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1.发明申请Poly-gamma-glutamate having ultra high molecular weight and method for using the same 审中-公开具有超高分子量的聚-γ-谷氨酸盐及其使用方法公开(公告)号：US20060127447A1
公开(公告)日：2006-06-15
申请号：US10520557
申请日：2003-07-10
申请人： Moon-Hee Sung , Chung Park , Seung-Pyo Hong , Kwang Seok Kim , Jae Jun Song , Eu Gene Rha , Kwang Kim , Kenji Soda , Makoto Ashiuchi , Ha Ryoung Poo , Seung Lee
发明人： Moon-Hee Sung , Chung Park , Seung-Pyo Hong , Kwang Seok Kim , Jae Jun Song , Eu Gene Rha , Kwang Kim , Kenji Soda , Makoto Ashiuchi , Ha Ryoung Poo , Seung Lee
CPC分类号： A61K9/0014 , A61K8/88 , A61K9/0095 , A61K47/42 , A61Q19/00 , C08H1/00 , C12P21/02
摘要： The present invention relates to a poly-gamma-glutamate (PGA) having an ultra-high molecular weight greater than 5,000 kDa. The ultra-high molecular weight PGA according to the present invention has a mean molecular weight greater than 13,000 kDa, and more than 95% of its molecules have a molecular weight ranging from 3,000 to 15,000 kDa. Also, it can be produced by the culturing of Bacillus subtilis var. chungkookjang. The ultra-high molecular weight PGA according to the present invention shows very excellent moisture-absorbing, moisture-retaining, sustained release, mineral solubility, and water-absorbing properties, and thus, can be used as a new and high value-added material in various applications.
摘要翻译： 本发明涉及超高分子量大于5,000kDa的聚-γ-谷氨酸（PGA）。 根据本发明的超高分子量PGA的平均分子量大于13000kDa，其分子的95％以上具有3,000至15,000kDa的分子量。 此外，它可以通过培养枯草芽孢杆菌变种产生。 ung ko ang。 根据本发明的超高分子量PGA显示出非常优异的吸湿性，保湿性，缓释性，矿物溶解性和吸水性，因此可用作新的高附加值材料 在各种应用中。
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2.发明申请Cell surface expression vector of sars virus antigen and microorganisms transformed thereby 审中-公开sars病毒抗原和微生物转化的细胞表面表达载体公开(公告)号：US20060140971A1
公开(公告)日：2006-06-29
申请号：US10559631
申请日：2004-06-04
申请人： Moon-Hee Sung , Chul-Joong Kim , Chang-Min Jung , Seung-Pyo Hong , Jong Su Lee , Jae Choi , Kwang Kim , Kuroda Shunichi , Ha Ryoung Poo
发明人： Moon-Hee Sung , Chul-Joong Kim , Chang-Min Jung , Seung-Pyo Hong , Jong Su Lee , Jae Choi , Kwang Kim , Kuroda Shunichi , Ha Ryoung Poo
IPC分类号： A61K39/02 , C12N1/21 , C12N15/74 , C07K14/165
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/523 , C07K2319/00 , C12N9/93 , C12N15/74 , C12N2710/20022 , C12N2770/20022 , Y02A50/476
摘要： The present invention relates to a surface expression vector of SARS coronavirus antigen containing a gene encoding an antigen of SARS inducing coronavirus and any one or two or more of genes pgsB, pgsC and pgsA encoding poly-gamma-glutamic acid synthase complex, a microorganism transformed by the surface expression vector, and a SARS vaccine comprising the microorganism. According to the present invention, it is possible to economically produce a vaccine for prevention and treatment of SARS using a recombinant strain expressing an SARS coronavirus antigen on their surface.
