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1.发明授权公开(公告)号：US06945638B2
公开(公告)日：2005-09-20
申请号：US10284425
申请日：2002-10-29
CPC分类号： B01L3/0268 , B01L3/0265 , B01L2200/147 , B01L2300/1805 , B01L2300/1827 , B01L2400/0439 , B01L2400/0487 , B01L2400/0633 , B33Y40/00 , B41J2/02 , B41J2/04528 , B41J2/04563 , B41J29/377 , B41J2002/022 , G05D23/1919
摘要： A device for controlling or altering the temperature of a liquid at the point of dispensing. A temperature-altering device is thermally coupled to a dispensing device to compensate for heat dissipated into the liquid as it passes through the dispensing device during dispensing. The dispensing device may be for example, a miniature solenoid valve (microvalve), a piezoelectric printhead, or the like. According to aspects of the invention, a temperature-altering device provides or reduces heat at the point of dispensing in order to alter, control or maintain a constant temperature of the dispensed liquid. As a result, improvement is obtained in the consistency of the fluid regime of the dispensed droplet stream. The temperature-altering device may be a thermoelectric device capable of moving heat either from or to the dispensing structure, or may be a heater. This device may be used beneficially even when the dispensing is performed near room temperature and the liquid does not require heating to maintain its liquid state.
摘要翻译： 用于在分配点控制或改变液体的温度的装置。 温度改变装置热耦合到分配装置以补偿在分配期间通过分配装置时散失到液体中的热量。 分配装置可以是例如微型电磁阀（微型阀），压电打印头等。 根据本发明的方面，改变温度的装置在分配点处提供或减少热量，以便改变，控制或维持所分配液体的恒定温度。 结果，在分配的液滴流的流体状态的一致性方面获得了改进。 温度改变装置可以是能够从分配结构移动热量的热电装置，也可以是加热器。 即使当在室温附近进行分配并且液体不需要加热以保持其液体状态时，该装置也可以有利地使用。
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公开(公告)号：US08357402B2
公开(公告)日：2013-01-22
申请号：US13176174
申请日：2011-07-05
CPC分类号： A61K31/715 , A61K38/39 , A61L26/0052 , A61L26/0085 , A61L26/0095 , A61L27/26 , A61L27/46 , A61L27/56 , A61L2400/06 , Y10T428/2982 , A61K2300/00 , C08L89/06
摘要： This invention relates to a flowable collagen/glycosaminoglycan (GAG) material including particles of collagen/GAG matrix that, when hydrated, can be effectively delivered to wounds having varying depths and geometries. The flowable collagen/GAG matrix allows a more intimate contact between the wound matrix and the wound bed, and provides a structural framework that serves as a scaffold for cell ingrowth.
摘要翻译： 本发明涉及可流动的胶原/糖胺聚糖（GAG）材料，其包括胶原/ GAG基质的颗粒，当水合时，可以有效地将其递送到具有不同深度和几何形状的伤口。 可流动的胶原蛋白/ GAG基质允许伤口基质和伤口床之间的更紧密的接触，并且提供用作细胞向内生长的支架的结构框架。
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公开(公告)号：US20100016967A1
公开(公告)日：2010-01-21
申请号：US12501089
申请日：2009-07-10
申请人： Arnold-Peter C. Weiss , Jignesh B. Patel , Karishma Vohra , Namrata Desai , Ronald T. Ingram , Mark Spilker , Timothy J. Pryor , Heather Beam-Brennan
发明人： Arnold-Peter C. Weiss , Jignesh B. Patel , Karishma Vohra , Namrata Desai , Ronald T. Ingram , Mark Spilker , Timothy J. Pryor , Heather Beam-Brennan
CPC分类号： A61F2/4261 , A61F2/3094 , A61F2002/2817 , A61F2002/30006 , A61F2002/30011 , A61F2002/30062 , A61F2002/30291 , A61F2002/30448 , A61F2002/30599 , A61F2002/30892 , A61F2002/30971 , A61F2002/4276 , A61F2210/0004 , A61F2220/005 , A61F2230/0091 , A61F2250/0015 , A61F2250/0023 , A61F2250/0063 , A61F2310/00365 , A61L27/24 , A61L27/58
摘要： Biocompatible, resorbable medical implants and related methods are disclosed in which the implant can be made of a collagen matrix for filling a space after partial or total resection of the trapezium bone of the wrist. The resorbable medical implant can include a plurality of surface projections, and the collagen matrix can be folded or spirally wound about itself to form a spiral roll.
