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公开(公告)号：US06685950B2
公开(公告)日：2004-02-03
申请号：US09903013
申请日：2001-07-11
申请人： Olaf Weber , Tobias Schlapp , Angela Siegling , Andreas Knorr , Claudia Hirth-Dietrich , Gudrun Theiss
发明人： Olaf Weber , Tobias Schlapp , Angela Siegling , Andreas Knorr , Claudia Hirth-Dietrich , Gudrun Theiss
IPC分类号： A61K4500
CPC分类号： A61K35/76 , C12N2710/24232
摘要： The present invention relates to the use of strains of Parapoxvirus ovis as immunotherapeutic agents for immunodeficiencies of an infectious or non-infectious nature, and to the use of strains of Parapoxvirus ovis for treating tumor diseases and viral infections, and diseases which accompany them, and the use of strains of Parapoxvirus ovis for producing medicaments for use in humans and animals.
摘要翻译： 本发明涉及副作用病毒ovis菌株作为感染性或非感染性免疫缺陷的免疫治疗剂的用途，以及使用Parapoxvirus ovis菌株治疗肿瘤疾病和病毒感染以及伴随它们的疾病的用途，以及 使用副毒素病毒ovis菌株生产用于人和动物的药物。
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公开(公告)号：US06632647B2
公开(公告)日：2003-10-14
申请号：US09903005
申请日：2001-07-11
申请人： Claudia Hirth-Dietrich , Tobias Schlapp , Angela Siegling , Andreas Knorr , Olaf Weber , Gudrun Theiss
发明人： Claudia Hirth-Dietrich , Tobias Schlapp , Angela Siegling , Andreas Knorr , Olaf Weber , Gudrun Theiss
IPC分类号： C12N708
CPC分类号： A61K35/76 , A61K2039/5252 , C12N2710/24232
摘要： The present invention relates to the use, in humans, of inactivated parapoxviruses for the prophylaxis and treatment of diseases which are accompanied by an increased deposition of collagen, with it being possible for both internal organs, such as the liver, and the skin and its appended structures, to be affected. The invention relates, in particular, to liver fibrosis and/or liver cirrhosis consequent upon virus hepatitis, or to ethanol-induced liver diseases and to cystic fibrosis.
摘要翻译： 本发明涉及在人类中用于预防和治疗伴随着胶原蛋白沉积增加的疾病的灭活的副代谢病毒，其中内脏器官例如肝脏和皮肤以及它们的可能性 附加结构，受影响。 本发明特别涉及由于病毒性肝炎引起的肝纤维化和/或肝硬化，或乙醇诱导的肝脏疾病和囊性纤维化。
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公开(公告)号：US10189856B2
公开(公告)日：2019-01-29
申请号：US13816020
申请日：2011-05-24
申请人： Claudia Hirth-Dietrich , Peter Sandner , Johannes-Peter Stasch , Andreas Knorr , Georges Von Degenfeld , Michael Hahn , Markus Follmann
发明人： Claudia Hirth-Dietrich , Peter Sandner , Johannes-Peter Stasch , Andreas Knorr , Georges Von Degenfeld , Michael Hahn , Markus Follmann
IPC分类号： A61K31/437 , A61K31/197 , A61K31/427 , A61K31/4439 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K45/06 , C07D495/04 , C07D471/04 , A61K31/426 , C07C229/38 , C07D261/10 , C07D277/30 , C07D333/34 , C07D401/04 , C07D417/06 , C07D487/04
摘要： The use of sGC stimulators, sGC activators alone, or in combination with PDE5 inhibitors for the prevention and treatment of fibrotic diseases, such as systemic sclerosis, scleroderma, and the concomitant fibrosis of internal organs.
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4.发明申请Use of sGC stimulators, sGC activators, alone and combinations with PDE5 inhibitors for the treatment of systemic sclerosis (SSc). 审中-公开使用sGC刺激剂，sGC激活剂，单独使用和与PDE5抑制剂的组合治疗系统性硬化症（SSc）。公开(公告)号：US20140038956A1
公开(公告)日：2014-02-06
申请号：US13816020
申请日：2011-05-24
申请人： Claudia Hirth-Dietrich , Peter Sandner , Johannes-Peter Stasch , Andreas Knorr , Georges Von Degenfeld , Michael Hahn , Markus Follmann
发明人： Claudia Hirth-Dietrich , Peter Sandner , Johannes-Peter Stasch , Andreas Knorr , Georges Von Degenfeld , Michael Hahn , Markus Follmann
IPC分类号： C07D495/04 , C07C229/38 , C07D333/34 , C07D261/10 , C07D401/04 , C07D417/06 , C07D277/30 , C07D487/04 , A61K31/5377 , A61K31/506 , A61K31/197 , A61K31/4439 , A61K31/427 , A61K31/426 , A61K31/519 , A61K45/06 , C07D471/04
CPC分类号： C07D495/04 , A61K31/197 , A61K31/426 , A61K31/427 , A61K31/437 , A61K31/4439 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K45/06 , C07C229/38 , C07D261/10 , C07D277/30 , C07D333/34 , C07D401/04 , C07D417/06 , C07D471/04 , C07D487/04 , A61K2300/00
摘要： The use of sGC stimulators, sGC activators alone, or in combination with PDE5 inhibitors for the prevention and treatment of fibrotic diseases, such as systemic sclerosis, scleroderma, and the concomitant fibrosis of internal organs.
