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61 条记录 (耗时 0.027 秒)

    Methods of concentrating ligands and active membranes used therefor
    1.
    发明授权
    Methods of concentrating ligands and active membranes used therefor 失效
    浓缩配体和活性膜的方法

    公开(公告)号：US4693985A

    公开(公告)日：1987-09-15

    申请号：US642899

    申请日：1984-08-21

    申请人： Peter J. Degen ,  Jerold Martin ,  Judy Schriefer ,  Brenda Shirley

    发明人： Peter J. Degen ,  Jerold Martin ,  Judy Schriefer ,  Brenda Shirley

    IPC分类号： A61K39/29 ,  A61M1/36 ,  B01D67/00 ,  B01D69/14 ,  C07K14/705 ,  C07K16/00 ,  C07K17/08 ,  C08J9/36 ,  C12N9/00 ,  C12P21/00 ,  G01N33/543 ,  G01N33/545 ,  B01D15/08 ,  B01D39/00

    CPC分类号： B01D67/0093 ,  A61K39/00 ,  B01D69/141 ,  C07K16/00 ,  G01N33/54353 ,  G01N33/545 ,  Y10S436/824 ,  Y10S436/827 ,  Y10S436/828

    摘要： A chemically active membrane having a large surface area is provided in which a hydrophilic, microporous, skinless, polyamide membrane is chemically bound to a residue of an activating agent which is capable of reacting with a biologically active material.The chemically active membrane, formed by reacting a hydrophilic, microporous, skinless, polyamide membrane with an activating agent may be used to prepare a biologically active membrane having a large surface area which comprises an acceptor molecule such as a monoclonal antibody, a polyclonal antibody, an antigenic substance, a glycoprotein, Protein A, a lectin, a carbohydrate, an enzyme substrate, a cofactor, an inhibitor, a hormone, an IgG class of immunoglobulin, a carrier protein, a receptor, heparin, a coagulation factor, or a histone covalently bound to the hydrophilic, microporous, skinless, polyamide membrane by reacting the chemically activate membrane with the acceptor molecule.

    摘要翻译： 提供了具有大表面积的化学活性膜，其中亲水性，微孔性，无皮性聚酰胺膜与能够与生物活性物质反应的活化剂的残基化学结合。 通过使亲水性，微孔性，无皮性聚酰胺膜与活化剂反应形成的化学活性膜可以用于制备具有大表面积的生物活性膜，其包含受体分子，例如单克隆抗体，多克隆抗体， 抗原性物质，糖蛋白，蛋白A，凝集素，碳水化合物，酶底物，辅因子，抑制剂，激素，免疫球蛋白的IgG类，载体蛋白，受体，肝素，凝血因子或 组蛋白通过使化学活化膜与受体分子反应而共价结合到亲水，微孔，无皮，聚酰胺膜。

    Well-type diagnostic plate device
    2.
    发明授权
    Well-type diagnostic plate device 失效
    井型诊断板装置

    公开(公告)号：US4797259A

    公开(公告)日：1989-01-10

    申请号：US941386

    申请日：1986-12-15

    申请人： Vlado I. Matkovich ,  Jerold Martin ,  Peter J. Degen

    发明人： Vlado I. Matkovich ,  Jerold Martin ,  Peter J. Degen

    IPC分类号： G01N31/22 ,  B01D61/18 ,  B01L3/00 ,  G01N33/48 ,  G01N33/52 ,  G01N33/543 ,  C12M1/20

    CPC分类号： B01L3/50255 ,  B01D61/18 ,  G01N33/54366

    摘要： A diagnostic test device is provided including a plate having at least one well, preferably a plurality of wells, each with an open bottom across which a composite membrane comprising three layers is placed, with a hydrophobic, liquid-tight seal provided at the periphery of each well. The composite membrane from the top of upstream side to the bottom or downstream side, in sequence, includes a first reaction or filtration layer formed from a thin, liquophilic, microporous membrane, a second or sealing layer, preferably a hydrophobic material in sheet or fiber form, such as nonwoven polypropylene fibers, and a liquophobic, preferably hydrophobic, barrier layer having one or more apertures which allows liquid to exit the well while eliminating lateral migration of a pendant liquid drop. The liquophobic seal provided by the liquophobic sealing layer eliminates "cross-talk" by lateral diffusion or wicking.

    Manufacturing method for producing sterile milk using dynamic microfiltration
    3.
    发明授权
    Manufacturing method for producing sterile milk using dynamic microfiltration 失效
    使用动态微量滤液生产无菌牛奶的制造方法

    公开(公告)号：US5356651A

    公开(公告)日：1994-10-18

    申请号：US998371

    申请日：1992-12-30

    申请人： Peter J. Degen ,  Tony Alex ,  Joseph W. Dehn, Jr.

    发明人： Peter J. Degen ,  Tony Alex ,  Joseph W. Dehn, Jr.

