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公开(公告)号：US20070238657A1
公开(公告)日：2007-10-11
申请号：US11405241
申请日：2006-04-17
申请人： Nobuyuki Itoh , Michael Kavanaugh
发明人： Nobuyuki Itoh , Michael Kavanaugh
CPC分类号： G01N33/57407 , A61K38/00 , C07K14/50 , C12P21/02 , G01N33/57426 , G01N33/57438 , G01N33/576 , G01N33/6872 , G01N33/689 , G01N2333/50 , G01N2500/00 , G01N2800/085 , G01N2800/367
摘要： This invention relates to human fibroblast growth factor (hFGF-21), and to variants thereof and to polynucleotides encoding FGF-21. The invention also relates to diagnostic and therapeutic agents related to the polynucleotides and proteins, including probes and antibodies, and to methods of treating liver disease such as cirrhosis and cancer, methods of treating conditions related to thymic function, and methods of treating conditions of the testis. The invention also relates to mouse fibroblast growth factor (mFGF-21), and to variants thereof and polynucleotides encoding mFGF-21.
摘要翻译： 本发明涉及人成纤维细胞生长因子（hFGF-21）及其变体，以及编码FGF-21的多核苷酸。 本发明还涉及与多核苷酸和蛋白质相关的诊断和治疗剂，包括探针和抗体，以及治疗肝脏疾病如肝硬化和癌症的方法，治疗与胸腺功能相关的病症的方法，以及治疗 睾丸。 本发明还涉及小鼠成纤维细胞生长因子（mFGF-21）及其变体和编码mFGF-21的多核苷酸。
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公开(公告)号：US06797695B1
公开(公告)日：2004-09-28
申请号：US09692945
申请日：2000-10-20
申请人： Nobuyuki Itoh , Michael Kavanaugh
发明人： Nobuyuki Itoh , Michael Kavanaugh
IPC分类号： A61K3818
CPC分类号： C07K14/50 , A61K38/00 , C12N2799/026
摘要： This invention relates to human fibroblast growth factor (hFGF-20), and to variants thereof and to polynucleotides encoding FGF-20. The invention also relates to diagnostic and therapeutic agents related to the polynucleotides and proteins, including probes and antibodies, to methods of treating neuronal degenerative disease such as Parkinson's disease and to methods of treating disorders of the cochlea including those causing hearing loss. The invention also relates to rat fibroblast growth factor (rFGF-20), and to variants thereof and polynucleotides encoding rFGF-20.
摘要翻译： 本发明涉及人成纤维细胞生长因子（hFGF-20）及其变体，以及编码FGF-20的多核苷酸。 本发明还涉及与多核苷酸和蛋白质相关的诊断和治疗剂，包括探针和抗体，治疗神经元退行性疾病如帕金森病的方法以及治疗耳蜗疾病的方法，包括导致听力损失的那些。 本发明还涉及大鼠成纤维细胞生长因子（rFGF-20）及其变体和编码rFGF-20的多核苷酸。
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公开(公告)号：US06716626B1
公开(公告)日：2004-04-06
申请号：US09715805
申请日：2000-11-16
申请人： Nobuyuki Itoh , Michael Kavanaugh
发明人： Nobuyuki Itoh , Michael Kavanaugh
IPC分类号： C12N1585
CPC分类号： G01N33/57407 , A61K38/00 , C07K14/50 , C12P21/02 , G01N33/57426 , G01N33/57438 , G01N33/576 , G01N33/6872 , G01N33/689 , G01N2333/50 , G01N2500/00 , G01N2800/085 , G01N2800/367
摘要： This invention relates to human fibroblast growth factor (hFGF-21), and to variants thereof and to polynucleotides encoding FGF-21. The invention also relates to diagnostic and therapeutic agents related to the polynucleotides and proteins, including probes and antibodies, and to methods of treating liver disease such as cirrhosis and cancer, methods of treating conditions related to thymic function, and methods of treating conditions of the testis. The invention also relates to mouse fibroblast growth factor (mFGF-21), and to variants thereof and polynucleotides encoding mFGF-21.
