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    Surface expression method of peptides P5 and Anal3 using the gene encoding poly-gamma-glutamate synthetase
    2.
    发明授权
    Surface expression method of peptides P5 and Anal3 using the gene encoding poly-gamma-glutamate synthetase 有权
    使用编码聚-γ-谷氨酸合成酶的基因的肽P5和Anal3的表面表达方法

    公开(公告)号：US08080402B2

    公开(公告)日：2011-12-20

    申请号：US11622158

    申请日：2007-01-11

    申请人： Moon-Hee Sung ,  Seung-Pyo Hong ,  Jong-Su Lee ,  Chang-Min Jung ,  Kyung-Soo Hahm ,  Dong-Gun Lee ,  Yoon Kyung Park ,  Chul-Joong Kim ,  Ha-Ryoung Poo

    发明人： Moon-Hee Sung ,  Seung-Pyo Hong ,  Jong-Su Lee ,  Chang-Min Jung ,  Kyung-Soo Hahm ,  Dong-Gun Lee ,  Yoon Kyung Park ,  Chul-Joong Kim ,  Ha-Ryoung Poo

    IPC分类号： C12N15/00 ,  C12N1/21 ,  A61K48/00

    CPC分类号： C07K14/32

    摘要： The present invention relates to a method for expressing each of peptide antibiotics P5 3 and Anal3 35 having amphiphilicity and showing antibacterial, antifungal and anticancer activities 61, 63, 65, 67, 69, 71, on the microbial surface, using a vector containing outer membrane protein genes (pgsBCA) that are derived from Bacillus sp. strains and involved in the synthesis of poly-gamma-glutamate. Moreover, the present invention relates to lactic acid-forming bacteria having each of the peptide antibiotics P5 15 and Anal3 43 expressed on their surface, and the use thereof. According to the present invention, the peptide antibiotics can be expressed on the surface of various microorganisms transformed with the surface expression vectors. The inventive method for the surface expression of the peptide antibiotics allows the peptide antibiotics to be mass-produced without a purification process. Thus, the inventive method has very high industrial applicability. Further, the present invention can be applied to other peptide antibiotics besides P5 3 and Anal 3 35.

    摘要翻译： 本发明涉及在微生物表面上表达具有两亲性的肽抗生素P5 3和Anal335各自表现出抗菌，抗真菌，抗癌活性的方法， 来自芽孢杆菌属的膜蛋白基因（pgsBCA） 菌株并参与了聚-γ-谷氨酸的合成。 此外，本发明涉及在其表面表达的各肽抗生素P515和Anal343各自的乳酸形成细菌及其用途。 根据本发明，肽抗生素可以在用表面表达载体转化的各种微生物的表面上表达。 肽抗生素表面表达的本发明方法允许肽抗生素在没有纯化过程的情况下批量生产。 因此，本发明的方法具有非常高的工业实用性。 此外，除了P5 3和Anal 3 35之外，本发明可以应用于其它肽抗生素。

    COMPOSITION FOR IMPROVING TLR-MEDIATED CELLULAR IMMUNITY COMPRISING POLY-GAMMA-GLUTAMIC ACID
    3.
    发明申请
    COMPOSITION FOR IMPROVING TLR-MEDIATED CELLULAR IMMUNITY COMPRISING POLY-GAMMA-GLUTAMIC ACID 审中-公开
    用于改善包含多糖 - 谷氨酸的TLR介导的细胞免疫的组合物

    公开(公告)号：US20100255040A1

    公开(公告)日：2010-10-07

    申请号：US12682662

    申请日：2007-10-15

    申请人： Moon-Hee Sung ,  Chul Joong Kim ,  Haryoung Poo ,  Il Han Lee ,  Yang-Hyun Kim

    发明人： Moon-Hee Sung ,  Chul Joong Kim ,  Haryoung Poo ,  Il Han Lee ,  Yang-Hyun Kim