摘要翻译： 公开了生物相容性，可再吸收的医疗植入物和相关方法，其中植入物可以由胶原基质制成，用于在部分或全部切除手腕的梯形骨之后填充空间。 可再吸收的医用植入物可以包括多个表面突起，并且胶原基质可以绕其自身折叠或螺旋缠绕以形成螺旋卷。
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公开(公告)号：US07027887B2
公开(公告)日：2006-04-11
申请号：US10189153
申请日：2002-07-03
CPC分类号： B41J3/4073 , B22F3/1055 , B22F2003/1057 , B29C35/0288 , B29C41/36 , B29C41/46 , B29C41/52 , B29C43/34 , B29C64/165 , B29C2035/0822 , B29C2043/3494 , B33Y10/00 , B33Y30/00 , B33Y40/00 , B33Y50/00 , Y02P10/295
摘要： Apparatus, systems and methods for use in three-dimensional printing are shown and described. Various embodiments of the invention allow for more precise and controlled delivery of heat to achieve interlayer drying; isolation of the working region from the outside for reasons of cleanliness and in connection with the vapors of organic solvents; better control of the temperature of the working region; better accuracy in the flowrates of binder fluid dispensed; matching of delivered flowrates for multiple dispensers; verification of delivered flowrate or drops; provision for easier changeover of the machine from one powder to another; cleanability; and other needs.
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公开(公告)号：US20090092674A1
公开(公告)日：2009-04-09
申请号：US12233936
申请日：2008-09-19
CPC分类号： A61K31/715 , A61K38/39 , A61L26/0052 , A61L26/0085 , A61L26/0095 , A61L27/26 , A61L27/46 , A61L27/56 , A61L2400/06 , Y10T428/2982 , A61K2300/00 , C08L89/06
摘要： This invention relates to a flowable collagen/glycosaminoglycan (GAG) material including particles of collagen/GAG matrix that, when hydrated, can be effectively delivered to wounds having varying depths and geometries. The flowable collagen/GAG matrix allows a more intimate contact between the wound matrix and the wound bed, and provides a structural framework that serves as a scaffold for cell ingrowth.
摘要翻译： 本发明涉及可流动的胶原/糖胺聚糖（GAG）材料，其包括胶原/ GAG基质的颗粒，当水合时，可以有效地将其递送到具有不同深度和几何形状的伤口。 可流动的胶原蛋白/ GAG基质允许伤口基质和伤口床之间的更紧密的接触，并且提供用作细胞向内生长的支架的结构框架。
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公开(公告)号：US07008209B2
公开(公告)日：2006-03-07
申请号：US10190333
申请日：2002-07-03
CPC分类号： B41J3/4073 , B22F3/1055 , B22F2003/1057 , B29C35/0288 , B29C41/36 , B29C41/46 , B29C41/52 , B29C43/34 , B29C64/165 , B29C2035/0822 , B29C2043/3494 , B33Y10/00 , B33Y30/00 , B33Y40/00 , B33Y50/00 , Y02P10/295
摘要： Apparatus, systems and methods for use in three-dimensional printing are shown and described. Various embodiments of the invention allow for more precise and controlled delivery of heat to achieve interlayer drying; isolation of the working region from the outside for reasons of cleanliness and in connection with the vapors of organic solvents; better control of the temperature of the working region; better accuracy in the flowrates of binder fluid dispensed; matching of delivered flowrates for multiple dispensers; verification of delivered flowrate or drops; provision for easier changeover of the machine from one powder to another; cleanability; and other needs.
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公开(公告)号：US20110262503A1
公开(公告)日：2011-10-27
申请号：US13176174
申请日：2011-07-05
CPC分类号： A61K31/715 , A61K38/39 , A61L26/0052 , A61L26/0085 , A61L26/0095 , A61L27/26 , A61L27/46 , A61L27/56 , A61L2400/06 , Y10T428/2982 , A61K2300/00 , C08L89/06
摘要： This invention relates to a flowable collagen/glycosaminoglycan (GAG) material including particles of collagen/GAG matrix that, when hydrated, can be effectively delivered to wounds having varying depths and geometries. The flowable collagen/GAG matrix allows a more intimate contact between the wound matrix and the wound bed, and provides a structural framework that serves as a scaffold for cell ingrowth.