摘要翻译： 本发明涉及人成纤维细胞生长因子（hFGF-21）及其变体，以及编码FGF-21的多核苷酸。 本发明还涉及与多核苷酸和蛋白质相关的诊断和治疗剂，包括探针和抗体，以及治疗肝脏疾病如肝硬化和癌症的方法，治疗与胸腺功能相关的病症的方法，以及治疗 睾丸。 本发明还涉及小鼠成纤维细胞生长因子（mFGF-21）及其变体和编码mFGF-21的多核苷酸。
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公开(公告)号：US20090074776A1
公开(公告)日：2009-03-19
申请号：US11894005
申请日：2007-08-16
申请人： Nobuyuki Itoh , Michael Kavanaugh
发明人： Nobuyuki Itoh , Michael Kavanaugh
IPC分类号： A61K39/395 , C07H21/04 , C12N15/63 , C12N15/00 , C12N5/00 , A61K35/12 , C12Q1/68 , A61K31/7088 , C12P21/06 , C07K14/435 , C07K16/00
CPC分类号： G01N33/57407 , A61K38/00 , C07K14/50 , C12P21/02 , G01N33/57426 , G01N33/57438 , G01N33/576 , G01N33/6872 , G01N33/689 , G01N2333/50 , G01N2500/00 , G01N2800/085 , G01N2800/367
摘要： This invention relates to human fibroblast growth factor (hF-GF-21), and to variants thereof and to polynucleotides encoding FGF-21. The invention also relates to diagnostic and therapeutic agents related to the polynucleotides and proteins, including probes and antibodies, and to methods of treating liver disease such as cirrhosis and cancer, methods of treating conditions related to thymic function, and methods of treating conditions of the testis. The invention also relates to mouse fibroblast growth factor (mFGF-21), and to variants thereof and polynucleotides encoding mFGF-21.
摘要翻译： 本发明涉及人成纤维细胞生长因子（hF-GF-21）及其变体和编码FGF-21的多核苷酸。 本发明还涉及与多核苷酸和蛋白质相关的诊断和治疗剂，包括探针和抗体，以及治疗肝脏疾病如肝硬化和癌症的方法，治疗与胸腺功能相关的病症的方法，以及治疗 睾丸。 本发明还涉及小鼠成纤维细胞生长因子（mFGF-21）及其变体和编码mFGF-21的多核苷酸。
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公开(公告)号：US07259248B2
公开(公告)日：2007-08-21
申请号：US10060765
申请日：2002-01-29
申请人： Nobuyuki Itoh , W Michael Kavanaugh
发明人： Nobuyuki Itoh , W Michael Kavanaugh
CPC分类号： G01N33/57407 , A61K38/00 , C07K14/50 , C12P21/02 , G01N33/57426 , G01N33/57438 , G01N33/576 , G01N33/6872 , G01N33/689 , G01N2333/50 , G01N2500/00 , G01N2800/085 , G01N2800/367
摘要： This invention relates to human fibroblast growth factor (hFGF-21), and to variants thereof and to polynucleotides encoding FGF-21. The invention also relates to diagnostic and therapeutic agents related to the polynucleotides and proteins, including probes and antibodies, and to methods of treating liver disease such as cirrhosis and cancer, methods of treating conditions related to thymic function, and methods of treating conditions of the testis. The invention also relates to mouse fibroblast growth factor (mFGF-21), and to variants thereof and polynucleotides encoding mFGF-21.
