MODIFIED FUNGAL HOST CELLS AND METHOD OF USING SAME
    9.
    发明申请
    MODIFIED FUNGAL HOST CELLS AND METHOD OF USING SAME 审中-公开
    改良真菌宿主细胞及其使用方法

    公开(公告)号:US20160060641A1

    公开(公告)日:2016-03-03

    申请号:US14782155

    申请日:2014-04-03

    Applicant: NOVOZYMES A/S

    Inventor: Hiroaki Udagawa

    CPC classification number: C12N15/80 C07K14/38 C12N9/2428 C12Y302/01003

    Abstract: Disclosed are modified filamentous fungal cells in which the selective autophagy system of the filamentous fungal cell has been partially or completely inactivated, methods of making such genetically modified filamentous fungal cells, and methods for producing biological products of interest in such modified filamentous fungal cells. Also disclosed are genetically modified filamentous fungal cells having disrupted or deleted atg11 activity, methods of making such genetically modified filamentous fungal cells, and methods for producing biological products of interest in such modified filamentous fungal cells.

    Abstract translation: 公开了丝状真菌细胞的选择性自噬系统被部分或完全灭活的修饰的丝状真菌细胞,制备这种遗传修饰的丝状真菌细胞的方法,以及在这种修饰的丝状真菌细胞中生产感兴趣的生物产物的方法。 还公开了具有破坏或缺失的atg11活性的遗传修饰丝状真菌细胞,制备这种遗传修饰的丝状真菌细胞的方法,以及用于在这种修饰的丝状真菌细胞中生产感兴趣的生物产物的方法。

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