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1.发明授权Surface expression method of peptides P5 and Anal3 using the gene encoding poly-gamma-glutamate synthetase 失效使用编码聚-γ-谷氨酸合成酶的基因的肽P5和Anal3的表面表达方法公开(公告)号：US07255855B2
公开(公告)日：2007-08-14
申请号：US10789164
申请日：2004-02-27
申请人： Moon-Hee Sung , Seung-Pyo Hong , Jong-Su Lee , Chang-Min Jung , Kyung-Soo Hahm , Dong-Gun Lee , Yoon Kyung Park , Chul-Joong Kim , Ha-Ryoung Poo
发明人： Moon-Hee Sung , Seung-Pyo Hong , Jong-Su Lee , Chang-Min Jung , Kyung-Soo Hahm , Dong-Gun Lee , Yoon Kyung Park , Chul-Joong Kim , Ha-Ryoung Poo
CPC分类号： C07K14/32
摘要： The present invention relates to a method for expressing each of peptide antibiotics P5 3 and Ana13 35 having amphiphilicity and showing antibacterial, antifungal and anticancer activities 61, 63, 65, 67, 69, 71, on the microbial surface, using a vector containing outer membrane protein genes (pgsBCA) that are derived from Bacillus sp. strains and involved in the synthesis of poly-gamma-glutamate. Moreover, the present invention relates to lactic acid-forming bacteria having each of the peptide antibiotics P5 15 and Ana13 43 expressed on their surface, and the use thereof.According to the present invention, the peptide antibiotics can be expressed on the surface of various microorganisms transformed with the surface expression vectors. The inventive method for the surface expression of the peptide antibiotics allows the peptide antibiotics to be mass-produced without a purification process. Thus, the inventive method has very high industrial applicability. Further, the present invention can be applied to other peptide antibiotics besides P5 3 and Ana13 35.
摘要翻译： 本发明涉及一种用于表达具有两亲性的肽抗生素P5 3和Ana1335的方法，并且在微生物表面上显示出抗菌，抗真菌和抗癌活性61,63,65,67,69,71，使用含有外源的载体 来自芽孢杆菌属的膜蛋白基因（pgsBCA） 菌株并参与了聚-γ-谷氨酸的合成。 此外，本发明涉及在其表面表达的各种肽抗生素P515和Ana1343的乳酸形成细菌及其用途。 根据本发明，肽抗生素可以在用表面表达载体转化的各种微生物的表面上表达。 肽抗生素表面表达的本发明方法允许肽抗生素在没有纯化过程的情况下批量生产。 因此，本发明的方法具有非常高的工业实用性。 此外，本发明可以应用于除P5 3和Ana1335之外的其它肽抗生素。
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2.发明授权Surface expression method of peptides P5 and Anal3 using the gene encoding poly-gamma-glutamate synthetase 有权使用编码聚-γ-谷氨酸合成酶的基因的肽P5和Anal3的表面表达方法公开(公告)号：US08080402B2
公开(公告)日：2011-12-20
申请号：US11622158
申请日：2007-01-11
申请人： Moon-Hee Sung , Seung-Pyo Hong , Jong-Su Lee , Chang-Min Jung , Kyung-Soo Hahm , Dong-Gun Lee , Yoon Kyung Park , Chul-Joong Kim , Ha-Ryoung Poo
发明人： Moon-Hee Sung , Seung-Pyo Hong , Jong-Su Lee , Chang-Min Jung , Kyung-Soo Hahm , Dong-Gun Lee , Yoon Kyung Park , Chul-Joong Kim , Ha-Ryoung Poo
CPC分类号： C07K14/32
摘要： The present invention relates to a method for expressing each of peptide antibiotics P5 3 and Anal3 35 having amphiphilicity and showing antibacterial, antifungal and anticancer activities 61, 63, 65, 67, 69, 71, on the microbial surface, using a vector containing outer membrane protein genes (pgsBCA) that are derived from Bacillus sp. strains and involved in the synthesis of poly-gamma-glutamate. Moreover, the present invention relates to lactic acid-forming bacteria having each of the peptide antibiotics P5 15 and Anal3 43 expressed on their surface, and the use thereof. According to the present invention, the peptide antibiotics can be expressed on the surface of various microorganisms transformed with the surface expression vectors. The inventive method for the surface expression of the peptide antibiotics allows the peptide antibiotics to be mass-produced without a purification process. Thus, the inventive method has very high industrial applicability. Further, the present invention can be applied to other peptide antibiotics besides P5 3 and Anal 3 35.
