公开(公告)号：US20050261708A1

公开(公告)日：2005-11-24

申请号：US11133002

申请日：2005-05-19

申请人： Pankaj Pasricha ,  Yuji Sakamoto ,  Satoshi Miyamoto ,  Yoshio Onuki ,  Norio Onishi

发明人： Pankaj Pasricha ,  Yuji Sakamoto ,  Satoshi Miyamoto ,  Yoshio Onuki ,  Norio Onishi

IPC分类号： A61B17/221 ,  A61B1/00 ,  A61B17/04 ,  A61B17/06 ,  A61B17/12

CPC分类号： A61B17/12013 ,  A61B17/0401 ,  A61B17/0467 ,  A61B17/0482 ,  A61B17/0487 ,  A61B17/12009 ,  A61B2017/0404 ,  A61B2017/0417 ,  A61B2017/0458 ,  A61B2017/0464 ,  A61B2017/0475 ,  A61B2017/0488 ,  A61B2017/0496 ,  A61B2017/06052

摘要： A treatment device for endoscopic therapy of the present invention includes a suturing-ligating member having a distal end portion and a proximal end portion, that carries out at least one of suturing and ligation of biological tissue, a stopper provided to be movable forward or backward on an proximal end side of the suturing or ligating member, and stoppable by friction on the suturing-ligating member to maintain the biological tissue in a sutured or ligated state by the suturing-ligating member, and a suturing-ligation releasing member provided movable with relative to the suturing-ligating member to release the suturing-ligation state maintained by firctional stopping between the suturing-ligating member and the stopper by moving the releasing member to the proximal end portion side of the suturing-ligating member.

摘要翻译： 用于本发明的内窥镜治疗的治疗装置包括具有前端部和近端部的缝合结合部件，其进行生物体组织的缝合和连接中的至少一个，设置为可向前或向后移动的止动器 在缝合或结扎构件的近端侧上，并且可以通过缝合结扎构件上的摩擦阻止通过缝合结扎构件将生物组织维持在缝合或结扎状态，以及缝合结扎释放构件，其可以与 相对于缝合结扎构件，通过将解除构件移动到缝合结扎构件的基端侧，来解除通过缝合结扎构件与止动件之间的停止而保持的缝合连接状态。

公开(公告)号：US20050251153A1

公开(公告)日：2005-11-10

申请号：US11099303

申请日：2005-04-05

申请人： Yuji Sakamoto ,  Yoshio Onuki ,  Koh Kimura ,  Satoshi Miyamoto ,  Pankaj Pasricha ,  Takayuki Suzuki ,  Koichi Kawashima

发明人： Yuji Sakamoto ,  Yoshio Onuki ,  Koh Kimura ,  Satoshi Miyamoto ,  Pankaj Pasricha ,  Takayuki Suzuki ,  Koichi Kawashima

IPC分类号： A61B17/06 ,  A61B1/00 ,  A61B17/00 ,  A61B17/04 ,  A61B17/10 ,  A61B17/24 ,  A61B17/28 ,  A61B17/30

CPC分类号： A61B17/0469 ,  A61B17/0482 ,  A61B17/0487 ,  A61B2017/00469 ,  A61B2017/0406 ,  A61B2017/0417 ,  A61B2017/0458 ,  A61B2017/0464 ,  A61B2017/0472 ,  A61B2017/0488 ,  A61B2017/0496 ,  A61B2017/06052 ,  A61B2017/2905 ,  A61B2017/306

摘要： A ligature and suture device for medical application that ligatures or sutures biomedical tissue that has been suctioned by a suction device using a suturing member. The ligature and suture device includes an insertion portion having a lumen into which an endoscope can be inserted, and a distal end portion that is connected to the lumen and in which at least one side aperture is provided, at least one hollow needle that is able to support inside itself the suturing member, and that is placed inside the insertion portion such that a tip of the hollow needle is able to move between a first position, which is on a base end side of the side aperture, and a second position, which is on a distal end side of the side aperture, an operating section that performs an operation to move the needle, and at least one pledget that can be penetrated by the needle, and that is placed in a vicinity of the distal end of the side aperture so as to be freely removable from the distal end portion.