摘要翻译： 单独使用sGC刺激剂，sGC激活剂或与PDE5抑制剂联合用于预防和治疗纤维化疾病，如系统性硬化症，硬皮病和伴随的内脏纤维化。
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公开(公告)号：US07700653B2
公开(公告)日：2010-04-20
申请号：US11210131
申请日：2005-08-22
申请人： Michael Härter , Michael G. Hahn , Claudia Hirth-Dietrich , Andreas Knorr , Elke Stahl , Johannes-Peter Stasch , Frank Wunder
发明人： Michael Härter , Michael G. Hahn , Claudia Hirth-Dietrich , Andreas Knorr , Elke Stahl , Johannes-Peter Stasch , Frank Wunder
IPC分类号： A61K31/195
CPC分类号： C07C229/38 , A61K31/197
摘要： This invention relates to methods for treating cardiovascular disorders selected from heart failure, thromboembolic disorders, venous diseases, and fibriotic disorders other than fibrosis of the liver, comprising administering an effective amount of a compound of formula (I) wherein the several variables are as defined in the specification and claims.
摘要翻译： 本发明涉及治疗选自心脏衰竭，血栓栓塞性疾病，静脉疾病和肝纤维化以外的纤维化疾病的心血管疾病的方法，包括施用有效量的式（I）化合物，其中若干变量如上所定义 在说明书和权利要求中。
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公开(公告)号：US20060111444A1
公开(公告)日：2006-05-25
申请号：US11210131
申请日：2005-08-22
申请人： Michael Harter , Michael Hahn , Claudia Hirth-Dietrich , Andreas Knorr , Elke Stahl , Johannes-Peter Stasch , Frank Wunder
发明人： Michael Harter , Michael Hahn , Claudia Hirth-Dietrich , Andreas Knorr , Elke Stahl , Johannes-Peter Stasch , Frank Wunder
IPC分类号： A61K31/195
CPC分类号： C07C229/38 , A61K31/197
摘要： This invention relates to methods for treating cardiovascular disorders selected from heart failure, thromboembolic disorders, venous diseases, and fibriotic disorders other than fibrosis of the liver, comprising administering an effective amount of a compound of formula (I) wherein the several variables are as defined in the specification and claims.
摘要翻译： 本发明涉及治疗选自心脏衰竭，血栓栓塞性疾病，静脉疾病和肝纤维化以外的纤维化疾病的心血管疾病的方法，包括施用有效量的式（I）化合物，其中若干变量如上所定义 在说明书和权利要求中。
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公开(公告)号：US20050288366A1
公开(公告)日：2005-12-29
申请号：US11209517
申请日：2005-08-22
申请人： Michael Harter , Michael Hahn , Claudia Hirth-Dietrich , Andreas Knorr , Elke Stahl , Johannes-Peter Stasch , Frank Wunder
发明人： Michael Harter , Michael Hahn , Claudia Hirth-Dietrich , Andreas Knorr , Elke Stahl , Johannes-Peter Stasch , Frank Wunder
IPC分类号： A61P1/16 , A61K31/195 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/06 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/02 , A61P13/08 , A61P15/08 , A61P15/10 , A61P15/12 , A61P25/04 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P27/06 , A61P29/00 , A61P29/02 , A61P43/00 , C07B61/00 , C07C227/02 , C07C229/38 , C07C253/30 , C07C255/54 , A61K31/277
CPC分类号： C07C229/38 , C07C2601/14
摘要： This invention relates to methods for treating cardiovascular disorder selected from heart failure, thromboembolic disorders, venous diseases, and fibrotic disorders other than fibrosis of the liver, comprising administering an effective amount of a compound of formula (I) in which the several variables are as defined in the specification and claims.
