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公开(公告)号：US07148476B2
公开(公告)日：2006-12-12
申请号：US10867893
申请日：2004-06-15
CPC分类号： B82Y30/00 , B01J19/0093 , B01L3/0268 , B01L3/5025 , B01L3/502715 , B01L3/50273 , B01L2200/0605 , B01L2200/10 , B01L2300/069 , B01L2300/0803 , B01L2300/0806 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0409 , B01L2400/0688 , G01N30/6095 , G01N30/7266 , G01N33/54366 , G01N35/00069 , G01N2035/00504
摘要： The present invention relates to a method for presenting an analyte of a liquid sample as an MS-analyte to a mass spectrometer. More particularly, the method comprises the steps of applying a liquid sample containing the analyte to a sample inlet port of a microchannel structure of a microfluidic device, said structure also comprising an outlet port (MS-port) that is capable of being interfaced with a mass spectrometer, passing the analyte to the MS-port thereby transforming it to an MS-analyte, and presenting the MS-analyte to mass spectrometer via the MS-port.
摘要翻译： 本发明涉及一种用于将液体样品的分析物作为MS分析物呈现给质谱仪的方法。 更具体地，该方法包括以下步骤：将含有分析物的液体样品施加到微流体装置的微通道结构的样品入口端口，所述结构还包括出口端口（MS端口），其能够与 质谱仪，将分析物通入MS端口，从而将其转化为MS分析物，并通过MS端口将MS分析物呈现给质谱仪。
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公开(公告)号：US06717136B2
公开(公告)日：2004-04-06
申请号：US09812123
申请日：2001-03-19
IPC分类号： B01D1508
CPC分类号： B82Y30/00 , B01J19/0093 , B01L3/5025 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L2200/0605 , B01L2200/10 , B01L2300/069 , B01L2300/0803 , B01L2300/0806 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0409 , B01L2400/0688 , G01N33/54366 , G01N35/00069 , G01N2035/00504 , H01J49/04 , Y10T436/24 , Y10T436/25 , Y10T436/25375
摘要： A microfluidic device comprising an MS-analyte presentation unit for a EDI-MS apparatus, said unit comprising an essentially planar support plate which on one side has one, two or more ports (MS-ports) comprising an area (EDI area) for presenting the MS-analyte to a mass spectrometer. The EDI area comprises a layer I of conducting material. The characteristic feature of the device is that layer (I) has a conductive connection and/or that there is a calibrator area in the proximity of the MS-port.
摘要翻译： 一种微流体装置，包括用于EDI-MS装置的MS分析物呈现单元，所述单元包括基本上平面的支撑板，其一侧具有一个，两个或更多个端口（MS端口），其包括用于呈现的区域（EDI区域） MS分析物到质谱仪。 EDI区域包括导电材料层I。 该设备的特征在于，层（I）具有导电连接和/或在MS端口附近存在校准器区域。
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公开(公告)号：US06812457B2
公开(公告)日：2004-11-02
申请号：US10621868
申请日：2003-07-17
IPC分类号： B01D2726
CPC分类号： B82Y30/00 , B01J19/0093 , B01L3/0268 , B01L3/5025 , B01L3/502715 , B01L3/50273 , B01L2200/0605 , B01L2200/10 , B01L2300/069 , B01L2300/0803 , B01L2300/0806 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0409 , B01L2400/0688 , G01N30/6095 , G01N30/7266 , G01N33/54366 , G01N35/00069 , G01N2035/00504
摘要： The present invention relates to a method for presenting an analyte of a liquid sample as an MS-analyte to a mass spectrometer. More particularly, the method comprises the steps of applying a liquid sample containing the analyte to a sample inlet port of a microchannel structure of a microfluidic device, said structure also comprising an outlet port (MS-port) that is capable of being interfaced with a mass spectrometer, passing the analyte to the MS-port thereby transforming it to an MS-analyte, and presenting the MS-analyte to mass spectrometer via the MS-port.
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公开(公告)号：US20050279925A1
公开(公告)日：2005-12-22
申请号：US10867893
申请日：2004-06-15
CPC分类号： B82Y30/00 , B01J19/0093 , B01L3/0268 , B01L3/5025 , B01L3/502715 , B01L3/50273 , B01L2200/0605 , B01L2200/10 , B01L2300/069 , B01L2300/0803 , B01L2300/0806 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0409 , B01L2400/0688 , G01N30/6095 , G01N30/7266 , G01N33/54366 , G01N35/00069 , G01N2035/00504
摘要： The present invention relates to a method for presenting an analyte of a liquid sample as an MS-analyte to a mass spectrometer. More particularly, the method comprises the steps of applying a liquid sample containing the analyte to a sample inlet port of a microchannel structure of a microfluidic device, said structure also comprising an outlet port (MS-port) that is capable of being interfaced with a mass spectrometer, passing the analyte to the MS-port thereby transforming it to an MS-analyte, and presenting the MS-analyte to mass spectrometer via the MS-port.