摘要翻译： 用于医疗应用的结扎和缝合装置，其连接或缝合已由使用缝合构件的抽吸装置抽吸的生物医学组织。 连线和缝合装置包括具有内窥镜可被插入的内腔的插入部分和连接到内腔并且至少设置有至少一个侧孔的远端部分，至少一个中空针头能够 将其固定在缝合部件的内侧，并将其放置在插入部内，使得中空针头的前端能够在侧孔的基端侧的第一位置与第二位置之间移动， 位于所述侧孔的前端侧的操作部，所述操作部进行所述针的移动操作，以及至少一个能够被针刺入的毛发，并且被放置在所述针的前端的附近 从而能够从前端部自由地移除。

公开(公告)号：US20070135822A1

公开(公告)日：2007-06-14

申请号：US11657328

申请日：2007-01-24

申请人： Yoshio Onuki ,  Satoshi Miyamoto ,  Koichi Kawashima ,  Pankaj Pasricha

发明人： Yoshio Onuki ,  Satoshi Miyamoto ,  Koichi Kawashima ,  Pankaj Pasricha

IPC分类号： A61B17/10

CPC分类号： A61B17/0469 ,  A61B17/0467 ,  A61B17/0482 ,  A61B17/0483 ,  A61B17/0487 ,  A61B17/32056 ,  A61B2017/0404 ,  A61B2017/0409 ,  A61B2017/0414 ,  A61B2017/0417 ,  A61B2017/0419 ,  A61B2017/0458 ,  A61B2017/0464 ,  A61B2017/0472 ,  A61B2017/0474 ,  A61B2017/0475 ,  A61B2017/0477 ,  A61B2017/0488 ,  A61B2017/0496 ,  A61B2017/06052 ,  A61B2017/061 ,  A61B2017/2905

摘要： In the case where the living tissues in the patient's body is resected as well, it is possible to suture the resected portion immediately without replacement with another treatment device after resection. Thus, prevention of bleeding from the resected portion or earlier repair of an ulcer that occurs with the resected portion can be carried out for the patent lowly invasively and easily.

摘要翻译： 在患者体内的活组织也被切除的情况下，可以在切除后立即缝合切除部分而不用另外的治疗装置。 因此，可以防止来自切除部分的出血或对切除部分发生的溃疡的较早修复，对于专利可以低侵入地和容易​​地进行。

公开(公告)号：US20060282100A1

公开(公告)日：2006-12-14

申请号：US11427836

申请日：2006-06-30

申请人： Pankaj Pasricha ,  Hideki Shimonaka ,  Koichi Kawashima ,  Takayuki Suzuki ,  Tsuyoshi Tsukagoshi ,  Yoshio Onuki

发明人： Pankaj Pasricha ,  Hideki Shimonaka ,  Koichi Kawashima ,  Takayuki Suzuki ,  Tsuyoshi Tsukagoshi ,  Yoshio Onuki

IPC分类号： A61B17/04

CPC分类号： A61B1/018 ,  A61B1/0014 ,  A61B17/00234 ,  A61B17/0467 ,  A61B17/0482 ,  A61B17/0485 ,  A61B17/06109 ,  A61B17/0643 ,  A61B17/068 ,  A61B17/29 ,  A61B2017/00269 ,  A61B2017/00827 ,  A61B2017/0472 ,  A61B2017/0474 ,  A61B2017/0475 ,  A61B2017/0496 ,  A61B2017/061 ,  A61B2017/0647 ,  A61B2017/2905 ,  A61B2017/2906

摘要： An endoscopic instrument used to form an artificial valve for treating gastroesophageal reflux disease (GERD).

摘要翻译： 一种用于形成用于治疗胃食管反流病（GERD）的人造瓣膜的内窥镜仪器。

公开(公告)号：US20170105781A1

公开(公告)日：2017-04-20

申请号：US15277704

申请日：2016-09-27

申请人： Pankaj Pasricha ,  Liansheng Liu

发明人： Pankaj Pasricha ,  Liansheng Liu

IPC分类号： A61B18/12 ,  A61B18/20 ,  A61N7/00 ,  A61B18/18

CPC分类号： A61B18/12 ,  A61B18/02 ,  A61B18/04 ,  A61B18/18 ,  A61B18/1815 ,  A61B18/20 ,  A61B2018/00434 ,  A61B2018/00494 ,  A61K31/165 ,  A61K31/357 ,  A61K31/36 ,  A61N7/00 ,  A61N2007/003

摘要： Methods of treatment in subjects suffering from diabetes mellitus or obesity are provided. The methods comprise ablation of a region of the small intestine in the subject, in particular ablation of a region of the duodenum. The ablation may be a mechanical, electrical, thermal, radiative, or chemical ablation and may in some cases target a sensory nerve. The methods may, in some cases, comprise the step of administering an active agent directly to the small intestine in the subject, in particular administering the active agent directly to the duodenum. The active agents useful in the treatments described herein include analgesic agents and, in particular, antinociceptive agents such as capsaicin, resiniferatoxin, and their analogues.

