公开(公告)号：US5744655A

公开(公告)日：1998-04-28

申请号：US667526

申请日：1996-06-19

申请人： P. J. Thomas ,  R. Garth Pews ,  Paul C. Vosejpka ,  George J. Frycek

发明人： P. J. Thomas ,  R. Garth Pews ,  Paul C. Vosejpka ,  George J. Frycek

IPC分类号： C07C29/141 ,  C07C31/36 ,  C07C45/35 ,  C07C45/63 ,  C07D301/26 ,  C07C31/34

CPC分类号： C07D301/26 ,  C07C29/141 ,  C07C45/35 ,  C07C45/63 ,  Y02P20/582

摘要： A 2,3-dihalopropanol is made by reacting 2,3-dihalopropanal with a hydrogenating agent in the presence of a transition metal-containing catalyst, under conditions such that 2,3-dihalopropanol is formed. The reaction is particularly useful as Step (3) in a process to make epihalohydrin by: (1) reacting a 3-carbon hydrocarbon with an oxidizing agent to form acrolein; (2) reacting acrolein with a molecular halogen to form 2,3-dihalopropanal; (3) reducing 2,3-dihalopropanal to form 2,3-dihalopropanol; and (4) cyclizing 2,3-dihalopropanol to make epihalohydrin. The process produces epihalohydrin using only about one mole of halogen per mole of epihalohydrin. It also uses substantially less water than existing processes.

摘要翻译： 在含过渡金属的催化剂存在下，在形成2,3-二卤丙醇的条件下，通过2,3-二卤代丙醛与氢化剂反应制备2,3-二卤丙醇。 在通过以下步骤制备表卤代醇的方法中，作为步骤（3）特别有用：（1）使3-碳烃与氧化剂反应形成丙烯醛; （2）使丙烯醛与分子卤素反应形成2,3-二卤代丙醛; （3）还原2,3-二卤丙醛以形成2,3-二卤丙醇; 和（4）环化2,3-二卤丙醇以制备表卤代醇。 该方法使用每摩尔表卤代醇仅使用约1摩尔卤素产生表卤代醇。 它还使用比现有工艺少得多的水。

公开(公告)号：US6008419A

公开(公告)日：1999-12-28

申请号：US994208

申请日：1997-12-19

申请人： P. J. Thomas ,  R. Garth Pews ,  Paul C. Vosejpka ,  George J. Frycek

发明人： P. J. Thomas ,  R. Garth Pews ,  Paul C. Vosejpka ,  George J. Frycek

IPC分类号： C07C29/141 ,  C07C31/36 ,  C07C45/35 ,  C07C45/63 ,  C07D301/26 ,  C07C29/38

CPC分类号： C07D301/26 ,  C07C29/141 ,  C07C45/35 ,  C07C45/63 ,  Y02P20/582

摘要： A 2,3-dihalopropanol is made by reacting 2,3-dihalopropanal with molecular hydrogen in the presence of a transition metal-containing catalyst, under conditions such that 2,3-dihalopropanol is formed. The reaction is particularly useful, for example, as Step (3) in a process to make epihalohydrin which may be generally prepared by:(1) reacting a 3-carbon hydrocarbon with an oxidizing agent to form acrolein;(2) reacting acrolein with a molecular halogen to form 2,3-dihalopropanal;(3) reducing 2,3-dihalopropanal with molecular hydrogen to form 2,3-dihalopropanol; and(4) cyclizing 2,3-dihalopropanol to make epihalohydrin.The process produces epihalohydrin using only about one mole of halogen per mole of epihalohydrin. It also uses substantially less water than existing processes.

摘要翻译： 在含过渡金属的催化剂的存在下，在形成2,3-二卤代丙醇的条件下，通过2,3-二卤代丙醛与分子氢反应制备2,3-二卤丙醇。 该反应特别有用，例如作为制备表卤代醇的方法中的步骤（3），其通常可通过以下制备：（1）使3-碳烃与氧化剂反应形成丙烯醛; （2）使丙烯醛与分子卤素反应形成2,3-二卤代丙醛; （3）用分子氢还原2,3-二卤代丙醛，形成2,3-二卤代丙醇; 和（4）环化2,3-二卤丙醇以制备表卤代醇。 该方法使用每摩尔表卤代醇仅使用约1摩尔卤素产生表卤代醇。 它还使用比现有工艺少得多的水。

