摘要:
A system includes a knot tying device for tying a filament in a knot around an article and a filament delivery device from which is drawn the filament. The filament delivery device may be in the form of a cartridge having a housing sized and arranged to be releasably attached to the knot tying device where the housing has an opening through which pre-cut or loosely coupled lengths of the filament can be drawn. The knot tying device includes a shuttle attachable to the filament where the shuttle is caused to be moved during a knot tying process around an article to be tied and a device for at least pulling the filament away from the article at appropriate times during the knot tying process.
摘要:
A system includes a knot tying device for tying a filament in a knot around an article and a filament delivery device from which is drawn the filament. The filament delivery device may be in the form of a cartridge having a housing sized and arranged to be releasably attached to the knot tying device where the housing has an opening through which pre-cut or loosely coupled lengths of the filament can be drawn. The knot tying device includes a shuttle attachable to the filament where the shuttle is caused to be moved during a knot tying process around an article to be tied and a device for at least pulling the filament away from the article at appropriate times during the knot tying process.
摘要:
Compounds of formula (I) and their use in therapy, particularly for the treatment of a disorder mediated by CB1 receptors, such as obesity, wherein: R1 is aryl or heteroaryl; R2 is alkyl, aryl or heteroaryl; R3 is alkyl, aryl, heteroaryl, NR9R10, OR15, or NR16C(O)R17; Y is C═O, C═S, SO2, or (CR7R8); m=1 or 2; n=1 or 2; and p=1, 2, 3 or 4, R7 to R17 being as defined in the specification; wherein if —Y—R3 is —C(O)NH(alkyl) then: R1 and/or R2 is selected from heteroaryl; and/or m and/or n is 2; and/or R11 and/or R12 is lower alkyl, or a pharmaceutically acceptable salt or prodrug thereof.
摘要翻译:式(I)化合物及其在治疗中的用途,特别是用于治疗CB 1受体介导的病症,例如肥胖症,其中:R 1是芳基或 杂芳基; R 2是烷基,芳基或杂芳基; R 3是烷基,芳基,杂芳基,NR 9 R 10,或15,或NR 15, 16 C(O)R 17; Y是C-O,C-S,SO 2,或(CR 7 R 8)。 m = 1或2; n = 1或2; 和p = 1,2,3或4,R 7至R 17如说明书中所定义; 其中如果-Y-R 3为-C(O)NH(烷基),那么:R 1和/或R 2选自杂芳基; 和/或m和/或n为2; 和/或R 11和/或R 12是低级烷基或其药学上可接受的盐或前药。
摘要:
Chemical compounds of formula (I): and pharmaceutically acceptable salts and addition compounds and prodrugs thereof are useful in therapy, particularly for the treatment of disorders of the central nervous system; damage to the central nervous system; cardiovascular disorders; gastrointestinal disorders; diabetes inspidus, and sleep apnea.
摘要:
A high density polymer-based integrated electrode apparatus that comprises a central electrode body and a multiplicity of arms extending from the electrode body. The central electrode body and the multiplicity of arms are comprised of a silicone material with metal features in said silicone material that comprise electronic circuits.
摘要:
An enclosure for a bathtub is constructed at a factory or other location remote from a site where the bathtub is to be permanently installed. The bathtub is placed permanently in the enclosure at the factory or remote location and once placed, the bathtub and enclosure are in condition for use at its permanent site without the necessity of further assembly.
摘要:
Methods, systems, assemblies, computer program products and devices deliver hyperpolarized gas by: (a) providing a gas delivery valve with at least one gas flow path therein, the valve comprising a valve body and at least one spool held in the valve body; (b) transmitting a pilot command fluid pulse signal to the at least one spool to introduce pressure onto the spool to force the spool to translate an actuation distance in the valve body; and (c) opening and/or closing the at least one gas flow path in response to the transmitted signal to deliver hyperpolarized gas to a subject.
摘要:
A chemical compound of formula (I) wherein R1 and R2 are independently selected from hydrogen and alkyl; R3 is alkyl; R4 and R5 are selected from hydrogen and alkyl; R6 and R7 are independently selected from hydrogen, halogen, hydroxyl, alkyl, aryl, amino, alkylamino, dialkylamino, alkoxy, aryloxy, alkylthio, alkylsulfoxyl, nitro, carbonitrile, carbo-alkoxy, carbo-aryloxy and carboxyl; and A is a 5- or 6-membered ring optionally containing one or more heteroatoms wherein the atoms of the ring A, other than the unsaturated carbon atoms of the phenyl ring to which the ring A is fused, are saturated or unsaturated, and pharmaceutically acceptable salts, addition compounds and prodrugs thereof; and the use thereof in therapy, particularly as an agonist or antagonist of a 5HT receptor, particularly a 5HT2C receptor, for instance in the treatment of disorders of the central nervous system; damage to the central nervous system; cardiovascular disorders; gastrointestinal disorders; diabetes insipidus, and sleep apnea, and particularly for the treatment of obesity.
摘要翻译:式(I)的化合物,其中R 1和R 2各自独立地选自氢和烷基; R 3是烷基; R 4和R 5选自氢和烷基; R 6和R 7独立地选自氢,卤素,羟基,烷基,芳基,氨基,烷基氨基,二烷基氨基,烷氧基,芳氧基,烷硫基,烷基亚砜基,硝基,腈 ,碳 - 烷氧基,碳 - 芳氧基和羧基; 并且A是任选地含有一个或多个杂原子的5-或6-元环,其中除了环A稠合的苯环的不饱和碳原子之外的环A的原子是饱和或不饱和的, 可接受的盐,加成化合物和前药; 以及其在治疗中的用途,特别是作为5HT受体,特别是5HT 2C受体的激动剂或拮抗剂,例如用于治疗中枢神经系统疾病; 损害中枢神经系统; 心血管疾病; 胃肠道疾病; 尿崩症和睡眠呼吸暂停,特别是用于治疗肥胖。
摘要:
A peel and stick electronic system comprises a silicone body, and at least one electronic unit operatively connected to the silicone body. The electronic system is produce by providing a silicone layer on a substrate, providing a metal layer on the silicone layer, and providing at least one electronic unit connected to the metal layer.
摘要:
A maraging steel preferably without cobalt, having the following chemical composition: Ni 18-23 wt. %, Mo 4.5-8 wt. %, Ti 1-2 wt. %, Al 0-0.3 wt. %, C.ltoreq.0.01 wt. %, remainder Fe and impurities. The composition also preferably satisfies the following conditions:Ni+Mo=23-27 wt. %, inclusively;Ni+3.times.Mo+20.times.Ti+10.times.Al.gtoreq.60 wt. %.