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公开(公告)号：US10323132B2
公开(公告)日：2019-06-18
申请号：US15554803
申请日：2016-03-02
发明人： Kazuhiko Ishihara , Yuuki Inoue , Kyoko Fukazawa , Masaru Matsuda , Satoshi Yamada , Tomozumi Noda
IPC分类号： C09D133/10 , A61L31/10 , C08J3/24 , C08F230/02 , C09D143/02 , A61L31/14 , B05D3/06 , C08F220/10 , A61L27/14 , A61L27/50
摘要： Provided are a copolymer having enough biocompatibility to be used in a medical material application, and a method of forming a crosslinked body, which involves modifying a substrate surface with the copolymer so that the surface may be biocompatible. More specifically, a protein adsorption-suppressing effect and a cell adhesion-suppressing effect, which are features of a phosphorylcholine group, are imparted to the substrate surface. It has been found that the object is achieved by a copolymer containing a phosphorylcholine constitutional unit, a hydrophobic constitutional unit, and a photoreactive constitutional unit at a specific ratio.
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公开(公告)号：US10927206B2
公开(公告)日：2021-02-23
申请号：US16313292
申请日：2017-06-28
IPC分类号： C08F230/02 , C08F212/08 , C08F220/18 , C08J3/28 , A61L27/34 , A61L33/06 , C08J3/24 , C09D143/02 , C08J7/04 , C08F12/22 , C08F12/26
摘要： Provided are a copolymer having biocompatibility sufficient for use in medical material applications, and a method of forming a crosslinked body, the method including imparting biocompatibility to a substrate surface through the use of the copolymer. More specifically, a protein adsorption-suppressing effect and a cell adhesion-suppressing effect, which are features of a phosphorylcholine group, are imparted to the substrate surface. It has been found that a copolymer containing a phosphorylcholine constitutional unit and a photoreactive constitutional unit, or a copolymer containing a phosphorylcholine constitutional unit, a photoreactive constitutional unit, and a hydrophobic constitutional unit can impart a protein adsorption-suppressing effect and a cell adhesion-suppressing effect to a substrate surface through a simple approach called photoirradiation.
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公开(公告)号：US10829710B2
公开(公告)日：2020-11-10
申请号：US16313515
申请日：2017-06-28
IPC分类号： C10M107/48 , C08F230/02
摘要： Provided is a lubricity-imparting agent that can impart durable lubricity (in particular, lubricity at the time of wetting) to a substrate. It has been found that a lubricity-imparting agent including a copolymer containing a constitutional unit (A) based on 2-methacryloyloxyethyl phosphorylcholine and a constitutional unit (B) based on a photoreactive functional group-containing monomer, or a copolymer containing a constitutional unit (A) based on 2-methacryloyloxyethyl phosphorylcholine, a constitutional unit (B) based on a photoreactive functional group-containing monomer, and a constitutional unit (C) based on a hydrophobic group-containing monomer can impart durable lubricity to a substrate surface through a simple approach called photoirradiation.
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公开(公告)号：US20180051140A1
公开(公告)日：2018-02-22
申请号：US15554803
申请日：2016-03-02
发明人： Kazuhiko Ishihara , Yuuki Inoue , Kyoko Fukazawa , Masaru Matsuda , Satoshi Yamada , Tomozumi Noda
IPC分类号： C08J3/24 , A61L31/10 , A61L31/14 , C08F230/02 , C09D143/02 , B05D3/06
CPC分类号： C08J3/24 , A61L27/14 , A61L27/50 , A61L27/507 , A61L31/10 , A61L31/14 , A61L2430/20 , B05D3/06 , B05D3/061 , C08F220/10 , C08F230/02 , C08F2800/10 , C08F2800/20 , C08J2343/02 , C09D133/10 , C09D143/02 , C08F2220/1825 , C08F2220/301 , C08F2220/1891
摘要： Provided are a copolymer having enough biocompatibility to be used in a medical material application, and a method of forming a crosslinked body, which involves modifying a substrate surface with the copolymer so that the surface may be biocompatible. More specifically, a protein adsorption-suppressing effect and a cell adhesion-suppressing effect, which are features of a phosphorylcholine group, are imparted to the substrate surface. It has been found that the object is achieved by a copolymer containing a phosphorylcholine constitutional unit, a hydrophobic constitutional unit, and a photoreactive constitutional unit at a specific ratio.
