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    VECTORS FOR MULTIPLE GENE EXPRESSION
    5.
    发明申请
    VECTORS FOR MULTIPLE GENE EXPRESSION 有权
    多基因表达载体

    公开(公告)号：US20100303838A1

    公开(公告)日：2010-12-02

    申请号：US12599971

    申请日：2008-01-29

    申请人： Nathalie Silvestre ,  Doris Schmitt

    发明人： Nathalie Silvestre ,  Doris Schmitt

    IPC分类号： A61K39/00 ,  C12N15/63 ,  C07H21/04 ,  C12N5/10 ,  A61K31/7088 ,  A61P37/00 ,  A61P31/00 ,  A61P35/04 ,  A61P31/12

    CPC分类号： A61K39/12 ,  A61K2039/53 ,  A61K2039/70 ,  C07K14/005 ,  C12N7/00 ,  C12N2710/20022 ,  C12N2710/20034 ,  C12N2710/24143 ,  C12N2840/20

    摘要： The present invention provides a vector for expressing at least a first and a second nucleic acid molecules which exhibit a percentage of homology of approximately 80% or greater than 80% over a portion of 40 or more continuous nucleotides and wherein said first nucleic acid molecule and/or said second nucleic acid molecule is modified so as to reduce said percentage of homology to less than 75%. The present invention also relates to substantially isolated nucleic acid molecules comprising a nucleotide sequence as defined in any of SEQ ID NO: 9-15 and 66-69. It also provides a host cell and a pharmaceutical composition comprising such a nucleic acid molecule or vector as well as their use for therapeutic or preventive purposes.

    摘要翻译： 本发明提供了用于表达至少第一和第二核酸分子的载体，其在40个或更多个连续核苷酸的一部分上表现出大约80％或大于80％的同源性百分比，其中所述第一核酸分子和 /或所述第二核酸分子被修饰以便将所述同源性百分比降低到小于75％。 本发明还涉及包含SEQ ID NO：9-15和66-69中任一项所定义的核苷酸序列的基本上分离的核酸分子。 它还提供宿主细胞和包含这种核酸分子或载体的药物组合物以及它们用于治疗或预防目的的用途。

    Vectors for multiple gene expression
    6.
    发明授权
    Vectors for multiple gene expression 有权
    多基因表达载体

    公开(公告)号：US08337859B2

    公开(公告)日：2012-12-25

    申请号：US12599971

    申请日：2008-01-29

    申请人： Nathalie Silvestre ,  Doris Schmitt

    发明人： Nathalie Silvestre ,  Doris Schmitt

    IPC分类号： A61K39/12 ,  A61K39/235 ,  A61K39/285 ,  A61K48/00 ,  C12N15/37 ,  C12N15/861 ,  C12N15/863 ,  C12N15/85 ,  C12N7/01 ,  C12N5/10

    CPC分类号： A61K39/12 ,  A61K2039/53 ,  A61K2039/70 ,  C07K14/005 ,  C12N7/00 ,  C12N2710/20022 ,  C12N2710/20034 ,  C12N2710/24143 ,  C12N2840/20

    摘要： The present invention provides a vector for expressing at least a first and a second nucleic acid molecules which exhibit a percentage of homology of approximately 80% or greater than 80% over a portion of 40 or more continuous nucleotides and wherein said first nucleic acid molecule and/or said second nucleic acid molecule is modified so as to reduce said percentage of homology to less than 75%. The present invention also relates to substantially isolated nucleic acid molecules comprising a nucleotide sequence as defined in any of SEQ ID NO: 9-15 and 66-69. It also provides a host cell and a pharmaceutical composition comprising such a nucleic acid molecule or vector as well as their use for therapeutic or preventive purposes.

    摘要翻译： 本发明提供了用于表达至少第一和第二核酸分子的载体，其在40个或更多个连续核苷酸的一部分上表现出大约80％或大于80％的同源性百分比，其中所述第一核酸分子和 /或所述第二核酸分子被修饰以便将所述同源性百分比降低到小于75％。 本发明还涉及包含SEQ ID NO：9-15和66-69中任一项所定义的核苷酸序列的基本上分离的核酸分子。 它还提供宿主细胞和包含这种核酸分子或载体的药物组合物以及它们用于治疗或预防目的的用途。

    SIGNALING PEPTIDES
    9.
    发明申请
    SIGNALING PEPTIDES 失效
    信号肽

    公开(公告)号：US20100160227A1

    公开(公告)日：2010-06-24

    申请号：US12600460

    申请日：2008-01-29

    申请人： Nathalie Silvestre ,  Eric Jacobs

    发明人： Nathalie Silvestre ,  Eric Jacobs

    IPC分类号： A61K38/16 ,  C07K14/00 ,  C07H21/00 ,  C12N15/74 ,  C12N7/01 ,  C12N5/10 ,  A61K31/7088 ,  C12P21/00 ,  A61P43/00

    CPC分类号： C12N15/85 ,  C07K14/005 ,  C07K2319/02 ,  C07K2319/03 ,  C12N2760/20122 ,  C12N2840/20

    摘要： The present invention provides novel peptides of specified sequence and their use as a signal peptide or a membrane-anchoring peptide. It also relates to chimeric polypeptide comprising one or more such peptides and a polypeptide of interest as well as nucleic acid molecules, vectors, infections vital particles and host cells encoding such peptides and chimeric polypeptides. The present invention also relates to a pharmaceutical composition comprising such elements and a pharmaceutically acceptable vehicle. The present invention also provides a method for recumbently producing a polypeptide using such peptides, especially for directing expression of a polypeptide of interest extracellularly or anchored at the surface of the plasma membrane.

    摘要翻译： 本发明提供具有特定序列的新型肽及其作为信号肽或膜 - 锚定肽的用途。 它还涉及包含一种或多种此类肽和感兴趣多肽以及核酸分子，载体，感染重要颗粒和编码这些肽和嵌合多肽的宿主细胞的嵌合多肽。 本发明还涉及包含这些元件和药学上可接受的载体的药物组合物。 本发明还提供了一种使用这些肽沉降产生多肽的方法，特别是用于引导细胞外或锚定在质膜表面的感兴趣多肽的表达。