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    Biologically active eburnamenine derivatives, pharmaceutical compositions containing them and process for preparing same
    2.
    发明授权
    Biologically active eburnamenine derivatives, pharmaceutical compositions containing them and process for preparing same 失效
    生物活性白蛋白衍生物，含有它们的药物组合物及其制备方法

    公开(公告)号：US5510345A

    公开(公告)日：1996-04-23

    申请号：US351447

    申请日：1994-12-08

    申请人： Zoltan Tuba ,  Sandor Maho ,  Aniko Gere ,  Pal Vittay ,  Bela Kiss ,  Eva Palosi ,  Laszlo Szporny ,  Csaba Szantay ,  Ferenc Soti ,  Zsuzsa Baloghne Kardos ,  Maria Incze ,  Gabor Balogh ,  Maria Gazdag

    发明人： Zoltan Tuba ,  Sandor Maho ,  Aniko Gere ,  Pal Vittay ,  Bela Kiss ,  Eva Palosi ,  Laszlo Szporny ,  Csaba Szantay ,  Ferenc Soti ,  Zsuzsa Baloghne Kardos ,  Maria Incze ,  Gabor Balogh ,  Maria Gazdag

    IPC分类号： C07D471/00 ,  A61K31/495 ,  A61K31/505 ,  A61K31/55 ,  A61P9/08 ,  A61P9/10 ,  A61P13/02 ,  A61P15/00 ,  A61P25/28 ,  C07D239/00 ,  C07D295/00 ,  C07D461/00 ,  C07D401/14 ,  C07D403/14

    CPC分类号： C07D461/00

    摘要： The invention relates to novel eburnamenine derivatives of formula (I): ##STR1## wherein R.sup.1 and R.sup.2 as well as R.sup.3 and R.sup.4, independently from each other, stand for hydrogen, C.sub.2-6 alkyl group, C.sub.2-6 alkenyl group; or a C.sub.3-10 alicyclic group involving 1 to 3 rings, and this latter group may be substituted by a C.sub.1-6 alkyl or C.sub.2-6 alkenyl group; or R.sup.1 and R.sup.2 and/or R.sup.3 and R.sup.4, together with the adjacent nitrogen atom and optionally with an additional oxygen or nitrogen atom, form a 4- to 6-membered, saturated or unsaturated cyclic group which may be substituted by a C.sub.1-6 alkyl or C.sub.2-6 alkenyl group; two of X, Y and Z are nitrogen whereas the third of them means a methine group; n is 1 or 2; W means oxygen or two hydrogen atoms; and the wavy line means .alpha.-/.alpha.-, .alpha.-/.beta.- or .beta.-/.alpha.- steric position, as well as their acid addition salts and solvates. The invention further relates to pharmaceutical compositions containing the above compounds as well as a process for preparing the compounds of formula (I). The compounds of formula (I) possess antioxidant effect and therefore, they are useful for inhibiting the peroxidation of lipids occurring in mammals (including human).

    摘要翻译： PCT No.PCT / Hu93 / 00036 Sec。 371日期1994年12月8日第 102（e）日期1994年12月8日PCT提交1993年6月8日PCT公布。 出版物WO93 / 25550 本发明涉及式（I）的新颖白蛋白衍生物：其中R 1和R 2以及R 3和R 4彼此独立地代表氢，C 2-6烷基 ，C 2-6烯基; 或含有1〜3个环的C 3〜10环亚烷基，后者可以被C 1-6烷基或C 2-6烯基取代; 或R 1和R 2和/或R 3和R 4与相邻的氮原子以及任选的另外的氧或氮原子一起形成可被C 1-6烷基取代的4-至6-元饱和或不饱和的环状基团 或C 2-6烯基; X，Y和Z中的两个是氮，而第三个是次甲基; n为1或2; W表示氧或两个氢原子; 波浪线表示α - /α - ，α - /β - 或β - / - - - 立体位置，以及它们的酸加成盐和溶剂合物。 本发明还涉及含有上述化合物的药物组合物以及制备式（I）化合物的方法。 式（I）化合物具有抗氧化作用，因此它们可用于抑制哺乳动物（包括人）中发生的脂质的过氧化反应。

    Steroids with pregnane skeleton, pharmaceutical compositions containing them
    7.
    发明授权
    Steroids with pregnane skeleton, pharmaceutical compositions containing them 失效
    具有孕烷骨架的类固醇，含有它们的药物组合物

    公开(公告)号：US5547949A

    公开(公告)日：1996-08-20

    申请号：US351448

    申请日：1994-12-08

    申请人： Sandor Maho ,  Zoltan Tuba ,  Aniko Gere ,  Pal Vittay ,  Bela Kiss ,  Eva Palosi ,  Laszlo Szporny ,  Erzsebet C. Francsicsne ,  Anna M. Boorne ,  Gabor Balogh ,  Sandor Gorog

    发明人： Sandor Maho ,  Zoltan Tuba ,  Aniko Gere ,  Pal Vittay ,  Bela Kiss ,  Eva Palosi ,  Laszlo Szporny ,  Erzsebet C. Francsicsne ,  Anna M. Boorne ,  Gabor Balogh ,  Sandor Gorog

    IPC分类号： A61K31/57 ,  A61K31/58 ,  A61P3/06 ,  C07D239/42 ,  C07D239/48 ,  C07D239/50 ,  C07D491/10 ,  C07J20060101 ,  C07J9/00 ,  C07J43/00 ,  A61K31/56

