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1.发明授权公开(公告)号：US07223758B2
公开(公告)日：2007-05-29
申请号：US10916175
申请日：2004-08-11
IPC分类号： C07D413/12 , C07D413/14 , A61K31/501 , A61P19/02
CPC分类号： C07D237/04
摘要： The invention relates to a pyridazine derivative of formula (I), wherein the variables are as defined herein, pharmaceutical composition thereof, process for its preparation, and its pharmaceutical use.
摘要翻译： 本发明涉及式（I）的哒嗪衍生物，其中变量如本文所定义，其药物组合物，其制备方法及其药物用途。
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2.发明申请公开(公告)号：US20050165017A1
公开(公告)日：2005-07-28
申请号：US10916175
申请日：2004-08-11
IPC分类号： A61K31/50 , A61K31/5377 , A61P1/02 , A61P3/14 , A61P5/24 , A61P5/38 , A61P9/00 , A61P9/10 , A61P9/12 , A61P19/00 , A61P19/02 , A61P19/08 , A61P19/10 , A61P25/00 , A61P25/28 , A61P29/00 , A61P31/00 , A61P35/00 , A61P37/08 , A61P43/00 , C07D237/04 , C07D413/02
CPC分类号： C07D237/04
摘要： The invention relates to a pyridazine derivative of formula (I), wherein the variables are as defined herein, pharmaceutical composition thereof, process for its preparation, and its pharmaceutical use.
摘要翻译： 本发明涉及式（I）的哒嗪衍生物，其中变量如本文所定义，其药物组合物，其制备方法及其药物用途。
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3.发明申请公开(公告)号：US20050215553A1
公开(公告)日：2005-09-29
申请号：US11009249
申请日：2004-12-10
IPC分类号： A61K31/50 , A61K31/501 , A61K31/5377 , A61P1/02 , A61P3/14 , A61P9/00 , A61P19/00 , A61P19/02 , A61P19/10 , A61P25/02 , A61P29/00 , A61P31/00 , A61P35/00 , C07B61/00 , C07D237/04 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12 , C07K5/06 , G01N33/53
CPC分类号： C07K5/06026 , C07B2200/11 , C07D237/04 , C40B40/00
摘要： The present invention discloses and claims hexahydropyridazine-3-carboxylic acid hydrazides and hydrazones of formula (I) as inhibitors of proteases and kinases, and methods of using said compounds of formula (I) for the prevention or treatment of certain cardiovascular, central nervous system, inflammatory, and bone diseases as well as infectious diseases and certain cancers. Combinatorial libraries of the compounds of formula (I), pharmaceutical compositions, and methods for the preparation of combinatorial libraries and the compounds of formula (I) are also disclosed and claimed.
摘要翻译： 本发明公开并要求具有式（I）的六氢哒嗪-3-羧酸酰肼和腙作为蛋白酶和激酶的抑制剂，以及使用所述式（I）化合物预防或治疗某些心血管，中枢神经系统的方法 ，炎症和骨疾病以及传染病和某些癌症。 还公开并要求保护式（I）化合物的组合文库，药物组合物和制备组合文库和式（I）化合物的方法。
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4.发明授权公开(公告)号：US07279480B2
公开(公告)日：2007-10-09
申请号：US11009249
申请日：2004-12-10
IPC分类号： C07D237/04 , A61K31/501 , A61K31/50
CPC分类号： C07K5/06026 , C07B2200/11 , C07D237/04 , C40B40/00
摘要： The present invention discloses and claims hexahydropyridazine-3-carboxylic acid hydrazides and hydrazones of formula (I) as inhibitors of proteases and kinases, and methods of using said compounds of formula (I) for the prevention or treatment of certain cardiovascular, central nervous system, inflammatory, and bone diseases as well as infectious diseases and certain cancers. Combinatorial libraries of the compounds of formula (I), pharmaceutical compositions, and methods for the preparation of combinatorial libraries and the compounds of formula (I) are also disclosed and claimed.
