公开(公告)号：US20070160504A1

公开(公告)日：2007-07-12

申请号：US11709373

申请日：2007-02-22

申请人： Ranjani Parthasarathy ,  Raj Rajagopal ,  Erin Olson ,  Frank Beissel ,  William Bedingham ,  Barry Robole

发明人： Ranjani Parthasarathy ,  Raj Rajagopal ,  Erin Olson ,  Frank Beissel ,  William Bedingham ,  Barry Robole

IPC分类号： B01L3/00

CPC分类号： C12N15/101 ,  B01F11/0002 ,  B01F13/0059 ,  B01F15/0201 ,  B01F15/0233 ,  B01J41/05 ,  B01J47/016 ,  B01L3/502753 ,  B01L2300/0806 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2400/0409 ,  B01L2400/0677 ,  B01L2400/0683 ,  Y10T436/25 ,  Y10T436/25125 ,  Y10T436/25375 ,  Y10T436/255 ,  Y10T436/2575

摘要： Methods and devices for removing small negatively charged molecules from a biological sample mixture that uses an anion exchange material that has associated therewith a polyoxyalkylene.

摘要翻译： 用于从使用具有与其相关联的阴离子交换材料的生物样品混合物中去除小的带负电荷的分子的方法和装置。

公开(公告)号：US20060013732A1

公开(公告)日：2006-01-19

申请号：US11226161

申请日：2005-09-14

申请人： Ranjani Parthasarathy ,  Raj Rajagopal ,  Erin Olson ,  Frank Beissel ,  William Bedingham ,  Barry Robole

发明人： Ranjani Parthasarathy ,  Raj Rajagopal ,  Erin Olson ,  Frank Beissel ,  William Bedingham ,  Barry Robole

IPC分类号： G01N1/10

CPC分类号： C12N15/101 ,  B01F11/0002 ,  B01F13/0059 ,  B01F15/0201 ,  B01F15/0233 ,  B01J41/05 ,  B01J47/016 ,  B01L3/502753 ,  B01L2300/0806 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2400/0409 ,  B01L2400/0677 ,  B01L2400/0683 ,  Y10T436/25 ,  Y10T436/25125 ,  Y10T436/25375 ,  Y10T436/255 ,  Y10T436/2575

摘要： Methods and devices for removing small negatively charged molecules from a biological sample mixture that uses an anion exchange material.

公开(公告)号：US20080103297A1

公开(公告)日：2008-05-01

申请号：US11937567

申请日：2007-11-09

申请人： Ranjani Parthasarathy ,  Raj Rajagopal ,  Vicky Morris ,  William Bedingham ,  Barry Robole

发明人： Ranjani Parthasarathy ,  Raj Rajagopal ,  Vicky Morris ,  William Bedingham ,  Barry Robole

IPC分类号： C07H21/00 ,  B01J19/00 ,  B32B5/16

CPC分类号： C12N15/1006 ,  Y10T428/25 ,  Y10T436/25 ,  Y10T436/25125 ,  Y10T436/25375 ,  Y10T436/255

摘要： Methods and devices for removing small negatively charged molecules from a biological sample mixture that uses a solid-phase extraction material that includes a hydrophilic solid support at least partially embedded within a hydrophobic matrix.

摘要翻译： 用于从使用固相萃取材料的生物样品混合物中去除小负电荷分子的方法和装置，所述固相萃取材料包括至少部分嵌入疏水基质内的亲水性固体支持物。

公开(公告)号：US20070148687A1

公开(公告)日：2007-06-28

申请号：US11684656

申请日：2007-03-12

申请人： William Bedingham ,  Barry Robole ,  Ranjani Parthasarathy ,  Katya Ericson

发明人： William Bedingham ,  Barry Robole ,  Ranjani Parthasarathy ,  Katya Ericson

IPC分类号： C12Q1/68 ,  C12P19/34

CPC分类号： B01L3/502738 ,  B01L2300/0806 ,  B01L2400/0409 ,  B01L2400/0677

摘要： Sample processing devices with variable valve structures and methods of using the same are disclosed. The valve structures allow for removal of selected portions of the sample material located within the process chamber. Removal of the selected portions is achieved by forming an opening in a valve septum at a desired location. The valve septums may be large enough to allow for adjustment of the location of the opening based on the characteristics of the sample material in the process chamber. If the sample processing device is rotated after the opening is formed, the selected portion of the material located closer to the axis of rotation exits the process chamber through the opening. The remainder of the sample material cannot exit through the opening because it is located farther from the axis of rotation than the opening.

