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    Recombinant microorganism for the fermentative production of methionine
    1.
    发明授权
    Recombinant microorganism for the fermentative production of methionine 有权
    用于发酵生产甲硫氨酸的重组微生物

    公开(公告)号：US09506093B2

    公开(公告)日：2016-11-29

    申请号：US14408378

    申请日：2012-06-18

    申请人： Wanda Dischert ,  Rainer Figge

    发明人： Wanda Dischert ,  Rainer Figge

    IPC分类号： C12P13/12 ,  C12N9/10

    CPC分类号： C12P13/12 ,  C12N9/1007 ,  C12Y201/01014 ,  Y02P20/52

    摘要： The present invention is related to a recombinant microorganism optimized for the fermentative production of methionine, wherein the activity of the cobalamin-independent methionine synthase MetE is attenuated in said microorganism. The invention is also related to a method for producing methionine by fermentation.

    摘要翻译： 本发明涉及针对甲硫氨酸的发酵生产而优化的重组微生物，其中所述微生物中不含钴胺素的甲硫氨酸合酶MetE的活性减弱。 本发明还涉及通过发酵生产甲硫氨酸的方法。

    Use of polypropylene glycol as a shrinkage-reducing additive in dispersion powder compositions for construction materials
    6.
    发明授权
    Use of polypropylene glycol as a shrinkage-reducing additive in dispersion powder compositions for construction materials 失效
    在建筑材料的分散粉末组合物中使用聚丙二醇作为减缩添加剂

    公开(公告)号：US5498665A

    公开(公告)日：1996-03-12

    申请号：US344401

    申请日：1994-11-23

    申请人： Joachim Schulze ,  Rainer Figge

    发明人： Joachim Schulze ,  Rainer Figge

    IPC分类号： C04B24/22 ,  C04B24/26 ,  C04B24/32 ,  C04B28/04 ,  C08K3/00 ,  C08K5/42 ,  C08L61/10 ,  C08L33/04 ,  C08L29/04 ,  C08L25/06

    CPC分类号： C04B40/0039 ,  C04B24/22 ,  C04B24/32 ,  C04B28/04 ,  C08K3/0033 ,  C08K5/42 ,  C04B2103/58 ,  C04B2111/34

    摘要： The invention relates to the use of polypropylene glycol as a shrinkage-reducing additive in dispersion powder compositions for construction materials containinga) a base polymer from the group consisting of vinyl ester polymers, (meth)acrylate and/or styrene (co)polymers and vinyl chloride polymers, andb) eitherb1) 2 to 20% by weight, based on the base polymer, of polyvinyl alcohol having a degree of hydrolysis of 85 to 94 mol % and a Hoppler viscosity of 2 to 40 mPa.s orb2) 2 to 20% by weight, based on the base polymer, of alkali metal salts or alkaline earth metal salts of phenolsulfonic acid-formaldehyde condensation products, andc) 3 to 30% by weight, based on the total weight of polymeric components, of fine antiblocking agents, whereind) the content of polypropylene glycol is 1 to 20% by weight, based on the base polymer.

    摘要翻译： 本发明涉及聚丙二醇作为收缩减少添加剂在用于建筑材料的分散粉末组合物中的用途，该组合物含有：a）由乙烯基酯聚合物，（甲基）丙烯酸酯和/或苯乙烯（共）聚合物组成的组的基础聚合物，以及 氯乙烯聚合物，和b）b1）基于聚合物的基于聚合物的2〜20重量％的水解度为85〜94摩尔％的聚乙烯醇，Höppler粘度为2〜40mPa.s或b2 ）基于所述基础聚合物的2-20重量％的酚磺酸 - 甲醛缩合产物的碱金属盐或碱土金属盐，和c）基于聚合物组分的总重量为3-30重量％ 的抗静电剂，其中d）聚丙二醇的含量为基于聚合物的1至20重量％。

    Increasing methionine production by overexpressing succinate dehydrogenase
    7.
    发明授权
    Increasing methionine production by overexpressing succinate dehydrogenase 有权
    通过过量表达琥珀酸脱氢酶增加甲硫氨酸生产

    公开(公告)号：US09267160B2

    公开(公告)日：2016-02-23

    申请号：US13519507

    申请日：2009-12-30

    申请人： Rainer Figge

    发明人： Rainer Figge

    IPC分类号： C12P13/12

    CPC分类号： C12P13/12 ,  C12N9/001 ,  C12Y103/05001

    摘要： The present invention relates to a process for improving the production of methionine by culturing a microorganism modified for enhancing the expression of genes involved in succinate dehydrogenase synthesis. The microorganisms were modified in a way that the methionine/carbon source yield is increased. The isolation of methionine from the fermentation medium is also claimed.

