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公开(公告)号：US10076570B2
公开(公告)日：2018-09-18
申请号：US13423193
申请日：2012-03-17
IPC分类号： A61K39/00 , A61K39/29 , C07K14/005 , A61K39/12
CPC分类号： A61K39/292 , A61K39/12 , A61K2039/53 , A61K2039/545 , C07K14/005 , C12N2710/10343 , C12N2710/24143 , C12N2730/10134 , C12N2770/24222
摘要： The present invention provides a composition comprising hepatitis B virus (HBV) component(s), and which may be either nucleic acid- or polypeptide-based as well as nucleic acid molecules and vectors encoding such HBV component(s). It also relates to infectious viral particles and host cells comprising such nucleic acid molecules or vectors. It also provides composition and kits of parts comprising such nucleic acid molecules, vectors, infectious viral particles or host cells and the therapeutic use thereof for preventing or treating HBV infections.
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公开(公告)号：US20120251569A1
公开(公告)日：2012-10-04
申请号：US13423193
申请日：2012-03-17
IPC分类号： A61K39/29 , C07K4/02 , C12N15/54 , C12N15/51 , A61P31/20 , A61P37/02 , A61P37/04 , C12N9/12 , C12N15/62 , C12N15/63 , C12N7/01 , C12N1/21 , C12N1/19 , C12N5/10 , C07K14/02
CPC分类号： A61K39/292 , A61K39/12 , A61K2039/53 , A61K2039/545 , C07K14/005 , C12N2710/10343 , C12N2710/24143 , C12N2730/10134 , C12N2770/24222
摘要： The present invention provides a composition comprising hepatitis B virus (HBV) component(s), and which may be either nucleic acid- or polypeptide-based as well as nucleic acid molecules and vectors encoding such HBV component(s). It also relates to infectious viral particles and host cells comprising such nucleic acid molecules or vectors. It also provides composition and kits of parts comprising such nucleic acid molecules, vectors, infectious viral particles or host cells and the therapeutic use thereof for preventing or treating HBV infections.
摘要翻译： 本发明提供包含乙型肝炎病毒（HBV）组分的组合物，其可以是基于核酸或多肽的核酸分子以及编码这样的HBV组分的载体。 它还涉及包含这种核酸分子或载体的感染性病毒颗粒和宿主细胞。 它还提供包含这种核酸分子，载体，感染性病毒颗粒或宿主细胞的组分和试剂盒以及用于预防或治疗HBV感染的治疗用途。
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公开(公告)号：US20130011435A1
公开(公告)日：2013-01-10
申请号：US13388826
申请日：2010-08-06
CPC分类号： A61K39/29 , A61K39/12 , A61K39/292 , A61K2039/53 , A61K2039/545 , A61K2039/57 , C12N7/00 , C12N9/1252 , C12N15/86 , C12N2710/10043 , C12N2710/24143 , C12N2730/10134 , C12Y207/07007
摘要： The present invention provides a composition comprising hepatitis B virus (HBV) component(s), and which may be either nucleic acid- or polypeptide-based as well as nucleic acid molecules and vectors encoding such HBV component(s). It also relates to infectious viral particles and host cells comprising such nucleic acid molecules or vectors. It also provides composition and kits of parts comprising such nucleic acid molecules, vectors, infectious viral particles or host cells and the therapeutic use thereof for preventing or treating HBV infections.
摘要翻译： 本发明提供包含乙型肝炎病毒（HBV）组分的组合物，其可以是基于核酸或多肽的核酸分子以及编码这样的HBV组分的载体。 它还涉及包含这种核酸分子或载体的感染性病毒颗粒和宿主细胞。 它还提供包含这种核酸分子，载体，感染性病毒颗粒或宿主细胞的组分和试剂盒以及用于预防或治疗HBV感染的治疗用途。
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公开(公告)号：US09393299B2
公开(公告)日：2016-07-19
申请号：US13388826
申请日：2010-08-06
CPC分类号： A61K39/29 , A61K39/12 , A61K39/292 , A61K2039/53 , A61K2039/545 , A61K2039/57 , C12N7/00 , C12N9/1252 , C12N15/86 , C12N2710/10043 , C12N2710/24143 , C12N2730/10134 , C12Y207/07007
摘要： The present invention provides a composition comprising hepatitis B virus (HBV) component(s), and which may be either nucleic acid- or polypeptide-based as well as nucleic acid molecules and vectors encoding such HBV component(s). It also relates to infectious viral particles and host cells comprising such nucleic acid molecules or vectors. It also provides composition and kits of parts comprising such nucleic acid molecules, vectors, infectious viral particles or host cells and the therapeutic use thereof for preventing or treating HBV infections.
摘要翻译： 本发明提供包含乙型肝炎病毒（HBV）组分的组合物，其可以是基于核酸或多肽的核酸分子以及编码这样的HBV组分的载体。 它还涉及包含这种核酸分子或载体的感染性病毒颗粒和宿主细胞。 它还提供包含这种核酸分子，载体，感染性病毒颗粒或宿主细胞的组分和试剂盒以及用于预防或治疗HBV感染的治疗用途。
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5.发明申请公开(公告)号：US20110020398A1
公开(公告)日：2011-01-27
申请号：US12653751
申请日：2009-12-17
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C12N2770/24222
摘要： The invention relates to peptide compositions for use in the preparation of pharmaceutical compositions against hepatitis C virus, as well as corresponding methods.
