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公开(公告)号：US07186513B2
公开(公告)日：2007-03-06
申请号：US10653047
申请日：2003-08-29
申请人： Randy M. Berka , Michael W. Rey , Jeffrey R. Shuster , Sakari Kauppinen , Ib Groth Clausen , Peter Bjarke Olsen
发明人： Randy M. Berka , Michael W. Rey , Jeffrey R. Shuster , Sakari Kauppinen , Ib Groth Clausen , Peter Bjarke Olsen
CPC分类号： C12Q1/6895 , C07K14/37 , C12Q1/6837 , C12Q2600/158
摘要： The present invention relates to methods for monitoring differential expression of a plurality of genes in a first filamentous fungal cell relative to expression of the same genes in one or more second filamentous fungal cells using microarrays containing filamentous fungal expressed sequenced tags. The present invention also relates to filamentous fungal expressed sequenced tags and to computer readable media and substrates containing such expressed sequenced tags for monitoring expression of a plurality of genes in filamentous fungal cells.
摘要翻译： 本发明涉及用于使用含有丝状真菌表达的测序标签的微阵列来监测第一丝状真菌细胞中多个基因的差异表达相对于在一个或多个第二丝状真菌细胞中表达相同基因的方法。 本发明还涉及丝状真菌表达的测序标签以及包含用于监测丝状真菌细胞中多种基因的表达的表达的测序标签的计算机可读介质和底物。
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公开(公告)号：US06902887B1
公开(公告)日：2005-06-07
申请号：US09533559
申请日：2000-03-22
申请人： Randy M. Berka , Michael W. Rey , Jeffrey R. Shuster , Sakari Kauppinen , Ib Groth Clausen , Peter Bjarke Olsen
发明人： Randy M. Berka , Michael W. Rey , Jeffrey R. Shuster , Sakari Kauppinen , Ib Groth Clausen , Peter Bjarke Olsen
CPC分类号： C12Q1/6895 , C07K14/37 , C12Q1/6837 , C12Q2600/158
摘要： The present invention relates to methods for monitoring differential expression of a plurality of genes in a first filamentous fungal cell relative to expression of the same genes in one or more second filamentous fungal cells using microarrays containing filamentous fungal expressed sequenced tags. The present invention also relates to filamentous fungal expressed sequenced tags and to computer readable media and substrates containing such expressed sequenced tags for monitoring expression of a plurality of genes in filamentous fungal cells.
摘要翻译： 本发明涉及用于使用含有丝状真菌表达的测序标签的微阵列来监测第一丝状真菌细胞中多个基因的差异表达相对于一个或多个第二丝状真菌细胞中相同基因表达的差异表达的方法。 本发明还涉及丝状真菌表达的测序标签以及包含用于监测丝状真菌细胞中多种基因的表达的表达的测序标签的计算机可读介质和底物。
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公开(公告)号：US08911969B2
公开(公告)日：2014-12-16
申请号：US12398803
申请日：2009-03-05
申请人： Jens Tonne Andersen , Steen Troels Jorgensen , Michael Dolbjerg Rasmussen , Peter Bjarke Olsen , Ib Groth Clausen
发明人： Jens Tonne Andersen , Steen Troels Jorgensen , Michael Dolbjerg Rasmussen , Peter Bjarke Olsen , Ib Groth Clausen
摘要： A Bacillus licheniformis mutant host cell derived from a parent B. licheniformis host cell, which mutant host cell is mutated in one or more gene(s) encoding one or more secreted polypeptide(s) which is at least 80% identical to one or more of the polypeptides shown in SEQ ID NO's: 2 to 248, wherein the mutant host cell secretes at least 5% less of the one or more secreted polypeptide(s) than the parent host cell, when they are cultivated under comparable conditions.
