公开(公告)号：US10729783B2

公开(公告)日：2020-08-04

申请号：US15681207

申请日：2017-08-18

申请人： NATIONAL TAIWAN UNIVERSITY

发明人： Chung-Yuan Mou ,  Nai-Yuan Kou ,  Si-Han Wu ,  Yi-Ping Chen

IPC分类号： A61K47/69 ,  A61K47/02 ,  A61K9/51 ,  A61K38/43 ,  A61K39/00

摘要： The present invention relates to hollow silica nanoparticles as a drug delivery system loading bioactive ingredients. Particularly, the present invention relates to silica nanoparticles comprising multi-layered silica shells with one or more bioactive ingredients encapsulated within and their applications in drug delivery; and processes of preparing the same.

公开(公告)号：US20160038608A1

公开(公告)日：2016-02-11

申请号：US14819438

申请日：2015-08-06

申请人： National Taiwan University

发明人： Chung-Yuan Mou ,  Yi-Ping Chen ,  Si-Han Wu

IPC分类号： A61K47/48 ,  A61K47/42 ,  A61K47/24

CPC分类号： A61K47/6923 ,  A61K39/385 ,  A61K47/62 ,  A61K47/6925 ,  A61K47/6929 ,  G01N33/552 ,  G01N2333/163

摘要： Mesoporous carriers for delivering targets into a cell are provided. The mesoporous carriers comprise hollow silica nanospheres (HSN) or mesoporous silica nanoparticles (MSN) and the targets bound to or encapsulated by the hollow silica nanospheres or the mesoporous silica nanoparticles. The targets includes at least two different targets, and the targets may include peptides, proteins, enzymes and/or enzymatic mimetics.

摘要翻译： 提供用于将靶物递送到细胞中的介孔载体。 介孔载体包括中空二氧化硅纳米球（HSN）或介孔二氧化硅纳米颗粒（MSN），并且靶与中空二氧化硅纳米球或介孔二氧化硅纳米粒子结合或包封。 靶标包括至少两个不同的靶标，靶标可能包括肽，蛋白质，酶和/或酶模拟物。

公开(公告)号：US11325076B2

公开(公告)日：2022-05-10

申请号：US16522960

申请日：2019-07-26

申请人： NATIONAL TAIWAN UNIVERSITY

发明人： Chung-Yuan Mou ,  Jingling Yang ,  Heng-Liang Wu

IPC分类号： B01D71/02 ,  B01D71/34 ,  B01D71/40 ,  B01D71/54 ,  B01D71/36 ,  H01M4/38 ,  H01M10/0525 ,  H01M10/0562 ,  H01M10/0565 ,  H01M50/411 ,  H01M50/431 ,  H01M50/449 ,  B82Y30/00

摘要： A battery and a method of fabricating a porous membrane are disclosed. The battery includes an anode, a cathode, and a battery separator. The battery separator is positioned between the anode and the cathode and includes a macroporous substrate and a mesoporous silica thin film (MSTF) with perpendicular mesopore channels. The MSTF is positioned on the macroporous substrate. The method includes the following steps. A polymer film is formed on a macroporous substrate. A MSTF with perpendicular mesopore channels is grown on the polymer film. The polymer film is removed to form the porous membrane.

公开(公告)号：US20180049431A1

公开(公告)日：2018-02-22

申请号：US15665547

申请日：2017-08-01

申请人： National Taiwan University

发明人： Chung-Yuan Mou ,  Yi-Ting Chen ,  Yi-Ping Chen

IPC分类号： A01N25/08 ,  A01N59/16 ,  A01N63/00

CPC分类号： A01N25/08 ,  A01N59/16 ,  A01N63/00 ,  A01N63/02 ,  C08K3/36 ,  C08K2003/0806 ,  C09D5/14 ,  C09D7/67 ,  C09D7/70 ,  C12Y302/01017 ,  A01N25/34

摘要： The present invention provides a composite that consists essentially of a mesoporous silica substrates and silver nanoparticles. In particular, the mesoporous silica substrate comprises a mesoporous silica thin film with perpendicular nanochannels and mesoporous silica nanoparticles with perpendicular nanochannels and the silver nanoparticles non-covalently bond onto surface of the mesoporous silica substrate and have a distribution density of 107-1013 number/cm2 on the surface. The preparing method and antibacterial application of the composite are also disclosed in the present invention.

公开(公告)号：US20160282274A1

公开(公告)日：2016-09-29

申请号：US15059526

申请日：2016-03-03

申请人： National Taiwan University

发明人： Chung-Yuan Mou ,  Kun-Che Kao ,  Tzu-Ying Chen ,  Yi-Wen Wang ,  Yi-Hsin Liu

IPC分类号： G01N21/65 ,  C01B33/12

CPC分类号： G01N21/658 ,  B82Y40/00 ,  C01B33/124 ,  C01B33/126 ,  C01P2002/80 ,  C01P2004/03 ,  C01P2004/04 ,  C01P2006/16

摘要： The present invention disclosed a mesoporous silica thin film with perpendicular nanochannels on a substrate, a process of forming the same and the application in surface-enhanced Raman spectroscopy. Furthermore, a gold nanoparticle array on a mesoporous silica material with perpendicular nanochannels and the process of forming the same is also present in the invention.