摘要翻译： 本发明涉及在微生物表面上表达具有两亲性的肽抗生素P5 3和Anal335各自表现出抗菌，抗真菌，抗癌活性的方法， 来自芽孢杆菌属的膜蛋白基因（pgsBCA） 菌株并参与了聚-γ-谷氨酸的合成。 此外，本发明涉及在其表面表达的各肽抗生素P515和Anal343各自的乳酸形成细菌及其用途。 根据本发明，肽抗生素可以在用表面表达载体转化的各种微生物的表面上表达。 肽抗生素表面表达的本发明方法允许肽抗生素在没有纯化过程的情况下批量生产。 因此，本发明的方法具有非常高的工业实用性。 此外，除了P5 3和Anal 3 35之外，本发明可以应用于其它肽抗生素。
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3.发明申请Surface expression method of peptides P5 and ANAL3 using the gene encoding poly-gamma-glutamate synthetase 失效使用编码聚-γ-谷氨酸合成酶的基因的肽P5和ANAL3的表达表达方法公开(公告)号：US20050191720A1
公开(公告)日：2005-09-01
申请号：US10789164
申请日：2004-02-27
申请人： Moon-Hee Sung , Seung-Pyo Hong , Jong-Su Lee , Chang-Min Jung , Kyung-Soo Hahm , Dong-Gun Lee , Yoon Park , Chul-Joong Kim , Ha-Ryoung Poo
发明人： Moon-Hee Sung , Seung-Pyo Hong , Jong-Su Lee , Chang-Min Jung , Kyung-Soo Hahm , Dong-Gun Lee , Yoon Park , Chul-Joong Kim , Ha-Ryoung Poo
CPC分类号： C07K14/32
摘要： The present invention relates to a method for expressing each of peptide antibiotics P5 3 and Anal3 35 having amphiphilicity and showing antibacterial, antifungal and anticancer activities 61, 63, 65, 67, 69, 71, on the microbial surface, using a vector containing outer membrane protein genes (pgsBCA) that are derived from Bacillus sp. strains and involved in the synthesis of poly-gamma-glutamate. Moreover, the present invention relates to lactic acid-forming bacteria having each of the peptide antibiotics P5 15 and Anal3 43 expressed on their surface, and the use thereof. According to the present invention, the peptide antibiotics can be expressed on the surface of various microorganisms transformed with the surface expression vectors. The inventive method for the surface expression of the peptide antibiotics allows the peptide antibiotics to be mass-produced without a purification process. Thus, the inventive method has very high industrial applicability. Further, the present invention can be applied to other peptide antibiotics besides P5 3 and Anal3 35.
摘要翻译： 本发明涉及在微生物表面上表达具有两亲性的肽抗生素P5 3和Anal335各自表现出抗菌，抗真菌，抗癌活性的方法， 来自芽孢杆菌属的膜蛋白基因（pgsBCA） 菌株并参与了聚-γ-谷氨酸的合成。 此外，本发明涉及在其表面表达的各肽抗生素P515和Anal343各自的乳酸形成细菌及其用途。 根据本发明，肽抗生素可以在用表面表达载体转化的各种微生物的表面上表达。 肽抗生素表面表达的本发明方法允许肽抗生素在没有纯化过程的情况下批量生产。 因此，本发明的方法具有非常高的工业实用性。 此外，本发明可以应用于除P5 3和Anal335之外的其它肽抗生素。
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4.发明授权Peptides with increased + charge and hydrophobicity by substituting one or more amino acids of CA-MA peptide and pharmaceutical compositions containing thereof 失效通过取代一种或多种CA-MA肽的氨基酸和含有它们的药物组合物，具有增加的+电荷和疏水性的肽公开(公告)号：US06800727B2
公开(公告)日：2004-10-05
申请号：US10081418
申请日：2002-02-22
申请人： Kyung-Soo Hahm , Dong Gun Lee , YoonKyung Park
发明人： Kyung-Soo Hahm , Dong Gun Lee , YoonKyung Park
IPC分类号： A61K3800
CPC分类号： C07K14/43563 , A61K38/00 , C07K14/435 , C07K14/463 , C07K2319/00
摘要： The present invention relates to novel peptides with increased + charge and hydrophobicity by substituting one or more amino acids of CA-MA peptide in which cecropin A (CA) and magainin 2(MA) were conjugated and pharmaceutical compositions containing thereof. More precisely, the present invention relates to synthetic peptides prepared by substituting one or more amino acids of CA-MA peptide represented by the SEQ. ID. NO: 1 with amino acids having + charge and hydrophobicity and anti-bacterial, anti-fungal and anticancer compositions containing thereof. The synthetic peptides of the present invention have no cytotoxicity but have excellent anti-bacterial, anti-fungal and anticancer activity, leading in an effective use thereof as a safe anticancer agent and antibiotics.