摘要翻译： 本发明涉及一种用于将液体样品的分析物作为MS分析物呈现给质谱仪的方法。 更具体地，该方法包括以下步骤：将含有分析物的液体样品施加到微流体装置的微通道结构的样品入口端口，所述结构还包括出口端口（MS端口），其能够与 质谱仪，将分析物通入MS端口，从而将其转化为MS分析物，并通过MS端口将MS分析物呈现给质谱仪。
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公开(公告)号：US06653625B2
公开(公告)日：2003-11-25
申请号：US09811741
申请日：2001-03-19
IPC分类号： B01D2726
CPC分类号： B82Y30/00 , B01J19/0093 , B01L3/0268 , B01L3/5025 , B01L3/502715 , B01L3/50273 , B01L2200/0605 , B01L2200/10 , B01L2300/069 , B01L2300/0803 , B01L2300/0806 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0409 , B01L2400/0688 , G01N30/6095 , G01N30/7266 , G01N33/54366 , G01N35/00069 , G01N2035/00504
摘要： The present invention relates to a method for presenting an analyte of a liquid sample as an MS-analyte to a mass spectrometer. More particularly, the method comprises the steps of applying a liquid sample containing the analyte to a sample inlet port of a microchannel structure of a microfluidic device, said structure also comprising an outlet port (MS-port) that is capable of being interfaced with a mass spectrometer, passing the analyte to the MS-port thereby transforming it to an MS-analyte, and presenting the MS-analyte to mass spectrometer via the MS-port.
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公开(公告)号：US06812456B2
公开(公告)日：2004-11-02
申请号：US10148083
申请日：2002-05-24
IPC分类号： H01J4900
CPC分类号： H01J49/0431 , B01F5/0646 , B01F5/0647 , B01F5/0655 , B01F13/0059 , B01F15/0201 , B01F15/0233 , B01J19/0093 , B01L3/5025 , B01L3/502715 , B01L2200/027 , B01L2200/0605 , B01L2200/10 , B01L2200/142 , B01L2300/069 , B01L2300/0803 , B01L2300/0806 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/16 , B01L2400/0406 , B01L2400/0409 , B01L2400/0418 , B01L2400/0633 , B01L2400/0688 , G01N33/54366 , G01N35/00069 , G01N2035/00504 , H01J49/0418
摘要： A microfluidic device in form of a disc comprising an MS-port for presentation of an MS-analyte to an EDI-MS apparatus, said MS-port is a part of a microchannel structure (I) comprising an inlet port for a sample, and comprises an EDI-area having a conductive layer (I) and an EDI-surface from which the MS-analyte is to be desorbed/ionised. The device is characterized in that layer (I) has a conductive connection and/or that there is a calibrator area in the proximity of each of said one, two or more MS-ports. In a typical variant the MS-port is in the form of a depression that is in fluid communication with upstream part of microchannel structure (I).
摘要翻译： 一种形式的微流体装置，包括用于向EDI-MS装置呈现MS分析物的MS端口，所述MS端口是包括用于样品的入口的微通道结构（I）的一部分，以及 包括具有导电层（I）的EDI区域和待分析/电离MS分析物的EDI表面。 该装置的特征在于，层（I）具有导电连接和/或在所述一个，两个或更多个MS端口中的每一个附近存在校准器区域。 在典型的变型中，MS端口是与微通道结构（I）的上游部分流体连通的凹陷的形式。
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公开(公告)号：US20050277195A1
公开(公告)日：2005-12-15
申请号：US10513084
申请日：2003-04-29
申请人： Mats Holmquist , Johan Engstrom , Anders Palm , Per Andersson , Gunnar Ekstrand
发明人： Mats Holmquist , Johan Engstrom , Anders Palm , Per Andersson , Gunnar Ekstrand
CPC分类号： B01L3/5027 , B01J2219/00536 , B01J2219/00725 , B01J2219/00738 , B01L2200/0605 , B01L2300/0806 , B01L2300/0864 , B01L2300/0867 , B01L2400/0406 , B01L2400/0409 , B01L2400/0633 , B01L2400/0688
摘要： A method for characterizing n components An of n catalytic systems. The method is characterized in comprising the steps of: I) providing a microfluidic device which comprises a plurality of identical microchannel structures, each microchannel structures comprising in the downstream direction (a) an inlet arrangement IA with at least one inlet port; (b) a catalytic microcavity MC1, which comprises an immobilized component Cim of the catalytic system CS used in the microchannel structure, and (c) a detection zone (DZ); ii) distributing to MC1 of each microchannel structure the remaining components of the CS used in the structure by a) dispensing to the inlet arrangement IA of each microchannel structure said remaining components; and b) transporting corresponding components for the microchannel structures in parallel to load MC1 in each microchannel structure; iii) performing the catalytic reaction in MC1 of each microchannel structure; iv) transporting in parallel the product formed in step (iii) from MC1 to DZ of each microchannel structure, if DZ and MC1 do not coincide; v) characterizing for each microchannel structure the result of the catalytic reaction performed in MC1 in DZ; and vi) characterizing An for each microchannel structure.
