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    Compositions and methods of detecting an analyte by using a nucleic acid hybridization switch probe
    3.
    发明申请
    Compositions and methods of detecting an analyte by using a nucleic acid hybridization switch probe 审中-公开
    通过使用核酸杂交开关探针检测分析物的组合物和方法

    公开(公告)号：US20060194240A1

    公开(公告)日：2006-08-31

    申请号：US11363848

    申请日：2006-02-28

    申请人： Lyle Arnold ,  Lizhong Dai ,  Steven Brentano ,  James Russell

    发明人： Lyle Arnold ,  Lizhong Dai ,  Steven Brentano ,  James Russell

    IPC分类号： C12Q1/68 ,  C07H21/04

    CPC分类号： C12Q1/6816 ,  C12Q2525/197 ,  C12Q2525/161 ,  C12Q2565/107 ,  C12Q2563/131 ,  C12Q2525/301

    摘要： Compositions are described for detecting binding of an analyte to a binding partner attached to a nucleic acid hybridization switch probe that includes first and second arm sequences and a support sequence that is at least partially complementary to both arm sequences, allowing the probe under hybridization conditions to form a first conformation in the absence of the analyte and to form a second conformation in the presence of the analyte, and a label associated with the probe that produces a signal that indicates the conformation of the probe. Methods are described for detecting an analyte that forms a specific binding pair with the binding partner attached to the hybridization switch probe, thereby changing the probe from a first to a second conformation that results in a detectable signal that indicates the presence of the analyte in the sample.

    摘要翻译： 描述了用于检测分析物与连接到核酸杂交开关探针的结合配偶体的结合的组合物，其包含第一和第二臂序列以及与两个臂序列至少部分互补的支持序列，允许探针在杂交条件下 在不存在分析物的情况下形成第一构象，并在分析物存在下形成第二构象，以及与探针相关联的标记，其产生指示探针构象的信号。 描述了用于检测与附着到杂交开关探针的结合配偶体形成特异性结合对的分析物的方法，从而将探针从第一至第二构象改变，从而导致可检测的信号，其指示分析物在 样品。

    Scaffolding
    5.
    发明授权
    Scaffolding 有权

    公开(公告)号：US11905723B2

    公开(公告)日：2024-02-20

    申请号：US17175066

    申请日：2021-02-12

    申请人： James Russell

    发明人： James Russell

    IPC分类号： E04G3/24 ,  E04G5/04 ,  E04G5/06 ,  E04G7/02

    CPC分类号： E04G3/24 ,  E04G5/045 ,  E04G5/061 ,  E04G5/067 ,  E04G7/02

    摘要： A scaffolding assembly adapted to be releasably attached to an elongate support member such as an overhead pipe. The scaffolding assembly has a split collar and a platform assembly adapted to be releasably attached to the split collar. The split collar comprises at least two segments which can encircle the pipe and be secured to one another. The platform assembly which includes a platform deck has a connector formation which extends laterally outwardly from the deck to an extent that it can engage a receiving formation on the collar assembly and thereby attach the platform assembly to the collar assembly.

    Method of manufacturing a flat bottom pouch
    6.
    发明授权
    Method of manufacturing a flat bottom pouch 有权
    制造平底袋的方法

    公开(公告)号：US09475248B1

    公开(公告)日：2016-10-25

    申请号：US14885172

    申请日：2015-10-16

    申请人： James Russell

    发明人： James Russell

    IPC分类号： B31B1/88 ,  B65D75/00 ,  B31B1/90 ,  B31B37/00

    CPC分类号： B31B1/88 ,  B31B70/00 ,  B31B70/88 ,  B31B2155/00 ,  B31B2155/0014 ,  B31B2160/20 ,  B65D75/008

    摘要： A method of manufacturing a flat bottom pouch from a single continuous sheet of webbing comprises unwinding the continuous sheet of webbing and forming an outwardly extending transverse lap seam. The unwound webbing is asymmetrically folded to form a folded sheet defining front and back panels. The folded sheet defines a first section and a second section having a folded edge therebetween, wherein the first section includes a first distal edge, and wherein the second section includes a second distal edge. The folded edge is pushed between the first and second sections to form a first side gusseted panel. A portion of the second section is folded between the first and second sections to form a second side gusseted panel. A transverse end seal is formed proximate the lap seam thereby defining a bottom gusseted panel and the first edge is sealed to the second edge to complete the pouch.

