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1.
公开(公告)号:US08039648B2
公开(公告)日:2011-10-18
申请号:US12485439
申请日:2009-06-16
申请人: Peter T. Czerney , Surbhi Desai , Matthias S. Wenzel , Boguslawa Dworecki , Frank G. Lehmann , Bernd G. Schweder , Wilhelm G. Frank
发明人: Peter T. Czerney , Surbhi Desai , Matthias S. Wenzel , Boguslawa Dworecki , Frank G. Lehmann , Bernd G. Schweder , Wilhelm G. Frank
IPC分类号: C07D311/08
CPC分类号: C07D405/12 , C07D311/94 , G01N33/533
摘要: Compounds used as dyes comparable to Alexa Fluor 350 dyes. The inventive compounds have high fluorescence quantum yield and high photostability. The dyes facilitate analysis of biological structures with enhanced sensitivity and selectivity.
摘要翻译: 用作染料的化合物与Alexa Fluor 350染料相当。 本发明化合物具有高荧光量子产率和高光稳定性。 染料促进生物结构的分析,增强灵敏度和选择性。
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2.
公开(公告)号:US20100317045A1
公开(公告)日:2010-12-16
申请号:US12485439
申请日:2009-06-16
申请人: Surbhi Desai , Boguslawa Dworecki , Matthias S. Wenzel , Peter T. Czerney , Frank G. Lehmann , Bernd G. Schweder , Wilhelm G. Frank
发明人: Surbhi Desai , Boguslawa Dworecki , Matthias S. Wenzel , Peter T. Czerney , Frank G. Lehmann , Bernd G. Schweder , Wilhelm G. Frank
IPC分类号: C12Q1/02 , C07D311/94
CPC分类号: C07D405/12 , C07D311/94 , G01N33/533
摘要: Compounds used as dyes comperable to Alexa Fluor 350 dyes. The inventive compounds have high fluorescence quantum yield and high photostability. The dyes facilitate analysis of biological structures with enhanced sensitivity and selectivity.
摘要翻译: 用作Alexa Fluor 350染料的染料的化合物。 本发明化合物具有高荧光量子产率和高光稳定性。 染料促进生物结构的分析,增强灵敏度和选择性。
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公开(公告)号:US20130045488A1
公开(公告)日:2013-02-21
申请号:US13571858
申请日:2012-08-10
申请人: Greg Hermanson , Peter T. Czerney , Surbhi Desai , Matthias S. Wenzel , Boguslawa Dworecki , Frank G. Lehmann , Marie Christine Nlend
发明人: Greg Hermanson , Peter T. Czerney , Surbhi Desai , Matthias S. Wenzel , Boguslawa Dworecki , Frank G. Lehmann , Marie Christine Nlend
IPC分类号: C07D403/14 , C07K16/00 , C12N9/96 , C07H21/00 , C07D235/02 , G01N27/447 , C07K14/575 , C07K14/475 , C12N5/00 , G01N33/566 , G01N33/53 , C07D403/06 , C07K14/00 , C07H1/00
CPC分类号: C07D403/06 , A61K49/0034 , A61K49/0058 , C07D495/04 , C07H3/00 , C07H21/00 , C07K14/00 , C07K14/475 , C07K14/575 , C07K16/00 , C09B23/083 , G01N33/5308
摘要: Compounds useful as labels with properties comparable to known fluorescent compounds. The compounds are conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided.
