公开(公告)号：US08278626B2

公开(公告)日：2012-10-02

申请号：US12561040

申请日：2009-09-16

申请人： Naoki Murakami ,  Hisashi Ohtsuka ,  Morihito Ikeda

发明人： Naoki Murakami ,  Hisashi Ohtsuka ,  Morihito Ikeda

IPC分类号： H01J27/24 ,  H01J49/16

CPC分类号： H01J49/0418

摘要： In a device for mass spectrometry, an analyte contained in a sample is desorbed from a surface of the device by irradiating the sample in contact with the surface with measurement light. The device includes a micro-structure having a plurality of metal bodies on a surface of a substrate, and the plurality of metal bodies have sizes that can excite localized plasmons by irradiation with the measurement light. Further, the device includes an initiator fixed at least to a part of a surface of the micro-structure.

摘要翻译： 在用于质谱的装置中，通过用测量光照射与表面接触的样品，将样品中包含的分析物从装置的表面解吸。 该装置包括在基板的表面上具有多个金属体的微结构，并且多个金属体具有可以通过用测量光照射激发局部等离子体激元的尺寸。 此外，该装置包括至少固定在微结构的表面的一部分上的引发剂。

公开(公告)号：US20100065735A1

公开(公告)日：2010-03-18

申请号：US12561040

申请日：2009-09-16

申请人： Naoki Murakami ,  Hisashi Ohtsuka ,  Morihito Ikeda

发明人： Naoki Murakami ,  Hisashi Ohtsuka ,  Morihito Ikeda

IPC分类号： H01J49/40 ,  H01J49/26

CPC分类号： H01J49/0418

摘要： In a device for mass spectrometry, an analyte contained in a sample is desorbed from a surface of the device by irradiating the sample in contact with the surface with measurement light. The device includes a micro-structure having a plurality of metal bodies on a surface of a substrate, and the plurality of metal bodies have sizes that can excite localized plasmons by irradiation with the measurement light. Further, the device includes an initiator fixed at least to a part of a surface of the micro-structure.

摘要翻译： 在用于质谱的装置中，通过用测量光照射与表面接触的样品，将样品中包含的分析物从装置的表面解吸。 该装置包括在基板的表面上具有多个金属体的微结构，并且多个金属体具有可以通过用测量光照射激发局部等离子体激元的尺寸。 此外，该装置包括至少固定在微结构的表面的一部分上的引发剂。

公开(公告)号：US07738107B2

公开(公告)日：2010-06-15

申请号：US11859027

申请日：2007-09-21

申请人： Hisashi Ohtsuka ,  Morihito Ikeda

发明人： Hisashi Ohtsuka ,  Morihito Ikeda

IPC分类号： G01N21/55

CPC分类号： G01N21/648 ,  G01N21/6428

摘要： A fluorescence sensor is constituted by: a light source, for emitting excitation light of a predetermined wavelength; a dielectric block, formed of a material that transmits the excitation light; a metal film, formed on a surface of the dielectric block; a non flexible film of a hydrophobic material, formed on the metal film at a film thickness within a range of 10 to 100 nm; a sample holding portion, for holding a sample such that the sample contacts the non flexible film; an incident optical system, for causing the excitation light to enter the interface between the dielectric block and the metal film through the dielectric block such that conditions for total internal reflection are satisfied; and fluorescence detecting means, for detecting fluorescence emitted by a substance within the sample, which is excited by evanescent waves that leak from the interface when the excitation light enters the interface.

摘要翻译： 荧光传感器由以下部分构成：光源，用于发射预定波长的激发光; 介电块，由透射激发光的材料形成; 金属膜，形成在介质块的表面上; 在10〜100nm的范围内，在金属膜上形成疏水性材料的非柔性膜， 样品保持部分，用于保持样品使得样品接触非柔性膜; 入射光学系统，用于使激发光通过介质块进入介电块和金属膜之间的界面，使得满足全内反射的条件; 以及荧光检测装置，用于检测样品内的物质发出的荧光，当激发光进入界面时，由从界面泄漏的ev逝波激发。