    摘要翻译： 从单个连续的织带片材制造平底袋的方法包括松开连续的织带片并形成向外延伸的横向搭接缝。 展开的织带不对称地折叠以形成限定前面板和后面板的折叠片。 折叠片材限定第一部分和第二部分，其间具有折叠的边缘，其中第一部分包括第一远侧边缘，并且其中第二部分包括第二远端边缘。 折叠的边缘被推在第一和第二部分之间以形成第一侧面角撑板。 第二部分的一部分在第一和第二部分之间折叠以形成第二侧面角撑板。 横向端部密封件靠近搭接接缝形成，由此限定了底部角撑板，并且第一边缘被密封到第二边缘以完成小袋。

    Method of manufacturing a bottom gusseted pouch
    7.
    发明授权
    Method of manufacturing a bottom gusseted pouch 有权

    公开(公告)号：US09365011B1

    公开(公告)日：2016-06-14

    申请号：US14733205

    申请日：2015-06-08

    申请人： James Russell ,  John Ferber

    发明人： James Russell ,  John Ferber

    IPC分类号： B31B23/00 ,  B31B29/60 ,  B31B21/00

    CPC分类号： B31B29/60 ,  B31B70/00 ,  B31B70/10 ,  B31B70/60 ,  B31B70/844 ,  B31B70/946 ,  B31B2150/00 ,  B31B2155/00 ,  B31B2155/0012 ,  B31B2160/10 ,  B31B2160/20

    摘要： A method of manufacturing a roll of bottom gusseted pouches serially connected in a top-to-bottom end orientation is provided. The method comprises unwinding a pouch webbing in a first flow direction, the pouch webbing defining front and back panels of a respective pouch; inserting a gusset webbing between the panels in a second flow direction; attaching the gusset webbing to the panels to form the bottom gusseted end of the pouch; inserting a closure mechanism between the panels in a third flow direction; attaching the closure mechanism to the panels to form the resealable top end of the pouch; sealing the side edges of the panels to complete the pouch; winding the completed pouch onto the roll; and repeating these steps to form the other bottom gusseted pouches in the roll. At least one of the pouch webbing and the gusset webbing is formed of a supported film.

    OSTEOINDUCTIVE DEMINERALIZED CANCELLOUS BONE
    10.
    发明申请
    OSTEOINDUCTIVE DEMINERALIZED CANCELLOUS BONE 有权

    公开(公告)号：US20140065239A9

    公开(公告)日：2014-03-06

    申请号：US12140025

    申请日：2008-06-16

    申请人： Keyvan Behnam ,  Nanette Forsyth ,  James Russell ,  John M. Winterbottom ,  Todd M. Boyce

    发明人： Keyvan Behnam ,  Nanette Forsyth ,  James Russell ,  John M. Winterbottom ,  Todd M. Boyce

    IPC分类号： A61K35/32

    CPC分类号： A61K35/32 ,  A61F2/28 ,  A61F2002/2817 ,  A61F2002/30059 ,  A61F2310/00359 ,  A61L27/3608 ,  A61L27/3641 ,  A61L27/3645 ,  A61L27/3683 ,  A61L27/3687 ,  A61L27/3691 ,  A61L27/3695 ,  A61L27/3878 ,  A61L2430/02

    摘要： An osteoinductive demineralized bone matrix, corresponding osteoimplants, and methods for making the osteoinductive demineralized bone matrix are disclosed. The osteoinductive demineralized bone matrix may be prepared by providing demineralized bone and altering the collagenous structure of the bone. The osteoinductive demineralized bone matrix may also be prepared by providing demineralized bone and compacting the bone, for example via mechanical compaction, grinding into a particulate, or treatment with a chemical. Additives such as growth factors or bioactive agents may be added to the osteoinductive demineralized bone matrix. The osteoinductive demineralized bone matrix may form an osteogenic osteoimplant. The osteoimplant, when implanted in a mammalian body, may induce at the locus of the implant the full developmental cascade of endochondral bone formation including vascularization, mineralization, and bone marrow differentiation. The osteoinductive demineralized bone matrix may also be used as a delivery device to administer bioactive agents.

    摘要翻译： 公开了一种骨诱导的软骨骨架，相应的骨关节植入物以及用于制造骨诱导性软骨骨架的方法。 可以通过提供软化骨和改变骨的胶原结构来制备骨诱导的软骨骨架。 还可以通过提供脱矿质骨和压实骨，例如通过机械压实，研磨成颗粒或用化学品处理来制备骨诱导的软化骨基质。 添加剂如生长因子或生物活性剂可以加入到骨诱导的软化骨基质中。 骨诱导的骨质疏松骨质可形成成骨植骨。 当植入植入哺乳动物体内的植骨植入物可能在植入物的位置诱导软骨内骨形成的完全发育级联，包括血管化，矿化和骨髓分化。 骨诱导的软化骨基质也可以用作施用生物活性剂的递送装置。