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公开(公告)号：US08617584B2
公开(公告)日：2013-12-31
申请号：US12787304
申请日：2010-05-25
申请人： Louis C. Sehl , Olof Mikael Trollsas , Donald G. Wallace , David Toman , Frank A. DeLustro , Jacqueline A. Schroeder , George H. Chu
发明人： Louis C. Sehl , Olof Mikael Trollsas , Donald G. Wallace , David Toman , Frank A. DeLustro , Jacqueline A. Schroeder , George H. Chu
IPC分类号： A61F13/00
CPC分类号： A61L24/043 , A61F2/0063 , A61L24/08 , A61L24/102 , A61L27/24 , A61L27/26 , A61L31/041 , A61L31/044 , C08B37/0075 , C08F283/00 , C08F283/04 , C08F283/06 , C08G65/329 , C08G75/045 , C08G75/26 , C08H1/00 , C08H1/06 , C08L51/003 , C08L53/00 , C08L67/06 , C08L71/02 , C08L81/02 , C09D167/02 , C09J151/003 , C09J153/00 , C09J189/06 , C08L89/06 , C08L5/16 , C08L91/06 , C08L2666/26 , C08L71/00
摘要： The present invention relates generally to synthetic polymer compositions that form interpenetrating polymer networks. In a preferred embodiment, the compositions comprise two multifunctionally activated synthetic polymers, along with a tensile strength enhancer. Such compositions form matrices that exhibit superior cohesive strength and in many instances can serve as adequate replacements for surgical means of attaching tissues, such as sutures, sponges and medical staples.
摘要翻译： 本发明一般涉及形成互穿聚合物网络的合成聚合物组合物。 在优选的实施方案中，组合物包含两种多功能活化的合成聚合物以及拉伸强度增强剂。 这样的组合物形成表现出优异的内聚强度的基质，并且在许多情况下可用作适当的替代物，用于附接组织例如缝合线，海绵和医用缝钉的外科手段。
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公开(公告)号：US20100233246A1
公开(公告)日：2010-09-16
申请号：US12787304
申请日：2010-05-25
申请人： Louis C. Sehl , Olof Mikael Trollsas , Donald G. Wallace , David Toman , Frank A. DeLustro , Jacqueline A. Schroeder , George H. Chu
发明人： Louis C. Sehl , Olof Mikael Trollsas , Donald G. Wallace , David Toman , Frank A. DeLustro , Jacqueline A. Schroeder , George H. Chu
IPC分类号： A61K9/70 , A61K38/00 , A61K38/39 , A61K38/38 , A61K31/726
CPC分类号： A61L24/043 , A61F2/0063 , A61L24/08 , A61L24/102 , A61L27/24 , A61L27/26 , A61L31/041 , A61L31/044 , C08B37/0075 , C08F283/00 , C08F283/04 , C08F283/06 , C08G65/329 , C08G75/045 , C08G75/26 , C08H1/00 , C08H1/06 , C08L51/003 , C08L53/00 , C08L67/06 , C08L71/02 , C08L81/02 , C09D167/02 , C09J151/003 , C09J153/00 , C09J189/06 , C08L89/06 , C08L5/16 , C08L91/06 , C08L2666/26 , C08L71/00
摘要： The present invention relates generally to synthetic polymer compositions that form interpenetrating polymer networks. In a preferred embodiment, the compositions comprise two multifunctionally activated synthetic polymers, along with a tensile strength enhancer. Such compositions form matrices that exhibit superior cohesive strength and in many instances can serve as adequate replacements for surgical means of attaching tissues, such as sutures, sponges and medical staples.