公开(公告)号：US08008620B2

公开(公告)日：2011-08-30

申请号：US12568197

申请日：2009-09-28

申请人： Morihito Ikeda ,  Naoki Murakami

发明人： Morihito Ikeda ,  Naoki Murakami

IPC分类号： H01J49/26

CPC分类号： H01J49/0418

摘要： A substrate for mass spectrometry includes a first reflective member that is semi-transmissive/semi-reflective, a transparent member, and a second reflective member that is reflective, sequentially provided to form an optical resonator. The optical resonator includes, on a surface of the first reflective member, a sample separation portion at which surface interaction occurs with a plurality of analytes contained in a sample liquid. The analytes are separated on the sample separation portion to perform mass spectrometry on each of the analytes. A sample in contact with the surface of the first reflective member is irradiated with laser beam L to generate resonance in the optical resonator, and an electric field on the surface of the first reflective member is enhanced by the resonance. The enhanced electric field is utilized to ionize analytes S in the sample and to desorb the analytes S from the surface.

摘要翻译： 用于质谱的衬底包括半透射/半反射的第一反射构件，透明构件和顺序地设置以形成光谐振器的反射的第二反射构件。 光学谐振器在第一反射构件的表面上包括样品分离部分，在样品分离部分处与样品液体中包含的多种分析物发生表面相互作用。 分析物在样品分离部分上分离，以对每种分析物进行质谱分析。 用激光束L照射与第一反射构件的表面接触的样品，以在光谐振器中产生谐振，并且通过谐振增强第一反射构件表面上的电场。 增强的电场用于电离样品中的分析物S并从表面解吸分析物S.

公开(公告)号：US20090081371A1

公开(公告)日：2009-03-26

申请号：US12212942

申请日：2008-09-18

申请人： Koichi Minami ,  Morihito Ikeda ,  Yohsuke Takeuchi

发明人： Koichi Minami ,  Morihito Ikeda ,  Yohsuke Takeuchi

IPC分类号： B05D3/00 ,  C12M1/34

CPC分类号： G01N33/54353 ,  C07K17/06 ,  C07K17/14 ,  G01N33/54386 ,  G01N33/54393

摘要： A substrate includes: a base material; and chelators which are three dimensionally covalently bound to the base material at a density of 7.8×1015/mm3 or greater and 4.5×1017/mm3 or less, or two dimensionally covalently bound to the base material at a planar density of 2.0×1011/mm2 or greater and 1.0×1013/mm2 or less. Metal ions are coordinately bound to the chelators, and a bioactive substance having histidine tags are coordinately bound to the metal ions. A blocking agent having ligand sets are coordinately bound to the metal ions to which the bioactive substance is not coordinately bound.

摘要翻译： 基板包括：基材; 和以7.8×10 15 / mm 3以上且4.5×10 17 / mm 3以下的密度三维共价结合于基材的螯合剂，或者以2.0×10 11 / mm 2以上的平面密度二维共价结合到基材上 和1.0×10 13 / mm 2以下。 金属离子与螯合剂配位结合，具有组氨酸标签的生物活性物质与金属离子配位结合。 具有配体组的封闭剂与生物活性物质不配位结合的金属离子配位结合。

公开(公告)号：US20070122308A1

公开(公告)日：2007-05-31

申请号：US11604698

申请日：2006-11-28

申请人： Morihito Ikeda ,  Taisei Nishimi ,  Hirohiko Tsuzuki ,  Toshihide Ezoe

发明人： Morihito Ikeda ,  Taisei Nishimi ,  Hirohiko Tsuzuki ,  Toshihide Ezoe

IPC分类号： G01N31/22

CPC分类号： G01N21/553 ,  B82Y15/00 ,  B82Y30/00 ,  G01N33/54373 ,  G01N33/544 ,  G01N2610/00

摘要： An object of the present invention is to provide a biosensor having high capability for suppressing nonspecific protein adsorption and high capability for extracting a target protein. The present invention provides a biosensor which comprises a flow channel that is formed on a substrate and is composed of a detection plane for detecting interaction between a physiologically active substance and a test substance and a non-detection plane where said interaction is not detected, wherein the substrate is a metal surface or a metal film and the surfaces of the detection plane and the non-detection plane are modified with a self-assembled monolayer (SAM) having a hydroxy group and a functional group for binding with a physiologically active substance.

