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    Bioactive surface coating
    1.
    发明授权
    Bioactive surface coating 失效
    生物活性表面涂层

    公开(公告)号：US06248811B1

    公开(公告)日：2001-06-19

    申请号：US09003033

    申请日：1998-01-05

    申请人： Peter Ottersbach ,  Britta Mensing ,  Gerard Helary ,  Marcel Jozefowicz ,  Veronique Migonney ,  Jean-Pierre Vairon

    发明人： Peter Ottersbach ,  Britta Mensing ,  Gerard Helary ,  Marcel Jozefowicz ,  Veronique Migonney ,  Jean-Pierre Vairon

    IPC分类号： C08K509

    CPC分类号： A01N25/24 ,  A61L27/34 ,  A61L29/085 ,  A61L31/10 ,  B05D3/067 ,  B05D7/02 ,  C08F220/18 ,  C08F230/08

    摘要： A process is disclosed for preparing bioactive, covalently fixed coatings on the surfaces of substrates, by grafting to a surface of the substrate a coating polymer which contains the following monomers in copolymerized form: (i) at least one monomer of the general formula: R—(A)a  (I), in which R is a mono- or diolefinically unsaturated organic radical having a valence a, A is a carboxyl group, a sulfuric acid group, a sulfonic acid group, a phosphoric acid group, a phosphonic acid group, a phosphorous acid group, a phenolic hydroxyl group, or a salt of one of these acid groups, and a is 1, 2 or 3; and (ii) at least one monomer which is sensitive to UV radiation.

    摘要翻译： 公开了一种用于在基材表面上制备生物活性的，共价固定的涂层的方法，该方法是通过将包含以下共聚形式的单体的涂料聚合物接枝到基材的表面上：（i）至少一种通式如下的单体： 其中R为一价或二元烯不饱和有机基团，其价数为a，A为羧基，硫酸基，磺酸基，磷酸基，膦酸基，亚磷酸基，酚羟基 ，或这些酸基之一的盐，和a为1,2或3; 和（ii）至少一种对UV辐射敏感的单体。

    Preparation of carboxylate-sulfonate polymers having cell proliferation-promoting properties
    2.
    发明授权
    Preparation of carboxylate-sulfonate polymers having cell proliferation-promoting properties 失效
    具有细胞增殖促进特性的羧酸盐 - 磺酸盐聚合物的制备

    公开(公告)号：US06365692B1

    公开(公告)日：2002-04-02

    申请号：US09001143

    申请日：1997-12-30

    申请人： Frank Hill ,  Peter Ottersbach ,  Graciella Djavid ,  Marcel Jozefowicz ,  Veronique Migonney ,  Jean-Pierre Vairon

    发明人： Frank Hill ,  Peter Ottersbach ,  Graciella Djavid ,  Marcel Jozefowicz ,  Veronique Migonney ,  Jean-Pierre Vairon

    IPC分类号： C08F228023

    CPC分类号： C08F246/00 ,  A61L27/16 ,  A61L27/34 ,  A61L33/064 ,  C08F220/04 ,  C08F228/00 ,  C08L33/14

    摘要： The invention relates to water-insoluble polymers which promote cell proliferation, contain carboxylate and sulfonate groups and are obtainable by free radical copolymerization of one or more aliphatically unsaturated monomers containing carboxylate groups, or the correspondingly functionalized derivatives of the monomers, as component I with one or more aliphatically unsaturated monomers containing sulfonate groups, or the correspondingly functionalized derivatives of the monomers, as component II and a component III which comprises an aliphatically unsaturated monomer or several aliphatically unsaturated monomers, the correspondingly functionalized derivatives being converted into carboxylate and sulfonate groups after the copolymerization, and to a process for their preparation, wherein the polymers are useful for forming articles which promote cell proliferation.

    摘要翻译： 本发明涉及促进细胞增殖，含有羧酸盐和磺酸盐基团的水不溶性聚合物，可通过一种或多种含有羧酸酯基的脂族不饱和单体或相应的官能化单体衍生物作为组分I与一种 或更多的含有磺酸盐基团的脂族不饱和单体，或单体的相应官能化衍生物作为组分II，组分III包含脂族不饱和单体或几种不饱和脂族不饱和单体，相应的官能化衍生物转变为羧酸盐和磺酸盐基团 共聚合，以及其制备方法，其中聚合物可用于形成促进细胞增殖的制品。

    Carboxylate-sulfonate polymers
    3.
    发明授权
    Carboxylate-sulfonate polymers 失效
    使用具有细胞增殖促进特性的羧酸盐 - 磺酸盐聚合物