摘要翻译： 本发明公开并要求具有式（I）的六氢哒嗪-3-羧酸酰肼和腙作为蛋白酶和激酶的抑制剂，以及使用所述式（I）化合物预防或治疗某些心血管，中枢神经系统的方法 ，炎症和骨疾病以及传染病和某些癌症。 还公开并要求保护式（I）化合物的组合文库，药物组合物和制备组合文库和式（I）化合物的方法。
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5.发明授权Hexahydropyridazine-3-carboxylic acid derivatives, pharmaceutical compositions containing same and methods of preparation 失效六氢哒嗪-3-羧酸衍生物，含有它们的药物组合物和制备方法公开(公告)号：US07034022B2
公开(公告)日：2006-04-25
申请号：US10979679
申请日：2004-11-02
IPC分类号： A01N43/58 , A61K31/50 , A61K31/501 , C07D237/00 , C07D237/02
CPC分类号： C07D401/12 , C07D237/04 , C07D403/12 , C07D409/12 , C07D413/12
摘要： The present invention discloses and claims compounds of formula (I) as inhibitors of proteases and kinases, method using said compounds of formula (I) for the prevention or treatment of certain cardiovascular, central nervous system, inflammatory, and bone diseases as well as infectious diseases and certain cancers. Combinatorial libraries of compounds of formula (I), pharmaceutical compositions and methods for preparation of combinatorial libraries and compounds of formula (I) are also disclosed and claimed.
摘要翻译： 本发明公开并要求作为蛋白酶和激酶抑制剂的式（I）化合物，使用所述式（I）化合物用于预防或治疗某些心血管，中枢神经系统，炎症和骨疾病以及感染性 疾病和某些癌症。 式（I）化合物的组合文库，药物组合物和制备组合文库和式（I）化合物的方法也被公开并要求保护。
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6.发明申请Hexahydropyridazine-3-carboxylic acid derivatives, pharmaceutical compositions containing same and methods of preparation 失效六氢哒嗪-3-羧酸衍生物，含有它们的药物组合物和制备方法公开(公告)号：US20050171346A1
公开(公告)日：2005-08-04
申请号：US10979679
申请日：2004-11-02
IPC分类号： A61K31/50 , A61K31/501 , A61K31/506 , A61P1/02 , A61P3/14 , A61P9/00 , A61P19/00 , A61P19/02 , A61P19/10 , A61P25/00 , A61P29/00 , A61P31/00 , A61P35/00 , A61P43/00 , C07D237/04 , C07D401/12 , C07D403/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D43/02 , C07D237/02
CPC分类号： C07D401/12 , C07D237/04 , C07D403/12 , C07D409/12 , C07D413/12
摘要： The present invention discloses and claims compounds of formula (I) as inhibitors of proteases and kinases, method using said compounds of formula (I) for the prevention or treatment of certain cardiovascular, central nervous system, inflammatory, and bone diseases as well as infectious diseases and certain cancers. Combinatorial libraries of compounds of formula (I), pharmaceutical compositions and methods for preparation of combinatorial libraries and compounds of formula (I) are also disclosed and claimed.
摘要翻译： 本发明公开并要求作为蛋白酶和激酶抑制剂的式（I）化合物，使用所述式（I）化合物用于预防或治疗某些心血管，中枢神经系统，炎症和骨疾病以及感染性 疾病和某些癌症。 式（I）化合物的组合文库，药物组合物和制备组合文库和式（I）化合物的方法也被公开并要求保护。
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7.发明授权2-alkoxy-3,4,5-trihydroxy-alkylamides, preparation thereof, compositions containing them and use thereof 失效2-烷氧基-3,4,5-三羟基烷基酰胺，其制备，含有它们的组合物及其用途公开(公告)号：US07550453B2
公开(公告)日：2009-06-23
申请号：US11753160
申请日：2007-05-24
申请人： Jidong Zhang , Neerja Bhatnagar , Jean-Marie Ruxer
发明人： Jidong Zhang , Neerja Bhatnagar , Jean-Marie Ruxer
IPC分类号： C07D223/10 , C07D223/12 , C07D215/16 , C07D211/72 , C07D207/00 , C07D207/12 , A61K31/55 , A61K31/47 , A61K31/40 , A61P35/00
CPC分类号： C07D223/12 , C07D205/085 , C07D207/273 , C07D207/277 , C07D211/76 , C07D215/38 , C07D223/16 , C07D243/08 , C07D281/06 , C07D281/08 , C07D417/06 , C07D471/04
摘要： The invention relates particularly to 2-alkoxy-3,4,5-trihydroxy-alkylamides, preparation thereof, compositions containing them and use thereof as a medicament, particularly as anti-cancer agents.