摘要翻译: 可用作具有与已知荧光化合物相当的性质的标记的化合物。 这些化合物与蛋白质和核酸结合,用于生物成像和分析。 提供了化合物的合成,共轭化合物的形成和用途,以及各自的具体非限制性实例。
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公开(公告)号:US09249307B2
公开(公告)日:2016-02-02
申请号:US13571858
申请日:2012-08-10
申请人: Greg Hermanson , Peter T. Czerney , Surbhi Desai , Matthias S. Wenzel , Boguslawa Dworecki , Frank G. Lehmann , Marie Christine Nlend
发明人: Greg Hermanson , Peter T. Czerney , Surbhi Desai , Matthias S. Wenzel , Boguslawa Dworecki , Frank G. Lehmann , Marie Christine Nlend
IPC分类号: G01N33/533 , A61K49/00 , C09B23/08
CPC分类号: C07D403/06 , A61K49/0034 , A61K49/0058 , C07D495/04 , C07H3/00 , C07H21/00 , C07K14/00 , C07K14/475 , C07K14/575 , C07K16/00 , C09B23/083 , G01N33/5308
摘要: Compounds useful as labels with properties comparable to known fluorescent compounds. The compounds are conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided.
摘要翻译: 可用作具有与已知荧光化合物相当的性质的标记的化合物。 这些化合物与蛋白质和核酸结合,用于生物成像和分析。 提供了化合物的合成,共轭化合物的形成和用途,以及各自的具体非限制性实例。
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公开(公告)号:US08889884B1
公开(公告)日:2014-11-18
申请号:US13546483
申请日:2012-07-11
申请人: Greg Hermanson , Peter T. Czerney , Surbhi Desai , Suk J. Hong , Matthias S. Wenzel , Boguslawa Dworecki , Frank G. Lehmann
发明人: Greg Hermanson , Peter T. Czerney , Surbhi Desai , Suk J. Hong , Matthias S. Wenzel , Boguslawa Dworecki , Frank G. Lehmann
IPC分类号: C07F9/535
CPC分类号: C07F9/6561 , C07F9/535 , C07F9/65583 , C07K1/13 , C07K14/00 , C07K16/00 , C07K2317/20 , G01N33/582
摘要: A phosphine derivative of DyLight dyes modified with ethylene glycol or (poly)ethylene glycol groups. In one embodiment, the compounds are useful in chemoselective ligation reactions.
摘要翻译: 用乙二醇或(聚)乙二醇基改性的DyLight染料的膦衍生物。 在一个实施方案中,所述化合物可用于化学选择性连接反应。
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公开(公告)号:US20120294807A9
公开(公告)日:2012-11-22
申请号:US13330993
申请日:2011-12-20
申请人: Greg Hermanson , Peter T. Czerney , Surbhi Desai , Matthias S. Wenzel , Boguslawa Dworecki , Frank G. Lehmann
发明人: Greg Hermanson , Peter T. Czerney , Surbhi Desai , Matthias S. Wenzel , Boguslawa Dworecki , Frank G. Lehmann
IPC分类号: G01N33/53 , C07K14/00 , C07K17/02 , C12N9/96 , C07H19/04 , C07H21/00 , C07K14/475 , C12N11/02 , C07K14/575 , C07H1/00 , G01N33/567 , A61K49/00 , C40B30/04 , G01N27/447 , C07D209/04
CPC分类号: C07D403/06 , C07D209/10
摘要: Compounds used as labels with properties comparable to known fluorescent compounds. The compounds can be conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided.
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公开(公告)号:US20120156140A1
公开(公告)日:2012-06-21
申请号:US13330993
申请日:2011-12-20
申请人: Greg Hermanson , Peter T. Czerney , Surbhi Desai , Matthias S. Wenzel , Boguslawa Dworecki , Frank G. Lehmann
发明人: Greg Hermanson , Peter T. Czerney , Surbhi Desai , Matthias S. Wenzel , Boguslawa Dworecki , Frank G. Lehmann
IPC分类号: G01N33/53 , C07K14/00 , C07K17/02 , C12N9/96 , C07H19/04 , C07H21/00 , C07K14/475 , C12N11/02 , C07K14/575 , C07H1/00 , G01N33/567 , A61K49/00 , C40B30/04 , G01N27/447 , C07D209/04
CPC分类号: C07D403/06 , C07D209/10
摘要: Compounds used as labels with properties comparable to known fluorescent compounds. The compounds can be conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided.