    公开(公告)号：US06417000B1

    公开(公告)日：2002-07-09

    申请号：US09999295

    申请日：2001-11-15

    申请人： Frank Hill ,  by Friedrich Frank Hill ,  by Regina Luise Hill ,  Peter Ottersbach ,  Graciella Djavid ,  Marcel Jozefowicz ,  Veronique Migonney ,  Jean-Pierre Vairon

    发明人： Frank Hill ,  by Friedrich Frank Hill ,  by Regina Luise Hill ,  Peter Ottersbach ,  Graciella Djavid ,  Marcel Jozefowicz ,  Veronique Migonney ,  Jean-Pierre Vairon

    IPC分类号： C12N500

    CPC分类号： C08F246/00 ,  A61L27/16 ,  A61L27/34 ,  A61L33/064 ,  C08F220/04 ,  C08F228/00 ,  C08L33/14

    摘要： The invention relates to water-insoluble polymers which promote cell proliferation, contain carboxylate and sulfonate groups and are obtainable by free radical copolymerization of one or more aliphatically unsaturated monomers containing carboxylate groups, or the correspondingly functionalized derivatives of the monomers, as component I with one or more aliphatically unsaturated monomers containing sulfonate groups, or the correspondingly functionalized derivatives of the monomers, as component II and a component III which comprises an aliphatically unsaturated monomer or several aliphatically unsaturated monomers, the correspondingly functionalized derivatives being converted into carboxylate and sulfonate groups after the copolymerization, and to a process for their preparation, wherein the polymers are useful for forming articles which promote cell proliferation.

    摘要翻译： 本发明涉及促进细胞增殖，含有羧酸盐和磺酸盐基团的水不溶性聚合物，可通过一种或多种含有羧酸酯基的脂族不饱和单体或相应的官能化单体衍生物作为组分I与一种 或更多的含有磺酸盐基团的脂族不饱和单体，或单体的相应官能化衍生物作为组分II，组分III包含脂族不饱和单体或几种不饱和脂族不饱和单体，相应的官能化衍生物转变为羧酸盐和磺酸盐基团 共聚合，以及其制备方法，其中聚合物可用于形成促进细胞增殖的制品。

    Water insoluble bacteriophobic polymers containing carboxyl and sulfonic acid groups
    4.
    发明授权
    Water insoluble bacteriophobic polymers containing carboxyl and sulfonic acid groups 失效
    含有羧基和磺酸基的水不溶性细菌性聚合物

    公开(公告)号：US06218492B1

    公开(公告)日：2001-04-17

    申请号：US09065457

    申请日：1998-04-24

    申请人： Frank Hill ,  Peter Ottersbach ,  Graciella Djavid ,  Marcel Jozefowicz ,  Veronique Migonney ,  Jean-Pierre Vairon

    发明人： Frank Hill ,  Peter Ottersbach ,  Graciella Djavid ,  Marcel Jozefowicz ,  Veronique Migonney ,  Jean-Pierre Vairon

    IPC分类号： C08F22802

    CPC分类号： C08F246/00 ,  A01N25/10 ,  A61L17/00 ,  A61L17/145 ,  A61L27/16 ,  A61L27/34 ,  A61L29/041 ,  A61L29/085 ,  A61L31/048 ,  A61L31/10 ,  C08F220/04 ,  C08L33/02 ,  C08L43/02 ,  C08L33/14

    摘要： The invention relates to water-insoluble, bacteriophobic and optionally cell proliferation-inhibiting polymers obtainable by free-radical polymerization of (a) at least one monomer of the general formula R—(A)a, in which R is an aliphatically unsaturated organic radical with the valence a, A is a carboxyl group —COOH, sulfuric acid group —OSO2OH, sulfonic acid group —SO3H, phosphoric acid group —OPO(OH)2, phosphonic acid group —PO(OH)2, phosphorous acid group —OP(OH)2, a phenolic hydroxyl group or a salt of one of the groups, and a is 1, 2 or 3, with the proviso that, if the monomer of the formula I contains a carboxyl group —COOH or a carboxylate group, either this monomer contains at least one further radical A having a different one of the definitions specified for A, or at least one further monomer of the formula I is also used in which A has a different one of the definitions specified for A; and (b) at least one other aliphatically unsaturated monomer, wherein the polymers are useful for forming bacteriophobic or cell proliferation-inhibiting articles.

