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    Pharmaceutical composition useful for the treatment of hepatocellular carcinoma
    6.
    发明申请
    Pharmaceutical composition useful for the treatment of hepatocellular carcinoma 审中-公开
    用于治疗肝细胞癌的药物组合物

    公开(公告)号：US20060280817A1

    公开(公告)日：2006-12-14

    申请号：US11440790

    申请日：2006-05-25

    申请人： Ajit Saxena ,  Bishan Gupta ,  Bal Kapahi ,  Shanmugavel Muthiah ,  Dilip Mondhe ,  Baleshwar ,  Ghulam Qazi ,  Vijay Kumar ,  Ganeshan Mathan

    发明人： Ajit Saxena ,  Bishan Gupta ,  Bal Kapahi ,  Shanmugavel Muthiah ,  Dilip Mondhe ,  Baleshwar ,  Ghulam Qazi ,  Vijay Kumar ,  Ganeshan Mathan

    IPC分类号： A61K36/48

    CPC分类号： A61K36/48

    摘要： The present invention relates to anticancer activity against hepatocellular carcinoma of an extract and fraction isolated from flowers of Butea monosperma. Particularly, this invention relates to anticancer activity against hepatocellular carcinoma of a composition containing markered flavonoid glycosides such as butrin and isobutrin in the range of 2 to 9% by weight, isolated from the flowers of Butea monosperma by extracting the flowers with polar solvent like ethanol, methanol, aqueous ethanol or water, removing fatty non-polar constituents by triturating the extract with solvents such as ethylene chloride, methylene chloride, chloroform or ethyl acetate, suspending the residue in water, extracting with n-butanol and freeze drying the aqueous part.

    摘要翻译： 本发明涉及一种提取物对肝细胞癌的抗癌活性和从白花单倍体花中分离的部分。 特别地，本发明涉及通过用极性溶剂如乙醇提取鲜花，从含有白芍的花中分离出含有2至9重量％的标记的类黄酮苷类的标记黄酮糖苷类化合物的抗癌活性 ，甲醇，乙醇水溶液或水中，通过用溶剂如氯化乙烯，二氯甲烷，氯仿或乙酸乙酯研磨提取物除去脂肪非极性组分，将残余物悬浮在水中，用正丁醇萃取并冷冻干燥含水部分 。

    Process for isolation of withaferin-A from plant materials and products therefrom
    10.
    发明申请
    Process for isolation of withaferin-A from plant materials and products therefrom 有权
    从植物材料和产品中分离嗜铬蛋白A的方法

    公开(公告)号：US20050226950A1

    公开(公告)日：2005-10-13

    申请号：US10822858

    申请日：2004-04-13

    申请人： Rajender Sangwan ,  Narayan Chaurasiya ,  Laxmi Misra ,  Payare Lal ,  Girish Uniyal ,  Neelam Sangwan ,  Avdhesh Srivastava ,  Krishan Suri ,  Ghulam Qazi ,  Rakesh Tuli

    发明人： Rajender Sangwan ,  Narayan Chaurasiya ,  Laxmi Misra ,  Payare Lal ,  Girish Uniyal ,  Neelam Sangwan ,  Avdhesh Srivastava ,  Krishan Suri ,  Ghulam Qazi ,  Rakesh Tuli

    IPC分类号： A61K36/81 ,  A61K35/78

    CPC分类号： A61K36/81

    摘要： The present invention relates to an improved process of analytical and quantitative isolation of withaferin-A from Withania somnifera (Sanskrit: Ashwagandha, English: winter cherry) and other plants and products therefrom, said method comprising steps of selecting most appropriate extraction medium composition, with extraction solvent system consisting of a defined admixture of water and alcohol in a range of proportion of alcohol within a narrow range of (methanol, ethanol etc.) (preferably 60% alcohol and 40% water) for the dry plant material and from 60% to 80% alcohol in the alcohol-water mixture for fresh plant material, the invented extractant composition leading to better/improved yields and accurate quantitative estimations of withaferin A existent in planta or in materia, selecting effective state of the tissue particularly use of the fresh materials improving yields, providing logistic benefits of isolations and diagnosis, and according several other advantages including technological, economic, preventing contaminations etc., the said method being valuable and advantageous for standardization of botanicals, metabolomic characterization of plants particularly chemotypes, analyzing metabolic transitions under physiological, genetical, environmental and biotic perturbations.

    摘要翻译： 本发明涉及一种分离和定量分离来自隐翅藻（梵语：Ashwagandha，英语：冬樱桃）和其他植物及其产物的咖啡因-A的改进方法，所述方法包括以下步骤：选择最合适的提取培养基组合物， 萃取溶剂体系，由干燥植物材料的（甲醇，乙醇等）（优选60％酒精和40％水）的窄范围内的醇的比例范围内的水和醇的混合物组成， 到新鲜植物材料的酒精 - 水混合物中的80％酒精，本发明的提取剂组合物导致在植物或物质中存在的更好/提高的产量和准确的定量估计，选择组织的有效状态，特别是使用新鲜的 材料提高产量，提供隔离和诊断的后勤优势，以及其他几个优势，包括技术 所述方法对于植物学的标准化，植物的代谢组学特征，特别是化学型，分析生理，遗传，环境和生物扰动下的代谢转变是有价值和有利的。