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    5-PHENYL-3-PYRIDAZINONE DERIVATIVE
    1.
    发明申请
    5-PHENYL-3-PYRIDAZINONE DERIVATIVE 有权
    5-苯基-3-吡啶酮衍生物

    公开(公告)号：US20100197698A1

    公开(公告)日：2010-08-05

    申请号：US12665492

    申请日：2008-06-19

    申请人： Noriaki Gomi ,  Shinji Ina ,  Kenjirou Yamana ,  Yoshio Kaneko

    发明人： Noriaki Gomi ,  Shinji Ina ,  Kenjirou Yamana ,  Yoshio Kaneko

    IPC分类号： A61K31/501 ,  C07D237/14 ,  A61K31/50 ,  C07D405/12 ,  A61P7/02

    CPC分类号： C07D237/14 ,  C07D401/06 ,  C07D405/12 ,  C07D417/06

    摘要： To find a compound having a tissue fibrinosis-inhibitory activity and a fibrinolytic activity, and to provide a novel compound that is useful for preventing and/or treating tissue fibrinosis diseases (pulmonary fibrosis, renal fibrosis etc.), diseases caused by pathological blood clots such as ischemic heart diseases (myocardial infarction, angina), intraatrial thrombus, pulmonary embolism, deep venous thrombosis, disseminated intravascular coagulation, ischemic cerebral diseases (cerebral infarction, cerebral bleeding) and arteriosclerosis and the like. To provide a pharmaceutical drug comprising a 5-phenyl-3-pyridazinone derivative represented by the following general formula (I): and an optical isomer thereof, or a pharmaceutically acceptable salt thereof, or a hydrate or solvate thereof, useful for preventing and/or treating disease conditions or symptoms mediated by plasminogen activator inhibitor-1.

    摘要翻译： 为了找到具有组织纤维蛋白沉积抑制活性和纤维蛋白溶解活性的化合物，并提供可用于预防和/或治疗组织纤维蛋白病（肺纤维化，肾纤维化等）的新型化合物，由病理性血块引起的疾病 心肌梗塞，心绞痛，心内膜血栓，肺栓塞，深静脉血栓形成，弥散性血管内凝血，缺血性脑疾病（脑梗死，脑出血），动脉硬化等。 提供一种药物，其含有下述通式（I）表示的5-苯基-3-哒嗪酮衍生物及其旋光异构体或其药学上可接受的盐或其水合物或溶剂合物，其用于预防和/ 或治疗由纤溶酶原激活物抑制剂-1介导的疾病状况或症状。

    5-phenyl-3-pyridazinone derivative
    2.
    发明授权
    5-phenyl-3-pyridazinone derivative 有权
    5-苯基-3-哒嗪酮衍生物

    公开(公告)号：US08106053B2

    公开(公告)日：2012-01-31

    申请号：US12665492

    申请日：2008-06-19

    申请人： Noriaki Gomi ,  Shinji Ina ,  Kenjirou Yamana ,  Yoshio Kaneko

    发明人： Noriaki Gomi ,  Shinji Ina ,  Kenjirou Yamana ,  Yoshio Kaneko

    IPC分类号： A61K31/50 ,  A61K31/501 ,  C07D237/02

    CPC分类号： C07D237/14 ,  C07D401/06 ,  C07D405/12 ,  C07D417/06

    摘要： To find a compound having a tissue fibrinosis-inhibitory activity and a fibrinolytic activity, and to provide a novel compound that is useful for preventing and/or treating tissue fibrinosis diseases (pulmonary fibrosis, renal fibrosis etc.), diseases caused by pathological blood clots such as ischemic heart diseases (myocardial infarction, angina), intraatrial thrombus, pulmonary embolism, deep venous thrombosis, disseminated intravascular coagulation, ischemic cerebral diseases (cerebral infarction, cerebral bleeding) and arteriosclerosis and the like. To provide a pharmaceutical drug comprising a 5-phenyl-3-pyridazinone derivative represented by the following general formula (I): and an optical isomer thereof, or a pharmaceutically acceptable salt thereof, or a hydrate or solvate thereof, useful for preventing and/or treating disease conditions or symptoms mediated by plasminogen activator inhibitor-1.

