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公开(公告)号：US06488828B1
公开(公告)日：2002-12-03
申请号：US09620191
申请日：2000-07-20
IPC分类号： G01N27327
CPC分类号： B01L3/5023 , B01L2200/082 , B01L2300/043 , B01L2300/046 , B01L2300/047 , B01L2300/0825 , B01L2300/0887 , B01L2300/105 , B01L2400/0406 , G01N33/52
摘要： A recloseable biosensor is provided that comprises a substrate, a sample site positioned on the substrate, and an openable and recloseable cover coupled to the substrate. The cover is operative to selectively block access to the sample site. The cover includes a fixed end coupled to the substrate, an opposite free end, and a middle portion extending across the sample site. The middle portion is releasably and recloseably adhered to the substrate.
摘要翻译： 提供了一种可重新开关的生物传感器，其包括衬底，位于衬底上的样品位置以及耦合到衬底的可打开和可再封闭的盖。 该盖可操作以选择性地阻止对样品位置的访问。 盖子包括一个连接到基片的固定端，一个相对的自由端，和一个延伸穿过样品位置的中间部分。 中间部分可释放地和可重新闭合地粘附到基底上。
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公开(公告)号：US06428664B1
公开(公告)日：2002-08-06
申请号：US09596846
申请日：2000-06-19
IPC分类号： C12M100
CPC分类号： G01N27/3272 , G01N33/4875
摘要： A biosensor is provided in accordance with this invention. The biosensor includes a bottom section with an edge and a flange extending from the edge, a top section supported on the bottom section and having an edge and flange extending from the edge in alignment with the flange of the bottom section. The flanges of the top and bottom sections cooperate to form a capillary channel, and first and second electrodes. Additionally, the first electrode is positioned on the flange of the bottom section in the capillary channel and the second electrode is positioned on the flange of the top section in the capillary channel.
摘要翻译： 根据本发明提供生物传感器。 生物传感器包括具有边缘的边缘和从边缘延伸的凸缘的底部，支撑在底部上的顶部，并且具有从边缘与底部的凸缘对准延伸的边缘和凸缘。 顶部和底部部分的凸缘协作形成毛细通道，以及第一和第二电极。 此外，第一电极位于毛细管通道中的底部的凸缘上，而第二电极位于毛细通道中顶部的凸缘上。
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公开(公告)号：US07063774B2
公开(公告)日：2006-06-20
申请号：US10281717
申请日：2002-10-28
IPC分类号： G01N27/327
CPC分类号： B01L3/5023 , B01L2200/082 , B01L2300/043 , B01L2300/046 , B01L2300/047 , B01L2300/0825 , B01L2300/0887 , B01L2300/105 , B01L2400/0406 , G01N33/52
摘要： A biosensor is provided that comprises a substrate, a sample site positioned on the substrate, a cover coupled to the substrate, and biocide positioned between the substrate and the cover. The biosensor may also include desiccant. The cover is operative to selectively block access to the sample site. The cover includes a fixed end coupled to the substrate, an opposite free end, and a middle portion extending across the sample site. The middle portion is releasably and recloseably adhered to the substrate.
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公开(公告)号：US06413395B1
公开(公告)日：2002-07-02
申请号：US09465870
申请日：1999-12-16
IPC分类号： G01N27327
CPC分类号： G01N27/3271 , B01L3/5027
摘要： According to an aspect of the invention a biosensor apparatus is provided, comprising a base, electrodes positioned on the base, a cover including ports, a plate positioned on the base and including apertures in communication with at least one of the electrodes, a cover including ports in communication with the plate and offset from the apertures, and at least one reagent positioned between the plate and the cover. According to a preferred embodiment the plate includes microstructures extending into the ports of the cover.
摘要翻译： 根据本发明的一个方面，提供了一种生物传感器装置，其包括基座，位于基座上的电极，包括端口的盖，位于基座上的板，并且包括与至少一个电极连通的孔，盖包括 与板连通并与孔偏移的端口以及位于板和盖之间的至少一个试剂。 根据优选实施例，板包括延伸到盖的端口中的微结构。
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公开(公告)号：USD441089S1
公开(公告)日：2001-04-24
申请号：US29125254
申请日：2000-06-19
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公开(公告)号：US06562210B1
公开(公告)日：2003-05-13
申请号：US09475904
申请日：1999-12-30
IPC分类号： G01N27327
CPC分类号： C12Q1/001
摘要： According to an aspect of the invention, an electrochemical cell for analysis of a sample is provided, comprising a dual electrode having a dielectric strip with electrical conductors on opposite sides. According to a preferred embodiment, the electrochemical cell comprises a base, and a first reagent the proximate the dual electrode. According to a further preferred embodiment, a second reagent is provided proximate the dual electrode. A cover may also be provided comprising a sample aperture. According to a particularly preferred embodiment, the first and second reagents are superposed, and the dual electrode is between the first and second reagents. The dual electrode separates the two and preserves chemical stability until a sample is applied.