公开(公告)号：US20110066208A1

公开(公告)日：2011-03-17

申请号：US12865292

申请日：2009-01-30

申请人： Pankaj Pasricha ,  Jiande Chen

发明人： Pankaj Pasricha ,  Jiande Chen

IPC分类号： A61N1/36

CPC分类号： A61N1/36007

摘要： The disclosure is a method of treatment for obesity, in an individual in need thereof comprising positioning stimulatory electrodes in the distal small intestines or ileum, and administering electrical stimulation in trains of pulses or repetitive pulses, where the electrical stimulation is effective, at least in part in, stimulating the vagal afferent and efferent activity, of the distal small intestines or ileum, in the individual. The stimulation of the vagal afferent and efferent activity leads to the regulation of the ileal brake. Specifically, the electrical stimulation is provided in trains of pulses. Also, described is a method of treatment for functional gastrointestinal disease by ileal electrical stimulation. Further this invention provides a method of treatment for an eating disorder comprising administering ileal electrical stimulation effective, at least in part, in stimulating the vagal and sympathetic pathways. The stimulatory electrodes are placed by laparoscopic, endoscopic or surgical means.

摘要翻译： 本公开是在需要的个体中治疗肥胖症的方法，包括将远端小肠或回肠中的刺激电极定位，并且在电刺激有效的脉冲或重复脉冲列中给予电刺激，至少在 部分地，刺激远端小肠或回肠的迷走神经传入和传出活动。 迷走神经传入和传出活动的刺激导致回肠制动器的调节。 具体地说，在脉冲串中提供电刺激。 此外，描述了通过回肠电刺激治疗功能性胃肠道疾病的方法。 此外，本发明提供了一种饮食障碍的治疗方法，包括给予至少部分刺激迷走神经和交感神经通路有效的回肠电刺激。 刺激电极通过腹腔镜，内窥镜或外科手段放置。

公开(公告)号：US20070150021A1

公开(公告)日：2007-06-28

申请号：US11681249

申请日：2007-03-02

申请人： Jiande Chen ,  Pankaj Pasricha

发明人： Jiande Chen ,  Pankaj Pasricha

IPC分类号： A61N1/36

CPC分类号： A61N1/36007

摘要： The present invention is directed to a method of stimulating the vagus nerve of a subject.

摘要翻译： 本发明涉及刺激受试者的迷走神经的方法。

公开(公告)号：US08326427B2

公开(公告)日：2012-12-04

申请号：US12836377

申请日：2010-07-14

申请人： Pankaj Pasricha ,  Jlande Chen

发明人： Pankaj Pasricha ,  Jlande Chen

IPC分类号： A61N1/00

CPC分类号： A61N1/36007 ,  A61N1/05 ,  A61N1/0517 ,  A61N1/0551

摘要： A method of preventing acute pancreatitis comprising positioning stimulatory electrodes in the stomach of an individual in need thereof; and administering repetitive trains of short pulse gastrointestinal electrical stimulation effective for suppressing the inflammatory response in the pancreas is provided herein. The electrodes are placed by laproscopic, endoscopic or surgical means. The gastrointestinal stimulation activates vagal reflexes. The activation of the vagal reflexes is via the gastric and pancreatic afferents. The gastrointestinal stimulation also activates the axonal reflexes. The activation of the axonal reflexes is via the dichotomous branches of the spinal nerves. The electrical stimulation is administered concurrently with an endoscopic procedure or immediately following an endoscopic procedure. Also, provided herein is a method of preventing inflammation of a visceral organ comprising positioning a stimulatory electrode in proximity of descending efferents in the vagus, innervating the visceral organ, of an individual in need thereof, and administering repetitive trains of short pulse electrical stimulation effective in activating nicotinic receptors.

