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    Polymeric supports
    6.
    发明授权
    Polymeric supports 失效
    聚合物载体

    公开(公告)号：US5336742A

    公开(公告)日：1994-08-09

    申请号：US891781

    申请日：1992-06-01

    申请人： Steven M. Heilmann ,  Jerald K. Rasmussen ,  Larry R. Krepski ,  Dean S. Milbrath ,  Patrick L. Coleman

    发明人： Steven M. Heilmann ,  Jerald K. Rasmussen ,  Larry R. Krepski ,  Dean S. Milbrath ,  Patrick L. Coleman

    IPC分类号： A61K39/395 ,  B01J20/26 ,  C07K17/08 ,  C08F8/00 ,  C08F8/48 ,  C08F20/58 ,  C12N11/08 ,  C08F226/06 ,  C08F220/58

    CPC分类号： C12N11/08 ,  A61K39/39525 ,  B01J20/26 ,  C07K17/08 ,  C08F20/58 ,  C08F8/00 ,  C08F8/48

    摘要： Azlactone-functional polymer supports are useful reactive supports for the attachment of functional materials to provide novel adduct beads. The adduct beads are useful as complexing agents, catalysts, polymeric reagents, chromatographic supports, and as enzyme- or other biologically active supports. Novel carboxylate-functional polymer beads, are intermediates in the preparation of the azlactone-functional beads.Azlactone-functional supports have units of the formula: ##STR1## wherein R.sup.1 is H or CH.sub.3,R.sup.2 and R.sup.3 independently can be an alkyl group having 1 to 14 carbon atoms, a cycloalkyl group having 3 to 14 carbon atoms, an aryl group having 5 to 12 ring atoms, an arenyl group having 6 to 26 carbon and 0 to 3 S, N, and nonperoxidic O heteroatoms, or R.sup.2 and R.sup.3 taken together with the carbon to which they are joined can form a carbocyclic ring containing 4 to 12 ring atoms, andn is an integer 0 or 1,the azlactone functional supports having 0.1 to 99 molar parts of crosslinking monomer incorporated therein.

    摘要翻译： 吖内酯官能聚合物载体是用于附着功能材料以提供新型加合珠的有用的反应性载体。 加合珠可用作络合剂，催化剂，聚合物试剂，色谱载体，以及酶或其它生物活性载体。 新型羧酸盐官能化聚合物珠粒是制备吖内酯官能团珠粒的中间体。 吖内酯官能载体具有下式的单元：其中R 1为H或CH 3，R 2和R 3可独立地为具有1至14个碳原子的烷基，具有3至14个碳原子的环烷基，芳基 具有5至12个环原子，具有6至26个碳和0至3个S，N和非过氧O的杂原子的芳基，或与其连接的碳一起的R 2和R 3可以形成含有4至 12个环原子，n为0或1的整数，所述吖内酯官能载体中含有0.1至99摩尔份的交联单体。

    Variably crosslinked polymeric supports
    8.
    发明授权
    Variably crosslinked polymeric supports 失效
    可变交联的聚合物载体

    公开(公告)号：US4871824A

    公开(公告)日：1989-10-03

    申请号：US158258

    申请日：1988-02-19

    申请人： Steven M. Heilmann ,  Jerald K. Rasmussen ,  Larry R. Krepski ,  Dean S. Milbrath ,  Patrick L. Coleman

    发明人： Steven M. Heilmann ,  Jerald K. Rasmussen ,  Larry R. Krepski ,  Dean S. Milbrath ,  Patrick L. Coleman

    IPC分类号： C08F8/12 ,  A61K39/395 ,  B01J20/26 ,  C07K17/08 ,  C08F8/00 ,  C08F8/30 ,  C08F8/32 ,  C08F8/48 ,  C08F20/52 ,  C08F20/58 ,  C08F26/00 ,  C08F220/58 ,  C08F226/06 ,  C12N11/08

    CPC分类号： C12N11/08 ,  A61K39/39525 ,  B01J20/26 ,  C07K17/08 ,  C08F20/58 ,  C08F8/00

    摘要： Azlactone-functional polymer beads are useful reactive supports for the attachment of functional materials to provide novel adduct beads. The adduct beads are useful as complexing agents, catalysts, polymeric reagents, chromatographic supports, and as enzyme- or other biomacromolecule-bearing supports. Novel carboxylate-functional polymer beads, are intermediates in the preparation of the azlactone-functional beads.Azlactone-functional beads have units of the formula: ##STR1## wherein R.sup.1 is H or CH.sub.3,R.sup.2 and R.sup.3 independently can be an alkyl group having 1 to 14 carbon atoms, a cycloalkyl group having 3 to 14 carbon atoms, an aryl group having 5 to 12 ring atoms, an arenyl group having 6 to 26 carbon and 0 to 3 S, N, and nonperoxidic O heteroatoms, or R.sup.2 and R.sup.3 taken together with the carbon to which they are joined can form a carbocyclic ring containing 4 to 12 ring atoms, andn is an integer 0 or 1, the azlactone functional beads having more than 5 and up to 99 molar parts of crosslinking monomer incorporated therein.

    摘要翻译： 吖内酯官能聚合物珠是用于附着功能材料以提供新型加合珠的有用的反应性载体。 加合珠可用作络合剂，催化剂，聚合物试剂，色谱载体，以及作为酶或其他生物大分子载体的载体。 新型羧酸盐官能化聚合物珠粒是制备吖内酯官能团珠粒的中间体。 吖内酯功能性珠粒具有下式的单元：其中R 1是H或CH 3，R 2和R 3可以独立地为具有1至14个碳原子的烷基，具有3至14个碳原子的环烷基，芳基 具有5至12个环原子，具有6至26个碳和0至3个S，N和非过氧O的杂原子的芳基，或与其连接的碳一起的R 2和R 3可以形成含有4至 12个环原子，并且n为整数0或1，所述吖内酯官能团珠具有多于5个且至多99摩尔份的交联单体。

    Substrates for the quantitative determination of proteolytic enzymes
    9.
    发明授权
    Substrates for the quantitative determination of proteolytic enzymes 失效
    用于定量测定蛋白水解酶的底物

    公开(公告)号：US4434096A

    公开(公告)日：1984-02-28

    申请号：US279161

    申请日：1981-06-30

    申请人： Patrick L. Coleman ,  John A. Wehrly

    发明人： Patrick L. Coleman ,  John A. Wehrly

    IPC分类号： C07K5/083 ,  C07K5/087 ,  C07C103/52

    CPC分类号： C07K5/0812 ,  C07K5/0808

    摘要： There is provided a group of tripeptide thiol ester substrates of the following generalized structure:B--AA.sub.3 --AA.sub.2 --AA.sub.1 --S--R.These substrates yield, upon enzymatic cleavage of the thiol ester bond, thiols which can be quantified accurately through certain coupling reactions. The substrates are useful for the quantitative determination of proteolytic enzymes in biological fluids.

    摘要翻译： 提供了一组具有以下通用结构的三肽硫羟酸酯底物：B-AA3-AA2-AA1-S-R。 这些底物在硫醇酯键的酶裂解时产生可通过某些偶联反应精确定量的硫醇。 底物可用于定量测定生物液体中的蛋白水解酶。