公开(公告)号：US5349095A

公开(公告)日：1994-09-20

申请号：US982213

申请日：1992-11-25

申请人： P. J. Thomas ,  R. Garth Pews

发明人： P. J. Thomas ,  R. Garth Pews

IPC分类号： C07C29/14 ,  C07C33/34 ,  C07C45/00 ,  C07C45/51 ,  C07C49/792

CPC分类号： C07C49/792 ,  C07C29/14 ,  C07C33/34 ,  C07C45/004 ,  C07C45/513 ,  C07C2101/06

摘要： A process for preparing a substituted or unsubstituted 3- or 4-hydroxyalkylbenzocyclobutene compound comprises reducing a corresponding 3- or 4-formyl or ketobenzocyclobutene compound with a hydride at a temperature below that at which dimerization or oligomerization of the formyl- or ketobenzocycloutene compound or the thus-produced hydroxyalkylbenzocyclobutene compound is a significant side reaction, for a time sufficient to convert the formyl- or ketobenzocyclobutene compound to the hydroxyalkylbenzocyclobutene compound. In a two-step process, formylbenzocyclobutenes are prepared from bromobenzocyclobutenes in 90% yield or from benzocyclobutenes in a 70% yield, and then converted to hydroxymethylbenzocyclobutenes for an overall yield of about 85% from a bromobenzocyclobutene or of about 65% from a benzocyclobutene. In a two-step process, ketobenzocyclobutenes from bromobenzocyclobutene Grignard reagents and an N-alkanoyl- or N-aroyl-2-methylaziridine are converted to hydroxyalkylbenzocyclobutenes in high yields.

摘要翻译： 取代或未取代的3-或4-羟基烷基苯并环丁烯化合物的方法包括在低于甲酰基或酮基苯并环丁烯化合物的二聚或低聚的温度下用氢化物还原相应的3-或4-甲酰基或酮基苯并环丁烯化合物或 因此产生的羟烷基苯并环丁烯化合物是足够将甲酰基或酮基苯并环丁烯化合物转化为羟烷基苯并环丁烯化合物的显着副反应。 在两步法中，甲酰基苯并环丁烯由90％产率的溴代苯并环丁烯或70％产率的苯并环丁烯制备，然后从溴代苯并环丁烯转化为羟甲基苯并环丁烯，总产率为约85％，或从苯并环丁烯转化为约65％。 在两步法中，来自溴苯并环丁烯格氏试剂和N-烷酰基或N-芳酰基-2-甲基氮丙啶的酮基苯并环丁烯以高产率转化为羟基烷基苯并环丁烯。

公开(公告)号：US5120884A

公开(公告)日：1992-06-09

申请号：US655875

申请日：1991-02-14

申请人： P. J. Thomas ,  R. Garth Pews

发明人： P. J. Thomas ,  R. Garth Pews

IPC分类号： C07C37/56 ,  C07C39/17

CPC分类号： C07C37/56 ,  C07C2102/06

摘要： Hydroxy arylcyclobutenes are prepared by the Baeyer-Villiger oxidation of arylcyclobutene aldehydes with permonophosphoric acid.

摘要翻译： 羟基芳基环丁烯通过Baeyer-Villiger氧化芳基环丁烯醛与permonophosphoric酸制备。

公开(公告)号：US5210339A

公开(公告)日：1993-05-11

申请号：US868812

申请日：1992-04-15

申请人： P. J. Thomas ,  R. Garth Pews

发明人： P. J. Thomas ,  R. Garth Pews

IPC分类号： C07C205/06 ,  C07C205/42

CPC分类号： C07C201/08 ,  C07C2101/04

摘要： An improved process for the nitration of a substituted or unsubstituted benzocyclobutene compound in a reaction mixture comprising a nitrating agent, an unhalogenated carboxylic acid anhydride, clay and a solvent to produce a corresponding nitrobenzocyclobutene compound, is that wherein:(a) the solvent has a density above that of the nitrating agent or an extractable precursor thereof;(b) the reaction mixture is heated at a temperature such that solvent is removed from the reaction mixture to a site outside the reaction mixture to extract nitrating agent or extractable precursor thereof; and(c) the thus-extracted nitrating agent or precursor thereof is fed into the reaction mixture to nitrate the benzocyclobutene compound.

