利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

72 条记录 (耗时 0.039 秒)

    Monoclonal antibodies to PACAP
    1.
    发明授权
    Monoclonal antibodies to PACAP 失效
    PACAP单克隆抗体

    公开(公告)号：US5486472A

    公开(公告)日：1996-01-23

    申请号：US924054

    申请日：1992-09-03

    申请人： Nobuhiro Suzuki ,  Chieko Kitada ,  Masao Tsuda

    发明人： Nobuhiro Suzuki ,  Chieko Kitada ,  Masao Tsuda

    IPC分类号： C07K16/00 ,  C07K14/435 ,  C07K14/575 ,  C07K16/18 ,  C07K16/26 ,  C12N5/10 ,  C12N15/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  C12N5/12

    CPC分类号： C07K16/26 ,  C07K14/57563

    摘要： Disclosed are a monoclonal antibody having affinity for PACAP, a partial peptide thereof, a precursor thereof or VIP; a hybridoma cell which produces the above monoclonal antibody; and an immunoassay for assaying PACAP by a competitive method or a sandwich method using the above antibody, whereby PACAP can be specifically detected with high sensitivity.

    摘要翻译： PCT No.PCT / JP91 / 00354 Sec。 371日期：1992年9月3日 102（e）日期1992年9月3日PCT 1991年3月15日PCT PCT。 WO91 / 14786 PCT公开 日期为1991年10月3日。公开是对PACAP，其部分肽，其前体或VIP具有亲和性的单克隆抗体; 产生上述单克隆抗体的杂交瘤细胞; 以及通过使用上述抗体的竞争性方法或夹心方法测定PACAP的免疫测定法，由此能够以高灵敏度特异性检测PACAP。

    Antiobestic agents methods for screening antiobestic agents and kits comprising same
    2.
    发明授权
    Antiobestic agents methods for screening antiobestic agents and kits comprising same 失效
    用于筛选抗生物剂的抗生物剂方法和包含其的试剂盒

    公开(公告)号：US06991908B1

    公开(公告)日：2006-01-31

    申请号：US09869540

    申请日：1999-12-27

    申请人： Masaaki Mori ,  Yukio Shimomura ,  Shiro Takekawa ,  Tsukasa Sugo ,  Yoshihiro Ishibashi ,  Chieko Kitada ,  Nobuhiro Suzuki

    发明人： Masaaki Mori ,  Yukio Shimomura ,  Shiro Takekawa ,  Tsukasa Sugo ,  Yoshihiro Ishibashi ,  Chieko Kitada ,  Nobuhiro Suzuki

    IPC分类号： G01N33/53

    CPC分类号： C07K7/08 ,  A61K38/10 ,  G01N33/74 ,  G01N2333/575 ,  G01N2333/726 ,  G01N2500/00 ,  G01N2500/02 ,  Y10S436/808

    摘要： The present invention provides a method for screening a compound or its salt that alters the binding property between MCH or its salt and SLC-1 or its salt, characterized by using MCH or its derivative or a salt thereof and SLC-1 or its salt is useful for screening an SLC-1 agonist which can be used not only as an appetite (eating) promoting agent but also as a prophylactic/therapeutic agent for weak pains, atonic bleeding, before and after expulsion, subinvolution of uterus, cesarean section, induced abortion, galactostasis, and the like, and an SLC-1 antagonist which can be used not only as an antiobestic agents (drug), an appetite (eating) modulator, and the like, but also as a prophylactic/therapeutic agent for hyperstimulation, ankylosing uterine contractions, fetal distress, uterine rupture, cervical laceration, preterm delivery, Prader-Wili syndrome and the like.

    摘要翻译： 本发明提供一种筛选化合物或其盐的方法，其改变MCH或其盐与SLC-1或其盐之间的结合性质，其特征在于使用MCH或其衍生物或其盐，SLC-1或其盐是 可用于筛选SLC-1激动剂，其不仅可以用作食欲（进食）促进剂，而且可用作弱疼痛，无症状出血，驱除前后，子宫切除，剖宫产，诱导 流产，半乳糖淀粉酶等，以及不仅可以用作抗生素（药物），食欲调节剂等的SLC-1拮抗剂，而且可以用作过度刺激的预防/治疗剂， 强直性子宫收缩，胎儿窘迫，子宫破裂，子宫颈撕裂，早产，Prader-Wili综合征等。