摘要翻译： 公开了具有可变阀结构的样品处理装置及其使用方法。 阀结构允许去除位于处理室内的样品材料的选定部分。 通过在期望的位置处在阀隔膜中形成开口来实现所选部分的移除。 阀隔件可以足够大以允许基于处理室中的样品材料的特性来调节开口的位置。 如果样品处理装置在形成开口后旋转，则位于更靠近旋转轴线的材料的选定部分通过开口离开处理室。 样品材料的其余部分不能通过开口离开，因为它比开口更远离旋转轴线。

公开(公告)号：US20050130177A1

公开(公告)日：2005-06-16

申请号：US10852642

申请日：2004-05-24

申请人： William Bedingham ,  Barry Robole ,  Ranjani Parthasarathy ,  Katya Ericson

发明人： William Bedingham ,  Barry Robole ,  Ranjani Parthasarathy ,  Katya Ericson

IPC分类号： B01L3/00 ,  C12M1/34 ,  C12N15/10 ,  C12Q1/68 ,  G01N30/00

CPC分类号： B01L3/502738 ,  B01L2300/0806 ,  B01L2400/0409 ,  B01L2400/0677

摘要： Sample processing devices with variable valve structures and methods of using the same are disclosed. The valve structures allow for removal of selected portions of the sample material located within the process chamber. Removal of the selected portions is achieved by forming an opening in a valve septum at a desired location. The valve septums may be large enough to allow for adjustment of the location of the opening based on the characteristics of the sample material in the process chamber. If the sample processing device is rotated after the opening is formed, the selected portion of the material located closer to the axis of rotation exits the process chamber through the opening. The remainder of the sample material cannot exit through the opening because it is located farther from the axis of rotation than the opening.

摘要翻译： 公开了具有可变阀结构的样品处理装置及其使用方法。 阀结构允许去除位于处理室内的样品材料的选定部分。 通过在期望的位置处在阀隔膜中形成开口来实现所选部分的移除。 阀隔件可以足够大以允许基于处理室中的样品材料的特性来调节开口的位置。 如果样品处理装置在形成开口后旋转，则位于更靠近旋转轴线的材料的选定部分通过开口离开处理室。 样品材料的其余部分不能通过开口离开，因为它比开口更远离旋转轴线。

公开(公告)号：US20070114229A1

公开(公告)日：2007-05-24

申请号：US11622643

申请日：2007-01-12

申请人： William Bedingham ,  Raj Rajagopal ,  Barry Robole ,  Kannan Seshadri

发明人： William Bedingham ,  Raj Rajagopal ,  Barry Robole ,  Kannan Seshadri

IPC分类号： H05B6/78

CPC分类号： G01N35/00069 ,  B01L3/5025 ,  B01L3/5027 ,  B01L3/50273 ,  B01L3/502738 ,  B01L7/52 ,  B01L2200/027 ,  B01L2300/0681 ,  B01L2300/0806 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2300/1822 ,  B01L2300/1861 ,  B01L2400/0409 ,  B01L2400/0661 ,  B01L2400/0677 ,  B03C1/30 ,  F27B9/16 ,  F27D5/00 ,  G01N35/0098 ,  H05B6/80 ,  Y10T436/2575

摘要： Devices, systems, and methods for processing sample materials. The sample materials may be located in a plurality of process chambers in the device, which is rotated during heating of the sample materials.

摘要翻译： 用于处理样品的设备，系统和方法。 样品材料可以位于装置中的多个处理室中，其在样品材料的加热期间旋转。

公开(公告)号：US20050242091A1

公开(公告)日：2005-11-03

申请号：US10840766

申请日：2004-05-06

申请人： William Bedingham ,  Raj Rajagopal ,  Barry Robole ,  Kannan Seshadri

发明人： William Bedingham ,  Raj Rajagopal ,  Barry Robole ,  Kannan Seshadri

IPC分类号： B01L3/00 ,  B01L7/00 ,  F27B9/16 ,  F27D5/00 ,  G01N35/00 ,  H05B6/78

CPC分类号： G01N35/00069 ,  B01L3/5025 ,  B01L3/5027 ,  B01L3/50273 ,  B01L3/502738 ,  B01L7/52 ,  B01L2200/027 ,  B01L2300/0681 ,  B01L2300/0806 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2300/1822 ,  B01L2300/1861 ,  B01L2400/0409 ,  B01L2400/0661 ,  B01L2400/0677 ,  B03C1/30 ,  F27B9/16 ,  F27D5/00 ,  G01N35/0098 ,  H05B6/80 ,  Y10T436/2575

摘要： Devices, systems, and methods for processing sample materials. The sample materials may be located in a plurality of process chambers in the device, which is rotated during heating of the sample materials.

摘要翻译： 用于处理样品的设备，系统和方法。 样品材料可以位于装置中的多个处理室中，其在样品材料的加热期间旋转。

公开(公告)号：US20070010007A1

公开(公告)日：2007-01-11

申请号：US11174757

申请日：2005-07-05

申请人： James Aysta ,  William Bedingham ,  Barry Robole

发明人： James Aysta ,  William Bedingham ,  Barry Robole

IPC分类号： C12M1/34

CPC分类号： B01L9/52 ,  B01L3/50851 ,  B01L3/50853 ,  B01L7/52 ,  B01L2200/0689 ,  B01L2300/041 ,  B01L2300/0803 ,  B01L2300/1805 ,  B01L2300/1861 ,  G01N35/025 ,  G01N2035/00366 ,  Y10S435/809

摘要： Sample processing systems and methods of using those systems for processing sample materials located in sample processing devices are disclosed. The sample processing systems include a rotating base plate on which the sample processing devices are located during operation of the systems. The systems also include a cover and compression structure designed to force a sample processing device towards the base plate. The preferred result is that the sample processing device is forced into contact with a thermal structure on the base plate. The systems and methods of the present invention may include one or more of the following features to enhance thermal coupling between the thermal structure and the sample processing device: a shaped transfer surface, magnetic compression structure, and floating or resiliently mounted thermal structure. The methods may preferably involve deformation of a portion of a sample processing device to conform to a shaped transfer surface.