摘要翻译： 在包含硝化剂，未卤化羧酸酐，粘土和溶剂以产生相应的硝基苯并环丁烯化合物的反应混合物中硝化取代或未取代的苯并环丁烯化合物的改进方法是其中：（a）溶剂具有 浓度高于硝化剂或其可萃取的前体; （b）将反应混合物在使反应混合物中除去溶剂至反应混合物外的位置的温度下加热以提取硝化剂或其可萃取的前体; 和（c）将由此提取的硝化剂或其前体进料到反应混合物中以使苯并环丁烯化合物硝酸化。

公开(公告)号：US5099083A

公开(公告)日：1992-03-24

申请号：US655872

申请日：1991-02-14

申请人： P. J. Thomas ,  R. Garth Pews

发明人： P. J. Thomas ,  R. Garth Pews

IPC分类号： C07C17/32

CPC分类号： C07C17/32 ,  C07C2102/06

摘要： 3-chloromethylbenzocyclobutene is prepared by reacting benzocyclobutene with chloromethyl methyl ether in the presence of stannic chloride at a temperature of about -120.degree. C. to about -40.degree. C. and neutralizing the resulting reaction mixture comprising 3-chloromethylbenzocyclobutene at a temperature of about -80.degree. C. to about -70.degree. C.

摘要翻译： 在氯化锡存在下，在约-120℃至约-40℃的温度下，使苯并环丁烯与氯甲基甲基醚反应制备3-氯甲基苯并环丁烯，并将所得到的包含3-氯甲基苯并环丁烯的反应混合物在约 -80℃至约-70℃

公开(公告)号：US5354929A

公开(公告)日：1994-10-11

申请号：US128611

申请日：1993-09-28

申请人： Robert A. Kirchhoff ,  P. J. Thomas ,  R. Garth Pews

发明人： Robert A. Kirchhoff ,  P. J. Thomas ,  R. Garth Pews

IPC分类号： C07C13/44 ,  C07C13/00

CPC分类号： C07C13/44 ,  C07C2102/06

摘要： The invention is a bis-BCB compound of the structure: ##STR1## a method for making same and polymers made therefrom. The novel compounds of this invention are useful in preparing polymers that can form thin film coatings for multichip midules (MCMs) and integrated circuits (ICs). These compounds can be isolated as liquids at room temperature, and can form polymers that are hydrophobic and have low dielectrical and dissipative properties.

摘要翻译： 本发明是一种双-BCB化合物，其结构如下：＆lt; IMAGE＆gt;其制备方法和由其制备的聚合物。 本发明的新型化合物可用于制备可形成多芯片（MCM）和集成电路（IC）的薄膜涂层的聚合物。 这些化合物可以在室温下作为液体分离，并且可以形成疏水性且具有低介电性和耗散性的聚合物。

公开(公告)号：US5264613A

公开(公告)日：1993-11-23

申请号：US861700

申请日：1992-04-10

申请人： P. J. Thomas ,  R. Garth Pews

发明人： P. J. Thomas ,  R. Garth Pews

IPC分类号： C07C69/007 ,  C07C69/44 ,  C07C69/80 ,  C07C69/82 ,  C07C69/96 ,  C07C69/76 ,  C07C69/34 ,  C07C313/00

CPC分类号： C07C69/007 ,  C07C69/44 ,  C07C69/80 ,  C07C69/82 ,  C07C69/96

摘要： A process for preparing carboxylic acid esters of of the formulaX--(COOCH.sub.2 A).sub.nwherein A is the residue of a substituted or unsubstituted 3- or 4-benzocyclobutene compound, X is an n-valent organic bridging group, and n is 2,3, or 4, comprises reacting a substituted or unsubstituted 3- or 4-hydroxymethylbenzocyclobutene compound with a compound of the formula X--(COY).sub.n, wherein X is an n-valent organic bridging group and Y is Cl or Br. Esters of inorganic acids of the formulaX'(OCH.sub.2 A).sub.nwherein X' is a residue of an inorganic acid halide, n is 2 or 3, and A is the residue of a substituted or unsubstituted 3- or 4-benzocyclobutene compound, are prepared by reacting an inorganic halide of the formula X'Y.sub.n, wherein Y is Br or Cl, with a substituted or unsubstituted 3- or 4-hydroxymethylbenzocyclobutene compound. Biscarbonates of the formula X"[OC(.dbd.O)CH.sub.2 A].sub.2 wherein X" is the residue of a diphenol are prepared by reaction between a bis(halocarbonyl) compound of the formula X"[OC(.dbd.O)Y].sub.2, wherein Y is Cl or Br, and a substituted or unsubstituted 3- or 4-hydroxymethylbenzocyclobutene compound. The resulting esters are useful for making resins.