    Antibodies to .beta.-amyloids or their derivatives and use thereof
    3.
    发明授权
    Antibodies to .beta.-amyloids or their derivatives and use thereof 失效
    β-淀粉样蛋白或其衍生物的抗体及其用途

    公开(公告)号：US5750349A

    公开(公告)日：1998-05-12

    申请号：US302808

    申请日：1994-09-15

    申请人： Nobuhiro Suzuki ,  Asano Odaka ,  Chieko Kitada

    发明人： Nobuhiro Suzuki ,  Asano Odaka ,  Chieko Kitada

    IPC分类号： A61K38/00 ,  C07K14/47 ,  C07K16/18 ,  C12N5/20 ,  C12P21/08 ,  G01N33/53

    CPC分类号： C07K14/4711 ,  C07K16/18 ,  A61K38/00

    摘要： According to this invention, antibodies which are useful and novel in that they have binding specificity to .beta.-amyloids or derivatives thereof, namely recognize the N-terminal, the C-terminal or central portions of the .beta.-amyloids, respectively, were obtained. By combining these antibodies, determination methods by which the .beta.-amyloids could be determined sensitively and specifically are provided. These determination methods are useful for diagnosis of diseases to which the .beta.-amyloids or their derivatives are related (for example, Alzheimer's disease), and the antibodies of this invention are useful for the development of preventive-therapeutic compositions for Alzheimer's disease.

    摘要翻译： PCT No.PCT / JP94 / 00089 Sec。 371日期1994年9月15日 102（e）1994年9月15日PCT PCT 1994年1月24日PCT公布。 第WO94 / 17197号公报 日期1994年8月4日根据本发明，有用和新颖的抗体，因为它们对β-淀粉样蛋白或其衍生物具有结合特异性，即识别β-淀粉样蛋白的N-末端，C-末端或中心部分， 分别得到。 通过组合这些抗体，可以灵敏和具体地确定β淀粉样蛋白的测定方法。 这些测定方法可用于诊断β-淀粉样蛋白或其衍生物相关的疾病（例如阿尔茨海默氏病），本发明的抗体可用于开发阿尔茨海默氏病的预防性治疗组合物。

    Antibodies to .beta.-amyloids or their derivatives and use thereof
    4.
    发明授权
    Antibodies to .beta.-amyloids or their derivatives and use thereof 失效
    β-淀粉样蛋白或其衍生物的抗体及其用途

    公开(公告)号：US5955317A

    公开(公告)日：1999-09-21

    申请号：US986948

    申请日：1997-12-08

    申请人： Nobuhiro Suzuki ,  Asano Odaka ,  Chieko Kitada

    发明人： Nobuhiro Suzuki ,  Asano Odaka ,  Chieko Kitada

    IPC分类号： A61K38/00 ,  C07K14/47 ,  C07K16/18 ,  C12P21/08 ,  C12P21/04 ,  C07K16/00

    CPC分类号： C07K14/4711 ,  C07K16/18 ,  A61K38/00

    摘要： According to this invention, antibodies which are useful and novel in that they have binding specificity to .beta.-amyloids or derivatives thereof, namely recognize the N-terminal, the C-terminal or central portions of the .beta.-amyloids, respectively, were obtained. By combining these antibodies, determination methods by which the .beta.-amyloids could be determined sensitively and specifically are provided. These determination methods are useful for diagnosis of diseases to which the .beta.-amyloids or their derivatives are related (for example, Alzheimer's disease), and the antibodies of this invention are useful for the development of preventive-therapeutic compositions for Alzheimer's disease.

    摘要翻译： 根据本发明，获得了对β-淀粉样蛋白或其衍生物具有结合特异性的有用和新颖的抗体，即分别识别β-淀粉样蛋白的N-末端，C-末端或中心部分。 通过组合这些抗体，可以灵敏和具体地确定β淀粉样蛋白的测定方法。 这些测定方法可用于诊断β-淀粉样蛋白或其衍生物相关的疾病（例如阿尔茨海默氏病），本发明的抗体可用于开发阿尔茨海默氏病的预防性治疗组合物。

    DNA encoding galanin receptor activating peptide
    6.
    发明授权
    DNA encoding galanin receptor activating peptide 失效
    编码甘丙肽受体激活肽的DNA

