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    METHODS AND COMPOSITIONS FOR CANCER IMMUNOTHERAPY
    1.
    发明申请
    METHODS AND COMPOSITIONS FOR CANCER IMMUNOTHERAPY 审中-公开
    癌症免疫学的方法和组成

    公开(公告)号：US20130302409A1

    公开(公告)日：2013-11-14

    申请号：US13810548

    申请日：2011-07-15

    申请人： Ephraim Joseph Fuchs ,  Tarek M. Fahmy

    发明人： Ephraim Joseph Fuchs ,  Tarek M. Fahmy

    IPC分类号： A61K39/00 ,  A61K38/46 ,  A61K45/06

    CPC分类号： A61K39/0011 ,  A61K9/0024 ,  A61K9/5153 ,  A61K31/00 ,  A61K31/675 ,  A61K38/46 ,  A61K45/06 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/55516 ,  A61K2039/55555 ,  A61K2039/55572 ,  C12N2710/16122 ,  A61K2300/00

    摘要： The present invention generally relates to the field of cancer and methods and compositions for cancer immunotherapy. In one embodiment, a method for treating cancer in a patient comprises the steps of (a) administering at or near the cancer site an effective amount of a composition that promotes a therapeutic immune response to the cancer; and (b) ablating the cancer. In another embodiment, a method for treating an abnormal cellular proliferation in a patient comprises the steps of (a) administering at or near the site of the abnormal cellular proliferation an effective amount of a composition that promotes a therapeutic immune response to the abnormal cellular proliferation comprising (i) a polymeric particle; and (ii) optionally one or more therapeutic agents encapsulated in or incorporated on or into the polymeric particle; and (b) ablating the abnormal cellular proliferation.

    摘要翻译： 本发明一般涉及癌症领域，癌症免疫疗法的方法和组合物。 在一个实施方案中，用于治疗患者癌症的方法包括以下步骤：（a）在癌症部位或其附近施用有效量的促进对癌症的治疗性免疫应答的组合物; 和（b）烧蚀癌症。 在另一个实施方案中，用于治疗患者异常细胞增殖的方法包括以下步骤：（a）在异常细胞增殖的位点处或附近施用有效量的促进对异常细胞增殖的治疗性免疫应答的组合物 包括（i）聚​​合物颗粒; 和（ii）任选地一种或多种包封在聚合物颗粒中或掺入聚合物颗粒中的治疗剂; 和（b）消融异常的细胞增殖。

    MODULAR NANOPARTICLES FOR ADAPTABLE VACCINES
    5.
    发明申请
    MODULAR NANOPARTICLES FOR ADAPTABLE VACCINES 有权
    用于适应性疫苗的模块化纳米颗粒

    公开(公告)号：US20100104503A1

    公开(公告)日：2010-04-29

    申请号：US12527143

    申请日：2008-02-15

    申请人： Ira S. Mellman ,  Tarek M. Fahmy ,  William Mark Saltzman ,  Michael J. Caplan

    发明人： Ira S. Mellman ,  Tarek M. Fahmy ,  William Mark Saltzman ,  Michael J. Caplan

    IPC分类号： A61K39/12 ,  A61K39/02 ,  A61K39/002 ,  A61K39/35 ,  A61K38/20 ,  A61K38/21 ,  A61K51/00 ,  A61P31/00

    CPC分类号： A61K39/00 ,  A61K47/6849 ,  A61K47/6931 ,  A61K47/6937 ,  B82Y5/00

    摘要： Modular nanoparticle vaccine compositions and methods of making and using the same have been developed. Modular nanoparticle vaccine compositions comprise an antigen encapsulated in a polymeric particle and adaptor elements which modularly couple functional elements to the particle. The modular design of these vaccine compositions, which involves flexible addition and subtraction of antigen, adjuvant, immune potentiators, molecular recognition and transport mediation elements, as well as intracellular uptake mediators, allows for exquisite control over variables that are important in optimizing an effective vaccine delivery system.

    摘要翻译： 已经开发了模块化纳米颗粒疫苗组合物及其制备和使用方法。 模块化纳米颗粒疫苗组合物包含包封在聚合物颗粒中的抗原和将功能元件模块化地连接到颗粒的接头元件。 这些疫苗组合物的模块化设计涉及抗原，佐剂，免疫增强剂，分子识别和转运中介元件以及细胞内摄取介质的灵活加和减，允许精确控制在优化有效疫苗中重要的变量 输送系统。

    Immuno-modulatory composition
    6.
    发明授权
    Immuno-modulatory composition 有权
    免疫调节组成

    公开(公告)号：US09101548B2

    公开(公告)日：2015-08-11

    申请号：US12739357

    申请日：2008-10-24

    申请人： Susan Marie Metcalfe ,  Tarek M. Fahmy

    发明人： Susan Marie Metcalfe ,  Tarek M. Fahmy

    IPC分类号： A61K38/17 ,  A61K38/19 ,  A61K39/395 ,  A61K9/51 ,  A61K9/127 ,  A61K47/48 ,  B82Y5/00

    CPC分类号： A61K47/48869 ,  A61K9/127 ,  A61K9/5153 ,  A61K38/19 ,  A61K47/6849 ,  A61K47/6913 ,  A61K47/6925 ,  B82Y5/00

    摘要： A composition for modulating the immune response in a mammal comprising a pharmaceutically acceptable carrier solution and a plurality of biodegradable nanoparticles, wherein the nanoparticles comprise a targeting moiety that is able to bind selectively to the surface of a T lymphocyte cell and/or of a vascular endothelial cell and wherein the nanoparticles further comprise leukaemia inhibitory factor (LIF). Nanoparticle-mediated targeted delivery of LIF can be used a means to guide tolerogenesis in a patient and has immediate clinical application for recipients of organ grafts and also for patients suffering from autoimmune disease.