    摘要翻译： 本发明涉及通过（a）至少一种通式R-（A）a的单体的自由基聚合可获得的水不溶性，细菌抑制和任选的细胞增殖抑制聚合物，其中R是脂族不饱和有机基团 化合价a，A为羧基-COOH，硫酸基-OSO2OH，磺酸基-SO3H，磷酸基-OPO（OH）2，膦酸基-PO（OH）2，亚磷酸基-POP （OH）2，酚羟基或其中一个的盐，a是1,2或3，条件是如果式I的单体含有羧基-COOH或羧酸酯基， 该单体含有至少一种具有与A相关的不同定义的另一个基团A，或者还使用至少一种另外的式I的单体，其中A具有不同的A定义的定义; 和（b）至少一种其它脂族不饱和单体，其中所述聚合物可用于形成抑制细菌抑制或细胞增殖的制品。

    Polymers derived from crosslinked polystyrenes and dextrans, their methods of preparation and their applications for the analysis and purification of molecules of biological origin
    7.
    发明授权
    Polymers derived from crosslinked polystyrenes and dextrans, their methods of preparation and their applications for the analysis and purification of molecules of biological origin 失效
    衍生自交联聚苯乙烯和葡聚糖的聚合物，其制备方法及其在分析和纯化生物来源分子中的应用

    公开(公告)号：US4950712A

    公开(公告)日：1990-08-21

    申请号：US235113

    申请日：1988-08-22

    申请人： Didier Letourneur ,  Colette Douzon ,  Veronique Migonney ,  Daniel A. Muller ,  Marcel Jozefowicz

    发明人： Didier Letourneur ,  Colette Douzon ,  Veronique Migonney ,  Daniel A. Muller ,  Marcel Jozefowicz

    IPC分类号： A61M1/36 ,  B01J20/26 ,  B01J39/12 ,  C08B37/02 ,  C08F8/30 ,  C08F8/34 ,  C08F8/40 ,  C08L25/00 ,  G01N33/545 ,  G01N33/86

    CPC分类号： G01N33/86 ,  A61M1/3679 ,  B01J20/26 ,  B01J39/12 ,  C08B37/0021 ,  C08F8/30 ,  C08F8/34 ,  C08F8/40 ,  G01N33/545

    摘要： These resins derived from a crosslinked styrene (co)-polymer, or from a crosslinked dextran, comprise a (co)-polymer chain which is substituted with one or more groups, which may be identical or different, belonging to the following categories: --Z--A.sub.1 ; --Z--A.sub.2 ; --Z--A.sub.1 --Z'--A.sub.2 ; --Z--A.sub.1 --A.sub.3 --A.sub.2 ; --Z--A.sub.1 --A.sub.4, where Z=spacer chain, Z'=linking chain, A.sub.1 =phosphate residue, A.sub.2 =residue of purine or pyrimidine base, A.sub.3 =sugar residue and A.sub.4 =residue of a molecule participating in the polar structure of various phospholipids. These resins are applicable for the analysis and purification of molecules of biological origin, in particular as a stationary phase in ion-exchange and affinity chromatography, especially for carrying out the fractionation of protein mixtures. Their interaction with proteins, in particular the anti-DNA and anti-phospholipid antibodies present in the serum of patients suffering from SLE, makes them applicable to operations for the selective purification of the different types of antibodies developed by lupus patients.

    摘要翻译： 衍生自交联苯乙烯（共）聚合物或交联葡聚糖的这些树脂包含被一个或多个可以相同或不同的基团取代的（共） - 聚合物链，属于以下类别： Z-A1; -Z-A2; -Z-A1-Z'-A2; -Z-A1-A3-A2; -Z-A1-A4，其中Z =间隔链，Z'=连接链，A1 =磷酸酯残基，A2 =嘌呤或嘧啶碱基的残基，A3 =糖残基，A4 =参与极性结构的分子的残基 各种磷脂。 这些树脂适用于分离和纯化生物来源的分子，特别是作为离子交换和亲和层析中的固定相，特别是用于进行蛋白质混合物的分级分离。 它们与蛋白质的相互作用，特别是存在于患有SLE的患者的血清中的抗DNA和抗磷脂抗体，使得它们适用于由狼疮患者开发的不同类型的抗体的选择性纯化的操作。

    Dextran derivatives, preparation and medicinal applications
    8.
    发明授权
    Dextran derivatives, preparation and medicinal applications 失效
    葡聚糖衍生物，制剂和药物应用

    公开(公告)号：US06646120B1

    公开(公告)日：2003-11-11

    申请号：US09367111

    申请日：2000-09-26

    申请人： Frederic Chaubet ,  Remi Huynh ,  Latifa Dahri ,  Jose Correia ,  Marcel Jozefowicz ,  Jacqueline Jozefonvicz