    公开(公告)号：US07374910B2

    公开(公告)日：2008-05-20

    申请号：US11376694

    申请日：2006-03-15

    申请人： Tetsuya Ohtaki ,  Hideki Matsui ,  Yoshihiro Ishibashi ,  Kazuhiro Ogi ,  Chieko Kitada

    发明人： Tetsuya Ohtaki ,  Hideki Matsui ,  Yoshihiro Ishibashi ,  Kazuhiro Ogi ,  Chieko Kitada

    IPC分类号： C01N15/11 ,  C01N15/63 ,  C01N5/10

    CPC分类号： C07K16/18 ,  A61K38/00 ,  C07K14/47 ,  C07K14/705 ,  C07K14/72

    摘要： The present invention relates to a peptide comprising an amino acid sequence identical to or substantially identical to an amino acid sequence represented by SEQ ID NO: 35 and having an ability of binding to a receptor protein comprising an amino acid sequence identical to or substantially identical to an amino acid sequence represented by SEQ ID NO: 1, SEQ ID NO: 2 or SEQ ID NO: 3, or a precursor thereof, its amide or ester, or a salt thereof.An inventive peptide-encoding DNA or equivalent can be employed in (1) a development of a receptor binding assay system using an expression system of a recombinant receptor protein and a screening for a pharmaceutical candidate compound, and (2) a development of a pharmaceutical having a reduced side effect such as a memory function improving agent, an appetite improving agent, an uterine, renal, prostatic, testicular or skeletal muscle function regulating agent.

    摘要翻译： 本发明涉及一种肽，其包含与SEQ ID NO：35所示的氨基酸序列相同或基本相同的氨基酸序列，并且具有与受体蛋白结合的能力，所述受体蛋白包含与 由SEQ ID NO：1，SEQ ID NO：2或SEQ ID NO：3表示的氨基酸序列，或其前体，其酰胺或酯或其盐。 本发明的编码编码DNA的DNA或等同物可以用于（1）使用重组受体蛋白质的表达系统和药物候选化合物的筛选的受体结合测定系统的开发，和（2）药物 具有减少的副作用，例如记忆功能改善剂，食欲改善剂，子宫，肾，前列腺，睾丸或骨骼肌功能调节剂。

    Antibodies and utilization thereof
    9.
    发明授权
    Antibodies and utilization thereof 失效
    抗体及其利用

    公开(公告)号：US07067268B1

    公开(公告)日：2006-06-27

    申请号：US09700643

    申请日：1999-05-20

    申请人： Hirokazu Matsumoto ,  Chieko Kitada ,  Shuji Hinuma

    发明人： Hirokazu Matsumoto ,  Chieko Kitada ,  Shuji Hinuma

    IPC分类号： G01N33/53

    CPC分类号： G01N33/74 ,  C07K16/18 ,  C07K16/26 ,  G01N33/6854

    摘要： The anti-19P2 ligand monoclonal antibodies of the invention (in particular P2L-1Ca) have very high binding ability and can neutralize the arachidonic acid metabolite releasing activity of the 19P2 ligand. Therefore, they can be used, among others, as diagnostic, prophylactic and/or therapeutic agents for various diseases caused by some or other abnormality in the pituitary function modulating activity (e.g. prolactin secretion promoting activity), central nervous system modulating activity and pancreatic function modulating activity, among others, supposedly possessed by the 19P2 ligand.The immunoassay method using the monoclonal antibodies of the invention by the sandwich technique (in particular the sandwich technique using the monoclonal antibody and an antibody recognizing an intermediate portion of the 19P2 ligand) can assay the 19P2 ligand or a derivative thereof specifically and with high sensitivity. This assay method can be used in elucidating the physiological functions of the 19P2 ligand or a derivative thereof.

    摘要翻译： 本发明的抗-19P2配体单克隆抗体（特别是P2L-1Ca）具有非常高的结合能力，可中和19P2配体的花生四烯酸代谢物释放活性。 因此，它们可以用作垂体功能调节活性（例如催乳素分泌促进活性），中枢神经系统调节活性和胰腺功能的一些或其他异常引起的各种疾病的诊断，预防和/或治疗剂 19P2配体据称具有调节活性。 使用本发明的单克隆抗体通过夹心技术（特别是使用单克隆抗体的夹心技术和识别19P2配体的中间部分的抗体）的免疫测定方法可以特异性且高灵敏度地测定19P2配体或其衍生物 。 该测定方法可用于阐明19P2配体或其衍生物的生理功能。