摘要翻译： 本发明一般涉及形成互穿聚合物网络的合成聚合物组合物。 在优选的实施方案中，组合物包含两种多功能活化的合成聚合物以及拉伸强度增强剂。 这样的组合物形成表现出优异的内聚强度的基质，并且在许多情况下可用作适当的替代物，用于附接组织例如缝合线，海绵和医用缝钉的外科手段。
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公开(公告)号：US06833408B2
公开(公告)日：2004-12-21
申请号：US10262640
申请日：2002-09-30
申请人： Louis C. Sehl , Olof Mikael Trollsas , Donald G. Wallace , David Toman , Frank A. DeLustro , Jacqueline A. Schroeder , George H. Chu
发明人： Louis C. Sehl , Olof Mikael Trollsas , Donald G. Wallace , David Toman , Frank A. DeLustro , Jacqueline A. Schroeder , George H. Chu
IPC分类号： C08F28300
CPC分类号： A61L24/043 , A61F2/0063 , A61L24/08 , A61L24/102 , A61L27/24 , A61L27/26 , A61L31/041 , A61L31/044 , C08B37/0075 , C08F283/00 , C08F283/04 , C08F283/06 , C08G65/329 , C08G75/045 , C08G75/26 , C08H1/00 , C08H1/06 , C08L51/003 , C08L53/00 , C08L67/06 , C08L71/02 , C08L81/02 , C09D167/02 , C09J151/003 , C09J153/00 , C09J189/06 , C08L89/06 , C08L5/16 , C08L91/06 , C08L2666/26 , C08L71/00
摘要： A method of tissue repair is provided using a biocompatible nonimmunogenic adhesive composition. The adhesive composition comprises collagen and a plurality of crosslinkable components having reactive functional groups thereon, with the functional groups selected so as to enable inter-reaction between the components, i.e., crosslinking. Kits for use in carrying out the method of the invention are also provided, as are pretreated surgically acceptable patches that have been coated with the aforementioned adhesive composition.
摘要翻译： 使用生物相容性非免疫原性粘合剂组合物提供组织修复的方法。 粘合剂组合物包含胶原和多个在其上具有反应性官能团的可交联组分，其中官能团被选择以使得组分之间能够进行交联，即交联。 还提供了用于实施本发明的方法的试剂盒，以及已经用上述粘合剂组合物涂覆的预处理的外科手术可接受的贴剂。
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4.发明申请COMPOSITIONS AND SYSTEMS FOR FORMING CROSSLINKED BIOMATERIALS AND METHODS OF PREPARATION AND USE 审中-公开用于形成交联的生物材料的组合物和系统及其制备和使用方法公开(公告)号：US20110159075A1
公开(公告)日：2011-06-30
申请号：US12979215
申请日：2010-12-27
申请人： Louis C. Sehl , Olof Mikael Trollsas , Donald G. Wallace , David Toman , Frank A. DeLustro , Jacqueline A. Schroeder , George H. Chu
发明人： Louis C. Sehl , Olof Mikael Trollsas , Donald G. Wallace , David Toman , Frank A. DeLustro , Jacqueline A. Schroeder , George H. Chu
IPC分类号： A61F2/00 , A61K38/43 , A61K38/22 , A61K38/18 , A61K35/28 , A61K39/395 , A61K35/00 , A61K48/00
CPC分类号： A61L17/145 , A61F2/0063 , A61L24/043 , A61L24/046 , A61L24/08 , A61L24/102 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/54 , A61L31/041 , A61L31/044 , A61L31/10 , A61L31/16 , C08B37/0075 , C08F283/00 , C08F283/04 , C08F283/06 , C08G65/329 , C08G65/33306 , C08G65/33337 , C08G75/045 , C08G75/26 , C08G2650/50 , C08H1/00 , C08H1/06 , C08L5/00 , C08L51/003 , C08L53/00 , C08L67/06 , C08L71/02 , C08L81/02 , C09D167/02 , C09J151/003 , C09J153/00 , C09J189/06 , C08L91/06 , C08L2666/26 , C08L89/06 , C08L5/16 , C08L71/00
摘要： Crosslinkable compositions are provided that readily crosslink in situ to provide biocompatible, nonimmunogenic crosslinked materials that may be used as adhesive compositions. The compositions comprise collagen and a plurality of crosslinkable components having reactive functional groups thereon, with the functional groups selected so as to enable inter-reaction between the components, i.e., crosslinking. Methods for preparing and using the compositions are also provided. Exemplary uses include tissue augmentation, biologically active agent delivery, bioadhesion, prevention of adhesions following surgery or injury, and coating of surgically acceptable patches and solid implants, the latter including sutures.