摘要翻译： 一种预防急性胰腺炎的方法，包括在有需要的个体的胃中定位刺激电极; 并且提供了有效抑制胰腺炎症反应的短脉冲胃肠电刺激重复列车。 电极通过腹腔镜，内窥镜或外科手段放置。 胃肠道刺激激活迷走神经反射。 迷走神经反射的激活是通过胃和胰腺传入的。 胃肠道刺激也激活轴突反射。 轴突反射的激活是通过脊神经的二分支。 电刺激与内窥镜手术同时进行或立即进行内镜手术。 此外，本文提供了一种防止内脏器官炎症的方法，包括将刺激电极定位在迷走神经中的下降传出物附近，有意义的个体的内脏器官，并施用有效的短脉冲电刺激重复训练 在激活烟碱受体。

公开(公告)号：US20110015695A1

公开(公告)日：2011-01-20

申请号：US12836377

申请日：2010-07-14

申请人： Pankaj Pasricha ,  Jiande Chen

发明人： Pankaj Pasricha ,  Jiande Chen

IPC分类号： A61N1/05

CPC分类号： A61N1/36007 ,  A61N1/05 ,  A61N1/0517 ,  A61N1/0551

摘要： A method of preventing acute pancreatitis comprising positioning stimulatory electrodes in the stomach of an individual in need thereof; and administering repetitive trains of short pulse gastrointestinal electrical stimulation effective for suppressing the inflammatory response in the pancreas is provided herein. The electrodes are placed by laproscopic, endoscopic or surgical means. The gastrointestinal stimulation activates vagal reflexes. The activation of the vagal reflexes is via the gastric and pancreatic afferents. The gastrointestinal stimulation also activates the axonal reflexes. The activation of the axonal reflexes is via the dichotomous branches of the spinal nerves. The electrical stimulation is administered concurrently with an endoscopic procedure or immediately following an endoscopic procedure. Also, provided herein is a method of preventing inflammation of a visceral organ comprising positioning a stimulatory electrode in proximity of descending efferents in the vagus, innervating the visceral organ, of an individual in need thereof, and administering repetitive trains of short pulse electrical stimulation effective in activating nicotinic receptors.

摘要翻译： 一种预防急性胰腺炎的方法，包括在有需要的个体的胃中定位刺激电极; 并且提供了有效抑制胰腺炎症反应的短脉冲胃肠电刺激重复列车。 电极通过腹腔镜，内窥镜或外科手段放置。 胃肠道刺激激活迷走神经反射。 迷走神经反射的激活是通过胃和胰腺传入的。 胃肠道刺激也激活轴突反射。 轴突反射的激活是通过脊神经的二分支。 电刺激与内窥镜手术同时进行或立即进行内镜手术。 此外，本文提供了一种防止内脏器官炎症的方法，包括将刺激电极定位在迷走神经中的下降传出物附近，有意义的个体的内脏器官，并施用有效的短脉冲电刺激重复训练 在激活烟碱受体。

公开(公告)号：US20050130189A1

公开(公告)日：2005-06-16

申请号：US10923035

申请日：2004-08-23

申请人： Pankaj Pasricha ,  Mohan Shenoy ,  John Winston

发明人： Pankaj Pasricha ,  Mohan Shenoy ,  John Winston

IPC分类号： A61K20060101 ,  A61K38/17 ,  A61K48/00 ,  C12M1/34 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/68

CPC分类号： G01N33/6893 ,  G01N2800/065

摘要： Compositions and methods for diagnosing and treating CVH and CVH-associated disorders are disclosed. Genes differentially expressed in CVH tissues relative to normal tissues are identified. The genes and the gene products (i.e., the polynucleotides transcribed from and polypeptides encoded by the genes) can be used as markers of CVH. The genes and the gene products can also be used to screen agents that modulate the gene expression or the activities of the gene products.

摘要翻译： 公开了用于诊断和治疗CVH和CVH相关疾病的组合物和方法。 鉴定出相对于正常组织在CVH组织中差异表达的基因。 可以将基因和基因产物（即从该基因转录的多核苷酸和由该基因编码的多肽）用作CVH的标记物。 基因和基因产物也可以用于筛选调节基因表达或基因产物活性的试剂。