摘要翻译： 本发明涉及治疗选自心脏衰竭，血栓栓塞性疾病，静脉疾病和肝纤维化以外的纤维化疾病的心血管疾病的方法，包括给予有效量的式（I）化合物，其中几个变量为 在说明书和权利要求中限定。
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公开(公告)号：US5318980A
公开(公告)日：1994-06-07
申请号：US18961
申请日：1993-02-18
申请人： Rudolf Hanko , Jurgen Dressel , Peter Fey , Walter Hubsch , Thomas Kramer , Ulrich E. Muller , Matthias Muller-Gliemann , Martin Beuck , Stanislav Kazda , Claudia Hirth-Dietrich , Andreas Knorr , Johannes-Peter Stasch , Stefan Wohlfeil , Ozkan Yalkinoglu
发明人： Rudolf Hanko , Jurgen Dressel , Peter Fey , Walter Hubsch , Thomas Kramer , Ulrich E. Muller , Matthias Muller-Gliemann , Martin Beuck , Stanislav Kazda , Claudia Hirth-Dietrich , Andreas Knorr , Johannes-Peter Stasch , Stefan Wohlfeil , Ozkan Yalkinoglu
IPC分类号： A61K31/415 , A61K31/40 , A61K31/4427 , A61K31/445 , A61P9/10 , A61P9/12 , A61P43/00 , C07D233/64 , C07D233/68 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/12 , A61K31/535 , A61K31/495
CPC分类号： C07D401/12 , C07D233/68 , C07D403/12
摘要： Sulphonylbenzyl-substituted imidazoles can be prepared by first reacting imidazolylaldehydes with sulphonylbenzyl compounds and then oxidising or reducing the aldehyde function in the customary manner.The sulphonylbenzyl-substituted imidazoles can be used as active compounds in medicaments.
摘要翻译： 磺酰基苄基取代的咪唑可以通过首先使咪唑基醛与磺酰基苄基化合物反应，然后以常规方式氧化或还原醛官能团来制备。 磺酰苄基取代的咪唑可用作药物中的活性化合物。
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公开(公告)号：US5221681A
公开(公告)日：1993-06-22
申请号：US823108
申请日：1992-01-16
IPC分类号： A61K31/55 , A61P9/08 , A61P9/12 , A61P11/08 , C07D311/22 , C07D335/06 , C07D405/12 , C07D409/12 , C07D491/08 , C07D495/08
CPC分类号： C07D335/06 , C07D311/22 , C07D491/08 , C07D495/08
摘要： The present invention relates to new substituted benzoxazepines and benzothiazepines of the general formula I ##STR1## in which X, R.sup.1, R.sup.2 and R.sup.3 have the meaning given in the description, processes for their preparation and their use in medicaments having vaso- and muscle-relaxing properties, in particular as circulatory agents.
摘要翻译： 本发明涉及通式I（I）的新的取代的苯并氧杂吖庚因和苯并硫氮杂，其中X，R 1，R 2和R 3具有说明书中给出的含义，其制备方法及其在具有血管生成的药物中的用途， 和肌肉松弛性质，特别是作为循环剂。
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公开(公告)号：US20070160614A1
公开(公告)日：2007-07-12
申请号：US11504527
申请日：2006-08-14
申请人： Clark Pan , Andreas Knorr , Michael Schauer , Claudia Hirth-Dietrich , Sabine Kraft , Barbara Krebs
发明人： Clark Pan , Andreas Knorr , Michael Schauer , Claudia Hirth-Dietrich , Sabine Kraft , Barbara Krebs
IPC分类号： A61K39/395 , C07H21/04 , C12P21/06 , C12N5/06 , C07K16/40
CPC分类号： C07K16/38 , A61K2039/505 , C07K16/005 , C07K16/18 , C07K16/40 , C07K2317/21 , C07K2317/55 , C07K2317/76
摘要： Human antibodies that bind to TIMP-1 can be used as reagents to diagnose and treat disorders in which TIMP-1 is elevated, such as liver fibrosis, alcoholic liver disease, cardiac fibrosis, acute coronary syndrome, lupus nephritis, glomerulosclerotic renal disease, benign prostate hypertrophy, colon cancer, lung cancer, and idiopathic pulmonary fibrosis.
摘要翻译： 结合TIMP-1的人抗体可用作诊断和治疗TIMP-1升高的疾病的试剂，如肝纤维化，酒精性肝病，心脏纤维化，急性冠状动脉综合征，狼疮性肾炎，肾小球硬化性肾病，良性 前列腺肥大，结肠癌，肺癌和特发性肺纤维化。
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