摘要翻译： 本发明涉及人成纤维细胞生长因子（hFGF-21）及其变体，以及编码FGF-21的多核苷酸。 本发明还涉及与多核苷酸和蛋白质相关的诊断和治疗剂，包括探针和抗体，以及治疗肝脏疾病如肝硬化和癌症的方法，治疗与胸腺功能相关的病症的方法，以及治疗 睾丸。 本发明还涉及小鼠成纤维细胞生长因子（mFGF-21）及其变体和编码mFGF-21的多核苷酸。
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公开(公告)号：US20070128619A1
公开(公告)日：2007-06-07
申请号：US11441666
申请日：2006-05-26
申请人： Nobuyuki Itoh , Michael Kavanaugh
发明人： Nobuyuki Itoh , Michael Kavanaugh
CPC分类号： G01N33/57407 , A61K38/00 , C07K14/50 , C12P21/02 , G01N33/57426 , G01N33/57438 , G01N33/576 , G01N33/6872 , G01N33/689 , G01N2333/50 , G01N2500/00 , G01N2800/085 , G01N2800/367
摘要： This invention relates to human fibroblast growth factor (hFGF-21), and to variants thereof and to polynucleotides encoding FGF-2 1. The invention also relates to diagnostic and therapeutic agents related to the polynucleotides and proteins, including probes and antibodies, and to methods of treating liver disease such as cirrhosis and cancer, methods of treating conditions related to thymic function, and methods of treating conditions of the testis. The invention also relates to mouse fibroblast growth factor (mFGF-21), and to variants thereof and polynucleotides encoding mFGF-21.
摘要翻译： 本发明涉及人成纤维细胞生长因子（hFGF-21）及其变体和编码FGF-2的多核苷酸。本发明还涉及与多核苷酸和蛋白质相关的诊断和治疗剂，包括探针和抗体，以及 治疗肝硬化和癌症的肝病的方法，治疗与胸腺功能相关的病症的方法以及治疗睾丸病症的方法。 本发明还涉及小鼠成纤维细胞生长因子（mFGF-21）及其变体和编码mFGF-21的多核苷酸。
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公开(公告)号：US20050037457A1
公开(公告)日：2005-02-17
申请号：US10771173
申请日：2004-02-03
申请人： Nobuyuki Itoh , Michael Kavanaugh
发明人： Nobuyuki Itoh , Michael Kavanaugh
CPC分类号： G01N33/57407 , A61K38/00 , C07K14/50 , C12P21/02 , G01N33/57426 , G01N33/57438 , G01N33/576 , G01N33/6872 , G01N33/689 , G01N2333/50 , G01N2500/00 , G01N2800/085 , G01N2800/367
摘要： This invention relates to human fibroblast growth factor (hFGF-21), and to variants thereof and to polynucleotides encoding FGF-21. The invention also relates to diagnostic and therapeutic agents related to the polynucleotides and proteins, including probes and antibodies, and to methods of treating liver disease such as cirrhosis and cancer, methods of treating conditions related to thymic function, and methods of treating conditions of the testis. The invention also relates to mouse fibroblast growth factor (mFGF-21), and to variants thereof and polynucleotides encoding mFGF-21.
摘要翻译： 本发明涉及人成纤维细胞生长因子（hFGF-21）及其变体，以及编码FGF-21的多核苷酸。 本发明还涉及与多核苷酸和蛋白质相关的诊断和治疗剂，包括探针和抗体，以及治疗肝脏疾病如肝硬化和癌症的方法，治疗与胸腺功能相关的病症的方法，以及治疗 睾丸。 本发明还涉及小鼠成纤维细胞生长因子（mFGF-21）及其变体和编码mFGF-21的多核苷酸。
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公开(公告)号：US07723297B2
公开(公告)日：2010-05-25
申请号：US11405241
申请日：2006-04-17
申请人： Nobuyuki Itoh , Michael Kavanaugh
发明人： Nobuyuki Itoh , Michael Kavanaugh
IPC分类号： A61K38/18 , C07K14/475
CPC分类号： G01N33/57407 , A61K38/00 , C07K14/50 , C12P21/02 , G01N33/57426 , G01N33/57438 , G01N33/576 , G01N33/6872 , G01N33/689 , G01N2333/50 , G01N2500/00 , G01N2800/085 , G01N2800/367
摘要： This invention relates to human fibroblast growth factor (hFGF-21), and to variants thereof and to polynucleotides encoding FGF-21. The invention also relates to diagnostic and therapeutic agents related to the polynucleotides and proteins, including probes and antibodies, and to methods of treating liver disease such as cirrhosis and cancer, methods of treating conditions related to thymic function, and methods of treating conditions of the testis. The invention also relates to mouse fibroblast growth factor (mFGF-21), and to variants thereof and polynucleotides encoding mFGF-21.