摘要翻译： 根据本发明的一个方面，提供了一种用于分析样品的电化学电池，包括具有在相对侧上具有电导体的介电条的双电极。 根据一个优选的实施方案，电化学电池包括基底和靠近双电极的第一试剂。 根据另一优选实施例，第二试剂设置在双电极附近。 还可以提供包括样品孔的盖。 根据特别优选的实施方案，第一和第二试剂叠加，双电极位于第一和第二试剂之间。 双电极分离两者并保持化学稳定性，直到施加样品。
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公开(公告)号：US06451264B1
公开(公告)日：2002-09-17
申请号：US09493883
申请日：2000-01-28
IPC分类号： B01L302
CPC分类号： B01L3/502746 , B01L2300/0861 , B01L2300/0887 , B01L2400/0406 , B01L2400/086
摘要： A capillary pathway is dimensioned so that the driving force for the movement of liquid through the capillary pathway arises from capillary pressure. A plurality of groups of microstructures are fixed in the capillary pathway within discrete segments of the pathway for facilitating the transport of a liquid around curved portions of pathway. Capillary channels can be coupled between two adjacent groups of microstructures to either the inner and outer wall of the capillary pathway. The width of each capillary channel is generally smaller than the capillary pathway to which it is connected, and can be varied to achieve differences in fill initiation. The grouped microstructures are spaced from each other within each group on a nearest neighbor basis by less than that necessary to achieve capillary flow of liquid with each group. Each group of microstructures are spaced from any adjacent group by an inter-group space greater than the width of any adjacent capillary channels connected to the capillary pathway. Generally, the microstructures are centered on centers which are equally spaced from each other, and microstructures that are located closer to the inner wall of any curve in the capillary pathway are generally smaller than the microstructures located closer to the outer wall. This combination of structural features causes fluids to flow through the capillary pathway so that the rate of flow is somewhat non-uniform as the fluid travels around curved portions of the capillary pathway, the meniscus appearing to pause momentarily at each inter-group space, the flow being somewhat slower near the inner wall of a curved portion than near the outer wall.
摘要翻译： 毛细管路径的尺寸被设计成使得液体通过毛细通道的运动的驱动力来自于毛细管压力。 多个微结构组在毛细管路径中固定在通路的离散区段内，以便于液体在路径的弯曲部分周围传输。 毛细管通道可以在两个相邻的微结构组之间连接到毛细管通路的内壁和外壁。 每个毛细通道的宽度通常小于其连接的毛细管路径，并且可以变化以实现填充开始的差异。 分组的微结构在每个组内以最近邻基础彼此间隔开，小于实现每个组的液体的毛细管流所必需的。 每组微结构与任何相邻组间隔开大于连接到毛细管路径的任何相邻毛细通道的宽度的组间空间。 通常，微结构以相互间隔相等的中心为中心，并且位于更靠近毛细管路径中任何曲线的内壁的微结构通常小于位于更靠近外壁的微结构。 结构特征的这种组合使得流体流过毛细管路径，使得当流体在毛细管路径的弯曲部分周围行进时，流动速率有些不均匀，弯月面在每个组间空间暂时暂停， 在靠近外壁的弯曲部分的内壁附近的流动稍慢。
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公开(公告)号：US06406672B1
公开(公告)日：2002-06-18
申请号：US09494072
申请日：2000-01-28
IPC分类号： G01N3386
CPC分类号： B01L3/502753 , B01L3/50273 , B01L2300/0645 , B01L2300/0681 , B01L2300/0816 , B01L2400/0406 , G01N33/491 , Y10T436/25125 , Y10T436/25375
摘要： A capillary hematocrit separation structure is included within a housing having a fluid inlet port, a reaction region, and a capillary pathway connecting the inlet port and the reaction region. The capillary pathway is dimensioned so that the driving force for the movement of liquid through the capillary pathway arises from capillary pressure. A plurality of obstructions are fixed in the capillary pathway, each obstruction having a concave portion facing toward the vented reaction region on the down stream side of the obstructions as viewed with reference to a liquid flowing from the inlet port to the reaction region. The capillary pathway in a hematocrit separation structure for a single drop sample size includes about 105 obstructions, each obstruction including a concave portion having a volume of between about 10−4 to 10−5 &mgr;l for selectively receiving hematocrit.