摘要翻译： 一种制备式X-（COOCH 2 A）n的羧酸酯的方法，其中A是取代或未取代的3-或4-苯并环丁烯化合物的残基，X是n价有机桥基，n是2， 3或4包括使取代或未取代的3-或4-羟甲基苯并环丁烯化合物与式X-（COY）n的化合物反应，其中X为n价有机桥基，Y为Cl或Br。 式X'（OCH 2 A）n的无机酸的酯，其中X'为无机酰卤的残基，n为2或3，A为取代或未取代的3-或4-苯并环丁烯化合物的残基，为 通过使式X'Yn的无机卤化物（其中Y是Br或Cl）与取代或未取代的3-或4-羟甲基苯并环丁烯化合物反应制备。 式X“[OC（= O）CH 2 A] 2的双碳酸酯，其中X”是二酚的残基，通过式X“[OC（= O）Y ] 2，其中Y是Cl或Br，以及取代或未取代的3-或4-羟甲基苯并环丁烯化合物。 所得的酯可用于制备树脂。

公开(公告)号：US07745652B2

公开(公告)日：2010-06-29

申请号：US12328868

申请日：2008-12-05

申请人： Zenon Lysenko ,  Bob R. Maughon ,  Jozef Bicerano ,  Kenneth A. Burdett ,  Christopher P. Christenson ,  Clark H. Cummins ,  Marvin L. Dettloff ,  Alan K. Schrock ,  P. J. Thomas ,  Richard D. Varjian ,  Jerry E. White ,  John Michael Maher

发明人： Zenon Lysenko ,  Bob R. Maughon ,  Jozef Bicerano ,  Kenneth A. Burdett ,  Christopher P. Christenson ,  Clark H. Cummins ,  Marvin L. Dettloff ,  Alan K. Schrock ,  P. J. Thomas ,  Richard D. Varjian ,  Jerry E. White ,  John Michael Maher

IPC分类号： C07C51/43

CPC分类号： C07D303/42 ,  C07C67/31 ,  C07C67/333 ,  C07C67/347 ,  C07C67/56 ,  C07C69/533 ,  C07C227/08 ,  C07C227/18 ,  C07C229/08 ,  Y02P20/125 ,  C07C69/716 ,  C07C69/675

摘要： Integrated processes of preparing industrial chemicals starting from seed oil feedstock compositions containing one or more unsaturated fatty acids or unsaturated fatty acid esters, which are essentially free of metathesis catalyst poisons, particularly hydroperoxides; metathesis of the feedstock composition with a lower olefin, such as ethylene, to form a reduced chain olefin, preferably, a reduced chain α-olefin, and a reduced chain unsaturated acid or ester, preferably, a reduced chain α,ω-unsaturated acid or ester. The reduced chain unsaturated acid or ester may be (trans)esterified to form a polyester polyolefin, which may be epoxidized to form a polyester polyepoxide. The reduced chain unsaturated acid or ester may be hydroformylated with reduction to produce an α,ω-hydroxy acid or α,ω-hydroxy ester, which may be (trans)esterified with a polyol to form an α,ω-polyester polyol. Alternatively, the reduced chain unsaturated acid or ester may be hydroformylated with reductive amination to produce an α,ω-amino acid or α,ω-amino ester, which may be (trans)esterified to form an α,ω-polyester polyamine.