摘要翻译： 提供可交联的组合物，其易于原位交联以提供可用作粘合剂组合物的生物相容性，非免疫原性交联材料。 所述组合物包含胶原和多个在其上具有反应性官能团的可交联组分，其中所述官能团被选择以使组分之间的相互反应，即交联。 还提供了制备和使用组合物的方法。 示例性用途包括组织增加，生物活性剂递送，生物粘附，预防手术或损伤后的粘连以及手术可接受的贴剂和固体植入物的涂覆，后者包括缝线。
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公开(公告)号：US08377466B2
公开(公告)日：2013-02-19
申请号：US10971684
申请日：2004-10-22
申请人： Louis C. Sehl , Olof Mikael Trollsas , Donald G. Wallace , David Toman , Frank A. DeLustro , Jacqueline A. Schroeder , George H. Chu
发明人： Louis C. Sehl , Olof Mikael Trollsas , Donald G. Wallace , David Toman , Frank A. DeLustro , Jacqueline A. Schroeder , George H. Chu
IPC分类号： A61F13/00
CPC分类号： A61L24/043 , A61F2/0063 , A61L24/08 , A61L24/102 , A61L27/24 , A61L27/26 , A61L31/041 , A61L31/044 , C08B37/0075 , C08F283/00 , C08F283/04 , C08F283/06 , C08G65/329 , C08G75/045 , C08G75/26 , C08H1/00 , C08H1/06 , C08L51/003 , C08L53/00 , C08L67/06 , C08L71/02 , C08L81/02 , C09D167/02 , C09J151/003 , C09J153/00 , C09J189/06 , C08L89/06 , C08L5/16 , C08L91/06 , C08L2666/26 , C08L71/00
摘要： A method of tissue repair is provided using a biocompatible nonimmunogenic adhesive composition. The adhesive composition comprises collagen and a plurality of crosslinkable components having reactive functional groups thereon, with the functional groups selected so as to enable inter-reaction between the components, i.e., crosslinking. Kits for use in carrying out the method of the invention are also provided, as are pretreated surgically acceptable patches that have been coated with the aforementioned adhesive composition.
摘要翻译： 使用生物相容性非免疫原性粘合剂组合物提供组织修复的方法。 粘合剂组合物包含胶原和多个在其上具有反应性官能团的可交联组分，其中官能团被选择以使得组分之间能够进行交联，即交联。 还提供了用于实施本发明的方法的试剂盒，以及已经用上述粘合剂组合物涂覆的预处理的外科手术可接受的贴剂。
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6.发明授权Compositions and systems for forming crosslinked biomaterials and methods of preparation of use 有权用于形成交联生物材料的组合物和系统及其制备和使用方法公开(公告)号：US07883693B2
公开(公告)日：2011-02-08
申请号：US11344752
申请日：2006-01-31
申请人： Louis C. Sehl , Olof Mikael Trollsas , Donald G. Wallace , David Toman , Frank A. DeLustro , Jacqueline A. Schroeder , George H. Chu
发明人： Louis C. Sehl , Olof Mikael Trollsas , Donald G. Wallace , David Toman , Frank A. DeLustro , Jacqueline A. Schroeder , George H. Chu
IPC分类号： A61K31/785
CPC分类号： A61L17/145 , A61F2/0063 , A61L24/043 , A61L24/046 , A61L24/08 , A61L24/102 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/54 , A61L31/041 , A61L31/044 , A61L31/10 , A61L31/16 , C08B37/0075 , C08F283/00 , C08F283/04 , C08F283/06 , C08G65/329 , C08G65/33306 , C08G65/33337 , C08G75/045 , C08G75/26 , C08G2650/50 , C08H1/00 , C08H1/06 , C08L5/00 , C08L51/003 , C08L53/00 , C08L67/06 , C08L71/02 , C08L81/02 , C09D167/02 , C09J151/003 , C09J153/00 , C09J189/06 , C08L91/06 , C08L2666/26 , C08L89/06 , C08L5/16 , C08L71/00
摘要： Crosslinkable compositions are provided that readily crosslink in situ to provide biocompatible, nonimmunogenic crosslinked materials that may be used as adhesive compositions. The compositions comprise collagen and a plurality of crosslinkable components having reactive functional groups thereon, with the functional groups selected so as to enable inter-reaction between the components, i.e., crosslinking. Methods for preparing and using the compositions are also provided. Exemplary uses include tissue augmentation, biologically active agent delivery, bioadhesion, prevention of adhesions following surgery or injury, and coating of surgically acceptable patches and solid implants, the latter including sutures.