摘要翻译： 本发明特别涉及2-烷氧基-3,4,5-三羟基 - 烷基酰胺，其制备方法，含有它们的组合物及其作为药物的用途，特别是作为抗癌剂。
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公开(公告)号：US5633400A
公开(公告)日：1997-05-27
申请号：US449389
申请日：1995-05-24
IPC分类号： B01J23/44 , A61K31/235 , A61K31/41 , C07B37/04 , C07B61/00 , C07C41/48 , C07C45/61 , C07C45/71 , C07C47/546 , C07C67/30 , C07C67/343 , C07C69/76 , C07C69/767 , C07C253/30 , C07C255/37 , C07C255/40 , C07C255/56 , C07C303/40 , C07C311/09 , C07C311/48 , C07C311/51 , C07C311/52 , C07C311/53 , C07C311/54 , C07C311/57 , C07C311/58 , C07D257/04 , C07C317/00 , C07C229/00 , C07C303/00
CPC分类号： C07D257/04 , C07B37/04 , C07C253/30 , C07C303/40 , C07C311/09 , C07C311/51 , C07C311/58 , C07C67/343
摘要： The invention relates to a process for the preparation of a compound of the formula (I) ##STR1## in which X is an optionally protected formyl group andR is a group which is itself inert to the reaction conditions of the synthesis,which comprises reacting a compound of the formula (II) ##STR2## where X is as defined above, with a substituted phenyl-halogen compound of the formula (III) ##STR3## where the substituent Hal is a halogen group and R is as defined above.
摘要翻译： 本发明涉及一种制备式（I）化合物（I）的方法，其中X是任选保护的甲酰基，R是本身对合成的反应条件是惰性的基团， 其包括使式（II）化合物（II）其中X如上定义，与式（III）取代的苯基 - 卤素化合物（III）反应，其中取代基Hal为卤素 基团和R如上所定义。
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9.发明授权Process for the preparation of 1-[(1,1'-biphenyl]-4-YL]-methyl-1H-imidazole-5-carboxylic acids 失效制备1 - [（1,1'-联苯] -4-YL] - 甲基-1H-咪唑-5-羧酸的方法
公开(公告)号：US5527919A
公开(公告)日：1996-06-18
申请号：US177153
申请日：1994-01-04
IPC分类号： C07D233/66 , A61K31/415 , A61K31/425 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/445 , A61K31/505 , A61P1/00 , A61P9/00 , A61P9/04 , A61P9/12 , A61P13/02 , A61P13/12 , A61P15/00 , A61P15/04 , A61P43/00 , C07C311/08 , C07C311/18 , C07C311/37 , C07C311/51 , C07C311/58 , C07C311/60 , C07C327/58 , C07D233/84 , C07D233/90 , C07D233/92 , C07D401/12 , C07D403/10 , C07D403/12 , C07D405/12 , C07D417/12
CPC分类号： C07D403/10 , C07C311/18 , C07C311/37 , C07C311/51 , C07C311/58 , C07C327/58 , C07D233/84 , C07D233/90
摘要： A novel process for the preparation of a compound of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are defined in the text.
摘要翻译： 用于制备式（I）的化合物的新方法，其中R 1，R 2，R 3和R 4在文中定义。
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10.发明申请BENGAMIDES WITH A SUBSTITUTED CAPROLACTAM CYCLE, METHOD FOR THE PREPARATION THEREOF, COMPOSITIONS CONTAINING THEM AND USE THEREOF 失效具有取代的缩水甘油循环的本体，其制备方法，包含它们的组合物及其用途公开(公告)号：US20080318928A1
公开(公告)日：2008-12-25
申请号：US12194119
申请日：2008-08-19
申请人： Jidong ZHANG , Neerja Bhatnagar
发明人： Jidong ZHANG , Neerja Bhatnagar
IPC分类号： A61K31/55 , C07D223/12 , A61P35/00 , C07D403/10
CPC分类号： C07D223/12
摘要： The invention relates to the preparation of substituted caprolactams, a method for the preparation thereof, compositions containing them and the use thereof as a medicament, particularly as anticancer agents.
摘要翻译： 本发明涉及取代己内酰胺的制备，其制备方法，含有它们的组合物及其作为药物的用途，特别是作为抗癌剂。
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