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公开(公告)号：US20110288639A1
公开(公告)日：2011-11-24
申请号：US13021523
申请日：2011-02-04
申请人： Nikhil S. Trilokekar , Dimitrios Stroumpoulis , Dustin Leslie , Kaustubh S. Chitre , Nicholas J. Manesis , David J. Schuessler , Thomas E. Powell , James A. Harders
发明人： Nikhil S. Trilokekar , Dimitrios Stroumpoulis , Dustin Leslie , Kaustubh S. Chitre , Nicholas J. Manesis , David J. Schuessler , Thomas E. Powell , James A. Harders
CPC分类号： A61F2/12 , A61B90/02 , A61F2210/0076 , A61F2250/0003 , A61F2250/0004
摘要： An inflatable tissue expander, suitable for implantation in a breast, is provided. The tissue expander includes a puncturable, self-sealing anterior portion forming a fillable cavity, and posterior portion that is puncture resistant. The anterior portion includes a silicone-based elastomer material having a mesh embedded therein. The posterior portion includes a first composite guard and a second composite guard, each composite guard including an arrangement of puncture resistant members and a flexible substrate having a first side on which the puncture resistant members are disposed in a spaced apart fashion.
摘要翻译： 提供了一种适合植入乳房的充气组织扩张器。 组织扩张器包括形成可填充空腔的可穿刺的，自密封的前部，以及防刺穿的后部。 前部包括具有嵌入其中的网的硅酮基弹性体材料。 后部包括第一复合防护件和第二复合防护件，每个复合护罩包括防穿刺构件的布置和具有第一侧面的柔性基底，抗穿刺构件以间隔开的方式设置在该第一侧上。
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公开(公告)号：US08882728B2
公开(公告)日：2014-11-11
申请号：US12703515
申请日：2010-02-10
CPC分类号： A61F5/0056 , A61F5/003 , A61F5/0043 , A61M39/0208 , A61M39/04 , A61M2039/0223
摘要： An implantable injection port facilitates filling and/or draining an inflatable portion of a gastric band. In an embodiment, the port comprises a movable cap that causes anchor wires to extend from anchor devices in order to implant the injection port in the tissue of a patient. In another embodiment, the port comprises a handle that rotates to implant curved anchors into the tissue of a patient. In yet another embodiment, a cap is configured to move towards a base of the port in order to cause the curved anchors to rotate into the tissue of a patient. The cap may also rotate with respect to the base in order to lock the cap and the anchors in position. Further, surfaces of the injection port may be textured to increase adhesiveness to the patient's tissue during installation and to facilitate simpler installation.
摘要翻译： 可植入注射口有助于填充和/或排出胃带的可充气部分。 在一个实施例中，端口包括可移动盖，其使锚线从锚定装置延伸以便将注射端口植入患者的组织中。 在另一个实施例中，端口包括旋转的手柄，以将弯曲的锚固件植入患者的组织中。 在另一个实施例中，帽构造成朝向端口的基部移动，以便使弯曲的锚固件旋转到患者的组织中。 盖子也可以相对于基座旋转，以便将盖子和锚固件锁定就位。 此外，注射端口的表面可以被纹理化以在安装期间增加对患者组织的粘附性并且便于更简单的安装。
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公开(公告)号：US20110196394A1
公开(公告)日：2011-08-11
申请号：US12703515
申请日：2010-02-10
IPC分类号： A61B17/12
CPC分类号： A61F5/0056 , A61F5/003 , A61F5/0043 , A61M39/0208 , A61M39/04 , A61M2039/0223
摘要： An implantable injection port facilitates filling and/or draining an inflatable portion of a gastric band. In an embodiment, the port comprises a movable cap that causes anchor wires to extend from anchor devices in order to implant the injection port in the tissue of a patient. In another embodiment, the port comprises a handle that rotates to implant curved anchors into the tissue of a patient. In yet another embodiment, a cap is configured to move towards a base of the port in order to cause the curved anchors to rotate into the tissue of a patient. The cap may also rotate with respect to the base in order to lock the cap and the anchors in position. Further, surfaces of the injection port may be textured to increase adhesiveness to the patient's tissue during installation and to facilitate simpler installation.
