    CPC分类号： G01N33/54366 ,  G01N33/54373 ,  G01N33/6863 ,  G01N33/6866 ,  G01N33/6869 ,  G01N2333/54 ,  G01N2333/555 ,  G01N2333/98

    摘要： The present invention relates to a device and method for determining the presence of a specific compound in solution. The device includes a nanosensor having an electrically conducting pathway between at least a first and second contact. The device also includes a first receptor, suitable for binding a specific compound in the solution, attached to the nanosensor, and a second receptor also suitable for binding the specific compound while the specific compound is bound to the first receptor. The second receptor is attached to an enzyme added to the solution. When the solution having the second receptor is added to the device, and a second compound that is a substrate for the enzyme is subsequently added to the solution, a measured difference in an electrical property in the device before and after the application of the second compound is indicative of the presence of the specific compound in the solution.

    摘要翻译： 本发明涉及一种用于测定溶液中特定化合物的存在的装置和方法。 该装置包括在至少第一和第二接触之间具有导电路径的纳米传感器。 该装置还包括适于结合附着于纳米传感器的溶液中的特定化合物的第一受体，以及也适于结合特定化合物而第二受体，而特异性化合物与第一受体结合。 第二受体与添加到溶液中的酶连接。 当将具有第二受体的溶液加入到装置中，并且随后将另外作为酶底物的第二化合物加入到溶液中时，测量第二化合物施用前后装置的电性能差异 表明该溶液中特定化合物的存在。

    NANOELECTRONIC-ENZYME LINKED IMMUNOSORBENT ASSAY SYSTEM AND METHOD
    2.
    发明申请
    NANOELECTRONIC-ENZYME LINKED IMMUNOSORBENT ASSAY SYSTEM AND METHOD 有权
    纳米电子连接免疫测定系统及方法

    公开(公告)号：US20100184104A1

    公开(公告)日：2010-07-22

    申请号：US12535396

    申请日：2009-08-04

    申请人： Tarek M. FAHMY ,  Eric D. Stern ,  Mark A. Reed ,  Aleksandar Vacic

    发明人： Tarek M. FAHMY ,  Eric D. Stern ,  Mark A. Reed ,  Aleksandar Vacic

    IPC分类号： G01N33/53 ,  C12M1/00

    CPC分类号： G01N33/54366 ,  G01N33/54373 ,  G01N33/6863 ,  G01N33/6866 ,  G01N33/6869 ,  G01N2333/54 ,  G01N2333/555 ,  G01N2333/98

    摘要： The present invention relates to a device and method for determining the presence of a specific compound in solution. The device includes a nanosensor having an electrically conducting pathway between at least a first and second contact. The device also includes a first receptor, suitable for binding a specific compound in the solution, attached to the nanosensor, and a second receptor also suitable for binding the specific compound while the specific compound is bound to the first receptor. The second receptor is attached to an enzyme added to the solution. When the solution having the second receptor is added to the device, and a second compound that is a substrate for the enzyme is subsequently added to the solution, a measured difference in an electrical property in the device before and after the application of the second compound is indicative of the presence of the specific compound in the solution.

    摘要翻译： 本发明涉及一种用于测定溶液中特定化合物的存在的装置和方法。 该装置包括在至少第一和第二接触之间具有导电路径的纳米传感器。 该装置还包括适于结合附着于纳米传感器的溶液中的特定化合物的第一受体，以及也适于结合特定化合物而第二受体，而特异性化合物与第一受体结合。 第二受体与添加到溶液中的酶连接。 当将具有第二受体的溶液加入到装置中，并且随后将另外作为酶底物的第二化合物加入到溶液中时，测量第二化合物施用前后装置的电性能差异 表明该溶液中特定化合物的存在。

    Calibration of nanostructure sensors
    3.
    发明授权
    Calibration of nanostructure sensors 有权

    公开(公告)号：US09599614B2

    公开(公告)日：2017-03-21

    申请号：US14005056

    申请日：2012-03-14

    申请人： Tarek M. Fahmy ,  Aleksandar Vacic ,  Mark A. Reed

    发明人： Tarek M. Fahmy ,  Aleksandar Vacic ,  Mark A. Reed

    IPC分类号： G01N27/414 ,  G01N33/543

    CPC分类号： G01N33/54373 ,  G01N27/4145 ,  G01N27/4146 ,  G01N33/5438

    摘要： The present invention relates to uniform nanostructure biosensors and methods of calibrating the response of nanostructure biosensors. The invention overcomes device to device variability that has made quantitative detection difficult. The described biosensors have uniform characteristics that allow for more reliable comparison across devices. The methods of the invention comprise normalizing the initial current rate, as measured by the nanostructure biosensor following the addition of an analyte, to device characteristics of the biosensor. The device characteristics of the biosensor which can be used to normalize the response include baseline current and transconductance. Calibration of responses allows for the generation of calibration curves for use in all devices to quantitatively detect an analyte, without the need for individual device calibration.