摘要翻译： 从含有一种或多种不饱和脂肪酸或不饱和脂肪酸酯的种子油原料组合物制备工业化学品的综合方法，其基本上不含复分解催化剂毒物，特别是氢过氧化物; 原料组合物与低级烯烃如乙烯的复分解以形成还原链烯烃，优选还原链α-烯烃和还原链不饱和酸或酯，优选还原链α，ω-不饱和酸 或酯。 还原链不饱和酸或酯可以（反式）酯化以形成聚酯聚烯烃，其可以被环氧化以形成聚酯多环氧化物。 还原链不饱和酸或酯可以通过还原加氢甲酰化以产生α，ω-羟基酸或α，ω-羟基酯，其可以与多元醇反应形成α，ω-聚酯多元醇。 或者，还原链不饱和酸或酯可以通过还原胺化加氢甲酰化以产生α，ω-氨基酸或α，ω-氨基酯，其可以（反式）酯化形成α，ω-聚酯多胺。

公开(公告)号：US20050154221A1

公开(公告)日：2005-07-14

申请号：US10508805

申请日：2003-04-17

申请人： Zenon Lysenko ,  Bob Maughon ,  Josef Bicerano ,  Kenneth Burdett ,  Christopher Christenson ,  Clark Cummins ,  Marvin Dettloff ,  Alan Schrock ,  P. J. Thomas ,  Richard Varjian ,  Jerry White ,  John Maher

发明人： Zenon Lysenko ,  Bob Maughon ,  Josef Bicerano ,  Kenneth Burdett ,  Christopher Christenson ,  Clark Cummins ,  Marvin Dettloff ,  Alan Schrock ,  P. J. Thomas ,  Richard Varjian ,  Jerry White ,  John Maher

IPC分类号： B01J31/24 ,  C07B61/00 ,  C07C6/04 ,  C07C11/02 ,  C07C67/333 ,  C07C67/347 ,  C07C67/475 ,  C07C67/56 ,  C07C69/533 ,  C07C69/58 ,  C07C227/08 ,  C07C227/18 ,  C07C229/08 ,  C07D303/42 ,  C07C51/43

CPC分类号： C07D303/42 ,  C07C67/31 ,  C07C67/333 ,  C07C67/347 ,  C07C67/56 ,  C07C69/533 ,  C07C227/08 ,  C07C227/18 ,  C07C229/08 ,  Y02P20/125 ,  C07C69/716 ,  C07C69/675

摘要： Integrated processes of preparing industrial chemicals starting from seed oil feedstock compositions containing one or more unsaturated fatty acids or unsaturated fatty acid esters, which are essentially free of metathesis catalyst poisons, particularly hydroperoxides; metathesis of the feedstock composition with a lower olefin, such as ethylene, to form a reduced chain olefin, preferably, a reduced chain α-olefin, and a reduced chain unsaturated acid or ester, preferably, a reduced chain α,Ω-unsaturated acid or ester. The reduced chain unsaturated acid or ester may be (trans)esterified to form a polyester polyolefin, which may be epoxidized to form a polyester polyepoxide. The reduced chain unsaturated acid or ester may be hydroformylated with reduction to produce an α,Ω-hydroxy acid or α,Ω-hydroxy ester, which may be (trans)esterified with a polyol to form an α,Ωpolyester polyol. Alternatively, the reduced chain unsaturated acid or ester may be hydroformylated with reductive amination to produce an α,Ω-amino acid or α,Ω-amino ester, which may be (trans)esterified to form an α,Ωpolyester polyamine.

摘要翻译： 从含有一种或多种不饱和脂肪酸或不饱和脂肪酸酯的种子油原料组合物制备工业化学品的综合方法，其基本上不含复分解催化剂毒物，特别是氢过氧化物; 原料组合物与低级烯烃如乙烯的复分解以形成还原链烯烃，优选还原链α-烯烃和还原链不饱和酸或酯，优选还原链α，ω-不饱和酸 或酯。 还原链不饱和酸或酯可以（反式）酯化以形成聚酯聚烯烃，其可以被环氧化以形成聚酯多环氧化物。 还原链不饱和酸或酯可以通过还原反应加氢甲酰化以产生α，ω-羟基酸或α，ω-羟基酯，其可以与多元醇反应形成α，ω-聚酯多元醇。 或者，还原链不饱和酸或酯可以通过还原胺化加氢甲酰化以产生α，ω-氨基酸或α，ω-氨基酯，其可以（反式）酯化形成α，ω-聚酯多胺。