摘要翻译： 本发明涉及人成纤维细胞生长因子（hFGF-21）及其变体，以及编码FGF-21的多核苷酸。 本发明还涉及与多核苷酸和蛋白质相关的诊断和治疗剂，包括探针和抗体，以及治疗肝脏疾病如肝硬化和癌症的方法，治疗与胸腺功能相关的病症的方法，以及治疗 睾丸。 本发明还涉及小鼠成纤维细胞生长因子（mFGF-21）及其变体和编码mFGF-21的多核苷酸。
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公开(公告)号：US20060172386A1
公开(公告)日：2006-08-03
申请号：US11318327
申请日：2005-12-27
申请人： Nobuyuki Itoh , Michael Kavanaugh
发明人： Nobuyuki Itoh , Michael Kavanaugh
CPC分类号： C07K14/50 , A61K38/00 , C12N2799/026
摘要： This invention relates to human fibroblast growth factor (hFGF-20), and to variants thereof and to polynucleotides encoding FGF-20. The invention also relates to diagnostic and therapeutic agents related to the polynucleotides and proteins, including probes and antibodies, to methods of treating neuronal degenerative disease such as Parkinson's disease and to methods of treating disorders of the cochlea including those causing hearing loss. The invention also relates to rat fibroblast growth factor (rFGF-20), and to variants thereof and polynucleotides encoding rFGF-20.
摘要翻译： 本发明涉及人成纤维细胞生长因子（hFGF-20）及其变体，以及编码FGF-20的多核苷酸。 本发明还涉及与多核苷酸和蛋白质相关的诊断和治疗剂，包括探针和抗体，治疗神经元退行性疾病如帕金森病的方法以及治疗耳蜗疾病的方法，包括导致听力损失的那些。 本发明还涉及大鼠成纤维细胞生长因子（rFGF-20），以及其变体和编码rFGF-20的多核苷酸。
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公开(公告)号：US20120251395A1
公开(公告)日：2012-10-04
申请号：US13505677
申请日：2010-09-06
申请人： Noriyuki Nakamura , Yujiro Okihara , Tetsuya Saitsu , Hatsuo Yotsumoto , Yoichiro Tabata , Nobuyuki Itoh
发明人： Noriyuki Nakamura , Yujiro Okihara , Tetsuya Saitsu , Hatsuo Yotsumoto , Yoichiro Tabata , Nobuyuki Itoh
IPC分类号： B01J7/00
CPC分类号： C01B13/11 , C01B2201/90
摘要： An ozone gas output flow rate management unit configured to receive a plurality of ozone gas outputs from a plurality of ozone generation units and capable of performing an ozone gas output flow rate control for selectively outputting one or a combination of two or more of the plurality of ozone gas outputs to any of a plurality of ozone treatment apparatuses by performing an opening/closing operation of a plurality of ozone gas control valves provided in the ozone gas output flow rate management unit.
摘要翻译： 一种臭氧气体输出流量管理单元，被配置为从多个臭氧发生单元接收多个臭氧气体输出，并且能够执行臭氧气体输出流量控制，以选择性地输出所述多个臭氧发生单元中的一个或多个的一个或多个 通过执行设置在臭氧气体输出流量管理单元中的多个臭氧气体控制阀的打开/关闭操作，臭氧气体输出到多个臭氧处理装置中的任一个。
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