    CMOS-compatible silicon nano-wire sensors with biochemical and cellular interfaces
    5.
    发明授权
    CMOS-compatible silicon nano-wire sensors with biochemical and cellular interfaces 有权
    CMOS兼容的硅纳米线传感器，具有生化和蜂窝接口

    公开(公告)号：US09076665B2

    公开(公告)日：2015-07-07

    申请号：US12517230

    申请日：2007-12-06

    申请人： Eric D. Stern ,  Tarek M. Fahmy ,  Mark A. Reed ,  James F. Klemic

    发明人： Eric D. Stern ,  Tarek M. Fahmy ,  Mark A. Reed ,  James F. Klemic

    IPC分类号： G01N27/414 ,  H01L29/06 ,  B82Y10/00 ,  H01L29/04 ,  H01L29/16

    CPC分类号： H01L29/0665 ,  B82Y10/00 ,  G01N27/4146 ,  H01L29/045 ,  H01L29/0673 ,  H01L29/16

    摘要： The systems and methods described herein include a sensor for suitable for sensing chemical and biological substances. The sensor comprises a semiconductor layer formed in or on a substrate and a channel having nano-scale dimensions formed in the semiconductor layer, where the structure creates an electrically conducting pathway between a first contact and a second contact on the semiconductor layer. In certain preferred embodiments, the nano-scale channel has a trapezoidal cross-section with an effective width and exposed lateral faces, where the effective width is selected to have same order of magnitude as a Debye length (LD) of the semiconductor material of which the semiconductor layer is formed.

    摘要翻译： 本文所述的系统和方法包括适于感测化学和生物物质的传感器。 传感器包括形成在衬底中或衬底上的半导体层和形成在半导体层中的具有纳米级尺寸的沟道，其中该结构在半导体层上的第一接触和第二接触之间形成导电通路。 在某些优选实施例中，纳米尺度通道具有具有有效宽度和暴露侧面的梯形横截面，其中有效宽度被选择为具有与其半导体材料的德拜长度（LD）相同的数量级 形成半导体层。

    Electronic device for pathogen detection
    8.
    发明授权
    Electronic device for pathogen detection 有权
    用于病原体检测的电子装置

    公开(公告)号：US09120105B2

    公开(公告)日：2015-09-01

    申请号：US13664967

    申请日：2012-10-31

    申请人： Monika Weber ,  Mark A. Reed

    发明人： Monika Weber ,  Siu Lung Lo ,  Hazael Fabrizio Montanaro Ochoa ,  Christopher Daniel Yerino ,  Mark A. Reed

    IPC分类号： G01N27/447 ,  B03C5/02 ,  G01N33/487 ,  B03C5/00 ,  B01L3/00 ,  G01N27/414

    CPC分类号： B03C5/024 ,  B01L3/502753 ,  B01L2300/0874 ,  B01L2400/0406 ,  B01L2400/0424 ,  B01L2400/0487 ,  B03C5/005 ,  B03C2201/26 ,  G01N27/4145 ,  G01N33/487

    摘要： An apparatus and method for separating an analyte from a test sample, such as bacteria from blood components, based on their dielectric properties, localizing or condensing the analyte, flushing substantially all remaining waste products from the test sample, and detecting low concentrations of the analyte. Species movement is caused by a module array imparting opposing dielectrophoretic forces. The module array includes a plurality of microfluidic channels with connecting microfluidic waste channels for directing undesired material away from the analyte. An electric field is applied causing a positive dielectrophoretic force to the analyte to capture the analyte. The Clausius-Mossotti factor of the analyte is changed by flushing the analyte with a reference solution, which causes a negative dielectrophoretic force to facilitate release of the analyte. A field effect nanowire or nanoribbon sensor detects the analyte after capture.

    摘要翻译： 基于它们的介电特性，将分析物从测试样品例如细菌分离出来的装置和方法，定位或冷凝分析物，基本上冲洗来自测试样品的所有剩余废物，以及检测低浓度的分析物 。 物种移动是由赋予相反介电电泳力的模块阵列引起的。 模块阵列包括具有连接微流体废物通道的多个微流体通道，用于将不期望的材料引导离开分析物。 施加电场使得分析物具有正的介电电泳力以捕获分析物。 通过用参比溶液冲洗分析物来改变分析物的克劳修斯 - 莫索蒂（Clausius-Mossotti）因子，这引起负介电电泳力以促进分析物的释放。 场效应纳米线或纳米纤维传感器在捕获后检测分析物。