    摘要翻译： 本发明涉及通过培养用于增强参与琥珀酸脱氢酶合成的基因的表达而修饰的微生物来改善甲硫氨酸的生产的方法。 微生物以甲硫氨酸/碳源产量增加的方式进行了修饰。 还要求从发酵培养基中分离甲硫氨酸。

    Method for producing glycolic acid using an inducible promoter
    8.
    发明授权
    Method for producing glycolic acid using an inducible promoter 有权
    使用诱导型启动子生产乙醇酸的方法

    公开(公告)号：US09121043B2

    公开(公告)日：2015-09-01

    申请号：US13704578

    申请日：2011-06-15

    申请人： Wanda Dischert ,  Rainer Figge ,  Philippe Soucaille

    发明人： Wanda Dischert ,  Rainer Figge ,  Philippe Soucaille

    IPC分类号： C12P7/42 ,  C12N15/70 ,  C12N15/63

    CPC分类号： C12P7/42 ,  C12N15/635 ,  C12N15/70

    摘要： The present invention relates to use of inducible promoters in the production of glycolic acid by fermentation. The present invention concerns a method for the production of glycolic acid in a fermentative process comprising the following steps: culturing a modified microorganism in an appropriate culture medium comprising a source of carbon, modulating in said microorganism the expression of a target gene with an external stimulus, and recovering glycolic acid from the culture medium, wherein in said modified microorganism, the expression of at least one gene involved in glycolic acid production is under the control of a heterologous inducible promoter whose activity is modulated with said external stimulus. The invention also concerned the modified microorganism used in the method of glycolic acid production.

    摘要翻译： 本发明涉及通过发酵在诱导型促进剂生产乙醇酸中的用途。 本发明涉及在发酵方法中生产乙醇酸的方法，包括以下步骤：在包含碳源的适当培养基中培养经修饰的微生物，在所述微生物中调节靶基因与外部刺激物的表达 并从培养基中回收乙醇酸，其中在所述修饰的微生物中，参与乙醇酸生产的至少一个基因的表达在异源诱导型启动子的控制下，其活性用所述外部刺激调节。 本发明还涉及用于乙醇酸生产方法中的改性微生物。

    MICROORGANISMS FOR 1,3-PROPANEDIOL PRODUCTION USING HIGH GLYCERINE CONCENTRATION
    9.
    发明申请
    MICROORGANISMS FOR 1,3-PROPANEDIOL PRODUCTION USING HIGH GLYCERINE CONCENTRATION 审中-公开
    使用高甘油浓度的1,3-丙二醇生产的微生物

    公开(公告)号：US20130177956A1

    公开(公告)日：2013-07-11

    申请号：US13823709

    申请日：2011-11-10

    申请人： Rainer Figge

    发明人： Rainer Figge

    IPC分类号： C12N15/74

    CPC分类号： C12N15/74 ,  C12N1/32 ,  C12P7/18 ,  C12R1/145

    摘要： The present invention is related to a population of Clostridium acetobutylicum useful for the production of 1,3-propanediol (PDO), wherein said population comprises at least one strain of a Clostridium acetobutylicum sp. comprising mutations selected among the mutations identified in table 1, wherein relative percentages of said mutations are selected among specific genes.

    摘要翻译： 本发明涉及可用于生产1,3-丙二醇（PDO）的丙酮丁醇梭菌的群体，其中所述群体包含至少一种丙酮丁醇梭菌菌株。 包括选自表1中鉴定的突变中的突变，其中所述突变的相对百分比选自具体基因。

    USE OF INDUCIBLE PROMOTERS IN THE PRODUCTION OF METHIONINE
    10.
    发明申请
    USE OF INDUCIBLE PROMOTERS IN THE PRODUCTION OF METHIONINE 有权
    可溶性促进剂在甲磺酸生产中的应用

    公开(公告)号：US20120252077A1

    公开(公告)日：2012-10-04

    申请号：US13515432

    申请日：2010-12-13

    申请人： Rainer Figge ,  Perrine Vasseur

    发明人： Rainer Figge ,  Perrine Vasseur

    IPC分类号： C12P13/12 ,  C12N1/21

    CPC分类号： C12P13/12

    摘要： The present invention relates to use of inducible promoters in the production of methionine by fermentation. The present invention concerns a method for the production of methionine, its precursors or derivatives in a fermentative process comprising the following steps: culturing a modified microorganism in an appropriate culture medium comprising a source of carbon, a source of sulphur and a source of nitrogen, and recovering methionine and/or its derivatives from the culture medium, wherein in said modified microorganism, the expression of at least one gene involved in methionine production is under the control, direct or indirect, of a heterologous inducible promoter. The invention also concerned the modified microorganism used in the method.

    摘要翻译： 本发明涉及通过发酵在诱导型启动子生产甲硫氨酸中的应用。 本发明涉及在发酵方法中生产甲硫氨酸，其前体或衍生物的方法，包括以下步骤：在包含碳源，硫源和氮源的合适的培养基中培养修饰的微生物， 以及从培养基中回收甲硫氨酸和/或其衍生物，其中在所述修饰的微生物中，参与甲硫氨酸生产的至少一个基因的表达是直接或间接的异源诱导型启动子的控制。 本发明还涉及该方法中使用的修饰微生物。