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18 条记录 (耗时 0.017 秒)

    Process for the preparation of 2-hydroxy carboxylic acids
    1.
    发明申请
    Process for the preparation of 2-hydroxy carboxylic acids 审中-公开
    2-羟基羧酸的制备方法

    公开(公告)号：US20050143600A1

    公开(公告)日：2005-06-30

    申请号：US10808965

    申请日：2004-03-25

    申请人： Raghunath Chaudhari ,  Sunil Tonde

    发明人： Raghunath Chaudhari ,  Sunil Tonde

    IPC分类号： C07C51/09 ,  C07C51/12

    CPC分类号： C07C51/09 ,  C07C59/08

    摘要： A two step preparation for hydroxy carboxylic acid (e.g. lactic acid) is disclosed. An enol ester (e.g. vinyl acetate) is carbonylated in the presence of a hydroxyl compound (e.g. methanol) using a palladium catalyst having one or more O-, N- and/or P-containing ligands (e.g. PdCl2(PPh3)2), and a solvent at 50-150° C./50-2000 psig to yield hydroxy ester (e.g. methyl lactate) and acetoxy ester (e.g. methyl-2-acetoxy propionate). The second step involves hydrolyzing the products of the carbonylation step using acid catalysts (e.g. TsOH, aq HCl, resin) at 10-125° C. to produce 2-hydroxy carboxylic acids (e.g. lactic acid). The carbonylation and hydrolysis catalysts may be separated and recycled.

    摘要翻译： 公开了羟基羧酸（例如乳酸）的两步制备。 使用具有一个或多个O，N-和/或P的配体（例如PdCl 2）的钯催化剂，在羟基化合物（例如甲醇）的存在下将烯醇酯（例如乙酸乙烯酯）羰基化， （PPh 3 N 2）2）和溶剂在50-150℃/ 50-2000psig下反应，得到羟基酯（例如乳酸甲酯）和乙酰氧基酯 （如甲基-2-乙酰氧基丙酸酯）。 第二步包括在10-125℃下使用酸催化剂（例如TsOH，HCl水溶液，树脂）水解羰基化步骤的产物以产生2-羟基羧酸（例如乳酸）。 羰基化和水解催化剂可以分离和再循环。

    Process for preparing dioxy-functionalized propane compounds
    2.
    发明申请
    Process for preparing dioxy-functionalized propane compounds 审中-公开
    制备二官能化丙烷化合物的方法

    公开(公告)号：US20050222452A1

    公开(公告)日：2005-10-06

    申请号：US10814859

    申请日：2004-03-31

    申请人： Raghunath Chaudhari ,  Yogesh Borole ,  Shubhangi Umbarkar

    发明人： Raghunath Chaudhari ,  Yogesh Borole ,  Shubhangi Umbarkar

    IPC分类号： C07C29/14 ,  C07C29/147 ,  C07C67/29 ,  C07C69/76

    CPC分类号： C07C29/147 ,  C07C67/29 ,  C07C67/293 ,  C07C69/003 ,  C07C69/14 ,  C07C69/145 ,  C07C31/205

    摘要： The present invention relates to a process for preparing, dioxy functionalised propane compounds using cobalt and/or rhodium catalysts. More particularly, the present invention relates to a process for the preparation of the dioxy functionalised propane compounds of the formula X—CH2—CH(Y)—CH2-Z, wherein X=R—C(═O)—O— or H or —OH, Y and Z=—H or —OH or —C(═O)H, and wherein at a time, only one of X, Y and Z is —H, in high yields from vinyl carboxylates of formula R—C(═O)—O—CH═CH2 wherein, R=substituted or unsubstituted alkyl or aryl group.

    摘要翻译： 本发明涉及使用钴和/或铑催化剂制备二氧官能化丙烷化合物的方法。 更具体地说，本发明涉及一种制备式X-CH 2 -CH（Y）-CH 2 -Z -Z（CH 2）-CH 2的二氧官能化丙烷化合物的方法， 其中X = RC（-O）-O-或H或-OH，Y和Z = -H或-OH或-C（-O）H，并且其中一次只有X，Y和Z中的一个 是-H，以高得率的式RC（-O）-O-CH-CH 2乙烯基羧酸酯，其中R =取代或未取代的烷基或芳基。

    Process for the preparation of 2-aryl propionic acids
    7.
    发明申请
    Process for the preparation of 2-aryl propionic acids 审中-公开
    2-芳基丙酸的制备方法

    公开(公告)号：US20050283020A1

    公开(公告)日：2005-12-22

    申请号：US11149804

    申请日：2005-06-10

    申请人： Raghunath Chaudhari ,  Seayad A. ,  Jayasree Seayad

    发明人： Raghunath Chaudhari ,  Seayad A. ,  Jayasree Seayad

    IPC分类号： C07C51/10 ,  C07C51/12 ,  C07C51/14 ,  C07C51/16

    CPC分类号： C07C51/12 ,  C07C51/10 ,  C07C51/14 ,  C07C57/30

    摘要： The present invention provides for the preparation of 2-aryl propionic acids, which comprises the steps of: reacting an aryl compound selected from an arylalkyl halide having general formula I, aryl alcohol having general formula II or aryl substituted olefins having general formula III, as shown in the accompanying drawings, wherein, R1 is aryl, substituted aryl, naphthyl or substituted naphthyl groups, R2, R3, R4 and R5 are independently hydrogen, alkyl, aryl, arylalkyl or cycloaliphatic groups with or without substituents and X is other a halogen atom selected from chlorine, bromine, iodine with a halide promoter, an organic acid, water and a palladium catalyst in an organic solvent selected from ketones or cyclic ethers in carbon monoxide atmosphere under homogeneous conditions, at a temperature ranging between 30 to 130° C., for a period ranging between 0.3 to 4 hrs, at pressures ranging between 50 to 1500 psig, cooling the reaction mixture to ambient temperature, flushing the reaction vessel with inert gas, removing the solvent by conventional methods, and separating the catalyst and isolating 2 aryl propionic acid having formula IV as shown in the accompanying drawings, wherein, R1 is aryl, substituted aryl, naphthyl or substituted naphthyl groups, R2, R3, R4 and R5 are independently hydrogen, alkyl, aryl, arylalkyl, cycloaliphatic groups with or without substituents.

    摘要翻译： 本发明提供2-芳基丙酸的制备，其包括以下步骤：使选自具有通式I的芳基烷基卤化物，具有通式II的芳基醇或具有通式III的芳基取代烯烃的芳基化合物与 如图所示，其中R 1是芳基，取代的芳基，萘基或取代的萘基，R 2，R 3，R R 4和R 5独立地为具有或不具有取代基的氢，烷基，芳基，芳基烷基或脂环族基团，X为选自氯，溴，碘的卤素原子，其中 卤化物助催化剂，有机酸，水和钯催化剂，在一氧化碳气氛中，在均一条件下，在30至130℃的温度范围内，在选自酮或环醚的有机溶剂中，时间范围为0.3-4 小时，压力范围在50至1500psig之间，冷却r 将反应混合物与环境温度反应，用惰性气体冲洗反应容器，通过常规方法除去溶剂，并分离催化剂并分离出具有式IV的芳基丙酸，如附图所示，其中R 1， R 2是芳基，取代的芳基，萘基或取代的萘基，R 2，R 3，R 4和R 5， 独立地是氢，烷基，芳基，芳基烷基，具有或不具有取代基的脂环族基团。