摘要翻译： 可植入注射口有助于填充和/或排出胃带的可充气部分。 在一个实施例中，端口包括可移动盖，其使锚线从锚定装置延伸以便将注射端口植入患者的组织中。 在另一个实施例中，端口包括旋转的手柄，以将弯曲的锚固件植入患者的组织中。 在另一个实施例中，帽构造成朝向端口的基部移动，以便使弯曲的锚固件旋转到患者的组织中。 盖子也可以相对于基座旋转，以便将盖子和锚固件锁定就位。 此外，注射端口的表面可以被纹理化以在安装期间增加对患者组织的粘附性并且便于更简单的安装。
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公开(公告)号：US20110276133A1
公开(公告)日：2011-11-10
申请号：US13104395
申请日：2011-05-10
CPC分类号： A61L27/56 , A61F2/12 , A61L27/18 , A61L27/34 , A61L31/06 , A61L31/146 , A61L2430/04 , C08J9/26 , C08J2201/046 , C08J2383/04 , C08J2467/00 , C08L83/04
摘要： The present specification discloses porous materials, methods of forming such porous materials, biocompatible implantable devices comprising such porous materials, and methods of making such biocompatible implantable devices.
摘要翻译： 本说明书公开了多孔材料，形成这种多孔材料的方法，包括这种多孔材料的生物相容性可植入装置以及制造这种生物相容性可植入装置的方法。
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公开(公告)号：US20110282444A1
公开(公告)日：2011-11-17
申请号：US13104888
申请日：2011-05-10
CPC分类号： A61L27/18 , A61L27/16 , A61L27/50 , A61L27/56 , A61L2430/04 , Y10T156/10 , C08L83/04 , C08L53/02 , C08L23/22
摘要： The present specification discloses porous materials, methods of forming such porous materials, biocompatible implantable devices comprising such porous materials, and methods of making such biocompatible implantable devices.
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公开(公告)号：US08889751B2
公开(公告)日：2014-11-18
申请号：US13247835
申请日：2011-09-28
CPC分类号： B29C67/202 , A61K47/34 , A61L26/0019 , B29K2067/04 , B29K2083/005 , B29K2105/0085 , B29L2031/753 , C08J9/26 , C08J2201/0462 , C08J2383/04 , Y10T428/249921
摘要： The present specification discloses porous materials, methods of forming such porous materials, materials and devices comprising such porous materials, and methods of making such materials and devices.
摘要翻译： 本说明书公开了多孔材料，形成这种多孔材料的方法，包括这种多孔材料的材料和装置以及制造这种材料和装置的方法。
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公开(公告)号：US20120077012A1
公开(公告)日：2012-03-29
申请号：US13247835
申请日：2011-09-28
CPC分类号： B29C67/202 , A61K47/34 , A61L26/0019 , B29K2067/04 , B29K2083/005 , B29K2105/0085 , B29L2031/753 , C08J9/26 , C08J2201/0462 , C08J2383/04 , Y10T428/249921
摘要： The present specification discloses porous materials, methods of forming such porous materials, materials and devices comprising such porous materials, and methods of making such materials and devices.
