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公开(公告)号：US20070148687A1
公开(公告)日：2007-06-28
申请号：US11684656
申请日：2007-03-12
CPC分类号： B01L3/502738 , B01L2300/0806 , B01L2400/0409 , B01L2400/0677
摘要： Sample processing devices with variable valve structures and methods of using the same are disclosed. The valve structures allow for removal of selected portions of the sample material located within the process chamber. Removal of the selected portions is achieved by forming an opening in a valve septum at a desired location. The valve septums may be large enough to allow for adjustment of the location of the opening based on the characteristics of the sample material in the process chamber. If the sample processing device is rotated after the opening is formed, the selected portion of the material located closer to the axis of rotation exits the process chamber through the opening. The remainder of the sample material cannot exit through the opening because it is located farther from the axis of rotation than the opening.
摘要翻译： 公开了具有可变阀结构的样品处理装置及其使用方法。 阀结构允许去除位于处理室内的样品材料的选定部分。 通过在期望的位置处在阀隔膜中形成开口来实现所选部分的移除。 阀隔件可以足够大以允许基于处理室中的样品材料的特性来调节开口的位置。 如果样品处理装置在形成开口后旋转，则位于更靠近旋转轴线的材料的选定部分通过开口离开处理室。 样品材料的其余部分不能通过开口离开，因为它比开口更远离旋转轴线。
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公开(公告)号：US20050130177A1
公开(公告)日：2005-06-16
申请号：US10852642
申请日：2004-05-24
CPC分类号： B01L3/502738 , B01L2300/0806 , B01L2400/0409 , B01L2400/0677
摘要： Sample processing devices with variable valve structures and methods of using the same are disclosed. The valve structures allow for removal of selected portions of the sample material located within the process chamber. Removal of the selected portions is achieved by forming an opening in a valve septum at a desired location. The valve septums may be large enough to allow for adjustment of the location of the opening based on the characteristics of the sample material in the process chamber. If the sample processing device is rotated after the opening is formed, the selected portion of the material located closer to the axis of rotation exits the process chamber through the opening. The remainder of the sample material cannot exit through the opening because it is located farther from the axis of rotation than the opening.
摘要翻译： 公开了具有可变阀结构的样品处理装置及其使用方法。 阀结构允许去除位于处理室内的样品材料的选定部分。 通过在期望的位置处在阀隔膜中形成开口来实现所选部分的移除。 阀隔件可以足够大以允许基于处理室中的样品材料的特性来调节开口的位置。 如果样品处理装置在形成开口后旋转，则位于更靠近旋转轴线的材料的选定部分通过开口离开处理室。 样品材料的其余部分不能通过开口离开，因为它比开口更远离旋转轴线。
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3.发明申请公开(公告)号：US20050142571A1
公开(公告)日：2005-06-30
申请号：US10852645
申请日：2004-05-24
CPC分类号： C12N15/10
摘要： The present invention provides methods and kits for isolating nucleic acid from a sample, preferably from a biological sample, using solid phase material.
摘要翻译： 本发明提供了使用固相材料从样品中分离核酸，优选从生物样品中分离核酸的方法和试剂盒。
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4.发明申请Methods for nucleic acid isolation and kits using a microfluidic device and sedimenting reagent 审中-公开使用微流体装置和沉淀试剂进行核酸分离的方法和试剂盒公开(公告)号：US20050142570A1
公开(公告)日：2005-06-30
申请号：US10852022
申请日：2004-05-24
CPC分类号： B01L3/502738 , B01L3/502753 , B01L2200/0605 , B01L2200/10 , B01L2300/0803 , B01L2400/0409 , B01L2400/0677 , C07H21/04 , C12Q1/6806 , C12Q2565/629
摘要： The present invention provides methods and kits for isolating nucleic acid from a sample, preferably from a biological sample, using a microfluidic device and sedimenting reagent.
摘要翻译： 本发明提供了使用微流体装置和沉降试剂从样品中分离核酸，优选来自生物样品的方法和试剂盒。
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5.发明申请Methods for nucleic acid isolation and kits using a microfluidic device and concentration step 有权核酸分离方法和使用微流控装置和浓缩步骤的试剂盒公开(公告)号：US20050142663A1
公开(公告)日：2005-06-30
申请号：US10852085
申请日：2004-05-24
CPC分类号： C12N15/10 , Y10T436/25
摘要： The present invention provides methods and kits for isolating nucleic acid from a sample, preferably from a biological sample, using a microfluidic device and a concentration step.