摘要翻译： 毛细管血细胞比容分离结构包括在具有连接入口和反应区域的流体入口，反应区域和毛细管道的壳体内。 毛细管路径的尺寸被设计成使得液体通过毛细通路的运动的驱动力由毛细管压力引起。 多个障碍物固定在毛细管路径中，每个阻塞件相对于从入口流向反应区域的液体观察，在障碍物的下游侧具有面向通气的反应区域的凹部。 用于单滴样品尺寸的血细胞比容分离结构中的毛细血管通路包括约105个障碍物，每个梗阻包括体积在约10-4至10-5μm之间的凹部，用于选择性地接受血细胞比容。
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公开(公告)号：US08603308B2
公开(公告)日：2013-12-10
申请号：US12770507
申请日：2010-04-29
IPC分类号： G01N27/327 , C12Q1/25 , H05K3/00
CPC分类号： G01N27/3277 , G01N27/3272 , G01N33/5438
摘要： The present invention provides an inventive biosensor that includes multiple regions in which the electrical pattern is formed from different electrically conductive materials. The present invention also provides an inventive method for mass producing biosensors as just described. In one embodiment of this method, first and second different electrically conductive materials are deposited side by side on a portion of an electrically insulating base material, and a plurality of electrical patterns is formed on the portion of the base material. Each electrical pattern includes a first region formed from the first electrically conductive material electrically connected to a second region formed from the second electrically conductive material. The electrically conductive materials can be deposited as layers on the base material and portions of the layers can be removed to form the electrical patterns, or, the electrical patterns can be formed by transferring the conductive material in the shape of the electrical pattern directly to the base material, such as by a laser direct transfer technique.
摘要翻译： 本发明提供了本发明的生物传感器，其包括多个区域，其中电图案由不同的导电材料形成。 本发明还提供了如上所述的用于批量生产生物传感器的发明方法。 在该方法的一个实施例中，第一和第二不同的导电材料并排地沉积在电绝缘基材的一部分上，并且在基材的部分上形成多个电图案。 每个电图案包括由第一导电材料形成的第一区域，电连接到由第二导电材料形成的第二区域。 导电材料可以作为层沉积在基底材料上，并且可以去除这些层的部分以形成电图案，或者可以通过将电图案形状的导电材料直接转移到 基材，例如通过激光直接转印技术。
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公开(公告)号：US20110000785A1
公开(公告)日：2011-01-06
申请号：US12770507
申请日：2010-04-29
CPC分类号： G01N27/3277 , G01N27/3272 , G01N33/5438
摘要： The present invention provides an inventive biosensor that includes multiple regions in which the electrical pattern is formed from different electrically conductive materials. The present invention also provides an inventive method for mass producing biosensors as just described. In one embodiment of this method, first and second different electrically conductive materials are deposited side by side on a portion of an electrically insulating base material, and a plurality of electrical patterns is formed on the portion of the base material. Each electrical pattern includes a first region formed from the first electrically conductive material electrically connected to a second region formed from the second electrically conductive material. The electrically conductive materials can be deposited as layers on the base material and portions of the layers can be removed to form the electrical patterns, or, the electrical patterns can be formed by transferring the conductive material in the shape of the electrical pattern directly to the base material, such as by a laser direct transfer technique.
摘要翻译： 本发明提供了本发明的生物传感器，其包括多个区域，其中电图案由不同的导电材料形成。 本发明还提供了如上所述的用于批量生产生物传感器的发明方法。 在该方法的一个实施例中，第一和第二不同的导电材料并排地沉积在电绝缘基材的一部分上，并且在基材的部分上形成多个电图案。 每个电图案包括由第一导电材料形成的第一区域，电连接到由第二导电材料形成的第二区域。 导电材料可以作为层沉积在基底材料上，并且可以去除这些层的部分以形成电图案，或者可以通过将电图案形状的导电材料直接转移到 基材，例如通过激光直接转印技术。
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