摘要翻译： 本发明涉及SARS冠状病毒抗原的表达表达载体，其含有编码SARS诱导冠状病毒抗原的基因和编码聚-γ-谷氨酸合酶复合物的pgsB，pgsC和pgsA基因中的一种或两种以上的基因，微生物转化 通过表面表达载体和包含该微生物的SARS疫苗。 根据本发明，可以在表面上使用表达SARS冠状病毒抗原的重组菌株经济地制备用于预防和治疗SARS的疫苗。
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公开(公告)号：US20080132440A1
公开(公告)日：2008-06-05
申请号：US11571269
申请日：2005-03-04
申请人： Moon-Hee Sung , Chung Park , Seok Chan Kim , Gyoo Soon Park , Hiroshi Uyama , Ha Ryoung Poo , Jae Jun Song
发明人： Moon-Hee Sung , Chung Park , Seok Chan Kim , Gyoo Soon Park , Hiroshi Uyama , Ha Ryoung Poo , Jae Jun Song
CPC分类号： A61Q19/00 , A61K8/67 , A61K8/676 , A61K8/88 , A61K31/375 , A61K2800/57 , A61Q5/02 , A61Q19/007 , A61Q19/08 , A61Q19/10
摘要： The present invention relates to PGA-vitamin complex containing poly-γ-glutamic acid(PGA), vitamin preparations containing said PGA-vitamin complex or cosmetic compositions. The inventive PGA-vitamin complex having excellent hygroscopicity, moisturizing property and skin compatibility, which is a complex of poly-γ-glutamic acid and vitamin, has the effect of sustained-release as well as improves stability of vitamin having the functions, such as promotion of metabolism, anti-oxidation effect, protection of cell wall, increasing immunity, prevention of dry skin and keratinization, anti-wrinkles and moisturizing skin, thereby being useful as cosmetic compositions and sustained-release vitamin preparations for various applications.
摘要翻译： 本发明涉及含有聚-γ-谷氨酸（PGA）的PGA-维生素复合物，含有所述PGA-维生素复合物或化妆品组合物的维生素制剂。 具有优异的吸湿性，保湿性和皮肤相容性的本发明的PGA-维生素复合物，其是聚-γ-谷氨酸和维生素的复合物，具有持续释放的作用，并提高具有功能的维生素的稳定性，例如 促进新陈代谢，抗氧化作用，保护细胞壁，增加免疫力，预防皮肤干燥和角质化，抗皱和保湿皮肤，从而可用作各种用途的化妆品组合物和缓释维生素制剂。
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公开(公告)号：US20080152615A1
公开(公告)日：2008-06-26
申请号：US11817021
申请日：2005-12-06
申请人： Moon-Hee Sung , Chul-Joong Kim , Ha Ryoung Poo , Seung Pyo Hong , Jong Soo Lee , Ji Youn Kim
发明人： Moon-Hee Sung , Chul-Joong Kim , Ha Ryoung Poo , Seung Pyo Hong , Jong Soo Lee , Ji Youn Kim
CPC分类号： A61K39/39 , A61K2039/55516
摘要： The present invention relates to a composition for an immunopotentiator (adjuvant) containing poly-gamma-glutamic acid and a composition for a vaccine containing the immunopotentiator, and more particularly, to an immunopotentiator containing poly-gamma-glutamic acid capable of enhancing antibody production rate by administering it to an animal together with antigen having low immunogenicity, and a composition for a vaccine containing the immunopotentiator and antigen. The inventive adjuvant has almost no toxicity and side effects, and show high antibody titer even when it is used with antigen having poor immunogenicity, so it can be used by adding to medical composition including preventive or curative vaccine for non-contagious chronic diseases as well as cancer, especially prostatic carcinoma, colon carcinoma, lung cancer, breast cancer, ovarian cancer, head and neck cancer, pudendum cancer, bladder cancer, brain tumor and glioma.
摘要翻译： 本发明涉及含有聚-γ-谷氨酸的免疫增强剂（佐剂）组合物和含有免疫增强剂的疫苗组合物，更具体地说，涉及含有能够提高抗体产生率的聚-γ-谷氨酸的免疫增强剂 通过将其与抗免疫原性低的抗原一起施用于动物，以及含有免疫增强剂和抗原的疫苗组合物。 本发明的佐剂几乎没有毒副作用，即使与抗免疫原性差的抗原一起使用也显示出高的抗体效价，因此可以通过添加包含用于非传染性慢性疾病的预防或治疗性疫苗的医药组合物 作为癌症，特别是前列腺癌，结肠癌，肺癌，乳腺癌，卵巢癌，头颈癌，pudendum癌，膀胱癌，脑肿瘤和胶质瘤。
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5.发明授权公开(公告)号：US07871816B2
公开(公告)日：2011-01-18
申请号：US11939546
申请日：2007-11-13
申请人： Moon-Hee Sung , Ha Ryoung Poo , Jong Soo Lee , Chang Min Jung , Seung Pyo Hong , Chul-Joong Kim , Sue-nie Park , Hyun-mi Pyo
发明人： Moon-Hee Sung , Ha Ryoung Poo , Jong Soo Lee , Chang Min Jung , Seung Pyo Hong , Chul-Joong Kim , Sue-nie Park , Hyun-mi Pyo
CPC分类号： C07K14/005 , A61K39/0011 , A61K2039/523 , C12N7/00 , C12N2710/20022 , C12N2730/10122 , C12N2830/008
摘要： Expression vectors that can efficiently produce virion capsid protein, tumor-associated protein of human papillomavirus on a microbial surface. Bacterial strains harboring such surface display vectors, and the use of the bacterial strains or their extracts or purified products as complex vaccines, are also described. The surface display vectors contain one or more than two genes selected from among pgsB, pgsC and pgsA, encoding a poly-χ-glutamic acid synthetase complex (pgsBCA) of a Bacillus sp. strain, and genes that encode virion capsid proteins, tumor-associated proteins of human papillomavirus. Methods for preparing the foregoing vectors, vaccines and transformed microorganisms are also described.