摘要翻译: 用作具有与已知荧光化合物相当的特性的标签的化合物。 这些化合物可以与蛋白质和核酸结合,用于生物成像和分析。 提供了化合物的合成,共轭化合物的形成和用途,以及各自的具体非限制性实例。
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公开(公告)号:US07947506B2
公开(公告)日:2011-05-24
申请号:US11421883
申请日:2006-06-02
申请人: Brian David Wolf , Surbhi Desai , Peter T. Czerney , Frank G. Lehmann , Bernd G. Schweder , Matthias S. Wenzel
发明人: Brian David Wolf , Surbhi Desai , Peter T. Czerney , Frank G. Lehmann , Bernd G. Schweder , Matthias S. Wenzel
CPC分类号: G01N33/6839
摘要: A hydroxyquinolone compound formulated as a fluorescent dye for protein detection, assay, quantitation, etc. The hydroxyquinolone compound may be modified, for example, by adding or removing sulfate groups, changing hydrocarbon chain lengths, etc. to result in more desirable properties such as enhanced binding to basic proteins, enhanced solubility, etc. The dye has enhanced sensitivity over commercially available protein stains, and may be used to stain proteins in solution, proteins separated on gels, proteins transferred to solid supports, etc. Methods of using the dyes are also disclosed.
摘要翻译: 配制为用于蛋白质检测,测定,定量等的荧光染料的羟基喹诺酮化合物。羟基喹诺酮化合物可以通过例如加入或除去硫酸根,改变烃链长度等来改变以产生更理想的性质,例如 增强的与碱性蛋白质的结合,增加的溶解度等。染料比商业上可获得的蛋白质污渍具有更高的灵敏度,并且可用于染色溶液中的蛋白质,凝胶上分离的蛋白质,转移到固体支持物上的蛋白质等。使用染料的方法 也被披露。
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公开(公告)号:US10053447B2
公开(公告)日:2018-08-21
申请号:US13330993
申请日:2011-12-20
申请人: Greg Hermanson , Peter T. Czerney , Surbhi Desai , Matthias S. Wenzel , Boguslawa Dworecki , Frank G. Lehmann
发明人: Greg Hermanson , Peter T. Czerney , Surbhi Desai , Matthias S. Wenzel , Boguslawa Dworecki , Frank G. Lehmann
IPC分类号: A61B10/00 , A61B5/00 , A61B8/00 , C07D403/06 , C07D209/10
CPC分类号: C07D403/06 , C07D209/10
摘要: Compounds used as labels with properties comparable to known fluorescent compounds. The compounds can be conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided.
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公开(公告)号:US20130251637A9
公开(公告)日:2013-09-26
申请号:US13330993
申请日:2011-12-20
申请人: Greg Hermanson , Peter T. Czerney , Surbhi Desai , Matthias S. Wenzel , Boguslawa Dworecki , Frank G. Lehmann
发明人: Greg Hermanson , Peter T. Czerney , Surbhi Desai , Matthias S. Wenzel , Boguslawa Dworecki , Frank G. Lehmann
IPC分类号: G01N33/53 , C07K14/00 , C07K17/02 , C12N9/96 , C07H19/04 , C07H21/00 , C07K14/475 , C12N11/02 , C07K14/575 , C07H1/00 , G01N33/567 , A61K49/00 , C40B30/04 , G01N27/447 , C07D209/04
CPC分类号: C07D403/06 , C07D209/10
摘要: Compounds used as labels with properties comparable to known fluorescent compounds. The compounds can be conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided.
摘要翻译: 用作具有与已知荧光化合物相当的特性的标签的化合物。 这些化合物可以与蛋白质和核酸结合,用于生物成像和分析。 提供了化合物的合成,共轭化合物的形成和用途,以及各自的具体非限制性实例。
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