    摘要翻译： 为了找到具有组织纤维蛋白沉积抑制活性和纤维蛋白溶解活性的化合物，并提供可用于预防和/或治疗组织纤维蛋白病（肺纤维化，肾纤维化等）的新型化合物，由病理性血块引起的疾病 心肌梗塞，心绞痛，心内膜血栓，肺栓塞，深静脉血栓形成，弥散性血管内凝血，缺血性脑疾病（脑梗死，脑出血），动脉硬化等。 提供一种药物，其含有下述通式（I）表示的5-苯基-3-哒嗪酮衍生物及其旋光异构体或其药学上可接受的盐或其水合物或溶剂合物，其用于预防和/ 或治疗由纤溶酶原激活物抑制剂-1介导的疾病状况或症状。

    Pyrazolone Derivative
    3.
    发明申请
    Pyrazolone Derivative 审中-公开
    吡唑啉酮衍生物

    公开(公告)号：US20100324091A1

    公开(公告)日：2010-12-23

    申请号：US12666015

    申请日：2008-06-23

    申请人： Noriaki Gomi ,  Shinji Ina ,  Kenjirou Yamana ,  Yoshio Kaneko

    发明人： Noriaki Gomi ,  Shinji Ina ,  Kenjirou Yamana ,  Yoshio Kaneko

    IPC分类号： A61K31/454 ,  C07D231/20 ,  A61K31/4152 ,  C07D401/06 ,  A61P7/02

    CPC分类号： C07D231/20 ,  C07D231/22 ,  C07D401/06 ,  C07D405/12

    摘要： A pyrazolone derivative represented by formula (I) below: wherein R1 to R3 are the same as defined in claims; or an optical isomer, a pharmaceutically acceptable salt thereof, or a hydrate or solvate thereof is provided. The novel pyrazolone derivative according to the present invention has a PAI-1 production inhibitory activity, a tissue fibrosis inhibitory activity, and a fibrolytic activity, and is effective for preventing and/or treating tissue fibrotic diseases (lung fibrosis, kidney fibrosis, etc.) and diseases of which a pathological thrombus becomes the cause, such as ischemic cardiac diseases (cardiac infarction and angina pectoris), atrial thrombus, lung embolism, deep thrombophlebitis, disseminated intravascular clotting, ischemic brain diseases (brain infarction, brain hemorrhage), and arterial sclerosis. In addition, a pharmaceutical agent for preventing and/or treating the disease conditions or the symptoms mediated by plasminogen activator inhibitor-1, comprising the novel pyrazolone derivative according to the present invention is also provided.

    摘要翻译： 由下式（I）表示的吡唑啉酮衍生物：其中R1至R3与权利要求中所定义相同; 或光学异构体，其药学上可接受的盐，或其水合物或溶剂化物。 根据本发明的新型吡唑啉酮衍生物具有PAI-1产生抑制活性，组织纤维化抑制活性和纤维分解活性，对预防和/或治疗组织纤维化疾病（肺纤维化，肾纤维化等）有效 ）和病理性血栓成为原因的疾病，如缺血性心脏病（心肌梗死和心绞痛），心房血栓，肺栓塞，深部血栓性静脉炎，弥漫性血管内凝血，缺血性脑病（脑梗死，脑出血）等） 动脉硬化。 此外，还提供了包含根据本发明的新型吡唑啉酮衍生物的用于预防和/或治疗疾病状况或由纤溶酶原激活物抑制剂-1介导的症状的药剂。

    Hub unit bearing
    4.
    发明授权
    Hub unit bearing 有权
    轮毂单元轴承

    公开(公告)号：US08419288B2

    公开(公告)日：2013-04-16

    申请号：US12669205

    申请日：2008-07-14

    申请人： Yoshio Kaneko ,  Eishi Shibuya ,  Masaru Hashida

    发明人： Yoshio Kaneko ,  Eishi Shibuya ,  Masaru Hashida

    IPC分类号： F16C33/76 ,  F16C32/00 ,  F16C13/00

    CPC分类号： G01P1/023 ,  B60B27/00 ,  B60B27/0068 ,  B60B27/0073 ,  F16C19/186 ,  F16C33/7883 ,  F16C33/7896 ,  F16C41/007 ,  F16C2326/02 ,  F16J15/326 ,  G01P3/443

    摘要： A hub unit bearing H1 includes a rotational speed detector 9 which is made up of an encoder 6 and a sensor 8. A seal 5b on a side facing a center side of a vehicle includes a primary seal 5bp and a secondary seal 5bq which are disposed in that order in an axial direction from rolling elements 32 on a side facing the center side of the vehicle towards the center side of the vehicle so as to define a primary sealed space portion I between the vehicle's center side facing rolling elements 32 and the primary seal 5bp and a secondary sealed space portion II between the primary seal 5bp and the secondary seal 5bq, with the rotational speed detector 9 disposed within the secondary sealed space portion II.