摘要翻译： 提供可交联的组合物，其易于原位交联以提供可用作粘合剂组合物的生物相容性，非免疫原性交联材料。 所述组合物包含胶原和多个在其上具有反应性官能团的可交联组分，其中所述官能团被选择以使组分之间的相互反应，即交联。 还提供了制备和使用组合物的方法。 示例性用途包括组织增加，生物活性剂递送，生物粘附，预防手术或损伤后的粘连以及手术可接受的贴剂和固体植入物的涂覆，后者包括缝线。
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7.发明授权Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use 有权用于形成交联生物材料的组合物和系统及其相关的制备和使用方法公开(公告)号：US06458889B1
公开(公告)日：2002-10-01
申请号：US09883138
申请日：2001-06-15
IPC分类号： C08F28300
CPC分类号： C08H1/06 , A61L24/043 , A61L24/046 , A61L24/08 , A61L27/26 , A61L27/34 , A61L27/54 , A61L31/041 , A61L31/16 , A61L2300/00 , C08B37/0075 , C08F283/00 , C08F283/04 , C08F283/06 , C08G65/329 , C08G75/045 , C08G75/26 , C08G2650/50 , C08H1/00 , C08L51/003 , C08L53/00 , C08L63/00 , C08L71/02 , C08L81/02 , C08L2203/02 , C09J151/003 , C09J153/00 , C09J171/02 , C08L5/16 , C08L71/00
摘要： Crosslinkable compositions are provided that readily crosslink in situ to provide biocompatible, nonimmunogenic crosslinked biomaterials. The compositions contain at least three biocompatible, nonimmunogenic components having reactive functional groups thereon, with the functional groups selected so as to enable inter-reaction between the components, i.e., crosslinking. In a preferred embodiment, a first component is polynucleophilic, a second component is polyelectrophilic, and at least one third component contains one or more functional groups reactive with the nucleophilic moieties one the first or second component. At least one of the components is a polyfunctional hydrophilic polymer; the other components may also comprise hydrophilic polymers, or they may be low molecular weight, typically hydrophobic, crosslinkers. Methods for preparing and using the compositions are also provided. Exemplary uses include tissue augmentation, biologically active agent delivery, bioadhesion, and prevention of adhesions following surgery or injury.
摘要翻译： 提供可交联的组合物，其易于原位交联以提供生物相容性，非免疫原性的交联生物材料。 所述组合物含有至少三种在其上具有反应性官能团的生物相容性，非免疫原性组分，其中所述官能团被选择以使组分之间进行交互反应，即交联。 在优选的实施方案中，第一组分是多亲核的，第二组分是多亲性的，并且至少一种第三组分含有一个或多个与亲核部分反应的官能团，第一组分或第二组分。 至少一种组分是多官能亲水性聚合物; 其它组分也可以包含亲水性聚合物，或它们可以是低分子量的，通常是疏水的交联剂。 还提供了制备和使用组合物的方法。 示例性用途包括组织增加，生物活性剂递送，生物粘附和预防手术或损伤后的粘连。
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8.发明授权公开(公告)号：US06624245B2
公开(公告)日：2003-09-23
申请号：US10012263
申请日：2001-11-05
申请人： Donald G. Wallace , Gregory M. Cruise , Woonza M. Rhee , Jacqueline Anne Schroeder , George T. Coker, III , Marcee M. Maroney , Olof Mikael Trollsas
发明人： Donald G. Wallace , Gregory M. Cruise , Woonza M. Rhee , Jacqueline Anne Schroeder , George T. Coker, III , Marcee M. Maroney , Olof Mikael Trollsas
IPC分类号： C08F28300
CPC分类号： A61L31/10 , A61L24/043 , A61L27/34 , A61L27/52 , A61L27/54 , A61L31/145 , A61L31/16 , A61L2300/418 , Y10S424/13 , Y10S435/975
摘要： A method is provided for the rapid formation of a biocompatible gel, and may be carried out in situ, i.e., at a selected site within a patient's body. The method involves admixing a biocompatible crosslinking component A having m sulfhydryl groups wherein m≧2 and a biocompatible crosslinking component B having n sulfhydryl-reactive groups wherein n≧2 and m+n>4, wherein the sulfhydryl-reactive groups are capable of covalent reaction with the sulfhydryl groups upon admixture of the components under effective crosslinking conditions to form a gel in less than one minute. Suitable reaction conditions for carrying out the crosslinking reaction will depend on the particular components and the type of reaction involved; that is, the “effective crosslinking conditions” may involve reaction in bulk or in a solvent, addition of a base, and/or irradiation of the admixture in the presence of a free radical initiator. Exemplary uses include tissue augmentation, biologically active agent delivery, bioadhesion, and prevention of adhesions following surgery or injury. Reactive gel-forming compositions and systems are also provided.