摘要翻译： 可以有效地产生病毒体衣壳蛋白，人乳头瘤病毒的肿瘤相关蛋白在微生物表面上的表达载体。 还描述了携带这种表面显示载体的细菌菌株，以及细菌菌株或其提取物或纯化产物作为复合疫苗的用途。 表面显示载体含有选自pgsB，pgsC和pgsA中的一种或多于两种的基因，编码芽孢杆菌属的多χ-谷氨酸合成酶复合物（pgsBCA）。 菌株和编码病毒载体衣壳蛋白，人乳头瘤病毒的肿瘤相关蛋白的基因。 还描述了制备前述载体，疫苗和转化的微生物的方法。
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6.发明授权Antibiotics-independent vector for constant high-expression and method for gene expression using the same 失效用于恒定高表达的抗生素无关载体和使用其的基因表达方法公开(公告)号：US07049097B2
公开(公告)日：2006-05-23
申请号：US10221349
申请日：2002-01-11
申请人： Moon Hee Sung , Seung Goo Lee , Seung Pyo Hong , Eun Ja Yoon , Yoon Ho Choi , Ha Ryoung Poo
发明人： Moon Hee Sung , Seung Goo Lee , Seung Pyo Hong , Eun Ja Yoon , Yoon Ho Choi , Ha Ryoung Poo
CPC分类号： C12N15/65
摘要： An antibiotic-independent vector for stable vector maintenance and high protein expression and a method for gene expression using this vector are disclosed. The stable maintenance of the vector is due to expression of a glutamic acid racemase to complement a D-glutamic acid auxotroph. No antibiotics, such as ampicillin, are necessary for the stable maintenance of this vector.
摘要翻译： 公开了一种用于稳定载体维持和高蛋白表达的抗生素非依赖载体和使用该载体的基因表达方法。 载体的稳定维持是由于表达谷氨酸消旋酶以补充D-谷氨酸营养缺陷型。 不需要抗生素如氨苄青霉素来稳定维持该载体。
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7.发明申请公开(公告)号：US20050249752A1
公开(公告)日：2005-11-10
申请号：US10530083
申请日：2003-10-17
申请人： Moon-Hee Sung , Ha Ryoung Poo , Jong-Soo Lee , Chang-Min Jung , Seong-Pyo Hong , Chul-Joong Kim , Sue-nie Park , Hyun-mi Pyo
发明人： Moon-Hee Sung , Ha Ryoung Poo , Jong-Soo Lee , Chang-Min Jung , Seong-Pyo Hong , Chul-Joong Kim , Sue-nie Park , Hyun-mi Pyo
IPC分类号： C12N15/86 , A61K31/00 , A61K39/00 , A61K39/02 , A61K39/12 , C07K14/02 , C07K14/025 , C12N1/21 , C12N15/63 , C12N15/74
CPC分类号： C07K14/005 , A61K39/0011 , A61K2039/523 , C12N7/00 , C12N2710/20022 , C12N2730/10122 , C12N2830/008
摘要： Expression vectors are described that can efficiently produce virion capsid protein, tumor-associated protein of human papillomavirus on a microbial surface. Bacterial strains harboring such surface display vectors, and the use of the bacterial strains or their extracts or purified products as complex vaccines, are also described. The surface display vectors contain one or more than two genes selected from among pgsB, pgsC and pgsA, encoding a poly-χ-glutamic acid synthetase complex (pgsBCA) of a Bacillus sp. strain, and genes that encode virion capsid proteins, tumor-associated proteins of human papillomavirus. Methodology for preparing the foregoing vectors, vaccines and transformed microorganisms are also described.
