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公开(公告)号：US09272231B2
公开(公告)日：2016-03-01
申请号：US14239289
申请日：2012-09-04
IPC分类号： B01D19/00 , A61B17/225 , A61B8/00
CPC分类号： B01D19/0036 , A61B8/546 , A61B17/2251
摘要： A device degasses fluid in a circulation loop. The device includes a degassing chamber coupled inline with the circulation loop, where a vacuum within the degassing chamber draws out dissolved gas and water vapor from the fluid. The degassing chamber has an opening enabling gas and water vapor drawn out from the fluid, and condensation formed from the water vapor, to flow out as a result of gravitational pull. The device further includes a cooler coupled to the opening in the degassing chamber and a water trap coupled to the cooler. The cooler includes a heat exchanger configured to condense a remaining portion of the water vapor into liquid, where the condensation and liquid accumulate in the water trap. The degassing chamber, water trap and cooler are maintained under vacuum, where the degassing chamber is maintained under vacuum through the opening via the cooler and the water trap.
摘要翻译： 一个装置使循环回路中的流体脱气。 该装置包括与循环回路联合的脱气室，其中脱气室内的真空从流体中抽出溶解的气体和水蒸气。 脱气室具有能够从流体中抽出的气体和水蒸气的开口，以及由水蒸气形成的冷凝物，由于引力而流出。 该装置还包括联接到脱气室中的开口的冷却器和联接到冷却器的水阱。 冷却器包括热交换器，其被配置为将剩余部分的水蒸汽冷凝成液体，其中冷凝和液体积聚在水阱中。 脱气室，集水器和冷却器保持在真空下，脱气室通过冷却器和水阱通过开口保持在真空下。
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公开(公告)号：US20140196607A1
公开(公告)日：2014-07-17
申请号：US14239289
申请日：2012-09-04
CPC分类号： B01D19/0036 , A61B8/546 , A61B17/2251
摘要： In one variation, a temperature-maintenance device includes a heater (1016) and is placeable in a circulation loop of an ultrasound transducer coupling bolus (1076), for degassing circulating liquid of the loop and for operating the heater for performing temperature control of the liquid. A temperature setpoint, such as a normal body temperature, for the liquid at the bolus may be entered. A device, either open- or closed-looped with respect to fluid flow, may include, in some variations, a degassing chamber, a water trap (1012), and an intervening cooler, all vacuumized by a vacuum pump (1024). The chamber may be configured and aligned for letting condensation automatically drain out. The water trap may be emptied, automatically and without the need for user intervention, by a motorized trap emptier and/or be emptiable by the user.
摘要翻译： 在一个变型中，温度维持装置包括加热器（1016），并且可放置在超声换能器联合推注器（1076）的循环回路中，用于对循环的循环液体进行脱气，并且用于操作加热器以执行温度控制 液体。 可以输入针对大剂量液体的温度设定点，例如正常体温。 在一些变型中，相对于流体流动开放或闭环的装置可以包括脱气室，水阱（1012）和中间冷却器，所有这些都由真空泵（1024）抽真空。 可以对腔室进行配置和对准，以使冷凝水自动排出。 自动疏水阀可以自动排空，不需要用户干预，电动疏水阀排空和/或可由用户清空。
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公开(公告)号：US20140249469A1
公开(公告)日：2014-09-04
申请号：US14347904
申请日：2012-08-29
申请人： Ralf Seip , Balasundar Iyyavu Raju , Evgeniy Leyvi
发明人： Ralf Seip , Balasundar Iyyavu Raju , Evgeniy Leyvi
IPC分类号： A61M37/00
CPC分类号： A61M37/0092 , A61B8/481
摘要： Bubble presence within a region is monitored to determine if a predetermined condition is met such as whether the presence is of sufficient magnitude, the bubbles being subject to energizing (240). In some embodiments, the energizing only occurs when time- wise preceded by the determination (S508, S510). The determining can include measuring a grayscale value (104), or assessing the energy carried by a frequency component of the echo signal, in the region in real time. The energizing may occur region-by-region, automatically and without need for user intervention, in a treatment pass (S428) over the regions. The regions (232) in the pass might be subject to respective instances of the energizing without intervening monitoring, or, in another embodiment, to both the determining and the responsive energizing. The determining can be subject to, automatically and without need for user intervention, interruption (S408) and concurrent switching to a next region.
