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    Marker for identification of tissue type of epithelial ovarian cancer, and method for determination of the occurrence of epithelial ovarian cancer based on tissue type by using the marker
    5.
    发明授权
    Marker for identification of tissue type of epithelial ovarian cancer, and method for determination of the occurrence of epithelial ovarian cancer based on tissue type by using the marker 有权
    用于鉴定上皮性卵巢癌组织类型的标记物，以及通过使用标记物来确定基于组织类型的上皮性卵巢癌发生的方法

    公开(公告)号：US08518651B2

    公开(公告)日：2013-08-27

    申请号：US12527191

    申请日：2008-02-15

    申请人： Taka-aki Sato ,  Atsuhiko Toyama ,  Takashi Shimada ,  Tetsuyoshi Sugita ,  Daisuke Aoki ,  Atsushi Suzuki ,  Nobuyuki Susumu ,  Hiroyuki Nomura

    发明人： Taka-aki Sato ,  Atsuhiko Toyama ,  Takashi Shimada ,  Tetsuyoshi Sugita ,  Daisuke Aoki ,  Atsushi Suzuki ,  Nobuyuki Susumu ,  Hiroyuki Nomura

    IPC分类号： G01N33/53

    CPC分类号： G01N33/57449 ,  G01N2800/56

    摘要： It is provided a method for identification of the morbidity of epithelial ovarian cancer based on a tissue-type in view of molecular typing which is different from a conventional histopathology, and a marker for identification of a tissue-type of epithelial ovarian cancer. A method for identification of the morbidity of epithelial ovarian cancer based on a tissue-type, comprising: subjecting a sample originated from an individual of interest to a treatment for detecting at least one selected from the group consisting of biological molecules specifically showing an upregulation in expression in a specific tissue-type of epithelial ovarian cancer, and/or at least one selected from the group consisting of biological molecules specifically showing a downregulation in expression in a specific tissue-type of epithelial ovarian cancer, and identifying whether or not the significant detection of the protein is achieved, thereby identifying the tissue-type.

    摘要翻译： 提供了一种鉴定与常规组织病理学不同的分子分型的基于组织型的上皮性卵巢癌的发病率的方法和用于鉴定组织型上皮性卵巢癌的标志物。 一种用于鉴定基于组织型的上皮性卵巢癌的发病率的方法，其包括：对来自感兴趣个体的样品进行处理，以检测选自特异性显示上调的生物分子中的至少一种 在特定组织型上皮性卵巢癌中的表达，和/或选自特异性显示特定组织型上皮性卵巢癌中的下调的生物分子中的至少一种，以及鉴定是否显着 实现蛋白质的检测，从而鉴定组织型。

    IMAGE FORMING APPARATUS FOR TRANSFERRING TRANSFER RESIDUAL TONER ONTO IMAGE BEARING MEMBER
    6.
    发明申请
    IMAGE FORMING APPARATUS FOR TRANSFERRING TRANSFER RESIDUAL TONER ONTO IMAGE BEARING MEMBER 有权
    用于将传输残留色调剂转印到图像轴承部件上的图像形成装置

    公开(公告)号：US20120128392A1

    公开(公告)日：2012-05-24

    申请号：US13349912

    申请日：2012-01-13

    申请人： Ken Nakagawa ,  Kenji Kanari ,  Masaru Shimura ,  Takashi Shimada ,  Tomoo Akizuki ,  Masahiro Suzuki

    发明人： Ken Nakagawa ,  Kenji Kanari ,  Masaru Shimura ,  Takashi Shimada ,  Tomoo Akizuki ,  Masahiro Suzuki

    IPC分类号： G03G15/14

    CPC分类号： G03G21/0047 ,  G03G21/10 ,  G03G2221/1627

    摘要： A charge member charges secondary transfer remaining toner on an intermediate transfer member to a polarity opposite to a normal charge polarity. The remaining toner is moved by a transfer bias, from the intermediate transfer member onto an image bearing member. A BK station is arranged on the downstream of other stations. In a continuous BK monochromatic mode, by applying a reverse bias to transfer portions of the other stations and applying the transfer bias only to the BK station, remaining toner can be collected into the BK station (simultaneously with the transfer). In a full-color mode, remaining toner is collected into the station on the uppermost stream. Thus, the image bearing member for collecting remaining toner on the intermediate transfer member differs according to the mode, thereby suppressing the collection of remaining toner being concentrated on one image bearing member.

    摘要翻译： 充电构件将中间转印构件上的二次转印剩余调色剂充电到与正常电荷极性相反的极性。 剩余的调色剂通过转印偏压从中间转印部件移动到图像承载部件上。 其他车站下游设有BK车站。 在连续的BK单色模式中，通过施加反向偏压来转移其它工位的部分并将转印偏压施加到BK工位，剩余的调色剂可以被收集到BK工位（与转印同时）。 在全色模式下，剩余碳粉被收集到最上游的车站。 因此，根据模式，用于收集中间转印部件上的剩余调色剂的图像承载部件不同，从而抑制剩余调色剂的收集集中在一个图像承载部件上。

    Pyrazolopyrimidine derivative
    7.
    发明授权
    Pyrazolopyrimidine derivative 有权
    吡唑并嘧啶衍生物

    公开(公告)号：US08158638B2

    公开(公告)日：2012-04-17

    申请号：US12442094

    申请日：2007-09-14

    申请人： Satoru Ohsuki ,  Atsushi Tengeiji ,  Masahiro Ikeda ,  Yoshihiro Shibata ,  Chikahiro Nagata ,  Takashi Shimada