摘要翻译： 描述了可以在微生物表面上有效地产生病毒载体衣壳蛋白，人乳头瘤病毒的肿瘤相关蛋白的表达载体。 还描述了携带这种表面显示载体的细菌菌株，以及细菌菌株或其提取物或纯化产物作为复合疫苗的用途。 表面显示载体含有一个或多于两个选自pgsB，pgsC和pgsA的基因，编码芽孢杆菌属的多基因 - 谷氨酸合成酶复合物（pgsBCA）。 菌株和编码病毒载体衣壳蛋白，人乳头瘤病毒的肿瘤相关蛋白的基因。 还描述了制备前述载体，疫苗和转化的微生物的方法。
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8.发明授权公开(公告)号：US07425438B2
公开(公告)日：2008-09-16
申请号：US10530083
申请日：2003-10-17
申请人： Moon-Hee Sung , Ha Ryoung Poo , Jong-Soo Lee , Chang-Min Jung , Seong-Pyo Hong , Chul-Joong Kim , Sue-nie Park , Hyun-mi Pyo
发明人： Moon-Hee Sung , Ha Ryoung Poo , Jong-Soo Lee , Chang-Min Jung , Seong-Pyo Hong , Chul-Joong Kim , Sue-nie Park , Hyun-mi Pyo
CPC分类号： C07K14/005 , A61K39/0011 , A61K2039/523 , C12N7/00 , C12N2710/20022 , C12N2730/10122 , C12N2830/008
摘要： Expression vectors are described that can efficiently produce virion capsid protein, tumor-associated protein of human papillomavirus on a microbial surface. Bacterial strains harboring such surface display vectors, and the use of the bacterial strains or their extracts or purified products as complex vaccines, are also described. The surface display vectors contain one or more than two genes selected from among pgsB, pgsC and pgsA, encoding a poly-χ-glutamic acid synthetase complex (pgsBCA) of a Bacillus sp. strain, and genes that encode virion capsid proteins, tumor-associated proteins of human papillomavirus, Methodology for preparing the foregoing vectors, vaccines and transformed microorganisms are also described.
摘要翻译： 描述了可以在微生物表面上有效地产生病毒载体衣壳蛋白，人乳头瘤病毒的肿瘤相关蛋白的表达载体。 还描述了携带这种表面显示载体的细菌菌株，以及细菌菌株或其提取物或纯化产物作为复合疫苗的用途。 表面显示载体含有一个或多于两个选自pgsB，pgsC和pgsA的基因，编码芽孢杆菌属的多基因 - 谷氨酸合成酶复合物（pgsBCA）。 菌株和编码病毒载体衣壳蛋白，人乳头瘤病毒的肿瘤相关蛋白的基因。 还描述了制备前述载体，疫苗和转化的微生物的方法。
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9.发明申请公开(公告)号：US20090117151A1
公开(公告)日：2009-05-07
申请号：US11939546
申请日：2007-11-13
申请人： Moon-Hee Sung , Ha Ryoung Poo , Jong-Soo Lee , Chang-Min Jung , Seong-Pyo Hong , Chul-Joong Kim , Sue-nie Park , Hyun-mi Pyo
发明人： Moon-Hee Sung , Ha Ryoung Poo , Jong-Soo Lee , Chang-Min Jung , Seong-Pyo Hong , Chul-Joong Kim , Sue-nie Park , Hyun-mi Pyo
CPC分类号： C07K14/005 , A61K39/0011 , A61K2039/523 , C12N7/00 , C12N2710/20022 , C12N2730/10122 , C12N2830/008
摘要： Expression vectors that can efficiently produce virion capsid protein, tumor-associated protein of human papillomavirus on a microbial surface. Bacterial strains harboring such surface display vectors, and the use of the bacterial strains or their extracts or purified products as complex vaccines, are also described. The surface display vectors contain one or more than two genes selected from among pgsB, pgsC and pgsA, encoding a poly-χ-glutamic acid synthetase complex (pgsBCA) of a Bacillus sp. strain, and genes that encode virion capsid proteins, tumor-associated proteins of human papillomavirus. Methods for preparing the foregoing vectors, vaccines and transformed microorganisms are also described.
摘要翻译： 可以有效地产生病毒体衣壳蛋白，人乳头瘤病毒的肿瘤相关蛋白在微生物表面上的表达载体。 还描述了携带这种表面显示载体的细菌菌株，以及细菌菌株或其提取物或纯化产物作为复合疫苗的用途。 表面显示载体含有一个或多于两个选自pgsB，pgsC和pgsA的基因，编码芽孢杆菌属的多基因 - 谷氨酸合成酶复合物（pgsBCA）。 菌株和编码病毒载体衣壳蛋白，人乳头瘤病毒的肿瘤相关蛋白的基因。 还描述了制备前述载体，疫苗和转化的微生物的方法。
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