    摘要翻译： 用于调节哺乳动物中免疫应答的组合物，其包含药学上可接受的载体溶液和多种可生物降解的纳米颗粒，其中所述纳米颗粒包含能够选择性地结合T淋巴细胞和/或血管的表面的靶向部分 内皮细胞，并且其中所述纳米颗粒进一步包含白血病抑制因子（LIF）。 纳米粒子介导的LIF的靶向递送可用于指导患者的耐受性发生，并且对于器官移植物的接受者以及患有自身免疫性疾病的患者具有即时临床应用。

    CMOS-compatible silicon nano-wire sensors with biochemical and cellular interfaces
    7.
    发明授权
    CMOS-compatible silicon nano-wire sensors with biochemical and cellular interfaces 有权
    CMOS兼容的硅纳米线传感器，具有生化和蜂窝接口

    公开(公告)号：US09076665B2

    公开(公告)日：2015-07-07

    申请号：US12517230

    申请日：2007-12-06

    申请人： Eric D. Stern ,  Tarek M. Fahmy ,  Mark A. Reed ,  James F. Klemic

    发明人： Eric D. Stern ,  Tarek M. Fahmy ,  Mark A. Reed ,  James F. Klemic

    IPC分类号： G01N27/414 ,  H01L29/06 ,  B82Y10/00 ,  H01L29/04 ,  H01L29/16

    CPC分类号： H01L29/0665 ,  B82Y10/00 ,  G01N27/4146 ,  H01L29/045 ,  H01L29/0673 ,  H01L29/16

    摘要： The systems and methods described herein include a sensor for suitable for sensing chemical and biological substances. The sensor comprises a semiconductor layer formed in or on a substrate and a channel having nano-scale dimensions formed in the semiconductor layer, where the structure creates an electrically conducting pathway between a first contact and a second contact on the semiconductor layer. In certain preferred embodiments, the nano-scale channel has a trapezoidal cross-section with an effective width and exposed lateral faces, where the effective width is selected to have same order of magnitude as a Debye length (LD) of the semiconductor material of which the semiconductor layer is formed.

    摘要翻译： 本文所述的系统和方法包括适于感测化学和生物物质的传感器。 传感器包括形成在衬底中或衬底上的半导体层和形成在半导体层中的具有纳米级尺寸的沟道，其中该结构在半导体层上的第一接触和第二接触之间形成导电通路。 在某些优选实施例中，纳米尺度通道具有具有有效宽度和暴露侧面的梯形横截面，其中有效宽度被选择为具有与其半导体材料的德拜长度（LD）相同的数量级 形成半导体层。

    Calibration of nanostructure sensors
    8.
    发明授权
    Calibration of nanostructure sensors 有权

    公开(公告)号：US09599614B2

    公开(公告)日：2017-03-21

    申请号：US14005056

    申请日：2012-03-14

    申请人： Tarek M. Fahmy ,  Aleksandar Vacic ,  Mark A. Reed

    发明人： Tarek M. Fahmy ,  Aleksandar Vacic ,  Mark A. Reed

    IPC分类号： G01N27/414 ,  G01N33/543

    CPC分类号： G01N33/54373 ,  G01N27/4145 ,  G01N27/4146 ,  G01N33/5438

    摘要： The present invention relates to uniform nanostructure biosensors and methods of calibrating the response of nanostructure biosensors. The invention overcomes device to device variability that has made quantitative detection difficult. The described biosensors have uniform characteristics that allow for more reliable comparison across devices. The methods of the invention comprise normalizing the initial current rate, as measured by the nanostructure biosensor following the addition of an analyte, to device characteristics of the biosensor. The device characteristics of the biosensor which can be used to normalize the response include baseline current and transconductance. Calibration of responses allows for the generation of calibration curves for use in all devices to quantitatively detect an analyte, without the need for individual device calibration.

    Modular nanoparticles for adaptable vaccines
    9.
    发明授权
    Modular nanoparticles for adaptable vaccines 有权
    适用于疫苗的模块化纳米粒子

    公开(公告)号：US08889117B2

    公开(公告)日：2014-11-18

    申请号：US12527143

    申请日：2008-02-15

    申请人： Ira S. Mellman ,  Tarek M. Fahmy ,  William Mark Saltzman ,  Michael J. Caplan

    发明人： Ira S. Mellman ,  Tarek M. Fahmy ,  William Mark Saltzman ,  Michael J. Caplan

    IPC分类号： A61K39/00 ,  C07K14/00 ,  A61K47/48 ,  B82Y5/00

    CPC分类号： A61K39/00 ,  A61K47/6849 ,  A61K47/6931 ,  A61K47/6937 ,  B82Y5/00

    摘要： Modular nanoparticle vaccine compositions and methods of making and using the same have been developed. Modular nanoparticle vaccine compositions comprise an antigen encapsulated in a polymeric particle and adaptor elements which modularly couple functional elements to the particle. The modular design of these vaccine compositions, which involves flexible addition and subtraction of antigen, adjuvant, immune potentiators, molecular recognition and transport mediation elements, as well as intracellular uptake mediators, allows for exquisite control over variables that are important in optimizing an effective vaccine delivery system.

    摘要翻译： 已经开发了模块化纳米颗粒疫苗组合物及其制备和使用方法。 模块化纳米颗粒疫苗组合物包含包封在聚合物颗粒中的抗原和将功能元件模块化地连接到颗粒的接头元件。 这些疫苗组合物的模块化设计涉及抗原，佐剂，免疫增强剂，分子识别和转运中介元件以及细胞内摄取介质的灵活加和减，允许精确控制在优化有效疫苗中重要的变量 输送系统。