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公开(公告)号：US06391908B1
公开(公告)日：2002-05-21
申请号：US09856942
申请日：2001-05-30
申请人： Nicholas James Bach , Richard Waltz Harper , Michael Dean Kinnick , Ho-Shen Lin , John Michael Morin, Jr. , Michael Enrico Richett
发明人： Nicholas James Bach , Richard Waltz Harper , Michael Dean Kinnick , Ho-Shen Lin , John Michael Morin, Jr. , Michael Enrico Richett
IPC分类号： A61K31404
CPC分类号： C07D209/22
摘要： A class of novel oxime indoles is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of inflammatory diseases such as septic shock.
摘要翻译： 公开了一类新型肟吲哚以及这些化合物用于抑制sPLA2介导的脂肪酸释放以治疗炎症性疾病如败血性休克的用途。
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公开(公告)号：US06713645B1
公开(公告)日：2004-03-30
申请号：US09688106
申请日：2000-10-13
申请人： Nicholas James Bach , Susan Elizabeth Draheim , Robert Delane Dillard , Edward David Mihelich , Jason Scott Sawyer , Douglas Wade Beight , Michael LeRoy Phillips , Tulio Suarez , Daniel Jon Sall , Jolie Anne Bastian , Michael Lyle Denney , Gary Alan Hite , Michael Dean Kinnick , Robert Theodore Vasileff , John Michael Morin, Jr. , Ho-Shen Lin , Michael Enrico Richett , Richard Waltz Harper , John McNeill McGill, III , Benjamin Alan Anderson , Nancy Kay Harn , Richard James Loncharich , Richard Walter Schevitz
发明人： Nicholas James Bach , Susan Elizabeth Draheim , Robert Delane Dillard , Edward David Mihelich , Jason Scott Sawyer , Douglas Wade Beight , Michael LeRoy Phillips , Tulio Suarez , Daniel Jon Sall , Jolie Anne Bastian , Michael Lyle Denney , Gary Alan Hite , Michael Dean Kinnick , Robert Theodore Vasileff , John Michael Morin, Jr. , Ho-Shen Lin , Michael Enrico Richett , Richard Waltz Harper , John McNeill McGill, III , Benjamin Alan Anderson , Nancy Kay Harn , Richard James Loncharich , Richard Walter Schevitz
IPC分类号： C07C6976
CPC分类号： C07D409/04 , C07D209/88 , C07F9/5728
摘要： A class of novel tricyclics is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as septic shock.
摘要翻译： 公开了一类新型三环类药物，以及这些化合物用于抑制sPLA2介导的脂肪酸释放以治疗诸如败血性休克的病症。
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公开(公告)号：US06177440B1
公开(公告)日：2001-01-23
申请号：US09063066
申请日：1998-04-21
申请人： Nicholas James Bach , Susan Elizabeth Draheim , Robert Delane Dillard , Edward David Mihelich , Jason Scott Sawyer , Douglas Wade Beight , Michael LeRoy Phillips , Tulio Suarez , Daniel Jon Sall , Jolie Anne Bastian , Michael Lyle Denney , Gary Alan Hite , Michael Dean Kinnick , Robert Theodore Vasileff , John Michael Morin, Jr. , Ho-Shen Lin , Michael Enrico Richett , Richard Waltz Harper , John McNeill McGill, III , Benjamin Alan Anderson , Nancy Kay Harn , Richard James Loncharich , Richard Walter Schevitz
发明人： Nicholas James Bach , Susan Elizabeth Draheim , Robert Delane Dillard , Edward David Mihelich , Jason Scott Sawyer , Douglas Wade Beight , Michael LeRoy Phillips , Tulio Suarez , Daniel Jon Sall , Jolie Anne Bastian , Michael Lyle Denney , Gary Alan Hite , Michael Dean Kinnick , Robert Theodore Vasileff , John Michael Morin, Jr. , Ho-Shen Lin , Michael Enrico Richett , Richard Waltz Harper , John McNeill McGill, III , Benjamin Alan Anderson , Nancy Kay Harn , Richard James Loncharich , Richard Walter Schevitz
IPC分类号： A61K3144
CPC分类号： C07D209/88
摘要： A class of novel tricyclics is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as septic shock.
摘要翻译： 公开了一类新型三环类药物，以及这些化合物用于抑制sPLA2介导的脂肪酸释放以治疗诸如败血性休克的病症。
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公开(公告)号：US06939890B2
公开(公告)日：2005-09-06
申请号：US10629992
申请日：2003-07-30
IPC分类号： C07D209/22 , A61K31/404 , C07D207/337
CPC分类号： C07D209/22
摘要： A class of novel indole is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock.