摘要翻译： 衍生自亲本地衣芽孢杆菌宿主细胞的地衣芽孢杆菌突变宿主细胞，所述突变宿主细胞在编码一种或多种分泌多肽的一个或多个基因中突变，所述多个基因与一种或多种至少80％相同 的SEQ ID NO：2至248所示的多肽，其中当它们在可比较的条件下培养时，突变宿主细胞分泌比亲本宿主细胞少至少5％的一种或多种分泌的多肽。
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公开(公告)号：US20090203074A1
公开(公告)日：2009-08-13
申请号：US12417420
申请日：2009-04-02
申请人： Jens Tonne Andersen , Steen Troels Jorgensen , Michael Dolbjerg Rasmussen , Peter Bjarke Olsen , Ib Groth Clausen
发明人： Jens Tonne Andersen , Steen Troels Jorgensen , Michael Dolbjerg Rasmussen , Peter Bjarke Olsen , Ib Groth Clausen
摘要： A Bacillus licheniformis mutant host cell derived from a parent B. licheniformis host cell, which mutant host cell is mutated in one or more gene(s) encoding one or more secreted polypeptide(s) which is at least 80% identical to one or more of the polypeptides shown in SEQ ID NO's: 2 to 248, wherein the mutant host cell secretes at least 5% less of the one or more secreted polypeptide(s) than the parent host cell, when they are cultivated under comparable conditions.
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公开(公告)号：US20090176290A1
公开(公告)日：2009-07-09
申请号：US12398803
申请日：2009-03-05
申请人： Jens Tonne Andersen , Steen Troels Jorgensen , Michael Dolbjerg Rasmussen , Peter Bjarke Olsen , Ib Groth Clausen
发明人： Jens Tonne Andersen , Steen Troels Jorgensen , Michael Dolbjerg Rasmussen , Peter Bjarke Olsen , Ib Groth Clausen
摘要： A Bacillus licheniformis mutant host cell derived from a parent B. licheniformis host cell, which mutant host cell is mutated in one or more gene(s) encoding one or more secreted polypeptide(s) which is at least 80% identical to one or more of the polypeptides shown in SEQ ID NO's: 2 to 248, wherein the mutant host cell secretes at least 5% less of the one or more secreted polypeptide(s) than the parent host cell, when they are cultivated under comparable conditions.
摘要翻译： 衍生自亲本地衣芽孢杆菌宿主细胞的地衣芽孢杆菌突变宿主细胞，所述突变宿主细胞在编码一种或多种分泌多肽的一个或多个基因中突变，所述多个基因与一种或多种至少80％相同 的SEQ ID NO：2至248所示的多肽，其中当它们在可比较的条件下培养时，突变宿主细胞分泌比亲本宿主细胞少至少5％的一种或多种分泌的多肽。
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公开(公告)号：US07521204B2
公开(公告)日：2009-04-21
申请号：US10510386
申请日：2003-03-25
申请人： Jens Tonne Andersen , Steen Troels Jorgensen , Michael Dolbjerg Rasmussen , Peter Bjarke Olsen , Ib Groth Clausen
发明人： Jens Tonne Andersen , Steen Troels Jorgensen , Michael Dolbjerg Rasmussen , Peter Bjarke Olsen , Ib Groth Clausen
摘要： A Bacillus licheniformis mutant host cell derived from a parent B. licheniformis host cell, which mutant host cell is mutated in one or more gene(s) encoding one or more secreted polypeptide(s) which is at least 80% identical to one or more of the polypeptides shown in SEQ ID NO's: 2 to 248, wherein the mutant host cell secretes at least 5% less of the one or more secreted polypeptide(s) than the parent host cell, when they are cultivated under comparable conditions.
摘要翻译： 衍生自亲本地衣芽孢杆菌宿主细胞的地衣芽孢杆菌突变宿主细胞，所述突变宿主细胞在编码一种或多种分泌多肽的一个或多个基因中突变，所述多个基因与一种或多种至少80％相同 的SEQ ID NO：2至248所示的多肽，其中当它们在可比较的条件下培养时，突变宿主细胞分泌比亲本宿主细胞少至少5％的一种或多种分泌的多肽。
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7.发明授权Polypeptides having succinyl-CoA: acetoacetate transferase activity and polynucleotides encoding same 有权具有琥珀酰-CoA：乙酰乙酸转移酶活性的多肽和编码该多肽的多核苷酸公开(公告)号：US08728804B2
公开(公告)日：2014-05-20
申请号：US13882343
申请日：2011-10-28
申请人： Bjarke Christensen , Peter Bjarke Olsen , Torsten Bak Regueira , Steen Troels Joergensen , Alan Berry
发明人： Bjarke Christensen , Peter Bjarke Olsen , Torsten Bak Regueira , Steen Troels Joergensen , Alan Berry
CPC分类号： C12N9/13 , C12Y208/03005
摘要： The present invention relates to isolated protein complexes having succinyl-CoA:acetoacetate transferase activity, isolated polypeptide subunits thereof, and isolated polynucleotides encoding the subunits. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides and protein complexes.