    摘要翻译： 轮毂单元轴承H1包括由编码器6和传感器8组成的转速检测器9.在面向车辆中心侧的一侧的密封件5b包括主密封件5bp和二次密封件5bq，其被布置 从车辆的中心侧的面向车辆的中心侧的滚动元件32沿轴向的顺序，以便在车辆的中心侧面对的滚动元件32和主车辆之间限定一个主密封空间部分I 密封件5bp和主密封件5bp和次密封件5bq之间的第二密封空间部分II，转速检测器9设置在第二密封空间部分II内。

    Clock generator
    5.
    发明授权
    Clock generator 失效
    时钟发生器

    公开(公告)号：US07777582B2

    公开(公告)日：2010-08-17

    申请号：US12190932

    申请日：2008-08-13

    申请人： Yoshio Kaneko

    发明人： Yoshio Kaneko

    IPC分类号： H03B27/00 ,  H03K3/03

    CPC分类号： H03K3/0315 ,  H03K3/013 ,  H03K7/06 ,  H04B15/02 ,  H04B2215/067

    摘要： A clock generator has a ring oscillator which has odd-numbered inverters connected in series, wherein an output of the inverter at a final stage is inputted into the inverter at a first stage to generate and output a clock signal, a frequency divider which receives the clock signal outputted from the ring oscillator, and divides frequency thereof for output, and a heater which is on-off controlled based on the output of the frequency divider and heats the ring oscillator when turned on.

    摘要翻译： 时钟发生器具有串联连接的奇数反相器的环形振荡器，其中最后一级的反相器的输出在第一级被输入到反相器中，以产生和输出时钟信号，分频器接收 从环形振荡器输出的时钟信号，并分频其输出，以及加热器，其基于分频器的输出进行开关控制，并在接通时加热环形振荡器。

    Tunnel junction device having oxide ferromagnetic electroconductive electrodes and three-layer structure tunneling film
    6.
    发明授权
    Tunnel junction device having oxide ferromagnetic electroconductive electrodes and three-layer structure tunneling film 失效
    具有氧化铁磁性导电电极和三层结构隧道膜的隧道连接装置

    公开(公告)号：US07633723B2

    公开(公告)日：2009-12-15

    申请号：US10569089

    申请日：2004-06-04

    申请人： Yoshinori Tokura ,  Masashi Kawasaki ,  Hiroyuki Yamada ,  Yoshihiro Ogawa ,  Yoshio Kaneko

    发明人： Yoshinori Tokura ,  Masashi Kawasaki ,  Hiroyuki Yamada ,  Yoshihiro Ogawa ,  Yoshio Kaneko

    IPC分类号： G11B5/39 ,  G11C11/00

    CPC分类号： B82Y25/00 ,  G01R33/06 ,  G11B5/3903 ,  H01F10/3254 ,  H01L43/08

    摘要： To provide a tunnel junction device having a high MR ratio even at room temperature, a tunneling film as a nonmagnetic layer of three-layer structure of LaMnO3/SrTiO3/LaMnO3 is arranged between a ferromagnetic metal material La0.6Sr0.4MnO3 (12) and a ferromagnetic metal film material La0.6Sr0.4MnO3 (14). The tunneling film comprises two unit layers of LaMnO3 (13A) arranged on the ferromagnetic metal material La0.6Sr0.4MnO3 (12); five unit layers of SrTiO3 (13B); and two unit layers of LaMnO3 (13C) arranged at the interface between the SrTiO3 (13B) and the ferromagnetic metal film material La0.6Sr0.4MnO3 (14).