摘要翻译： 公开了一类新型吲哚以及这些化合物用于抑制脂肪酸介导的释放脂肪酸用于治疗炎性疾病如败血性休克的用途。
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公开(公告)号：US06448422B1
公开(公告)日：2002-09-10
申请号：US09609871
申请日：2000-07-03
申请人： Patrick Irving Eacho , Patricia Sue Foxworthy-Mason , Richard Waltz Harper , Ho-Shen Lin , Jose Eduardo Lopez , Michael Enrico Richett
发明人： Patrick Irving Eacho , Patricia Sue Foxworthy-Mason , Richard Waltz Harper , Ho-Shen Lin , Jose Eduardo Lopez , Michael Enrico Richett
IPC分类号： C07F902
摘要： This application relates to a novel compound of formula I, as defined herein, processes and intermediates for its preparation and the use of the compound of formula I as a substrate for a pharmaceutical screen.
摘要翻译： 本申请涉及如本文定义的式I的新化合物，其制备方法和中间体以及式I化合物作为药物筛选的底物的用途。
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公开(公告)号：US06251921B1
公开(公告)日：2001-06-26
申请号：US09312593
申请日：1999-05-14
申请人： Jolie Anne Bastian , Nickolay Yuri Chirgadze , Michael Lyle Denney , Matthew Joseph Fisher , Robert James Foglesong , Richard Waltz Harper , Mary George Johnson , Valentine Joseph Klimkowski , Todd Jonathan Kohn , Ho-Shen Lin , Michael Patrick Lynch , Jefferson Ray McCowan , Alan David Palkowitz , Michael Enrico Richett , Daniel Jon Sall , Gerald Floyd Smith , Kumiko Takeuchi , Jennifer Marie Tinsley , Minsheng Zhang
发明人： Jolie Anne Bastian , Nickolay Yuri Chirgadze , Michael Lyle Denney , Matthew Joseph Fisher , Robert James Foglesong , Richard Waltz Harper , Mary George Johnson , Valentine Joseph Klimkowski , Todd Jonathan Kohn , Ho-Shen Lin , Michael Patrick Lynch , Jefferson Ray McCowan , Alan David Palkowitz , Michael Enrico Richett , Daniel Jon Sall , Gerald Floyd Smith , Kumiko Takeuchi , Jennifer Marie Tinsley , Minsheng Zhang
IPC分类号： A61K314436
CPC分类号： C07D333/62 , A61K31/381 , A61K31/4025 , A61K31/4178 , A61K31/422 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/497 , A61K31/5377 , A61K31/55 , C07D231/12 , C07D233/56 , C07D249/08 , C07D333/56 , C07D333/58 , C07D333/64 , C07D333/66 , C07D409/04 , C07D409/06 , C07D409/12 , C07D413/06
摘要： This application relates to the use as thrombin inhibitors, coagulation inhibitors and thromboembolic disorder agents of diamines of formula I as defined herein. It also provides novel compounds of formula I, processes and intermediates for their preparation, and pharmaceutical formulations comprising the novel compounds of formula I.
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公开(公告)号：US06933313B2
公开(公告)日：2005-08-23
申请号：US10467965
申请日：2002-03-15
IPC分类号： A61K31/403 , A61P1/04 , A61P1/18 , A61P9/10 , A61P11/00 , A61P11/06 , A61P19/00 , A61P19/02 , A61P19/06 , A61P25/28 , A61P27/14 , A61P29/00 , A61P31/00 , A61P43/00 , C07D209/88 , C07D403/12 , C07D409/04
CPC分类号： C07D403/12 , A61K31/403 , C07D209/88 , C07D409/04 , Y02A50/401
摘要： Carbazoles of formula (I) with R2=hydroxyfunctional amide (hydroxamic or esters) are disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as septic shock.
摘要翻译： 公开了具有R 2 =羟基官能酰胺（异羟肟酸或酯）的式（I）的咔唑以及这些化合物用于抑制sPLA 2介导的脂肪酸释放的用途 治疗脓毒性休克等病症。
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8.发明授权Hydroxyfunctional amide 1h-indole derivatives active as sPLA2 inhibitors 失效活性为sPLA2抑制剂的羟基官能酰胺1h-吲哚衍生物公开(公告)号：US06831095B1
公开(公告)日：2004-12-14
申请号：US10069824
申请日：2002-02-21
IPC分类号： C07D20736
CPC分类号： C07D209/22
摘要： A class of novel indole is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock.