    CPC分类号： C07D239/42 ,  C07D239/48 ,  C07D239/50 ,  C07D491/10 ,  C07J43/003

    摘要： Novel, therapeutically active 21-aminosteroids of formula (I) ##STR1## with pregnane skeleton, are disclosed wherein two of X, Y and Z are a nitrogen atom each and the third one is a methine group; R.sup.1 and R.sup.2 are independently from each other, a primary amino group bearing as substituent a branched-chain C.sub.4-8 alkyl -alkenyl or -alkynyl group, or a C.sub.4-10 cycloalkyl group comprising 1 to 3 ring(s) and being optionally substituted by at least one C.sub.1-3 alkyl group; or R.sup.1 and R.sup.2 are each a spiro-heterocyclic secondary amino group containing at most 10 carbon atoms and optionally at least one oxygen atom as additional heteroatom; or one of R.sup.1 and R.sup.2 is an unsubstituted heterocyclic secondary amino group containing 4 to 7 carbon atoms and the other one is an above-identified primary amino group, an above-identified spiro-heterocyclic secondary amino group, or a heterocyclic secondary amino group containing 4 to 7 carbon atoms and substituted by at least one C.sub.1-4 alkyl group; and n is 1 or 2, as well as their acid addition salts and pharmaceutical compositions containing these compounds.

    摘要翻译： PCT No.PCT / HU93 / 00035 Sec。 371日期1994年12月8日第 102（e）日期1994年12月8日PCT提交1993年6月8日PCT公布。 公开号WO93 / 25570 日期：1993年12月23日公开了具有孕烷骨架的式（I）＆lt; IMAGE＆gt;（I）＆lt; IMAGE＆gt;中的新型治疗活性的21-氨基甾体，其中X，Y和Z中的两个各自为氮原子， 次甲基; R1和R2彼此独立地是带有支链C4-8烷基 - 烯基或 - 炔基的取代基的伯氨基或包含1〜3个环的C4-10环烷基，并且任选地被 至少一个C 1-3烷基; 或R 1和R 2各自为含有至多10个碳原子的螺杂环仲氨基和任选的至少一个氧原子作为其它杂原子; R 1和R 2中的一个是含有4至7个碳原子的未取代的杂环仲氨基，另一个是上述的伯氨基，上述的螺杂环仲氨基或含有 4至7个碳原子并被至少一个C 1-4烷基取代; 和n为1或2，以及它们的酸加成盐和含有这些化合物的药物组合物。

    Apparatus for supplying high power electric loads operated in a pulse-like manner, especially for X-ray equipment
    9.
    发明授权
    Apparatus for supplying high power electric loads operated in a pulse-like manner, especially for X-ray equipment 失效
    用于提供以脉冲状操作的高功率电负载的装置，特别是用于X射线设备

    公开(公告)号：US4355276A

    公开(公告)日：1982-10-19

    申请号：US29352

    申请日：1979-04-11

    申请人： Pal Vittay

    发明人： Pal Vittay

    IPC分类号： F16F15/30 ,  H02K7/02 ,  H02K19/38 ,  H02K39/00 ,  H02P9/12 ,  H05G1/24 ,  H05G1/32 ,  H05G1/36

    CPC分类号： F16F15/30 ,  H02K19/38 ,  H02K39/00 ,  H02K7/025 ,  H02P9/12 ,  H05G1/24 ,  H05G1/32 ,  H05G1/36 ,  Y02E60/16

    摘要： The invention relates to an apparatus for supplying high-power electric loads operated in a pulse-like manner, particularly to X-ray equipment.The apparatus makes use of the mechanical energy of rotation of a flywheel rotated through a time period which is substantially longer than the pulse duration of the load by a driving power being substantially smaller than the pulse power of the load to generate a supply voltage for the load in expense of this mechanical energy. The driving period of the flywheel and the associated moderate driving power provide an energy balance with the short pulses with high power consumption. The apparatus comprises a generator unit with at least one electric rotary machine which has a rotor that rotates together with the flywheel. The excitation of the rotary machine is provided by a field power supply being controlled by a control unit. The control unit controls the excitation of the generator unit to provide predetermined output voltage and current levels for the load.The apparatus according to the invention can provide a specified operation control for the load.According to an aspect of the invention a method has been provided for carrying out fluorography which can see to an increased sensed light intensity. According to this method fluoroscopy is carried out by pulsed X-ray irradiation with small average intensity and high pulse intensity, in which the repetition frequency of the pulse is high enough to provide for a continuous light sensation. Such pulsed irradiation provides for an image on the fluoroscopic screen in which the sensed light intensity is increased by the ratio of the peak and average radiation intensities compared to the light intensity of a conventional continuous irradiation with the average intensity.

    摘要翻译： 本发明涉及一种用于提供以脉冲状方式操作的大功率电负载的装置，特别涉及用于X射线设备的装置。 该装置利用通过基本上比负载的脉冲功率小得多的时间段旋转的飞轮的旋转机械能，该时间段基本上比负载的脉冲持续时间长，以产生用于 负担这种机械能的代价。 飞轮的驱动周期和相关的中等驱动功率与具有高功率消耗的短脉冲提供能量平衡。 该装置包括具有至少一个电动旋转机器的发电机单元，其具有与飞轮一起旋转的转子。 旋转机器的激励由控制单元控制的现场电源提供。 控制单元控制发电机单元的激励以为负载提供预定的输出电压和电流水平。 根据本发明的装置可以为负载提供指定的操作控制。 根据本发明的一个方面，已经提供了一种用于进行荧光成像的方法，其可以看到增加的感测光强度。 根据该方法，通过脉冲X射线照射，以较小的平均强度和高的脉冲强度进行荧光透视，其中脉冲的重复频率足够高以提供连续的光感。 这样的脉冲照射提供荧光镜屏幕上的图像，其中感测的光强度与平均强度的常规连续照射的光强度相比，峰值和平均辐射强度的比率增加。