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9.发明申请COMPOSITIONS AND SYSTEMS FOR FORMING CROSSLINKED BIOMATERIALS AND ASSOCIATED METHODS OF PREPARATION AND USE 有权用于形成交联生物材料的组合物和系统及其制备和使用的相关方法公开(公告)号：US20120041481A1
公开(公告)日：2012-02-16
申请号：US13279987
申请日：2011-10-24
申请人： George Y. Daniloff , Louis C. Sehl , Olof Mikael Trollsas , Jacqueline Schroeder , David M. Gravett , Philip M. Toleikis
发明人： George Y. Daniloff , Louis C. Sehl , Olof Mikael Trollsas , Jacqueline Schroeder , David M. Gravett , Philip M. Toleikis
CPC分类号： A61L31/041 , A61K9/1075 , A61K9/1647 , A61K9/5153 , A61K47/34 , A61L24/043 , A61L27/16 , A61L27/26 , A61L27/50
摘要： Kits comprising dry power compositions are provided that readily crosslink in situ to provide crosslinked biomaterials. The dry powder composition contains at least two biocompatible, non-immunogenic components having reactive groups thereon, with the functional groups selected so as to enable inter-reaction between the components, i.e., crosslinking. Exemplary uses for the crosslinked biomaterials include tissue augmentation, biologically active agent delivery, bioadhesion, and prevention of adhesions following surgery or injury.
摘要翻译： 提供了包含干重组合物的试剂盒，其容易地原位交联以提供交联的生物材料。 干粉组合物含有至少两种在其上具有反应性基团的生物相容性，非免疫原性组分，选择官能团以使组分之间进行交联即交联。 用于交联生物材料的示例性用途包括组织增加，生物活性剂递送，生物粘附和预防手术或损伤后的粘连。
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10.发明申请MULTIFUNCTIONAL COMPOUNDS FOR FORMING CROSSLINKED BIOMATERIALS AND METHODS OF PREPARATION AND USE 失效用于形成交联生物材料的多功能化合物及其制备和使用方法公开(公告)号：US20130012683A1
公开(公告)日：2013-01-10
申请号：US13618989
申请日：2012-09-14
申请人： George Y. Daniloff , Michael Huy Ngo , Olof Mikael Trollsas , David M. Gravett , Philip M. Toleikis
发明人： George Y. Daniloff , Michael Huy Ngo , Olof Mikael Trollsas , David M. Gravett , Philip M. Toleikis
IPC分类号： C08G65/00
CPC分类号： C08G65/005 , A61F2/44 , A61F2002/30677 , A61K9/0024 , A61K9/0048 , A61K9/1641 , A61K38/00 , A61L27/54 , A61L31/16 , C08G65/332 , C08G65/3342 , C08G2210/00 , C08G2650/32 , C08L71/02 , C08L2203/02
摘要： Multifunctional compounds are provided that readily crosslink in situ to provide crosslinked biomaterials. The multifunctional compounds contain a single component having at least three reactive functional groups thereon, with the functional groups selected so as to be non-reactive in an initial environment and inter-reactive in a modified environment. Reaction of a plurality of the multifunctional compounds results in a three-dimensional crosslinked matrix. In one embodiment, a first functional group is nucleophilic, a second functional group is electrophilic, and at least one additional functional group is nucleophilic or electrophilic. Methods for preparing and using the multifunctional compounds, and kits including the multifunctional compounds are also provided. Exemplary uses for the multifunctional compounds include tissue augmentation, biologically active agent delivery, bioadhesion, and prevention of adhesions following surgery or injury.
摘要翻译： 提供多功能化合物，其易于原位交联以提供交联的生物材料。 多官能化合物含有在其上具有至少三个反应性官能团的单一组分，其官能团被选择为在初始环境中是非反应性的并且在改性环境中具有互反应性。 多个多官能化合物的反应产生三维交联的基质。 在一个实施方案中，第一官能团是亲核的，第二官能团是亲电子的，并且至少一个另外的官能团是亲核或亲电子的。 还提供了制备和使用多官能化合物的方法，以及包括多官能化合物的试剂盒。 多功能化合物的示例性用途包括组织增加，生物活性剂递送，生物粘附和预防手术或损伤后的粘连。
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