    IPC分类号： A61K39/00 ,  A61P31/12 ,  A61P31/04 ,  A61P35/00

    CPC分类号： A61K31/765

    摘要： The present invention relates to a composition for improving cellular immunity, which comprises an effective dose of poly-gamma-glutamic acid, and more particularly, to a composition for improving cellular immunity comprising poly-gamma-glutamic acid, which has effects of inducing enhancement of TLR-mediated Th1 cellular immunity and improving antigen presenting activity to maintain the improved activity. The inventive composition comprising an effective dose of poly-gamma-glutamic acid has very little toxicity and side effects, and can be added to a vaccine composition for preventing and treating animal viral or bacterial infections and cancer, or a vaccine composition for preventing and treating human viral or bacterial infections and cancer to show cellular immunity-enhancing effects.

    摘要翻译： 本发明涉及一种用于改善细胞免疫的组合物，其包含有效剂量的聚-γ-谷氨酸，更具体地，涉及包含多聚γ-谷氨酸的组合物，所述组合物具有诱导增强的作用 的TLR介导的Th1细胞免疫并改善抗原呈递活性以维持改善的活性。 包含有效剂量的聚-γ-谷氨酸的本发明组合物具有非常少的毒性和副作用，并且可以加入用于预防和治疗动物病毒或细菌感染和癌症的疫苗组合物或用于预防和治疗的疫苗组合物 人类病毒或细菌感染和癌症显示细胞免疫增强作用。

    Surface expression vector for fusion protein of Myo-2 peptide multimer and myostatin, and microorganism transformed by thereof
    6.
    发明授权
    Surface expression vector for fusion protein of Myo-2 peptide multimer and myostatin, and microorganism transformed by thereof 有权
    Myo-2肽多聚体和肌生成抑制素融合蛋白的表面表达载体，以及由其转化的微生物

    公开(公告)号：US08470551B2

    公开(公告)日：2013-06-25

    申请号：US12682453

    申请日：2007-11-30

    申请人： Moon-Hee Sung ,  Chul Joong Kim ,  Haryoung Poo ,  Ji Yeon Kim ,  Young Suk Kim ,  Long Chun Xu

    发明人： Moon-Hee Sung ,  Chul Joong Kim ,  Haryoung Poo ,  Ji Yeon Kim ,  Young Suk Kim ,  Long Chun Xu

    IPC分类号： C12N15/09 ,  C12N1/21 ,  C12N15/63 ,  C07K1/00

    CPC分类号： C07K14/475

    摘要： The present invention relates to a fusion protein in which a myostatin mature protein is fused to a multimer of myostatin-derived antigenic peptide Myo-2, a surface expression vector containing a polynucleotide encoding the fusion protein, a recombinant microorganism transformed with the vector, and a feedstuff additive or a pharmaceutical composition containing the microorganism as an effective ingredient. The feedstuff additive or pharmaceutical composition according to the present invention can be used for muscle development and regulation of muscle growth in livestock and poultry, as well as for preventing and treating muscle-wasting diseases and degenerative diseases such as muscular dystrophy, muscular atrophy and the like. In addition, the transformed strain shows the same effect even if the strain itself after culture thereof is directly used, and thus it is very economical.

    摘要翻译： 本发明涉及一种融合蛋白，其中肌生成抑制素成熟蛋白质与产生肌生成抑制素的抗原肽Myo-2的多聚体融合，含有编码融合蛋白的多核苷酸的表面表达载体，用载体转化的重组微生物，以及 饲料添加剂或含有该微生物作为有效成分的药物组合物。 根据本发明的饲料添加剂或药物组合物可用于肌肉发育和调节家畜和家禽中的肌肉生长，以及用于预防和治疗肌肉消瘦疾病和退行性疾病如肌营养不良症，肌肉萎缩症和 喜欢。 此外，即使直接使用其培养后的菌株本身，转化菌株也显示相同的效果，因此是非常经济的。