摘要翻译： 本发明的目的是提供一种能够抑制非特异性蛋白质吸附的能力高，提取目标蛋白质的能力高的生物传感器。 本发明提供一种生物传感器，其包括形成在基板上的流路，其由用于检测生理活性物质与检测物质之间的相互作用的检测面以及未检测到相互作用的非检测面构成， 基板是金属表面或金属膜，检测面和非检测面的表面用具有羟基和官能团的自组装单层（SAM）修饰，用于与生理活性物质结合。

公开(公告)号：US20070048796A1

公开(公告)日：2007-03-01

申请号：US11508904

申请日：2006-08-24

申请人： Toshiaki Kubo ,  Toshihide Ezoe ,  Hirohiko Tsuzuki ,  Morihito Ikeda

发明人： Toshiaki Kubo ,  Toshihide Ezoe ,  Hirohiko Tsuzuki ,  Morihito Ikeda

IPC分类号： G01N33/53 ,  C12M1/34

CPC分类号： G01N33/54393 ,  B82Y15/00 ,  B82Y30/00 ,  B82Y40/00

摘要： It is an object of the present invention to provide a biosensor with an improved recovery yield of a test substance interacting with a physiologically active substance. The present invention provides a biosensor having a flow channel formed on a substrate, which is composed of a detection surface for detecting the interaction of a physiologically active substance with a test substance and a non-detection surface that does not detect said interaction, wherein the detection surface and non-detection surface are modified in such a way that the physiologically active substance can be immobilized thereon.

摘要翻译： 本发明的目的是提供一种与生理活性物质相互作用的测试物质的回收率提高的生物传感器。 本发明提供一种生物传感器，其具有形成在基板上的流路，该流路由用于检测生理活性物质与检测物质的相互作用的检测面和不检测所述相互作用的非检测面构成， 检测表面和非检测表面以使生理活性物质固定在其上的方式被修饰。

公开(公告)号：US20110084025A1

公开(公告)日：2011-04-14

申请号：US12897441

申请日：2010-10-04

申请人： Jo Tominaga ,  Morihito Ikeda ,  Fumio Mogi ,  Kimiaki Miyamoto

发明人： Jo Tominaga ,  Morihito Ikeda ,  Fumio Mogi ,  Kimiaki Miyamoto

IPC分类号： C02F1/04 ,  C02F1/42 ,  B01D3/34 ,  B01D61/00

CPC分类号： B01D61/002 ,  B01D5/006 ,  B01D2311/06 ,  C02F1/04 ,  C02F1/14 ,  C02F1/16 ,  C02F1/44 ,  C02F1/445 ,  C02F5/08 ,  C02F2209/05 ,  Y02W10/37 ,  B01D2311/2673 ,  B01D2311/2626 ,  B01D2311/2669

摘要： To provide a water purifier containing: a diluting unit configured to bring targeted water into contact with a nonvolatile compound-containing aqueous solution via a semi-permeable membrane to separate water from the targeted water by the membrane, and to dilute the nonvolatile compound-containing aqueous solution with the separated water; a separating unit configured to heat the diluted aqueous solution so as to separate water vapor from the diluted aqueous solution, and to obtain the concentrated aqueous solution; a condensing unit configured to cool the separated water vapor to generate water; an evaporating unit configured to collect, as purified water, part of the generated water, and to evaporate the rest of the generated water under the reduced pressure to obtain water vapor; and an absorbing unit configured to allow the concentrated aqueous solution obtained by the separating unit to absorb the water vapor obtained by the evaporating unit.