    发明人： Satoru Ohsuki ,  Atsushi Tengeiji ,  Masahiro Ikeda ,  Yoshihiro Shibata ,  Chikahiro Nagata ,  Takashi Shimada

    IPC分类号： A61K31/505 ,  A61K31/415 ,  C07D491/00 ,  C07D487/02

    CPC分类号： C07D495/16 ,  C07D495/20 ,  C07D495/22 ,  C07D498/22

    摘要： Problem to be SolvedTo provide a novel compound inhibiting the effect of HSP90, in particular a novel compound inhibiting the function of HSP90 as a chaperone protein and having antitumor activity.SolutionThe present invention provides a pyrazolopyrimidine compound represented by the formula (1) having various substituents which inhibits the ATPase activity of HSP90 and which has antitumor activity, an HSP90 inhibitor comprising the compound represented by the formula (1), a medicament comprising the compound represented by the formula (1), an anticancer agent comprising the compound represented by the formula (1), a pharmaceutical composition comprising the compound represented by the formula (1) and a method for treating cancer using the compound represented by the formula (1).

    摘要翻译： 要解决的问题提供抑制HSP90的作用的新型化合物，特别是抑制HSP90作为伴侣蛋白的功能并具有抗肿瘤活性的新化合物。 溶液本发明提供了具有抑制HSP90的ATP酶活性且具有抗肿瘤活性的各种取代基的式（1）表示的吡唑并嘧啶化合物，包含由式（1）表示的化合物的HSP90抑制剂，包含化合物 （1）代表的抗癌剂，包含由式（1）表示的化合物的抗癌剂，包含式（1）表示的化合物的药物组合物和使用式（1）表示的化合物治疗癌症的方法 ）。

    Hair growth method
    9.
    发明申请
    Hair growth method 审中-公开
    头发生长法

    公开(公告)号：US20100166719A1

    公开(公告)日：2010-07-01

    申请号：US12656139

    申请日：2010-01-19

    申请人： Katsutoshi Yoshizato ,  Takashi Shimada ,  Koei Toyoshima ,  Mikaru Matsunaga

    发明人： Katsutoshi Yoshizato ,  Takashi Shimada ,  Koei Toyoshima ,  Mikaru Matsunaga

    IPC分类号： A61K35/12 ,  A61P43/00

    CPC分类号： A61L27/3869 ,  A61F2/10 ,  A61K35/12 ,  A61L27/362 ,  A61L27/3666 ,  A61L27/3813 ,  A61L2430/18 ,  C12N5/0627 ,  C12N2501/115

    摘要： A method of enabling effective hair growth and furthermore, inducing hair growth closely similar to the natural hair state in the case of transplanting dermal papillae or cultured dermal papilla cells into the skin to regenerate the hair, characterized by comprising transplanting a composition containing the following components into an epidermis defect site: (a) dermal papillae or dermal papilla cells, (b) an epidermal tissue or epidermal cells and/or (c) a tissue constituting hair follicles or cells thereof.

    摘要翻译： 此外，在将真皮乳头或培养的真皮乳头细胞移植到皮肤中以再生毛发的情况下，能够有效地进行毛发生长的方法，此外，诱导与天然毛发状态非常相似的毛发生长，其特征在于，包括移植含有以下成分的组合物 进入表皮缺损部位：（a）真皮乳头或真皮乳头细胞，（b）表皮组织或表皮细胞和/或（c）构成毛囊或其细胞的组织。

    MASS SPECTROMETRY OF BIOLOGICAL SAMPLE USING IMMUNOPRECIPITATION
    10.
    发明申请
    MASS SPECTROMETRY OF BIOLOGICAL SAMPLE USING IMMUNOPRECIPITATION 审中-公开
    使用免疫反应的生物样品的质谱分析

    公开(公告)号：US20100086938A1

    公开(公告)日：2010-04-08

    申请号：US12516790

    申请日：2007-10-02

    申请人： Takashi Shimada ,  Atsuhiko Toyama ,  Taka-aki Sato

    发明人： Takashi Shimada ,  Atsuhiko Toyama ,  Taka-aki Sato

    IPC分类号： G01N33/53 ,  G01N33/543 ,  G01N33/553 ,  G01N33/552 ,  G01N33/544

    CPC分类号： G01N33/6848

    摘要： It is intended to provide an analysis method for a biological sample with clinical significance, which is a system being simple to such an extent that it can be applied to a clinical field, and capable of capping a molecule ionization suppression in mass spectrometry. Mass spectrometry of a biological sample using immunoprecipitation, comprising the steps of: preparing a sample containing an objective biological molecule; concentrating the biological molecule in the sample by immunoprecipitation using an antibody-bound carrier or a carrier to which a molecule capable of specifically binding to an antibody is bound; washing an immunoprecipitate of the biological molecule by using an aqueous solution containing a charge neutralizing agent as a washing liquid; and detecting the biological molecule by subjecting the washed immunoprecipitate to mass spectrometry.

    摘要翻译： 旨在为具有临床意义的生物样品提供分析方法，该方法简单到能够应用于临床领域并且能够在质谱法中限制分子离子化抑制的系统。 使用免疫沉淀的生物样品的质谱法，包括以下步骤：制备含有客观生物分子的样品; 通过使用抗体结合的载体或能够与抗体特异性结合的分子结合的载体通过免疫沉淀将生物分子浓缩在样品中; 通过使用含有电荷中和剂的水溶液作为洗涤液来洗涤生物分子的免疫沉淀物; 并通过对洗涤的免疫沉淀物进行质谱检测来检测生物分子。