摘要翻译： 本发明提供了使用微流体装置和浓缩步骤从样品，优选来自生物样品中分离核酸的方法和试剂盒。
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6.发明申请Methods and devices for removal of organic molecules from biological mixtures using anion exchange 审中-公开使用阴离子交换从生物混合物中除去有机分子的方法和装置公开(公告)号：US20070160504A1
公开(公告)日：2007-07-12
申请号：US11709373
申请日：2007-02-22
申请人： Ranjani Parthasarathy , Raj Rajagopal , Erin Olson , Frank Beissel , William Bedingham , Barry Robole
发明人： Ranjani Parthasarathy , Raj Rajagopal , Erin Olson , Frank Beissel , William Bedingham , Barry Robole
IPC分类号： B01L3/00
CPC分类号： C12N15/101 , B01F11/0002 , B01F13/0059 , B01F15/0201 , B01F15/0233 , B01J41/05 , B01J47/016 , B01L3/502753 , B01L2300/0806 , B01L2300/0864 , B01L2300/087 , B01L2400/0409 , B01L2400/0677 , B01L2400/0683 , Y10T436/25 , Y10T436/25125 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： Methods and devices for removing small negatively charged molecules from a biological sample mixture that uses an anion exchange material that has associated therewith a polyoxyalkylene.
摘要翻译： 用于从使用具有与其相关联的阴离子交换材料的生物样品混合物中去除小的带负电荷的分子的方法和装置。
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7.发明申请公开(公告)号：US20060013732A1
公开(公告)日：2006-01-19
申请号：US11226161
申请日：2005-09-14
申请人： Ranjani Parthasarathy , Raj Rajagopal , Erin Olson , Frank Beissel , William Bedingham , Barry Robole
发明人： Ranjani Parthasarathy , Raj Rajagopal , Erin Olson , Frank Beissel , William Bedingham , Barry Robole
IPC分类号： G01N1/10
CPC分类号： C12N15/101 , B01F11/0002 , B01F13/0059 , B01F15/0201 , B01F15/0233 , B01J41/05 , B01J47/016 , B01L3/502753 , B01L2300/0806 , B01L2300/0864 , B01L2300/087 , B01L2400/0409 , B01L2400/0677 , B01L2400/0683 , Y10T436/25 , Y10T436/25125 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： Methods and devices for removing small negatively charged molecules from a biological sample mixture that uses an anion exchange material.
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8.发明申请METHODS AND DEVICES FOR REMOVAL OF ORGANIC MOLECULES FROM BIOLOGICAL MIXTURES USING A HYDROPHILIC SOLID SUPPORT IN A HYDROPHOBIC MATRIX 审中-公开从生物混合物中移除有机分子的方法和设备使用HYDROPHILIC固体支持在疏水基质公开(公告)号：US20080103297A1
公开(公告)日：2008-05-01
申请号：US11937567
申请日：2007-11-09
CPC分类号： C12N15/1006 , Y10T428/25 , Y10T436/25 , Y10T436/25125 , Y10T436/25375 , Y10T436/255
摘要： Methods and devices for removing small negatively charged molecules from a biological sample mixture that uses a solid-phase extraction material that includes a hydrophilic solid support at least partially embedded within a hydrophobic matrix.
摘要翻译： 用于从使用固相萃取材料的生物样品混合物中去除小负电荷分子的方法和装置，所述固相萃取材料包括至少部分嵌入疏水基质内的亲水性固体支持物。
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9.发明授权Methods for nucleic acid isolation and kits using a microfluidic device and concentration step 有权核酸分离方法和使用微流控装置和浓缩步骤的试剂盒公开(公告)号：US07939249B2
公开(公告)日：2011-05-10
申请号：US10852085
申请日：2004-05-24
IPC分类号： C12Q1/68
CPC分类号： C12N15/10 , Y10T436/25
摘要： The present invention provides methods and kits for isolating nucleic acid from a sample, preferably from a biological sample, using a microfluidic device and a concentration step.
摘要翻译： 本发明提供了使用微流体装置和浓缩步骤从样品，优选来自生物样品中分离核酸的方法和试剂盒。
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公开(公告)号：US20100167304A1
公开(公告)日：2010-07-01
申请号：US12719704
申请日：2010-03-08
CPC分类号： B01L3/502738 , B01L2300/0806 , B01L2400/0409 , B01L2400/0677
摘要： Sample processing devices with variable valve structures and methods of using the same are disclosed. The valve structures allow for removal of selected portions of the sample material located within the process chamber. Removal of the selected portions is achieved by forming an opening in a valve septum at a desired location. The valve septums may be large enough to allow for adjustment of the location of the opening based on the characteristics of the sample material in the process chamber. If the sample processing device is rotated after the opening is formed, the selected portion of the material located closer to the axis of rotation exits the process chamber through the opening. The remainder of the sample material cannot exit through the opening because it is located farther from the axis of rotation than the opening.
摘要翻译： 公开了具有可变阀结构的样品处理装置及其使用方法。 阀结构允许去除位于处理室内的样品材料的选定部分。 通过在期望的位置处在阀隔膜中形成开口来实现所选部分的移除。 阀隔件可以足够大以允许基于处理室中的样品材料的特性来调节开口的位置。 如果样品处理装置在形成开口后旋转，则位于更靠近旋转轴线的材料的选定部分通过开口离开处理室。 样品材料的其余部分不能通过开口离开，因为它比开口更远离旋转轴线。
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