摘要翻译： 监视区域内的气泡存在以确定是否满足预定条件，例如存在是否足够大，气泡受到激励（240）。 在一些实施例中，激励仅在经过确定之后时间才发生（S508，S510）。 该确定可以包括实时地测量灰度值（104）或者评估该区域中的回波信号的频率分量携带的能量。 在区域内的治疗通行证（S428）中，能量自动地可以逐区发生，而不需要用户干预。 通过中的区域（232）可能受到激励的相应实例而不进行中间监视，或者在另一个实施例中涉及确定和响应通电两者。 该决定可以自动地进行，并且不需要用户干预，中断（S408）并且并发切换到下一个区域。
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公开(公告)号：US09643000B2
公开(公告)日：2017-05-09
申请号：US14347904
申请日：2012-08-29
申请人： Ralf Seip , Balasundar Iyyavu Raju , Evgeniy Leyvi
发明人： Ralf Seip , Balasundar Iyyavu Raju , Evgeniy Leyvi
CPC分类号： A61M37/0092 , A61B8/481
摘要： Bubble presence within a region is monitored to determine if a predetermined condition is met such as whether the presence is of sufficient magnitude, the bubbles being subject to energizing (240). In some embodiments, the energizing only occurs when time- wise preceded by the determination (S508, S510). The determining can include measuring a grayscale value (104), or assessing the energy carried by a frequency component of the echo signal, in the region in real time. The energizing may occur region-by-region, automatically and without need for user intervention, in a treatment pass (S428) over the regions. The regions (232) in the pass might be subject to respective instances of the energizing without intervening monitoring, or, in another embodiment, to both the determining and the responsive energizing. The determining can be subject to, automatically and without need for user intervention, interruption (S408) and concurrent switching to a next region.
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公开(公告)号：US20120150035A1
公开(公告)日：2012-06-14
申请号：US13397283
申请日：2012-02-15
申请人： Ralf Seip , Wo-Hsing Chen , Roy F. Carlson , Narendra T. Sanghvi , Kris A. Dines , Michael A. Penna , Richard Pfile
发明人： Ralf Seip , Wo-Hsing Chen , Roy F. Carlson , Narendra T. Sanghvi , Kris A. Dines , Michael A. Penna , Richard Pfile
CPC分类号： A61B8/06 , A61B8/12 , A61B8/483 , A61B34/10 , A61B2017/00274 , A61B2018/00547 , A61B2090/378 , A61N7/02 , A61N7/022
摘要： A HIFU System (100) is disclosed which may automatically generate a proposed treatment plan for treating a tissue treatment area (10) with HIFU Therapy. In one example, the proposed treatment plan includes a plurality of treatment sites selected based on a three-dimensional model generated from ultrasound data. In another example, the proposed treatment plan excludes portions of the tissue treatment area (10) corresponding to blood flow, such as the neuro-vascular bundles (20) when treating the prostate (11).
摘要翻译： 公开了一种HIFU系统（100），其可以自动产生用HIFU治疗来治疗组织治疗区域（10）的建议治疗计划。 在一个示例中，所提出的治疗计划包括基于从超声数据生成的三维模型选择的多个治疗部位。 在另一个例子中，所提出的治疗方案排除了在治疗前列腺时，诸如神经 - 维管束（20）的对应于血流的组织治疗区域（10）的部分（11）。
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公开(公告)号：US20050240127A1
公开(公告)日：2005-10-27
申请号：US11070371
申请日：2005-03-02
申请人： Ralf Seip , Wo-Hsing Chen , Narendra Sanghvi
发明人： Ralf Seip , Wo-Hsing Chen , Narendra Sanghvi
CPC分类号： A61N7/02 , A61N2007/0052 , A61N2007/0065 , A61N2007/0078 , A61N2007/0095 , A61N2007/027
摘要： Ultrasound transducers are disclosed which focus acoustic energy at various focal locations while minimizing focal spot degradation and the generation of unwanted on-axis or off-axis energy concentrations through using a generally constant f-number at the various focal locations.
摘要翻译： 公开了超声换能器，其将各种焦点位置处的声能集中，同时通过在各种焦点位置使用通常恒定的f数来最小化焦点劣化和产生不期望的轴上或离轴能量浓度。
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公开(公告)号：US20160279449A1
公开(公告)日：2016-09-29
申请号：US14902012
申请日：2014-07-02
IPC分类号： A61N7/00
CPC分类号： A61N7/00 , A61B8/0833 , A61B8/483 , A61B8/5246 , A61B17/22004 , A61B2017/22007 , A61B2017/22008 , A61N2007/0004 , A61N2007/0039 , A61N2007/0052 , A61N2007/0078 , A61N2007/0086
摘要： Ultrasonic sonothrombolysis systems to produce two acoustic pressure levels of insonation during stroke therapy, mid/high acoustic pressure insonation directed to the site of a blood clot where microbubbles are present to induce microbubble-mediated blood clot lysis, and low acoustic insonation directed to the region surrounding the site of the blood clot where microbubbles are present to stimulate microvascular reperfusion of the surrounding tissue. The systems simultaneously produce blood clot lysis at the site of an occlusion and stimulate reperfusion of tissue affected by the occlusion.