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公开(公告)号：US11192990B2
公开(公告)日：2021-12-07
申请号：US16482175
申请日：2018-03-20
摘要： A resin molded body, includes: a polyolefin element including a crystalline region and an amorphous region; and a hydrophilic polymer contained in a region from a surface of the polyolefin element to part of the amorphous region located below the surface. Or, a method for producing a resin molded body, includes: preparing a polyolefin element including a crystalline region and an amorphous region; forming a coating of a hydrophilic polymer on a surface of the polyolefin element; and applying heat treatment to the polyolefin element on which the coating of the hydrophilic polymer is formed, wherein by applying the heat treatment, the coating of the hydrophilic polymer is immersed in a region from the surface to part of the amorphous region located below the surface.
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6.发明授权Biomaterial, joint prosthesis using the biomaterial and method of producing the same 有权生物材料，使用生物材料的关节假体及其生产方法公开(公告)号：US09034414B2
公开(公告)日：2015-05-19
申请号：US14186183
申请日：2014-02-21
申请人： KYOCERA Medical Corporation , THE UNIVERSITY OF TOKYO , NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY
发明人： Masayuki Kyomoto , Kazuhiko Ishihara , Yasuhiko Iwasaki , Toru Moro , Kozo Nakamura , Yoshio Takatori , Hiroshi Kawaguchi , Tomohiro Konno , Noboru Yamawaki
IPC分类号： A61L27/34 , B05D3/10 , B05D1/36 , A61F2/30 , A61L27/42 , C22F1/11 , C22F1/18 , B05D1/18 , B05D3/06 , A61F2/32 , A61F2/34 , A61F2/36 , B23K35/36
CPC分类号： A61L27/34 , A61F2/30767 , A61F2/32 , A61F2/34 , A61F2002/30685 , A61F2002/30934 , A61F2002/3611 , A61F2310/00011 , A61F2310/00179 , A61L27/42 , B05D1/18 , B05D3/067 , B23K35/3618 , C22F1/11 , C22F1/183 , Y10T428/24917 , Y10T428/24926 , Y10T428/31536
摘要： The object of the present invention is to provide a joint prosthesis, bearing material and a production method thereof, which suppresses wear in a sliding section and suppresses the production of abrasive powder even during repeated daily operation. To achieve the object, there is provided a biomaterial comprising: a substrate made of metal, alloy or ceramic; and a biocompatible material layer laminated on the substrate, wherein hydroxyl groups are formed on the substrate by surface-treating, while the biocompatible material layer comprises a polymer containing phosphorylcholine groups, the substrate and the biocompatible material layer are bound via a binder layer which is combined with the hydroxyl groups of the substrate and with the biocompatible material layer.
摘要翻译： 本发明的目的是提供一种关节假体，轴承材料及其制造方法，其抑制滑动部分的磨损，并且即使在重复的日常操作中也抑制磨料粉末的生产。 为了实现该目的，提供了一种生物材料，包括：由金属，合金或陶瓷制成的基底; 以及层叠在基材上的生物相容性材料层，其中通过表面处理在基材上形成羟基，而生物相容性材料层包含含有磷酸胆碱基团的聚合物，基材和生物相容性材料层通过粘合剂层结合， 与基材的羟基和生物相容性材料层结合。
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公开(公告)号：US11111367B2
公开(公告)日：2021-09-07
申请号：US16489370
申请日：2018-03-20
摘要： A resin molded body includes: a polyolefin element formed of polyolefin, including a crystalline region and an amorphous region; and a hydrophilic copolymer contained in at least part of a surface of the polyolefin element, the hydrophilic copolymer including a copolymer of 2-methacryloyloxyethyl phosphorylcholine (MPC) of 45% or greater on a mole fraction basis and at least one other monomer. In the resin molded body, the MPC polymer is immersed through the surface by applying heat treatment.
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公开(公告)号：US11015078B2
公开(公告)日：2021-05-25
申请号：US16315473
申请日：2017-07-05
IPC分类号： C09D143/02 , C08F230/02 , C09K3/18 , B05D7/24 , C09D157/06
摘要： [Problem] To provide a surface treatment polymer.
[Solution] A compound represented by formula (1), and a surface treatment agent including the compound.
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