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    Fc fusion
    2.
    发明申请
    Fc fusion 审中-公开
    Fc融合

    公开(公告)号：US20060083747A1

    公开(公告)日：2006-04-20

    申请号：US11166496

    申请日：2005-06-24

    申请人： Gregory Winter ,  Ian Tomlinson ,  Olga Ignatovich ,  Neil Brewis

    发明人： Gregory Winter ,  Ian Tomlinson ,  Olga Ignatovich ,  Neil Brewis

    IPC分类号： A61K39/395 ,  C07H21/04 ,  C12P21/06 ,  C12N5/06 ,  C07K16/46

    CPC分类号： C07K16/00 ,  A61K2039/505 ,  C07K16/241 ,  C07K16/40 ,  C07K2317/52 ,  C07K2317/569 ,  C07K2317/94 ,  C07K2319/00

    摘要： The present invention relates to a simple method for generating antibody-based structures suitable for in vivo use. In particular, the invention relates to a method for the generation of antibody-based structures suitable for in vivo use comprising the steps of: (a) selecting an antibody single variable domain having an epitope binding specificity; and (b) attaching the single domain of step (a) to an effector group. Uses of molecules generated using the method of the Invention are also described.

    摘要翻译： 本发明涉及一种生成适用于体内使用的基于抗体的结构的简单方法。 特别地，本发明涉及一种生成适合于体内应用的基于抗体的结构的方法，包括以下步骤：（a）选择具有表位结合特异性的抗体单可变结构域; 和（b）将步骤（a）的单一结构域连接到效应子组。 还描述了使用本发明的方法生成的分子的用途。

    Curable amine flux composition and method of soldering
    8.
    发明授权
    Curable amine flux composition and method of soldering 有权
    可固化胺助焊剂组成及焊接方法

    公开(公告)号：US08070045B1

    公开(公告)日：2011-12-06

    申请号：US12958487

    申请日：2010-12-02

    申请人： David D. Fleming ,  Mike K. Gallagher ,  Kim Sang Ho ,  Xiang-Qian Liu ,  Mark R. Winkle ,  Asghar Akber Peera ,  Glenn N. Robinson ,  Ian Tomlinson

    发明人： David D. Fleming ,  Mike K. Gallagher ,  Kim Sang Ho ,  Xiang-Qian Liu ,  Mark R. Winkle ,  Asghar Akber Peera ,  Glenn N. Robinson ,  Ian Tomlinson

    IPC分类号： B23K31/02 ,  B23K35/34

    CPC分类号： B23K35/3615 ,  B23K1/0016 ,  B23K1/203 ,  B23K35/362 ,  B23K2101/38 ,  B23K2101/42

    摘要： A curable amine flux composition is provided, comprising, as initial components: a resin component having at least two oxirane groups per molecule; an amine fluxing agent represented by formula I: wherein R1, R2, R3 and R4 are independently selected from a hydrogen, a substituted C1-80 alkyl group, an unsubstituted C1-80 alkyl group, a substituted C7-80 arylalkyl group and an unsubstituted C7-80 arylalkyl group; wherein R7 and R8 are independently selected from a C1-20 alkyl group, a substituted C1-20 alkyl group, a C6-20 aryl group and a substituted C6-20 aryl group or wherein R7 and R8, together with the carbon to which they are attached, form a C3-20 cycloalkyl ring optionally substituted with a C1-6 alkyl group; wherein R10 and R11 are independently selected from a C1-20 alkyl group, a substituted C1-20 alkyl group, a C6-20 aryl group and a substituted C6-20 aryl group or wherein R10 and R11, together with the carbon to which they are attached, form a C3-20 cycloalkyl ring optionally substituted with a C1-6 alkyl group; and, wherein R9 is selected from a hydrogen, a C1-30 alkyl group, a substituted C1-30 alkyl group, a C6-30 aryl group and a substituted C6-30 aryl group; and, optionally, a curing agent. Also provided is a method of soldering an electrical contact using the curable amine flux composition.

    摘要翻译： 提供了一种可固化胺助剂组合物，其包含作为初始组分的树脂组分：每分子具有至少两个环氧乙烷基团的树脂组分; 由式I表示的胺助熔剂：其中R 1，R 2，R 3和R 4独立地选自氢，取代的C 1-8烷基，未取代的C 1-80烷基，取代的C 7〜80芳烷基和未取代的 C7-80芳基烷基; 其中R 7和R 8独立地选自C 1-20烷基，取代的C 1-20烷基，C 6-20芳基和取代的C 6-20芳基，或者其中R 7和R 8与它们 连接，形成任选被C 1-6烷基取代的C 3-20环烷基环; 其中R 10和R 11独立地选自C 1-20烷基，取代的C 1-20烷基，C 6-20芳基和取代的C 6-20芳基，或其中R 10和R 11与它们 连接，形成任选被C 1-6烷基取代的C 3-20环烷基环; 并且其中R 9选自氢，C 1-30烷基，取代的C 1-30烷基，C 6-30芳基和取代的C 6-30芳基; 和任选的固化剂。 还提供了使用可固化胺助剂组合物焊接电接触的方法。