    发明人： Frederic Chaubet ,  Remi Huynh ,  Latifa Dahri ,  Jose Correia ,  Marcel Jozefowicz ,  Jacqueline Jozefonvicz

    IPC分类号： C08B3702

    CPC分类号： C08B37/0021

    摘要： The invention concerns dextran derivatives, their applications as medicines with specific biological action, and their preparation method. Said derivatives correspond to the general formula DMCaBbSUcSd, in which: D represents a polysaccharide chain, preferably consisting of sequences of glucoside units, MC represents methylcarboxylate groups, B represents carboxymethylbenzylamide groups, Su represents sulphate groups, S represents sulphonate groups, a, b, c and d represent the degree of substitution (ds), respectively in groups, MC, B, Su and S; a being equal to 0 or ≧0.3, b being equal to 0 or ≧0.1, c being equal to 0 or ≧0.1 and d being equal to 0 or ≧0.1 provided that when d=0, a and/or b are not equal to 0, said products having homogeneity of chain size distribution, illustrated by a gauss elution profile symmetrical in high performance steric exclusion chromatography, and homogeneity in the distribution of charged chemical groups, illustrated by an elution profile with a single symmetrical peak in low pressure ion-exchange chromatography.

    摘要翻译： 本发明涉及葡聚糖衍生物，它们作为具有特定生物作用的药物的应用及其制备方法。 所述衍生物对应于通式DMCaBbSUcSd，其中：D表示多糖链，优选由葡萄糖苷单元序列组成，MC表示甲基羧酸酯基，B表示羧甲基苄基酰胺基，Su表示硫酸基，S表示磺酸酯基，a，b， c和d分别代表组，MC，B，Su和S的取代度（ds）; a等于0或> = 0.3，b等于0或> = 0.1，c等于0或> = 0.1，d等于0或> = 0.1，条件是当d = 0时，a和/或 b不等于0，所述产物具有链尺寸分布的均匀性，由高效空间排阻色谱中对称的高斯洗脱曲线所示，以及带电化学基团分布的均匀性，通过具有单个对称峰的洗脱曲线 在低压离子交换层析中。

    Pharmaceutical compositions with wound healing or anti-complementary activity comprising a dextran derivative
    9.
    发明授权
    Pharmaceutical compositions with wound healing or anti-complementary activity comprising a dextran derivative 失效
    具有伤口愈合或抗互补活性的药物组合物，其包含葡聚糖衍生物

    公开(公告)号：US07101863B2

    公开(公告)日：2006-09-05

    申请号：US10020044

    申请日：2001-12-13

    申请人： Latifa Dahricorreia ,  Jacqueline Jozefonvicz ,  Marcel Jozefowicz ,  José Correia ,  Rémi Huynh

    发明人： Latifa Dahricorreia ,  Jacqueline Jozefonvicz ,  Marcel Jozefowicz ,  José Correia ,  Rémi Huynh

    IPC分类号： A61K31/721 ,  C08B37/02

    CPC分类号： A61K31/721 ,  C08B37/0021

    摘要： The invention concerns pharmaceutical compositions with wound healing or anti-complementary activity, and their uses, said compositions comprising, (1) at least a dextran derivative of general formula DMCaBbSuc, a, b, and c respectively representing the degrees of substitution in the groups MC, B and Su, wherein a≧0.6, b=0 or ≧0.1, and c=0 or ranges widely between 0.1 and 0.5 for a wound healing composition, and a≧0.3, b≧0.1 and c=0 or ranges widely between 0.1 and 0.4 for a composition with anti-complementary activity; (2) and at least a pharmaceutically acceptable carrier, said dextran derivative being present in a single unit dose or at a concentration adapted to the desired wound healing or anti-complementary activity.

    摘要翻译： 本发明涉及具有伤口愈合或抗互补活性的药物组合物及其用途，所述组合物包含：（1）至少一种通式DMC的一种葡聚糖衍生物， 分别代表组MC，B和Su中取代度的a，b和c，其中a> = 0.6，b = 0或> = 0.1，c = 0 或对于伤口愈合组合物，范围广泛在0.1至0.5之间，对于具有抗互补活性的组合物，≥0.3，b> = 0.1和c = 0或广泛范围在0.1至0.4范围内; （2）和至少一种药学上可接受的载体，所述葡聚糖衍生物以单一单位剂量或以适合于所需伤口愈合或抗互补活性的浓度存在。