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    Variable Valve Apparatus and Methods
    3.
    发明申请
    Variable Valve Apparatus and Methods 审中-公开
    可变阀装置及方法

    公开(公告)号：US20070148687A1

    公开(公告)日：2007-06-28

    申请号：US11684656

    申请日：2007-03-12

    申请人： William Bedingham ,  Barry Robole ,  Ranjani Parthasarathy ,  Katya Ericson

    发明人： William Bedingham ,  Barry Robole ,  Ranjani Parthasarathy ,  Katya Ericson

    IPC分类号： C12Q1/68 ,  C12P19/34

    CPC分类号： B01L3/502738 ,  B01L2300/0806 ,  B01L2400/0409 ,  B01L2400/0677

    摘要： Sample processing devices with variable valve structures and methods of using the same are disclosed. The valve structures allow for removal of selected portions of the sample material located within the process chamber. Removal of the selected portions is achieved by forming an opening in a valve septum at a desired location. The valve septums may be large enough to allow for adjustment of the location of the opening based on the characteristics of the sample material in the process chamber. If the sample processing device is rotated after the opening is formed, the selected portion of the material located closer to the axis of rotation exits the process chamber through the opening. The remainder of the sample material cannot exit through the opening because it is located farther from the axis of rotation than the opening.

    摘要翻译： 公开了具有可变阀结构的样品处理装置及其使用方法。 阀结构允许去除位于处理室内的样品材料的选定部分。 通过在期望的位置处在阀隔膜中形成开口来实现所选部分的移除。 阀隔件可以足够大以允许基于处理室中的样品材料的特性来调节开口的位置。 如果样品处理装置在形成开口后旋转，则位于更靠近旋转轴线的材料的选定部分通过开口离开处理室。 样品材料的其余部分不能通过开口离开，因为它比开口更远离旋转轴线。

    Variable valve apparatus and methods
    5.
    发明申请
    Variable valve apparatus and methods 审中-公开
    可变阀装置及方法

    公开(公告)号：US20050130177A1

    公开(公告)日：2005-06-16

    申请号：US10852642

    申请日：2004-05-24

    申请人： William Bedingham ,  Barry Robole ,  Ranjani Parthasarathy ,  Katya Ericson

    发明人： William Bedingham ,  Barry Robole ,  Ranjani Parthasarathy ,  Katya Ericson

    IPC分类号： B01L3/00 ,  C12M1/34 ,  C12N15/10 ,  C12Q1/68 ,  G01N30/00

    CPC分类号： B01L3/502738 ,  B01L2300/0806 ,  B01L2400/0409 ,  B01L2400/0677

    摘要： Sample processing devices with variable valve structures and methods of using the same are disclosed. The valve structures allow for removal of selected portions of the sample material located within the process chamber. Removal of the selected portions is achieved by forming an opening in a valve septum at a desired location. The valve septums may be large enough to allow for adjustment of the location of the opening based on the characteristics of the sample material in the process chamber. If the sample processing device is rotated after the opening is formed, the selected portion of the material located closer to the axis of rotation exits the process chamber through the opening. The remainder of the sample material cannot exit through the opening because it is located farther from the axis of rotation than the opening.

    摘要翻译： 公开了具有可变阀结构的样品处理装置及其使用方法。 阀结构允许去除位于处理室内的样品材料的选定部分。 通过在期望的位置处在阀隔膜中形成开口来实现所选部分的移除。 阀隔件可以足够大以允许基于处理室中的样品材料的特性来调节开口的位置。 如果样品处理装置在形成开口后旋转，则位于更靠近旋转轴线的材料的选定部分通过开口离开处理室。 样品材料的其余部分不能通过开口离开，因为它比开口更远离旋转轴线。

    Liposomal aerosols for delivery of chemotherapeutic retinoids to the lungs
    9.
    发明授权
    Liposomal aerosols for delivery of chemotherapeutic retinoids to the lungs 失效
    用于将化学治疗性类维生素A递送至肺的脂质体气溶胶

    公开(公告)号：US06334999B1

    公开(公告)日：2002-01-01

    申请号：US09385104

    申请日：1999-08-27

    申请人： Brian E. Gilbert ,  Ranjani Parthasarathy ,  Kapil Mehta

    发明人： Brian E. Gilbert ,  Ranjani Parthasarathy ,  Kapil Mehta

    IPC分类号： A61K912

    CPC分类号： A61K9/0078 ,  A61K9/127 ,  Y10S977/907 ,  Y10S977/926

    摘要： To optimize the delivery of all-trans retinoic acid to lung tissue, the potential of vehiculating this drug in liposomes and delivering it via aerosol was determined. Liposomes provide a means to prevent local irritation of lung tissue, reduce pulmonary toxicity, prolong therapeutic levels, and generate high drug concentrations at the tumor sites. Therefore, the delivery of ATRA to the lung tissue in mice was accomplished by nebulization of L-ATRA. The liposomes in the aerosol were uniform, stable, and retained the drug well. The drug was effectively delivered at high concentrations to the lungs of mice and was retained at least up to 96 h after a single exposure to L-ATRA aerosols. The aerosol-delivered ATRA was biologically active as demonstrated by its ability to induce the expression of tissue-type transglutaminase. Aerosol delivery of L-ATRA offers an effective way to deliver high levels of ATRA to the lung without apparent pulmonary toxic effects.

    摘要翻译： 为了优化全反式视黄酸向肺组织的递送，确定了将该药物在脂质体中载药并通过气溶胶递送的潜力。 脂质体提供了一种手段来防止肺组织的局部刺激，降低肺毒性，延长治疗水平，并在肿瘤部位产生高药物浓度。 因此，通过L-ATRA的雾化来实现ATRA向小鼠肺组织的输送。 气溶胶中的脂质体均匀，稳定，并保持良好的药物。 药物以高浓度有效递送到小鼠的肺部，并且在单次暴露于L-ATRA气溶胶后至少保持96小时。 气溶胶递送的ATRA具有生物活性，如通过其诱导组织型转谷氨酰胺酶的表达的能力所证明的。 L-ATRA的气溶胶递送提供了一种有效的方法，可以向肺部提供高水平的ATRA，而无明显的肺部毒性作用。