摘要翻译： 本发明公开了一种在衬底上具有垂直纳米通道的介孔二氧化硅薄膜，其形成方法以及在表面增强拉曼光谱中的应用。 此外，具有垂直纳米通道的介孔二氧化硅材料上的金纳米颗粒阵列及其形成方法也存在于本发明中。

公开(公告)号：US11801481B2

公开(公告)日：2023-10-31

申请号：US17846323

申请日：2022-06-22

申请人： NATIONAL TAIWAN UNIVERSITY

发明人： Chung-Yuan Mou ,  Jingling Yang ,  Kuo-Lun Tung ,  Geng-Sheng Lin

IPC分类号： B01D71/02 ,  B01D71/34 ,  B01D71/40 ,  B01D71/54 ,  B01D71/36 ,  H01M4/38 ,  H01M10/0525 ,  H01M10/0562 ,  H01M10/0565 ,  B82Y30/00

CPC分类号： B01D71/027 ,  B01D71/34 ,  B01D71/36 ,  B01D71/40 ,  B01D71/54 ,  H01M4/386 ,  H01M10/0525 ,  H01M10/0562 ,  H01M10/0565 ,  B01D2325/02 ,  B01D2325/04 ,  B82Y30/00

摘要： Methods of fabricating a porous membrane are disclosed. The first method includes the following operations. A mesoporous silica thin film with perpendicular mesopore channels is grown on a polymer film. The mesoporous silica thin film and the polymer film are transferred onto a macroporous substrate, in which the polymer film is positioned between the macroporous substrate and the mesoporous silica thin film. The polymer film is removed to form the porous membrane. The second method includes the following operations. A polymer film is formed on a macroporous substrate, wherein the polymer film includes crosslinked polymers including cross-linked polystyrene, cross-linked polymethyl methacrylate, or a combination thereof. A mesoporous silica thin film with perpendicular mesopore channels is grown on the polymer film. The polymer film is removed to form the porous membrane.

公开(公告)号：US11666662B2

公开(公告)日：2023-06-06

申请号：US15750759

申请日：2016-01-20

申请人： NATIONAL TAIWAN UNIVERSITY

发明人： Chung-Yuan Mou ,  Yi-Ping Chen ,  Si-Han Wu

IPC分类号： A61K47/69 ,  A61K47/62 ,  A61K39/385 ,  G01N33/552

CPC分类号： A61K47/6923 ,  A61K39/385 ,  A61K47/62 ,  A61K47/6925 ,  A61K47/6929 ,  G01N33/552 ,  G01N2333/163

摘要： Silica-based biomolecule carriers, compositions comprising the same and preparation methods and uses thereof for delivering biomolecules into a cell are provided. The silica-based biomolecule carrier comprises a porous core; a first bioactive moiety; a second bioactive moiety functionally associated with the first bioactive moiety; and linkers for respectively conjugating the first bioactive moiety and the second bioactive moiety to the porous core.

公开(公告)号：US10005746B2

公开(公告)日：2018-06-26

申请号：US14504681

申请日：2014-10-02

申请人： Academia Sinica ,  National Taiwan University

发明人： Sunney Ignatius Chan ,  Sheng-Fa Yu ,  Penumaka Nagababu ,  Suman Maji ,  Ping-Yu Chen ,  Ravirala Ramu ,  Chung-Yuan Mou ,  Chih-Cheng Liu

IPC分类号： C07C29/48 ,  C07C45/28 ,  B01J31/22 ,  C07D301/02 ,  C07C49/04 ,  C07C49/303 ,  C07F1/08

CPC分类号： C07D301/02 ,  B01J31/2243 ,  B01J2231/70 ,  B01J2231/72 ,  B01J2531/0216 ,  B01J2531/0241 ,  B01J2531/16 ,  C07C29/48 ,  C07C45/28 ,  C07C49/04 ,  C07C49/303 ,  C07C2601/14 ,  C07C2601/16 ,  C07F1/08 ,  Y02P20/52 ,  C07C31/04 ,  C07C31/08 ,  C07C31/10 ,  C07C31/12 ,  C07C31/125 ,  C07C35/08 ,  C07C31/207

摘要： This invention relates to molecular catalysts and chemical reactions utilizing the same, and particularly to molecular catalysts for efficient catalytic oxidation of hydrocarbons, such as hydrocarbons from natural gas. The molecular catalytic platform provided herein is capable of the facile oxidation of hydrocarbons, for example, under ambient conditions such as near room temperature and atmospheric pressure.