摘要翻译： 一种用于表征n种催化体系的n组分的方法。 该方法的特征在于包括以下步骤：I）提供微流体装置，其包括多个相同的微通道结构，每个微通道结构在下游方向（a）包括具有至少一个入口的入口装置1A; （b）催化微腔MC1，其包含在微通道结构中使用的催化体系CS的固定组分C 1和（c）检测区（DZ）; ii）通过以下方式向每个微通道结构的MC1分配用于结构中的CS的剩余部件：a）将每个微通道结构的入口装置1A分配给所述剩余部件; 和b）将微通道结构的相应部件平行运送到每个微通道结构中的负载MC1; iii）在每个微通道结构的MC1中进行催化反应; iv）如果DZ和MC1不重合，则将步骤（iii）中形成的产品从MC1至DZ平行运输; v）表征每个微通道结构在DZ中在MC1中进行的催化反应的结果; 和vi）表征每个微通道结构的An。
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公开(公告)号：US07945355B2
公开(公告)日：2011-05-17
申请号：US12354230
申请日：2009-01-15
IPC分类号： G01C23/00
CPC分类号： G05D1/101 , G01W1/02 , G08G5/0013 , G08G5/0091
摘要： The invention involves a method comprising the steps of providing (S3) a wind data set (3) including wind data of a plurality of positions, receiving (S4) data for a predicted airplane trajectory (311), providing (S5), based on the wind data set (3), a set of wind data elements (302), each including data concerning wind at a position along the predicted airplane trajectory (311), repeating steps of selecting a subset of wind data elements (302S), creating a wind profile (303), and comparing the wind profile (303) to the set of wind data elements (302), and selecting (S10) to be sent to a subscriber (2, 4) a subset of wind data elements (302S) based at least partly on which a wind profile (303) was created corresponding to the largest extent to the set of wind data elements (302).
摘要翻译： 本发明涉及一种方法，包括以下步骤：提供（S3）包括多个位置的风数据的风数据集（3），接收用于预测的飞机轨迹（311）的（S4）数据，提供（S5）基于 风数据组（3），一组风数据元素（302），每一组包括关于沿着预测的飞机轨迹（311）的位置处的风的数据，重复选择风数据元素（302S）的子集的步骤，创建 风廓线（303），并且将风廓线（303）与风数据元素集合（302）进行比较，以及选择（S10）发送给订户（2,4）风数据元素（302S）的子集 ）至少部分地基于所述风廓线（303）被创建，对应于所述一组风数据元素（302）的最大范围。
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公开(公告)号：US20100049382A1
公开(公告)日：2010-02-25
申请号：US12354230
申请日：2009-01-15
IPC分类号： G06F19/00
CPC分类号： G05D1/101 , G01W1/02 , G08G5/0013 , G08G5/0091
摘要： The invention involves a method comprising the steps of providing (S3) a wind data set (3) including wind data of a plurality of positions, receiving (S4) data for a predicted airplane trajectory (311), providing (S5), based on the wind data set (3), a set of wind data elements (302), each including data concerning wind at a position along the predicted airplane trajectory (311), repeating steps of selecting a subset of wind data elements (302S), creating a wind profile (303), and comparing the wind profile (303) to the set of wind data elements (302), and selecting (S10) to be sent to a subscriber (2, 4) a subset of wind data elements (302S) based at least partly on which a wind profile (303) was created corresponding to the largest extent to the set of wind data elements (302).
摘要翻译： 本发明涉及一种方法，包括以下步骤：提供（S3）包括多个位置的风数据的风数据集（3），接收用于预测的飞机轨迹（311）的（S4）数据，提供（S5）基于 风数据组（3），一组风数据元素（302），每一组包括关于沿着预测的飞机轨迹（311）的位置处的风的数据，重复选择风数据元素（302S）的子集的步骤，创建 风廓线（303），并且将风廓线（303）与风数据元素集合（302）进行比较，以及选择（S10）发送给订户（2,4）风数据元素（302S）的子集 ）至少部分地基于所述风廓线（303）被创建，对应于所述一组风数据元素（302）的最大范围。
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