摘要翻译： 公开了使用这些系统来处理位于样品处理装置中的样品材料的样品处理系统和方法。 样品处理系统包括在系统操作期间样品处理装置位于其上的旋转底板。 该系统还包括设计成迫使样品处理装置朝向底板的盖和压缩结构。 优选的结果是，样品处理装置被迫与基板上的热结构接触。 本发明的系统和方法可以包括以下特征中的一个或多个，以增强热结构和样品处理装置之间的热耦合：成形转印表面，磁性压缩结构以及浮动或弹性安装的热结构。 该方法可以优选地包括样品处理装置的一部分的变形以符合成形的转印表面。

公开(公告)号：US20050031494A1

公开(公告)日：2005-02-10

申请号：US10929044

申请日：2004-08-27

申请人： Michael Harms ,  William Bedingham ,  Christopher Kokaisel ,  Barry Robole ,  Kenneth Wood

发明人： Michael Harms ,  William Bedingham ,  Christopher Kokaisel ,  Barry Robole ,  Kenneth Wood

IPC分类号： G01N1/00 ,  B01J19/00 ,  B01L3/00 ,  B01L7/00 ,  B01L9/00 ,  B81B1/00 ,  C12M1/00 ,  F27B9/16 ,  F27D5/00 ,  G01N1/28 ,  G01N35/00 ,  G01N37/00

CPC分类号： G01N35/00069 ,  B01L3/5025 ,  B01L3/50255 ,  B01L3/502707 ,  B01L3/502738 ,  B01L7/52 ,  B01L7/525 ,  B01L9/527 ,  B01L2200/0642 ,  B01L2200/0689 ,  B01L2200/142 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0887 ,  B01L2400/0406 ,  B01L2400/0409 ,  B01L2400/0481 ,  B01L2400/0655 ,  B01L2400/0661 ,  F27B9/16 ,  F27D5/00 ,  Y10T436/25 ,  Y10T436/2575

摘要： Methods and devices for thermal processing of multiple samples at the same time are disclosed. The assemblies include carriers and sample processing devices with process arrays that include conduits useful in distributing sample materials to a group pf process chambers located in fluid communication with the main conduits. The sample processing devices may include one or more of the following features in various combinations: deformable seals, process chambers connected to the main conduit by feeder conduits exiting the main conduit at offset locations, U-shaped loading chambers, and a combination of melt bonded and adhesively bonded areas. The carriers may be used to apply selective compression to the sample processing devices.

摘要翻译： 同时公开了多个样品的热处理方法和装置。 组件包括具有过程阵列的载体和样品处理装置，其包括可用于将样品材料分配到与主管道流体连通的组pf处理室的导管。 样品处理装置可以包括以下各种组合中的一个或多个以下特征：可变形密封件，通过在偏移位置处离开主管道的进料管道连接到主管道的处理室，U形加载室和熔融粘合的组合 和粘合区域。 载体可以用于对样品处理装置施加选择性压缩。

公开(公告)号：US20080050276A1

公开(公告)日：2008-02-28

申请号：US11930628

申请日：2007-10-31

申请人： William Bedingham ,  Barry Robole

发明人： William Bedingham ,  Barry Robole

IPC分类号： G01N37/00

CPC分类号： G01N35/025

摘要： Modular sample processing apparatus kits that can provide a user with the flexibility to customize a disk-based assay in view of a variety of factors are disclosed. The sample processing apparatus kits of the present invention include one or more process modules that can be retained within openings in a frame. The frame and process modules of the sample processing apparatus kits are preferably adapted for use in sample processing systems that compress the apparatus. The process modules may contain different reagents to perform different tests on the same sample materials or a variety of sample materials. As a result, a single sample processing apparatus can be used to perform a variety of different tests and may include a quality control module capable of providing feedback to the user as to the accuracy of the processes run using the sample processing apparatus. Methods of using the sample processing apparatus that include deforming the process modules and frame are also disclosed.

摘要翻译： 公开了可以根据各种因素为用户提供定制基于磁盘的测定的灵活性的模块化样品处理装置套件。 本发明的样品处理装置试剂盒包括可以保持在框架中的开口内的一个或多个处理模块。 样品处理装置套件的框架和处理模块优选地适用于压缩装置的样品处理系统。 过程模块可以包含不同的试剂以对相同的样品材料或各种样品材料进行不同的测试。 结果，可以使用单个样本处理装置来执行各种不同的测试，并且可以包括质量控制模块，其能够向用户提供关于使用样本处理装置运行的处理的准确性的反馈。 还公开了使用包括使处理模块和框架变形的样品处理装置的方法。