    IPC分类号： A23C3/00 ,  A23C9/142 ,  B01D61/14 ,  B01D65/02 ,  B01D65/06 ,  A23C1/00 ,  B01D61/00

    CPC分类号： B01D65/02 ,  A23C9/1422 ,  B01D61/147 ,  A23C2210/208 ,  B01D2321/02 ,  B01D2321/04 ,  B01D2321/08 ,  B01D2321/168

    摘要： A method for treating raw milk to produce treated milk having a lower bacterial content than the raw milk. The milk is homogenized and, within about 5 minutes from the homogenization, subjected to dynamic microfiltration, to yield a filtrate which has a lower bacterial content than the initial raw milk. When the flow rate of milk through the microfilter drops below a predetermined level, the dynamic microfilter is removed from milk filtration service, flushed with water, and returned to milk filtration service, the steps being repeated as necessary until the membrane cannot be rejuvenated to a minimum filtration capacity, at which time the membrane is subjected to chemical cleaning to essentially restore the original filtration capacity of the membrane.

    摘要翻译： 一种用于处理生奶以生产具有低于生奶的细菌含量较低的处理过的牛奶的方法。 将乳均匀化，在均化后约5分钟内进行动态微量过滤，得到的滤液的细菌含量低于初始生奶。 当通过微过滤器的牛奶流量下降到预定水平以下时，将动态微型过滤器从牛奶过滤服务中取出，用水冲洗，并返回到牛奶过滤服务中，根据需要重复步骤，直到膜不能复原至 最小过滤能力，此时膜经过化学清洗，基本上恢复了膜的原始过滤能力。

    Method of making a supported microporous membrane
    7.
    发明授权
    Method of making a supported microporous membrane 失效
    制备负载微孔膜的方法

    公开(公告)号：US4826642A

    公开(公告)日：1989-05-02

    申请号：US203821

    申请日：1988-06-08

    申请人： Peter J. Degen ,  Thomas C. Gsell

    发明人： Peter J. Degen ,  Thomas C. Gsell

    IPC分类号： A41D31/02 ,  B01D69/10 ,  B01D13/04

    CPC分类号： A41D31/02 ,  B01D69/10 ,  Y10S264/48 ,  Y10S264/62 ,  Y10S264/75

    摘要： A supported microporous membrane comprising a composite of a microporous membrane and a synthetic thermoplastic web of microfibers secured to the membrane without the use of added adhesive components and having an ASTM D903 peel strength of at least about 2 grams per centimeter, the composite having a modulus of flexure at leasts 10 percent greater than that of the membrane, and the method of manufacturing such supported membranes by contacting thermplastic microfibers with the membrane while the microfibers are at an elevated temperature.

    摘要翻译： 支撑的微多孔膜，其包括微孔膜和合成的纤维的合成热塑性纤维网的复合材料，其固定到膜上，而不使用添加的粘合剂组分，并且具有至少约2克/厘米的ASTM D903剥离强度，所述复合材料具有模量 的挠曲比膜的至少10％，以及当微纤维处于升高的温度时通过使热塑性微纤维与膜接触来制造这种支撑膜的方法。

    Fibrous structure and method of manufacture
    8.
    发明授权
    Fibrous structure and method of manufacture 失效
    纤维结构和制造方法

    公开(公告)号：US4702947A

    公开(公告)日：1987-10-27

    申请号：US846803

    申请日：1986-04-01

    申请人： David B. Pall ,  Peter J. Degen ,  Thomas C. Gsell ,  Eleni C. Yanakis

    发明人： David B. Pall ,  Peter J. Degen ,  Thomas C. Gsell ,  Eleni C. Yanakis

    IPC分类号： D04H1/56 ,  D04H1/64 ,  B32B27/00

    CPC分类号： D04H1/56 ,  D04H1/587 ,  D04H1/64 ,  Y10S261/72 ,  Y10S428/903 ,  Y10T428/1372 ,  Y10T442/614

    摘要： Polymeric microfibrous structures comprised of normally hydrophobic microfibers coated with a cured, precipitated, cationic, thermosetting binder resin or polymer and characterized by being hydrophilic and having a positive zeta potential with enhanced capability for the removal of negatively-charged particulate material in a fluid medium are prepared by a process comprising the steps:(1) combining in a controlled manner a first solution of a water-soluble, non-colloidal, cationic, thermosetting binder resin or polymer and a second solution or dispersion of a precipitating agent to form a stable emulsion or suspension;(2) impregnating the microfibrous structure of normally hydrophobic microfibers with the stable emulsion or suspension to form a fibrous structure wetted with the stable emulsion or suspension; and(3) drying the wetted microfibrous structure and curing the binder resin or polymer.