    摘要翻译： 为了提供即使在室温下也具有高MR比的隧道结装置，作为LaMnO 3 / SrTiO 3 / LaMnO 3的三层结构的非磁性层的隧道膜设置在强磁性金属材料La0.6Sr0.4MnO3（12）和 铁磁金属膜材料La0.6Sr0.4MnO3（14）。 隧道膜包括布置在强磁性金属材料La0.6Sr0.4MnO3（12）上的两个单位层的LaMnO3（13A）; 五个单位层的SrTiO3（13B）; 和布置在SrTiO 3（13B）和铁磁性金属膜材料La0.6Sr0.4MnO3（14）之间的界面处的LaMnO 3（13C）的两个单位层。

    Memory card and contents distributing system and method
    9.
    发明授权
    Memory card and contents distributing system and method 失效
    存储卡及内容分发系统及方法

    公开(公告)号：US06832731B2

    公开(公告)日：2004-12-21

    申请号：US10289785

    申请日：2002-11-07

    申请人： Yoshio Kaneko

    发明人： Yoshio Kaneko

    IPC分类号： G06K1906

    CPC分类号： G07F7/1008 ,  G06Q20/341 ,  G06Q20/40975

    摘要： A memory card is disclosed, which comprises a content interface, an interface driver, a card interface controller, a security processing section which supplies an encryption key to the card interface controller upon a content reproduction request, a memory core interface including a binary counter which counts one of the amount and the number of times of content reproduced, in response to a request for reproduction of a content, and a memory core which records one of the amount and the number of times of content reproduced, if a request for reproduction of a content is input to the memory core, the memory core outputting the encrypted content to the memory core interface if the reproduction request does not cause one of the amount and the number of times of possible content reproduction to be exceeded.

    摘要翻译： 公开了一种存储卡，其包括内容接口，接口驱动器，卡接口控制器，在内容再现请求时向卡接口控制器提供加密密钥的安全处理部分，包括二进制计数器的存储器核心接口， 计算内容再现的数量和次数的一个，以及响应于内容的再现请求的记录核心，以及记录重现的内容的数量和次数之一的存储器核心，如果请求再现的内容 如果再现请求不导致超过可能的内容再现的数量和次数之一，则内容被输入到存储器核心，存储器核心将加密的内容输出到存储器核心接口。

    Method of manufacturing fet semiconductor devices with polysilicon gate having large grain sizes
    10.
    发明授权
    Method of manufacturing fet semiconductor devices with polysilicon gate having large grain sizes 失效
    制造具有大晶粒尺寸的多晶硅栅极的半导体器件的方法

    公开(公告)号：US5563093A

    公开(公告)日：1996-10-08

    申请号：US431822

    申请日：1995-05-01

    申请人： Munetaka Koda ,  Yoshikatsu Shida ,  Junichi Kawaguchi ,  Takehiro Murakami ,  Yoshio Kaneko

    发明人： Munetaka Koda ,  Yoshikatsu Shida ,  Junichi Kawaguchi ,  Takehiro Murakami ,  Yoshio Kaneko

    IPC分类号： H01L21/20 ,  H01L21/28 ,  H01L21/8238 ,  H01L21/265 ,  H01L21/70 ,  H01L27/00

    CPC分类号： H01L21/2022 ,  H01L21/28052 ,  H01L21/823828

    摘要： The present invention provides the method of manufacturing a dual-gate CMOS device which has high transconductance and improved breakdown voltage, in which depletion in the interface between a gate oxide and a gate electrode is prevented without the increase of the steps of process.A gate oxide film (5) formed on a semiconductor substrate (1) is washed with an aqueous solution, or exposed to a gas atomosphere containing hydrogen, and an amorphous silicon film (3) is formed on the whole surface of the gate oxide film (5). The amorphous silicon film (3) is then crystallized. Alternatively, after a silicon oxide film (53) or a silicon nitrided film is formed on the amorphous silicon film (3), the amorhpous silicon film (3) is crystallized.

    摘要翻译： 本发明提供制造具有高跨导和改善的击穿电压的双栅极CMOS器件的方法，其中在不增加处理步骤的情况下，防止栅极氧化物和栅电极之间的界面的耗尽。 形成在半导体基板（1）上的栅极氧化膜（5）用水溶液洗涤或暴露于含有氢的气体大气圈，并且在栅极氧化膜的整个表面上形成非晶硅膜（3） （5）。 然后使非晶硅膜（3）结晶。 或者，在非晶硅膜（3）上形成氧化硅膜（53）或硅氮化膜之后，使非阳极硅膜（3）结晶化。