摘要翻译： 公开了一类新型吲哚以及这些化合物用于抑制sPLA2介导的脂肪酸释放以治疗炎性疾病如脓毒性休克的用途。
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公开(公告)号：US6025382A
公开(公告)日：2000-02-15
申请号：US846647
申请日：1997-04-30
申请人： Jolie Anne Bastian , Nickolay Yuri Chirgadze , Michael Lyle Denney , Matthew Joseph Fisher , Robert James Foglesong , Richard Waltz Harper , Mary George Johnson , Valentine Joseph Klimkowski , Todd Jonathan Kohn , Ho-Shen Lin , Michael Patrick Lynch , Jefferson Ray McCowan , Alan David Palkowitz , Michael Enrico Richett , Daniel Jon Sall , Gerald Floyd Smith , Kumiko Takeuchi , Jennifer Marie Tinsley , Minsheng Zhang
发明人： Jolie Anne Bastian , Nickolay Yuri Chirgadze , Michael Lyle Denney , Matthew Joseph Fisher , Robert James Foglesong , Richard Waltz Harper , Mary George Johnson , Valentine Joseph Klimkowski , Todd Jonathan Kohn , Ho-Shen Lin , Michael Patrick Lynch , Jefferson Ray McCowan , Alan David Palkowitz , Michael Enrico Richett , Daniel Jon Sall , Gerald Floyd Smith , Kumiko Takeuchi , Jennifer Marie Tinsley , Minsheng Zhang
IPC分类号： C07D295/08 , A61K31/381 , A61K31/4025 , A61K31/4178 , A61K31/422 , A61K31/4436 , A61K31/4439 , A61K31/4453 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61K31/497 , A61K31/5377 , A61K31/55 , A61P7/02 , C07D333/56 , C07D333/58 , C07D333/62 , C07D333/64 , C07D333/66 , C07D409/04 , C07D409/06 , C07D409/10 , C07D409/12 , C07D413/06 , C07D521/00 , A61K31/40 , A61K31/38 , C07D409/14
CPC分类号： C07D333/62 , A61K31/381 , A61K31/4025 , A61K31/4178 , A61K31/422 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/497 , A61K31/5377 , A61K31/55 , C07D231/12 , C07D233/56 , C07D249/08 , C07D333/56 , C07D333/58 , C07D333/64 , C07D333/66 , C07D409/04 , C07D409/06 , C07D409/12 , C07D413/06
摘要： This application relates to the use as thrombin inhibitors, coagulation inhibitors and thromboembolic disorder agents of diamines of formula I as defined herein. It also provides novel compounds of formula I, processes and intermediates for their preparation, and pharmaceutical formulations comprising the novel compounds of formula I.
摘要翻译： 本申请涉及作为本文定义的式I二胺的凝血酶抑制剂，凝血抑制剂和血栓栓塞障碍剂的用途。 它还提供式I的新型化合物，其制备方法和中间体，以及包含式I化合物的药物制剂。
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公开(公告)号：US06359136B1
公开(公告)日：2002-03-19
申请号：US09716605
申请日：2000-11-20
申请人： Jolie Ann Bastian , Matthew Joseph Fisher , Richard Waltz Harper , Ho-Shen Lin , Jefferson Ray McCowan , Daniel Jon Sall , Gerald Floyd Smith , Kumiko Takeuchi , Michael Robert Wiley , Minsheng Zhang
发明人： Jolie Ann Bastian , Matthew Joseph Fisher , Richard Waltz Harper , Ho-Shen Lin , Jefferson Ray McCowan , Daniel Jon Sall , Gerald Floyd Smith , Kumiko Takeuchi , Michael Robert Wiley , Minsheng Zhang
IPC分类号： C07D47104
CPC分类号： C07D471/04
摘要： This application relates to novel compounds of formula I (and their pharmaceutically acceptable salts), as defined herein, processes and intermediates for their preparation, pharmaceutical formulations comprising the novel compounds of formula I, and the use of the compounds of formula I as thrombin inhibitors.
摘要翻译： 本申请涉及本文定义的式I（及其药学上可接受的盐）的新型化合物，其制备方法和中间体，包含式I的新型化合物的药物制剂以及式I化合物作为凝血酶抑制剂的用途 。
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