摘要翻译： 提供一种净水器，其特征在于，含有：稀释单元，其配置为使目标水通过半透膜与含有挥发性化合物的水溶液接触，以通过所述膜将水与目标水分离，并稀释所述非挥发性化合物 水溶液与分离的水分; 分离单元，其被配置为加热所述稀释的水溶液以从所述稀释的水溶液中分离出水蒸气，并获得所述浓缩水溶液; 冷凝单元，其被配置为冷却分离的水蒸气以产生水; 蒸发单元，其构造成作为净化水收集部分产生的水，并在减压下蒸发剩余的产生的水以获得水蒸汽; 以及吸收单元，被配置为允许由分离单元获得的浓缩水溶液吸收由蒸发单元获得的水蒸汽。

公开(公告)号：US20110020649A1

公开(公告)日：2011-01-27

申请号：US12934322

申请日：2009-03-13

申请人： Morihito Ikeda ,  Taisei Nishimi ,  Junichi Katada

发明人： Morihito Ikeda ,  Taisei Nishimi ,  Junichi Katada

IPC分类号： C07F7/02 ,  C08G63/91 ,  C07K2/00 ,  C07K14/76 ,  C07H99/00 ,  C07K14/78 ,  C08F120/10 ,  C08F120/06 ,  C08F20/56 ,  C08F226/10 ,  B32B5/16

CPC分类号： C07F7/1804 ,  G01N33/54353 ,  G01N33/54393 ,  Y10T428/2991

摘要： An immobilization method for immobilizing a physiologically active substance on a solid phase carrier, the method including: bringing the solid phase carrier into contact with an acid anhydride functional group-containing silane coupling agent represented by the following Formula (I); and carrying out a process of binding of the physiologically active substance to the acid anhydride functional group while maintaining the solid phase carrier after the contact at a temperature within the range of 0° C. to 60° C.; a physiologically active substance-immobilized carrier, and a carrier for immobilization are provided. Further, a carrier including a porous material treated with an acid anhydride functional group-containing silane coupling agent represented by the following Formula (I), a blocking agent that is immobilized to the porous material; and a method for producing it is provided.

摘要翻译： 一种用于将生理活性物质固定在固相载体上的固定方法，所述方法包括：使固相载体与由下式（I）表示的含酸酐官能团的硅烷偶联剂接触; 并且在0℃至60℃的范围内的温度下，将生理活性物质与酸酐官能团结合，同时保持接触后的固相载体; 提供生理活性物质固定化载体和用于固定的载体。 此外，包括用下述通式（I）表示的含酸酐官能团的硅烷偶联剂处理的多孔材料的载体，固定在多孔材料上的封端剂; 并提供其制造方法。

公开(公告)号：US08529766B2

公开(公告)日：2013-09-10

申请号：US12915973

申请日：2010-10-29

申请人： Koichi Minami ,  Morihito Ikeda ,  Hiroshi Arakatsu

发明人： Koichi Minami ,  Morihito Ikeda ,  Hiroshi Arakatsu

IPC分类号： B01D11/00 ,  B01D61/00 ,  B01D3/00 ,  C02F1/44 ,  C02F1/00

CPC分类号： C02F1/44 ,  B01D61/00 ,  B01D61/002 ,  B01D61/145 ,  B01D61/243 ,  B01D61/364 ,  B01D61/422 ,  B01D61/58 ,  B01D2311/2626 ,  C02F1/444 ,  C02F1/445 ,  C02F1/4693 ,  C02F2301/08 ,  C02F2303/16

摘要： To provide a water purifier, containing: a diluting unit configured to bring targeted water for purification into contact with an aqueous solution containing a volatile solute and a polymer via a semi-permeable membrane so as to separate water from the targeted water by the semi-permeable membrane, and configured to dilute the aqueous solution with the separated water; a separating unit configured to separate the volatile solute and the polymer from the diluted aqueous solution obtained by the diluting unit so as to obtain purified water; and a dissolving unit configured to return the separated volatile solute by the separating unit to the aqueous solution containing the polymer, and to allow the separated volatile solute to dissolve in the aqueous solution containing the polymer.

摘要翻译： 本发明提供一种净水器，其特征在于，含有：稀释单元，其配置为使净化物与含有挥发性溶质的水溶液和聚合物通过半透膜接触，以通过半透过膜将水与目标水分离， 并且被配置为用分离的水稀释水溶液; 分离单元，被配置为从由稀释单元获得的稀释水溶液中分离挥发性溶质和聚合物以获得纯化水; 以及溶解单元，其被配置为将分离单元中分离的挥发性溶质返回到含有聚合物的水溶液中，并且使分离的挥发性溶质溶解在含有聚合物的水溶液中。