摘要翻译： 本发明涉及用于制备抗丙型肝炎病毒的药物组合物的肽组合物，以及相应的方法。
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6.发明授权公开(公告)号：US08293528B2
公开(公告)日：2012-10-23
申请号：US12653751
申请日：2009-12-17
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C12N2770/24222
摘要： The invention relates to peptide compositions for use in the preparation of pharmaceutical compositions against hepatitis C virus, as well as corresponding methods.
摘要翻译： 本发明涉及用于制备抗丙型肝炎病毒的药物组合物的肽组合物，以及相应的方法。
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7.发明授权Method for production of bioresorbable microparticles, microparticles thus obtained and use thereof 有权生产可再生微粒的方法，由此获得的微粒及其用途公开(公告)号：US08377477B2
公开(公告)日：2013-02-19
申请号：US12081296
申请日：2008-04-14
申请人： Yasemin Ataman-Onal , Thierry Delair , Geneviève Inchauspe , Pascale Jeannin , Glaucia Paranhos-Baccala , Bernard Verrier
发明人： Yasemin Ataman-Onal , Thierry Delair , Geneviève Inchauspe , Pascale Jeannin , Glaucia Paranhos-Baccala , Bernard Verrier
IPC分类号： A61K9/14 , A61K31/765 , A61K39/21 , A61K39/29 , A61K47/30
CPC分类号： C07K16/40 , A61K9/167 , A61K9/5153 , A61K9/5192 , A61K39/00 , A61K47/34 , A61K47/6935 , A61K2039/6093 , C07K14/005 , C07K16/1054 , C07K16/1072 , C12N2740/16222 , C12N2740/16322 , C12N2770/24222 , G01N33/54346
摘要： The present invention relates to a method for preparing nonlamellar bioresorbable microparticles to which protein substances are bonded, characterized in that it comprises the steps of: (i) preparing said microparticles from at least one bioresorbable polymer without stabilizer and without surfactant, and (ii) bonding said protein substances to the microparticles obtained in step (i) without surfactant. It further relates to the bioresorbable microparticles thus obtained and use thereof in diagnosis and therapy.
摘要翻译： 本发明涉及一种制备与蛋白质物质结合的非水溶性生物可再吸收微粒的方法，其特征在于其包括以下步骤：（i）从不含稳定剂和不含表面活性剂的至少一种生物可再吸收聚合物制备所述微粒，和（ii） 将所述蛋白质物质与不含表面活性剂的步骤（i）中获得的微粒结合。 它还涉及由此获得的生物可再吸收的微粒及其在诊断和治疗中的用途。
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8.发明授权Composition comprising the polyprotein NS3/NS4 and the polypeptide NS5B of HCV, expression vectors including the corresponding nucleic sequences and their therapeutic use 失效包含HCV蛋白NS3 / NS4和多肽NS5B的组合物，包括相应的核酸序列的表达载体及其治疗用途公开(公告)号：US07695960B2
公开(公告)日：2010-04-13
申请号：US11723638
申请日：2007-03-21
申请人： Geneviève Inchauspe , Anne Fournillier , Jean-Daniel Abraham , Maria Dimitrova-Tchomakov , Marie Parnot
发明人： Geneviève Inchauspe , Anne Fournillier , Jean-Daniel Abraham , Maria Dimitrova-Tchomakov , Marie Parnot
CPC分类号： A61K38/162 , A61K39/12 , A61K39/29 , A61K48/00 , A61K2039/525 , A61K2039/53 , C07K14/005 , C07K16/109 , C12N2710/10343 , C12N2710/24143 , C12N2770/24222 , C12N2770/24234
摘要： The invention relates to a peptidic compound containing a polyprotein NS3/NS4 of a hepatitis C virus and a polypeptide NS5b of hepatitis C virus. Said invention also relates to expression vectors such as adenovirus and poxyvirus in which nucleic sequences coding for the polyprotein NS3/NS4 and the polypeptide NS5b. The inventive compound can be used for a therapeutic application.
摘要翻译： 本发明涉及含有丙型肝炎病毒的多蛋白NS3 / NS4和丙型肝炎病毒的多肽NS5b的肽化合物。 所述发明还涉及表达载体，例如腺病毒和痘病毒，其中编码多蛋白NS3 / NS4和多肽NS5b的核酸序列。 本发明化合物可用于治疗应用。
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公开(公告)号：US07393831B2
公开(公告)日：2008-07-01
申请号：US10514762
申请日：2003-05-15
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C12N2770/24222
摘要： The invention relates to novel peptide compositions. In particular, the invention relates to a peptide composition comprising at least two peptides which are selected from among the following peptides: a peptide A having at least the amino acid sequence of SEQ ID No1, a peptide B having at least the amino acid sequence of SEQ ID No45, a peptide C having at least the amino acid sequence of SEQ ID No127, a peptide D having at least the amino acid sequence of SEQ. ID No174. The inventive compositions can be used, in particular, in the preparation of active pharmaceutical compositions against the hepatitis C virus.
摘要翻译： 本发明涉及新型肽组合物。 特别地，本发明涉及包含至少两种选自以下肽的肽的肽组合物：至少具有SEQ ID NO：1的氨基酸序列的肽A，肽 B至少具有SEQ ID NO：45的氨基酸序列，至少具有SEQ ID NO：127的氨基酸序列的肽C，肽D具有 至少SEQ ID NO：1的氨基酸序列。 174 N。 本发明的组合物特别可用于制备抗丙型肝炎病毒的活性药物组合物。
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