摘要翻译： 本发明涉及可流动的胶原/糖胺聚糖（GAG）材料，其包括胶原/ GAG基质的颗粒，当水合时，可以有效地将其递送到具有不同深度和几何形状的伤口。 可流动的胶原蛋白/ GAG基质允许伤口基质和伤口床之间的更紧密的接触，并且提供用作细胞向内生长的支架的结构框架。
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公开(公告)号：US07993679B2
公开(公告)日：2011-08-09
申请号：US12233936
申请日：2008-09-19
CPC分类号： A61K31/715 , A61K38/39 , A61L26/0052 , A61L26/0085 , A61L26/0095 , A61L27/26 , A61L27/46 , A61L27/56 , A61L2400/06 , Y10T428/2982 , A61K2300/00 , C08L89/06
摘要： This invention relates to a flowable collagen/glycosaminoglycan (GAG) material including particles of collagen/GAG matrix that, when hydrated, can be effectively delivered to wounds having varying depths and geometries. The flowable collagen/GAG matrix allows a more intimate contact between the wound matrix and the wound bed, and provides a structural framework that serves as a scaffold for cell ingrowth.
摘要翻译： 本发明涉及可流动的胶原/糖胺聚糖（GAG）材料，其包括胶原/ GAG基质的颗粒，当水合时，可以有效地将其递送到具有不同深度和几何形状的伤口。 可流动的胶原蛋白/ GAG基质允许伤口基质和伤口床之间的更紧密的接触，并且提供用作细胞向内生长的支架的结构框架。
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9.发明授权Method and apparatus for engineered regenerative biostructures such as hydroxyapatite substrates for bone healing applications 失效用于骨愈合应用的工程再生生物结构的方法和装置，例如羟基磷灰石底物公开(公告)号：US07122057B2
公开(公告)日：2006-10-17
申请号：US10122129
申请日：2002-04-12
申请人： Heather Ann Beam , Thomas J. Bradbury , Kathleen D. Chesmel , Christopher M. Gaylo , Alfred Anthony Litwak , Qing Liu , Peter Albert Materna , Donald Monkhouse , Jennifer Patterson , Timothy J. Pryor , Sunil Saini , Henry Leon Surprenant , Chen-Chao Wang , Thomas George West , Jaedeok Yoo
发明人： Heather Ann Beam , Thomas J. Bradbury , Kathleen D. Chesmel , Christopher M. Gaylo , Alfred Anthony Litwak , Qing Liu , Peter Albert Materna , Donald Monkhouse , Jennifer Patterson , Timothy J. Pryor , Sunil Saini , Henry Leon Surprenant , Chen-Chao Wang , Thomas George West , Jaedeok Yoo
IPC分类号： A61F2/28
CPC分类号： A61L27/46 , A61F2/28 , A61F2002/30034 , A61F2002/30059 , A61F2002/30062 , A61F2002/30225 , A61F2002/30271 , A61F2002/30971 , A61F2210/0004 , A61F2230/0069 , A61F2230/0082 , A61F2250/0031 , A61F2310/00293 , A61L27/12 , A61L27/50 , A61L27/56 , A61L2430/02 , B33Y30/00 , B33Y80/00 , C04B28/34 , C04B35/447 , C04B35/634 , C04B35/638 , C04B38/06 , C04B2111/00181 , C04B2111/00836 , C04B2235/3212 , C04B2235/447 , C04B2235/5436 , C04B2235/6026 , C04B2235/616 , C04B2235/6567 , C04B2235/80 , C04B2235/96 , C04B35/00 , C04B38/0054 , C04B38/0074
摘要： An engineered regenerative biostructure (erb) for implantation into a human body as a bone substitute, which includes an internal microstructure, mesostructure and/or macrostructure to provide improved bone in-growth, and methods for making the erb. Under one aspect of the invention, the biostructure has resorbable and nonresorbable regions. Under another aspect of the invention, the biostructure is constructed of hydroxyapatite, tricalcium phosphate and/or demineralized bone. Under yet another aspect of the invention, the porous biostructure is partially or fully infused with a resorbable, nonresorbable or dissolvable material.
摘要翻译： 用于作为骨替代物植入人体的工程再生生物结构（erb），其包括内部微观结构，介观结构和/或宏观结构以提供改善的骨生长，以及用于制备所述erb的方法。 在本发明的一个方面，生物结构具有可再吸收和不可再吸收的区域。 在本发明的另一方面，生物结构由羟基磷灰石，磷酸三钙和/或脱矿质骨构成。 在本发明的另一方面，多孔生物结构部分或全部注入可再吸收的，不可再吸收或可溶解的材料。
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