摘要翻译： 超音波声波溶解系统在中风治疗期间产生两个声压级别的声压，中/高声压力导向到血块的位置，其中存在微泡以诱导微泡介导的血块溶解，以及针对该区域的低声压 围绕存在微泡的血块的位置以刺激周围组织的微血管再灌注。 系统同时在闭塞部位产生血块裂解并刺激受到闭塞影响的组织的再灌注。
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8.发明申请METHOD OF DIAGNOSIS AND TREATMENT OF TUMORS USING HIGH INTENSITY FOCUSED ULTRASOUND 审中-公开使用高强度聚焦超声波诊断和治疗肿瘤的方法公开(公告)号：US20130018260A1
公开(公告)日：2013-01-17
申请号：US13571644
申请日：2012-08-10
申请人： Narendra T. Sanghvi , Chandan Guha , Russell James Fedewa , Roy Francis Carlson , Ralf Seip , Wo-Hsing Chen
发明人： Narendra T. Sanghvi , Chandan Guha , Russell James Fedewa , Roy Francis Carlson , Ralf Seip , Wo-Hsing Chen
IPC分类号： A61B8/00
CPC分类号： A61N7/02 , A61B8/08 , A61B8/0833 , A61B10/0051 , A61B10/007 , A61B18/04 , A61B2017/2253 , A61N2007/0004 , A61N2007/0073 , A61N2007/0082
摘要： A method of diagnosis and treatment of tumors using High Intensity Focused Ultrasound is provided. The method of diagnosing the presence of a tumor in a patient comprises the steps of subjecting a tumor to high intensity focused ultrasound (HIFU) to cause the tumor cells to release cellular material and evaluating the cellular material for a tumor marker. The method of treating a tumor in a patient can also comprise the step of subjecting a tumor to high intensity focused ultrasound (HIFU) to provoke an immune response.
摘要翻译： 提供了使用高强度聚焦超声诊断和治疗肿瘤的方法。 诊断患者肿瘤存在的方法包括以下步骤：使肿瘤进行高强度聚焦超声（HIFU）以使肿瘤细胞释放细胞物质并评估肿瘤标志物的细胞材料。 治疗患者肿瘤的方法还可以包括使肿瘤进行高强度聚焦超声（HIFU）以引起免疫应答的步骤。
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公开(公告)号：US07559905B2
公开(公告)日：2009-07-14
申请号：US11524864
申请日：2006-09-21
申请人： Shuhei Kagosaki , Yutaka Shimazaki , Kenji Yamashita , Bernard J. Esarey , Artur P. Katny , Ralf Seip , Narendra T. Sanghvi
发明人： Shuhei Kagosaki , Yutaka Shimazaki , Kenji Yamashita , Bernard J. Esarey , Artur P. Katny , Ralf Seip , Narendra T. Sanghvi
IPC分类号： A61N7/00
CPC分类号： A61B8/00 , A61B2017/2253 , A61B2018/00023 , A61B2090/378 , A61N7/02
摘要： A HIFU system is disclosed including a fluid circulation system including a degasser.
摘要翻译： 公开了一种HIFU系统，包括包括脱气器的流体循环系统。
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10.发明授权公开(公告)号：US06782332B2
公开(公告)日：2004-08-24
申请号：US10261641
申请日：2002-09-30
申请人： Ralf Seip , Russell C. Watts
发明人： Ralf Seip , Russell C. Watts
IPC分类号： G01K1500
CPC分类号： B60H1/00742 , B06B1/0215 , B06B2201/40 , B06B2201/51 , B06B2201/70 , B60H1/00735 , B60H1/00771 , B60H1/00814 , B60R21/01536 , B60W30/18054 , B60W40/09 , B60W2040/0818 , G01S7/52006 , G01S7/5205 , G01S7/521
摘要： Method, apparatus and computer programs are described for compensating for the effect of temperature on the sensitivity of electrostatic ultrasound (US) transducers, particularly as used in an automotive occupancy sensing (AOS) systems for sensing the nature or type of occupant and the location of the occupant with respect to the vehicle interior. The invention permits the AOS to classify the occupancy state of the vehicle from a US echo signal substantially free of the effects of temperature on signal amplitude. A capacitive divider or voltage monitor is employed to measure the capacitance of the transducer. The voltage monitor output is used by the scaling algorithm of a compensator to determine the scaling factor to be applied to the US transducer signal to compensate for the effect of temperature on the transducer sensitivity. Calibration procedures and software are disclosed for determining the coefficients of the scaling algorithm to compensate for temperature effects and also to compensate for installation factors, transducer manufacturing variations, and circuit board effects. The system disclosed is useful for other types of signal processing in addition to temperature compensation of AOS ultrasonic signals, and may be used in other ranging devices such as cameras, golf or binocular range finders, and measuring devices and instruments.
摘要翻译： 描述了用于补偿温度对静电超声波（US）传感器的灵敏度的影响的方法，装置和计算机程序，特别是在用于感测乘员的性质或类型的汽车占用感测（AOS）系统中使用的位置以及 乘客相对于车辆内部。 本发明允许AOS从基本上不受温度对信号幅度的影响的美国回波信号分类车辆的占用状态。 采用电容分压器或电压监视器来测量传感器的电容。 电压监视器输出由补偿器的缩放算法使用，以确定应用于美国换能器信号的比例因子，以补偿温度对传感器灵敏度的影响。 公开了用于确定缩放算法的系数以补偿温度影响并且还补偿安装因素，换能器制造变化和电路板效应的校准程序和软件。 除了AOS超声波信号的温度补偿之外，所公开的系统对于其它类型的信号处理也是有用的，并且可以用于其他测距装置，例如相机，高尔夫或双目测距仪，以及测量装置和仪器。
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