摘要翻译： 本说明书公开了多孔材料，形成这种多孔材料的方法，包括这种多孔材料的材料和装置以及制造这种材料和装置的方法。
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公开(公告)号：US08394783B2
公开(公告)日：2013-03-12
申请号：US13439566
申请日：2012-04-04
IPC分类号： A61K31/70
CPC分类号： A61K8/042 , A61K8/492 , A61K8/60 , A61K8/602 , A61K8/676 , A61K8/678 , A61K8/73 , A61K8/731 , A61K8/735 , A61K8/736 , A61K9/0024 , A61K31/715 , A61K31/717 , A61K31/721 , A61K31/727 , A61K31/728 , A61K31/737 , A61K31/738 , A61K47/12 , A61K47/36 , A61K2800/522 , A61Q19/08 , C08B37/0072 , C08J3/075 , C08J3/12 , C08J3/128 , C08J3/24 , C08J2351/02 , C08K5/0025 , C08L1/02 , C08L5/04 , C08L5/08 , C08L5/10
摘要： Described herein are polysaccharide gel formulations including at least one inhibitor of polysaccharide degradation and methods of making the same. The methods described herein involve the steps of providing at least one polysaccharide and incorporating at least one inhibitor of degradation into the polysaccharide.
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公开(公告)号：US08318695B2
公开(公告)日：2012-11-27
申请号：US12178574
申请日：2008-07-23
IPC分类号： A61K31/715
CPC分类号： C08B37/0072 , A61L27/20 , A61L2430/34 , C08L5/08
摘要： The present invention generally relates to novel biocompatible crosslinked polysaccharide gel compositions, methods of their manufacture and use, and the novel crosslinkers used to make them. In one aspect of the invention, a novel polyethylene glycol crosslinking agent is described for crosslinking hyaluronic acid. In another aspect of the invention, novel crosslinking agents comprising more than two functional groups are described. These multifunctional crosslinking agents can be used on their own to crosslink hyaluronic acid, or they may be combined with bifunctional crosslinking agents in varying ratios to make hyaluronic acid of tunable mechanical strength and hardness. The present invention also discloses novel hyaluronic acid compositions that have been coated with polyethylene glycol and methods of their use.
摘要翻译： 本发明一般涉及新的生物相容性交联多糖凝胶组合物，其制造和使用方法，以及用于制备它们的新型交联剂。 在本发明的一个方面，描述了用于交联透明质酸的新型聚乙二醇交联剂。 在本发明的另一方面，描述了包含多于两个官能团的新型交联剂。 这些多功能交联剂可以单独使用以交联透明质酸，或者它们可以以不同比例与双功能交联剂组合，以使透明质酸具有可调节的机械强度和硬度。 本发明还公开了已经涂覆有聚乙二醇的新型透明质酸组合物及其使用方法。
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公开(公告)号：US08513216B2
公开(公告)日：2013-08-20
申请号：US12558270
申请日：2009-09-11
IPC分类号： A61K31/70
CPC分类号： A61L27/26 , A61K8/042 , A61K8/492 , A61K8/60 , A61K8/602 , A61K8/676 , A61K8/678 , A61K8/73 , A61K8/731 , A61K8/735 , A61K8/736 , A61K31/715 , A61K31/717 , A61K31/721 , A61K31/727 , A61K31/728 , A61K31/737 , A61K31/738 , A61K47/183 , A61K47/26 , A61K47/36 , A61K47/38 , A61K47/42 , A61K2800/522 , A61L27/505 , A61Q19/08 , C08B37/0072 , C08J3/075 , C08J2305/08 , C08K5/053 , C08L5/08 , C08L2205/02
摘要： Described herein are polysaccharide gel formulations including at least one inhibitor of polysaccharide degradation and methods of making the same. The methods described herein involve the steps of providing at least one polysaccharide and incorporating at least one inhibitor of degradation into the polysaccharide. In some embodiments, the incorporating step comprises 1) mixing the at least one inhibitor with the at least one polysaccharide at a highly hydrated state thereby encapsulating the at least one inhibitor in a polysaccharide network, and 2) dehydrating the polysaccharide network thereby controlling release kinetics or final swell ratio. In another embodiment, the incorporating step comprises 1) encapsulating at least one inhibitor into a biocompatible or biodegradable vessel and 2) combining the polysaccharide and the vessel into a gel formulation. The polysaccharide gel formulations described herein can be used for a variety of cosmetic applications.
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