摘要翻译： 本发明涉及具有琥珀酰-CoA：乙酰乙酸转移酶活性的分离的蛋白复合物，其分离的多肽亚基，以及编码亚基的分离的多核苷酸。 本发明还涉及包含多核苷酸的核酸构建体，载体和宿主细胞以及产生和使用多肽和蛋白质复合物的方法。
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公开(公告)号：US20080050774A1
公开(公告)日：2008-02-28
申请号：US10983128
申请日：2004-11-05
申请人： Randy Berka , Michael Rey , Preethi Ramaiya , Jens Tonne Andersen , Michael Dolberg Rasmussen , Peter Bjarke Olsen
发明人： Randy Berka , Michael Rey , Preethi Ramaiya , Jens Tonne Andersen , Michael Dolberg Rasmussen , Peter Bjarke Olsen
IPC分类号： C12P21/04 , C07H21/04 , C12N1/08 , C12N15/00 , C40B30/04 , C40B40/08 , C12N15/11 , C12N15/87 , C12N9/00
摘要： The present invention relates to an isolated polynucleotide of the complete chromosome of Bacillus licheniformis. The present invention also relates to isolated genes of the chromosome of Bacillus licheniformis which encode biologically active substances and to nucleic acid constructs, vectors, and host cells comprising the genes as well as methods for producing biologically active substances encoded by the genes and to methods of using the isolated genes of the complete chromosome of Bacillus licheniformis.
摘要翻译： 本发明涉及地衣芽孢杆菌的完整染色体的分离的多核苷酸。 本发明还涉及编码生物活性物质的地衣芽孢杆菌染色体和包含该基因的核酸构建体，载体和宿主细胞的分离基因以及用于产生由该基因编码的生物活性物质的方法和 使用地衣芽孢杆菌完整染色体的分离基因。
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9.发明申请Polypeptides Having Succinyl-CoA: Acetoacetate Transferase Activity and Polynucleotides Encoding Same 有权具有琥珀酰辅酶A的多肽：乙酰乙酸转移酶活性和编码相同的多核苷酸公开(公告)号：US20130295644A1
公开(公告)日：2013-11-07
申请号：US13882343
申请日：2011-10-28
申请人： Bjarke Christensen , Peter Bjarke Olsen , Torsten Bak Regueira , Steen Troels Joergensen , Alan Berry
发明人： Bjarke Christensen , Peter Bjarke Olsen , Torsten Bak Regueira , Steen Troels Joergensen , Alan Berry
IPC分类号： C12N9/10
CPC分类号： C12N9/13 , C12Y208/03005
摘要： The present invention relates to isolated protein complexes having succinyl-CoA:acetoacetate transferase activity, isolated polypeptide subunits thereof, and isolated polynucleotides encoding the subunits. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides and protein complexes.
摘要翻译： 本发明涉及具有琥珀酰-CoA：乙酰乙酸转移酶活性的分离的蛋白复合物，其分离的多肽亚基，以及编码亚基的分离的多核苷酸。 本发明还涉及包含多核苷酸的核酸构建体，载体和宿主细胞以及产生和使用多肽和蛋白质复合物的方法。
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公开(公告)号：US07494798B2
公开(公告)日：2009-02-24
申请号：US10983128
申请日：2004-11-05
申请人： Randy Berka , Michael Rey , Preethi Ramaiya , Jens Tønne Andersen , Michael Dolberg Rasmussen , Peter Bjarke Olsen
发明人： Randy Berka , Michael Rey , Preethi Ramaiya , Jens Tønne Andersen , Michael Dolberg Rasmussen , Peter Bjarke Olsen
摘要： The present invention relates to an isolated polynucleotide of the complete chromosome of Bacillus licheniformis. The present invention also relates to isolated genes of the chromosome of Bacillus licheniformis which encode biologically active substances and to nucleic acid constructs, vectors, and host cells comprising the genes as well as methods for producing biologically active substances encoded by the genes and to methods of using the isolated genes of the complete chromosome of Bacillus licheniformis.
摘要翻译： 本发明涉及地衣芽孢杆菌的完整染色体的分离的多核苷酸。 本发明还涉及编码生物活性物质的地衣芽孢杆菌染色体和包含该基因的核酸构建体，载体和宿主细胞的分离基因以及用于产生由该基因编码的生物活性物质的方法和 使用地衣芽孢杆菌完整染色体的分离基因。
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