摘要翻译： 本发明涉及通过取代一种或多种CA-MA肽的氨基酸，其中螯合了天蚕素A（CA）和magainin 2（MA）和其含有的药物组合物，其具有增加的+电荷和疏水性的新型肽。 更准确地说，本发明涉及通过用SEQ ID NO：1所示的CA-MA肽取代一个或多个氨基酸制备的合成肽。 ID。 NO：1，其具有+电荷和疏水性的氨基酸和含有它们的抗细菌，抗真菌和抗癌组合物。 本发明的合成肽不具有细胞毒性，但具有优良的抗细菌，抗真菌，抗癌活性，有效地用作安全抗癌剂和抗生素。
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5.发明申请NOVEL ANTIBIOTIC PEPTIDE DERIVED FROM RIBOSOMAL PROTEIN L1 OF HELICOBACTER PYLORI AND USE THEREOF 有权HELICOBACTER PYLORI的RIBOSOMAL蛋白L1衍生的新型抗生素肽及其用途公开(公告)号：US20110053834A1
公开(公告)日：2011-03-03
申请号：US12863406
申请日：2008-11-25
CPC分类号： C07K14/21 , A61K38/00 , C07K14/195 , C07K14/24 , C07K14/245 , C07K14/255 , C07K14/31 , C07K14/32 , Y02A50/473 , Y02A50/481
摘要： The present invention relates to a new antibiotic peptide and a usage thereof, which are derived from ribosomal protein L1, RPL1 of Helicobacter pylori. Specifically, the antibiotic peptide comprising the amino acid sequence of SEQ. ID. NO:1 derived from ribosomal protein L1, RPL1 of Helicobacter pylori is substituted with a Phenylalanine, which is situated at the first and the eighth position from the antibiotic peptide, or in addition an Asparagine, which is situated at the thirteenth position of the antibiotic peptide, is substituted with lysine, wherein the produced peptides have maintained more decreased cytotoxicity when comparing to the existing antibiotic peptides and can be used as a safe antibiotics by showing more antibacterial activity.
摘要翻译： 本发明涉及从幽门螺杆菌的核糖体蛋白L1，RPL1衍生的新的抗生素肽及其用途。 具体地，包含SEQ ID NO：1的氨基酸序列的抗生素肽。 ID。 来自核糖体蛋白L1的NO：1，幽门螺旋杆菌的RPL1被苯丙氨酸取代，苯丙氨酸位于抗生素肽的第一和第八位，或另外位于抗生素的第十三位的天冬酰胺 肽被赖氨酸取代，其中所产生的肽与现有的抗生素肽相比保持更多的细胞毒性，并且可以通过显示更多的抗菌活性而被用作安全的抗生素。
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6.发明授权Antibiotic peptide derived from ribosomal protein L1 of Helicobacter pylori and use thereof 有权衍生自幽门螺杆菌的核糖体蛋白L1的抗生素肽及其用途公开(公告)号：US08410046B2
公开(公告)日：2013-04-02
申请号：US12863406
申请日：2008-11-25
CPC分类号： C07K14/21 , A61K38/00 , C07K14/195 , C07K14/24 , C07K14/245 , C07K14/255 , C07K14/31 , C07K14/32 , Y02A50/473 , Y02A50/481
摘要： The present invention relates to a new antibiotic peptide and a usage thereof, which are derived from ribosomal protein L1, RPL1 of Helicobacter pylori. Specifically, the antibiotic peptide comprising the amino acid sequence of SEQ. ID. NO:1 derived from ribosomal protein L1, RPL1 of Helicobacter pylori is substituted with a Phenylalanine, which is situated at the first and the eighth position from the antibiotic peptide, or in addition an Asparagine, which is situated at the thirteenth position of the antibiotic peptide, is substituted with lysine, wherein the produced peptides have maintained more decreased cytotoxicity when comparing to the existing antibiotic peptides and can be used as a safe antibiotics by showing more antibacterial activity.
摘要翻译： 本发明涉及从幽门螺杆菌的核糖体蛋白L1，RPL1衍生的新的抗生素肽及其用途。 具体地，包含SEQ ID NO：1的氨基酸序列的抗生素肽。 ID。 来自核糖体蛋白L1的NO：1，幽门螺旋杆菌的RPL1被苯丙氨酸取代，苯丙氨酸位于抗生素肽的第一和第八位，或另外位于抗生素的第十三位的天冬酰胺 肽被赖氨酸取代，其中所产生的肽与现有的抗生素肽相比保持更多的细胞毒性，并且可以通过显示更多的抗菌活性而被用作安全的抗生素。
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