    摘要翻译： 聚合物微纤维结构包括用固化，沉淀，阳离子，热固性粘合剂树脂或聚合物涂覆的通常疏水的微纤维，其特征在于亲水性并具有增强的在流体介质中去除带负电荷的颗粒材料的能力的正ζ电位， 通过包括以下步骤的方法制备：（1）以受控的方式组合水溶性非胶体阳离子热固性粘合剂树脂或聚合物的第一溶液和沉淀剂的第二溶液或分散体以形成稳定的 乳液或悬浮液; （2）用稳定的乳液或悬浮液浸渍通常疏水的微纤维的微纤维结构，以形成用稳定的乳液或悬浮液润湿的纤维结构; 和（3）干燥湿润的微纤维结构并固化粘合剂树脂或聚合物。

    Dispersion system and method
    9.
    发明授权
    Dispersion system and method 失效
    分散系统和方法

    公开(公告)号：US4534388A

    公开(公告)日：1985-08-13

    申请号：US501889

    申请日：1983-06-07

    申请人： David B. Pall ,  Peter J. Degen ,  John Mischenko, III

    发明人： David B. Pall ,  Peter J. Degen ,  John Mischenko, III

    IPC分类号： B01F3/12 ,  B01F5/06 ,  B02C17/16 ,  H01F1/11 ,  B65B3/04

    CPC分类号： B01F5/068 ,  B01F5/0664 ,  Y10T137/7879

    摘要： A self-cleaning system and method for dispersing aggregates in a fluid medium is provided. The system is comprised of first and second members operatively associated to form an internal chamber and having an inlet to the chamber for admitting the fluid to be treated. At least one of the members is biased toward the other whereby the introduction of a fluid medium to be treated into the chamber under an operating pressure in the range of from about 50 to about 1,000 psid (3.5 to 70.3 kg/cm.sup.2) provides an elongated orifice between the first and second members having a transverse dimension or width of from about 1 to about 1,500 micrometers for egress of the fluid medium. As the fluid passes through the elongated orifice, aggregates contained therein are dispersed. The system is self-cleaning by virtue of the biased nature of at least one of the members toward the other, thereby providing longer onstream operation and requiring less servicing. The system can be used for treating aggregate-containing fluids such as oil well completion fluids, dispersions used in the manufacture of magnetic tape, and dispersion of particulates such as carbon black and other pigments.

    摘要翻译： 提供了一种用于将聚集体分散在流体介质中的自清洁系统和方法。 该系统包括第一和第二构件，第一和第二构件可操作地相关联以形成内部腔室并且具有用于容纳被处理流体的腔室的入口。 至少一个构件偏向另一个，由此在约50至约1,000psid（3.5至70.3kg / cm 2）的操作压力下将待处理的流体介质引入室中，提供细长的 在第一和第二构件之间的孔口具有约1至约1,500微米的横向尺寸或宽度，用于流体介质的流出。 当流体通过细长的孔口时，其中包含的聚集体被分散。 该系统由于至少一个构件朝向另一个的偏压性质而自行清洁，从而提供更长的上游操作并且需要较少的维修。 该系统可用于处理含石油的流体，例如油井完井液，用于制造磁带的分散体，以及诸如炭黑和其它颜料的颗粒分散体。

    Method for producing beer
    10.
    发明授权
    Method for producing beer 失效
    啤酒生产方法

    公开(公告)号：US07132119B1

    公开(公告)日：2006-11-07

    申请号：US09402721

    申请日：1998-04-07

    申请人： Diter Pelz ,  Gilbert Moser ,  Gerald Zanker ,  Walter Serro ,  Volker Ribitsch ,  Horst Randhahn ,  Peter J. Degen

    发明人： Diter Pelz ,  Gilbert Moser ,  Gerald Zanker ,  Walter Serro ,  Volker Ribitsch ,  Horst Randhahn ,  Peter J. Degen

    IPC分类号： C12S9/00

    CPC分类号： B01D65/02 ,  B01D2321/166 ,  C12H1/063

    摘要： The present invention provides a method for producing beer comprising filtering beer through a porous membrane until such time that the porous membrane is in need of cleaning, contacting the porous membrane with an enzyme selected from the group consisting of cellulases, amylases, and combinations thereof, particularly a cellulase having a crystalline:soluble cellulose activity ratio at 60 minutes of at least about 0.1, to clean the porous membrane, and then reusing the porous membrane to continue filtering beer. The present invention further provides a method for producing beer comprising filtering beer through a porous membrane that progressively clogs during filtration, monitoring the streaming or zeta potential of the porous membrane as a measure of the extent of clogging of the porous membrane, halting filtration of the beer through the porous membrane before the porous membrane becomes fully clogged as determined by the streaming or zeta potential of the porous membrane, cleaning the porous membrane, and then reusing the porous membrane to continue filtering beer.

    摘要翻译： 本发明提供一种生产啤酒的方法，其包括通过多孔膜过滤啤酒直到多孔膜需要清洗，使多孔膜与选自纤维素酶，淀粉酶及其组合的酶接触， 特别是在60分钟时具有至少约0.1的结晶：可溶性纤维素活性比的纤维素酶，以清洁多孔膜，然后再利用多孔膜继续过滤啤酒。 本发明还提供一种生产啤酒的方法，其包括通过在过滤期间逐渐堵塞的多孔膜过滤啤酒，监测多孔膜的流动或ζ电位，作为多孔膜堵塞程度的量度，停止过滤 在通过多孔膜的流动或ζ电位确定多孔膜完全堵塞之前，通过多孔膜进行啤酒，清洗多孔膜，然后重新使用多孔膜继续过滤啤酒。